Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.
Identifieur interne : 002C27 ( PubMed/Corpus ); précédent : 002C26; suivant : 002C28Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.
Auteurs : Adrian R. Parry-Jones ; Mario Di Napoli ; Joshua N. Goldstein ; Floris H B M. Schreuder ; Sami Tetri ; Turgut Tatlisumak ; Bernard Yan ; Koen M. Van Nieuwenhuizen ; Nelly Dequatre-Ponchelle ; Matthew Lee-Archer ; Solveig Horstmann ; Duncan Wilson ; Fulvio Pomero ; Luca Masotti ; Christine Lerpiniere ; Daniel Agustin Godoy ; Abigail S. Cohen ; Rik Houben ; Rustam Al-Shahi Salman ; Paolo Pennati ; Luigi Fenoglio ; David Werring ; Roland Veltkamp ; Edith Wood ; Helen M. Dewey ; Charlotte Cordonnier ; Catharina J M. Klijn ; Fabrizio Meligeni ; Stephen M. Davis ; Juha Huhtakangas ; Julie Staals ; Jonathan Rosand ; Atte MeretojaSource :
- Annals of neurology [ 1531-8249 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Anticoagulants (adverse effects), Antifibrinolytic Agents (therapeutic use), Blood Coagulation Factors (therapeutic use), Cerebral Hemorrhage (chemically induced), Cerebral Hemorrhage (mortality), Cerebral Hemorrhage (therapy), Female, Humans, Male, Plasma, Proportional Hazards Models, Registries, Retrospective Studies, Treatment Outcome, Vitamin K (antagonists & inhibitors), Vitamin K (therapeutic use).
- MESH :
- chemical , adverse effects : Anticoagulants.
- chemical , antagonists & inhibitors : Vitamin K.
- chemical , therapeutic use : Antifibrinolytic Agents, Blood Coagulation Factors, Vitamin K.
- chemically induced : Cerebral Hemorrhage.
- mortality : Cerebral Hemorrhage.
- therapy : Cerebral Hemorrhage.
- Aged, Aged, 80 and over, Female, Humans, Male, Plasma, Proportional Hazards Models, Registries, Retrospective Studies, Treatment Outcome.
Abstract
There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies.
DOI: 10.1002/ana.24416
PubMed: 25857223
Links to Exploration step
pubmed:25857223Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.</title><author><name sortKey="Parry Jones, Adrian R" sort="Parry Jones, Adrian R" uniqKey="Parry Jones A" first="Adrian R" last="Parry-Jones">Adrian R. Parry-Jones</name><affiliation><nlm:affiliation>University of Manchester, Manchester Academic Health Sciences Centre, Salford Royal National Health Service Foundation Trust, Salford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Di Napoli, Mario" sort="Di Napoli, Mario" uniqKey="Di Napoli M" first="Mario" last="Di Napoli">Mario Di Napoli</name><affiliation><nlm:affiliation>Neurological Service, San Camillo de' Lellis General Hospital, Rieti, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Goldstein, Joshua N" sort="Goldstein, Joshua N" uniqKey="Goldstein J" first="Joshua N" last="Goldstein">Joshua N. Goldstein</name><affiliation><nlm:affiliation>Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Schreuder, Floris H B M" sort="Schreuder, Floris H B M" uniqKey="Schreuder F" first="Floris H B M" last="Schreuder">Floris H B M. Schreuder</name><affiliation><nlm:affiliation>Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Tetri, Sami" sort="Tetri, Sami" uniqKey="Tetri S" first="Sami" last="Tetri">Sami Tetri</name><affiliation><nlm:affiliation>Department of Neurology, Oulu University Hospital, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Tatlisumak, Turgut" sort="Tatlisumak, Turgut" uniqKey="Tatlisumak T" first="Turgut" last="Tatlisumak">Turgut Tatlisumak</name><affiliation><nlm:affiliation>Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Bernard" sort="Yan, Bernard" uniqKey="Yan B" first="Bernard" last="Yan">Bernard Yan</name><affiliation><nlm:affiliation>Department of Neurology, Royal Melbourne Hospital, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Nieuwenhuizen, Koen M" sort="Van Nieuwenhuizen, Koen M" uniqKey="Van Nieuwenhuizen K" first="Koen M" last="Van Nieuwenhuizen">Koen M. Van Nieuwenhuizen</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, Rudolf Magnus Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Dequatre Ponchelle, Nelly" sort="Dequatre Ponchelle, Nelly" uniqKey="Dequatre Ponchelle N" first="Nelly" last="Dequatre-Ponchelle">Nelly Dequatre-Ponchelle</name><affiliation><nlm:affiliation>Department of Neurology, University of Lille Nord de France (UDSL), Lille University Hospital Center, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lee Archer, Matthew" sort="Lee Archer, Matthew" uniqKey="Lee Archer M" first="Matthew" last="Lee-Archer">Matthew Lee-Archer</name><affiliation><nlm:affiliation>Department of Neurology, Austin Hospital, Heidelberg, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Horstmann, Solveig" sort="Horstmann, Solveig" uniqKey="Horstmann S" first="Solveig" last="Horstmann">Solveig Horstmann</name><affiliation><nlm:affiliation>Department of Neurology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, Duncan" sort="Wilson, Duncan" uniqKey="Wilson D" first="Duncan" last="Wilson">Duncan Wilson</name><affiliation><nlm:affiliation>University College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Pomero, Fulvio" sort="Pomero, Fulvio" uniqKey="Pomero F" first="Fulvio" last="Pomero">Fulvio Pomero</name><affiliation><nlm:affiliation>Department of Internal Medicine, Santa Croce e Carle Hospital, Cuneo, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Masotti, Luca" sort="Masotti, Luca" uniqKey="Masotti L" first="Luca" last="Masotti">Luca Masotti</name><affiliation><nlm:affiliation>Internal Medicine, Cecina Hospital, Cecina, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Lerpiniere, Christine" sort="Lerpiniere, Christine" uniqKey="Lerpiniere C" first="Christine" last="Lerpiniere">Christine Lerpiniere</name><affiliation><nlm:affiliation>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Godoy, Daniel Agustin" sort="Godoy, Daniel Agustin" uniqKey="Godoy D" first="Daniel Agustin" last="Godoy">Daniel Agustin Godoy</name><affiliation><nlm:affiliation>Neurointensive Care Unit, Pasteur Sanatorium, Catamarca, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Cohen, Abigail S" sort="Cohen, Abigail S" uniqKey="Cohen A" first="Abigail S" last="Cohen">Abigail S. Cohen</name><affiliation><nlm:affiliation>Department of Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Houben, Rik" sort="Houben, Rik" uniqKey="Houben R" first="Rik" last="Houben">Rik Houben</name><affiliation><nlm:affiliation>Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Al Shahi Salman, Rustam" sort="Al Shahi Salman, Rustam" uniqKey="Al Shahi Salman R" first="Rustam" last="Al-Shahi Salman">Rustam Al-Shahi Salman</name><affiliation><nlm:affiliation>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Pennati, Paolo" sort="Pennati, Paolo" uniqKey="Pennati P" first="Paolo" last="Pennati">Paolo Pennati</name><affiliation><nlm:affiliation>Internal Medicine, Cecina Hospital, Cecina, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fenoglio, Luigi" sort="Fenoglio, Luigi" uniqKey="Fenoglio L" first="Luigi" last="Fenoglio">Luigi Fenoglio</name><affiliation><nlm:affiliation>Department of Internal Medicine, Santa Croce e Carle Hospital, Cuneo, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Werring, David" sort="Werring, David" uniqKey="Werring D" first="David" last="Werring">David Werring</name><affiliation><nlm:affiliation>University College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Veltkamp, Roland" sort="Veltkamp, Roland" uniqKey="Veltkamp R" first="Roland" last="Veltkamp">Roland Veltkamp</name><affiliation><nlm:affiliation>Department of Neurology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wood, Edith" sort="Wood, Edith" uniqKey="Wood E" first="Edith" last="Wood">Edith Wood</name><affiliation><nlm:affiliation>Greater Manchester Neurosciences Centre, Salford Royal National Health Service Foundation Trust, Salford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Dewey, Helen M" sort="Dewey, Helen M" uniqKey="Dewey H" first="Helen M" last="Dewey">Helen M. Dewey</name><affiliation><nlm:affiliation>Department of Neurology, Austin Hospital, Heidelberg, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name><affiliation><nlm:affiliation>Department of Neurology, University of Lille Nord de France (UDSL), Lille University Hospital Center, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Klijn, Catharina J M" sort="Klijn, Catharina J M" uniqKey="Klijn C" first="Catharina J M" last="Klijn">Catharina J M. Klijn</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, Rudolf Magnus Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Meligeni, Fabrizio" sort="Meligeni, Fabrizio" uniqKey="Meligeni F" first="Fabrizio" last="Meligeni">Fabrizio Meligeni</name><affiliation><nlm:affiliation>Department of Medical Emergency, San Camillo de' Lellis General Hospital, Rieti, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name><affiliation><nlm:affiliation>Department of Neurology, Royal Melbourne Hospital, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Huhtakangas, Juha" sort="Huhtakangas, Juha" uniqKey="Huhtakangas J" first="Juha" last="Huhtakangas">Juha Huhtakangas</name><affiliation><nlm:affiliation>Department of Neurology, Oulu University Hospital, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Staals, Julie" sort="Staals, Julie" uniqKey="Staals J" first="Julie" last="Staals">Julie Staals</name><affiliation><nlm:affiliation>Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation><nlm:affiliation>Department of Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Meretoja, Atte" sort="Meretoja, Atte" uniqKey="Meretoja A" first="Atte" last="Meretoja">Atte Meretoja</name><affiliation><nlm:affiliation>Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25857223</idno><idno type="pmid">25857223</idno><idno type="doi">10.1002/ana.24416</idno><idno type="wicri:Area/PubMed/Corpus">002C27</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C27</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.</title><author><name sortKey="Parry Jones, Adrian R" sort="Parry Jones, Adrian R" uniqKey="Parry Jones A" first="Adrian R" last="Parry-Jones">Adrian R. Parry-Jones</name><affiliation><nlm:affiliation>University of Manchester, Manchester Academic Health Sciences Centre, Salford Royal National Health Service Foundation Trust, Salford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Di Napoli, Mario" sort="Di Napoli, Mario" uniqKey="Di Napoli M" first="Mario" last="Di Napoli">Mario Di Napoli</name><affiliation><nlm:affiliation>Neurological Service, San Camillo de' Lellis General Hospital, Rieti, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Goldstein, Joshua N" sort="Goldstein, Joshua N" uniqKey="Goldstein J" first="Joshua N" last="Goldstein">Joshua N. Goldstein</name><affiliation><nlm:affiliation>Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Schreuder, Floris H B M" sort="Schreuder, Floris H B M" uniqKey="Schreuder F" first="Floris H B M" last="Schreuder">Floris H B M. Schreuder</name><affiliation><nlm:affiliation>Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Tetri, Sami" sort="Tetri, Sami" uniqKey="Tetri S" first="Sami" last="Tetri">Sami Tetri</name><affiliation><nlm:affiliation>Department of Neurology, Oulu University Hospital, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Tatlisumak, Turgut" sort="Tatlisumak, Turgut" uniqKey="Tatlisumak T" first="Turgut" last="Tatlisumak">Turgut Tatlisumak</name><affiliation><nlm:affiliation>Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Yan, Bernard" sort="Yan, Bernard" uniqKey="Yan B" first="Bernard" last="Yan">Bernard Yan</name><affiliation><nlm:affiliation>Department of Neurology, Royal Melbourne Hospital, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Nieuwenhuizen, Koen M" sort="Van Nieuwenhuizen, Koen M" uniqKey="Van Nieuwenhuizen K" first="Koen M" last="Van Nieuwenhuizen">Koen M. Van Nieuwenhuizen</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, Rudolf Magnus Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Dequatre Ponchelle, Nelly" sort="Dequatre Ponchelle, Nelly" uniqKey="Dequatre Ponchelle N" first="Nelly" last="Dequatre-Ponchelle">Nelly Dequatre-Ponchelle</name><affiliation><nlm:affiliation>Department of Neurology, University of Lille Nord de France (UDSL), Lille University Hospital Center, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Lee Archer, Matthew" sort="Lee Archer, Matthew" uniqKey="Lee Archer M" first="Matthew" last="Lee-Archer">Matthew Lee-Archer</name><affiliation><nlm:affiliation>Department of Neurology, Austin Hospital, Heidelberg, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Horstmann, Solveig" sort="Horstmann, Solveig" uniqKey="Horstmann S" first="Solveig" last="Horstmann">Solveig Horstmann</name><affiliation><nlm:affiliation>Department of Neurology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, Duncan" sort="Wilson, Duncan" uniqKey="Wilson D" first="Duncan" last="Wilson">Duncan Wilson</name><affiliation><nlm:affiliation>University College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Pomero, Fulvio" sort="Pomero, Fulvio" uniqKey="Pomero F" first="Fulvio" last="Pomero">Fulvio Pomero</name><affiliation><nlm:affiliation>Department of Internal Medicine, Santa Croce e Carle Hospital, Cuneo, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Masotti, Luca" sort="Masotti, Luca" uniqKey="Masotti L" first="Luca" last="Masotti">Luca Masotti</name><affiliation><nlm:affiliation>Internal Medicine, Cecina Hospital, Cecina, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Lerpiniere, Christine" sort="Lerpiniere, Christine" uniqKey="Lerpiniere C" first="Christine" last="Lerpiniere">Christine Lerpiniere</name><affiliation><nlm:affiliation>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Godoy, Daniel Agustin" sort="Godoy, Daniel Agustin" uniqKey="Godoy D" first="Daniel Agustin" last="Godoy">Daniel Agustin Godoy</name><affiliation><nlm:affiliation>Neurointensive Care Unit, Pasteur Sanatorium, Catamarca, Argentina.</nlm:affiliation></affiliation></author><author><name sortKey="Cohen, Abigail S" sort="Cohen, Abigail S" uniqKey="Cohen A" first="Abigail S" last="Cohen">Abigail S. Cohen</name><affiliation><nlm:affiliation>Department of Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Houben, Rik" sort="Houben, Rik" uniqKey="Houben R" first="Rik" last="Houben">Rik Houben</name><affiliation><nlm:affiliation>Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Al Shahi Salman, Rustam" sort="Al Shahi Salman, Rustam" uniqKey="Al Shahi Salman R" first="Rustam" last="Al-Shahi Salman">Rustam Al-Shahi Salman</name><affiliation><nlm:affiliation>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Pennati, Paolo" sort="Pennati, Paolo" uniqKey="Pennati P" first="Paolo" last="Pennati">Paolo Pennati</name><affiliation><nlm:affiliation>Internal Medicine, Cecina Hospital, Cecina, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fenoglio, Luigi" sort="Fenoglio, Luigi" uniqKey="Fenoglio L" first="Luigi" last="Fenoglio">Luigi Fenoglio</name><affiliation><nlm:affiliation>Department of Internal Medicine, Santa Croce e Carle Hospital, Cuneo, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Werring, David" sort="Werring, David" uniqKey="Werring D" first="David" last="Werring">David Werring</name><affiliation><nlm:affiliation>University College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Veltkamp, Roland" sort="Veltkamp, Roland" uniqKey="Veltkamp R" first="Roland" last="Veltkamp">Roland Veltkamp</name><affiliation><nlm:affiliation>Department of Neurology, University of Heidelberg, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wood, Edith" sort="Wood, Edith" uniqKey="Wood E" first="Edith" last="Wood">Edith Wood</name><affiliation><nlm:affiliation>Greater Manchester Neurosciences Centre, Salford Royal National Health Service Foundation Trust, Salford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Dewey, Helen M" sort="Dewey, Helen M" uniqKey="Dewey H" first="Helen M" last="Dewey">Helen M. Dewey</name><affiliation><nlm:affiliation>Department of Neurology, Austin Hospital, Heidelberg, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name><affiliation><nlm:affiliation>Department of Neurology, University of Lille Nord de France (UDSL), Lille University Hospital Center, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Klijn, Catharina J M" sort="Klijn, Catharina J M" uniqKey="Klijn C" first="Catharina J M" last="Klijn">Catharina J M. Klijn</name><affiliation><nlm:affiliation>Department of Neurology and Neurosurgery, Rudolf Magnus Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Meligeni, Fabrizio" sort="Meligeni, Fabrizio" uniqKey="Meligeni F" first="Fabrizio" last="Meligeni">Fabrizio Meligeni</name><affiliation><nlm:affiliation>Department of Medical Emergency, San Camillo de' Lellis General Hospital, Rieti, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Davis, Stephen M" sort="Davis, Stephen M" uniqKey="Davis S" first="Stephen M" last="Davis">Stephen M. Davis</name><affiliation><nlm:affiliation>Department of Neurology, Royal Melbourne Hospital, Parkville, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Huhtakangas, Juha" sort="Huhtakangas, Juha" uniqKey="Huhtakangas J" first="Juha" last="Huhtakangas">Juha Huhtakangas</name><affiliation><nlm:affiliation>Department of Neurology, Oulu University Hospital, Oulu, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Staals, Julie" sort="Staals, Julie" uniqKey="Staals J" first="Julie" last="Staals">Julie Staals</name><affiliation><nlm:affiliation>Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation><nlm:affiliation>Department of Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation></affiliation></author><author><name sortKey="Meretoja, Atte" sort="Meretoja, Atte" uniqKey="Meretoja A" first="Atte" last="Meretoja">Atte Meretoja</name><affiliation><nlm:affiliation>Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Annals of neurology</title><idno type="eISSN">1531-8249</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Anticoagulants (adverse effects)</term><term>Antifibrinolytic Agents (therapeutic use)</term><term>Blood Coagulation Factors (therapeutic use)</term><term>Cerebral Hemorrhage (chemically induced)</term><term>Cerebral Hemorrhage (mortality)</term><term>Cerebral Hemorrhage (therapy)</term><term>Female</term><term>Humans</term><term>Male</term><term>Plasma</term><term>Proportional Hazards Models</term><term>Registries</term><term>Retrospective Studies</term><term>Treatment Outcome</term><term>Vitamin K (antagonists & inhibitors)</term><term>Vitamin K (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anticoagulants</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Vitamin K</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antifibrinolytic Agents</term><term>Blood Coagulation Factors</term><term>Vitamin K</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Plasma</term><term>Proportional Hazards Models</term><term>Registries</term><term>Retrospective Studies</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25857223</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>23</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1531-8249</ISSN><JournalIssue CitedMedium="Internet"><Volume>78</Volume><Issue>1</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Annals of neurology</Title><ISOAbbreviation>Ann. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.</ArticleTitle><Pagination><MedlinePgn>54-62</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ana.24416</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We pooled individual ICH patient data from 16 stroke registries in 9 countries (n = 10 282), of whom 1,797 (17%) were on VKA. After excluding 250 patients with international normalized ratio < 1.3 and/or missing data required for analysis, we compared all-cause 30-day case fatality using Cox regression.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We included 1,547 patients treated with FFP (n = 377, 24%), PCC (n = 585, 38%), both (n = 131, 9%), or neither (n = 454, 29%). The crude case fatality and adjusted hazard ratio (HR) were highest with no reversal (61.7%, HR = 2.540, 95% confidence interval [CI] = 1.784-3.616, p < 0.001), followed by FFP alone (45.6%, HR = 1.344, 95% CI = 0.934-1.934, p = 0.112), then PCC alone (37.3%, HR = 1.445, 95% CI = 1.014-2.058, p = 0.041), compared to reversal with both FFP and PCC (27.8%, reference). Outcomes with PCC versus FFP were similar (HR = 1.075, 95% CI = 0.874-1.323, p = 0.492); 4-factor PCC (n = 441) was associated with higher case fatality compared to 3-factor PCC (n = 144, HR = 1.441, 95% CI = 1.041-1.995, p = 0.027).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">The combination of FFP and PCC might be associated with the lowest case fatality in reversal of VKA-ICH, and FFP may be equivalent to PCC. Randomized controlled trials with functional outcomes are needed to establish the most effective treatment.</AbstractText><CopyrightInformation>© 2015 The Authors Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Parry-Jones</LastName><ForeName>Adrian R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>University of Manchester, Manchester Academic Health Sciences Centre, Salford Royal National Health Service Foundation Trust, Salford, United Kingdom.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Greater Manchester Neurosciences Centre, Salford Royal National Health Service Foundation Trust, Salford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Di Napoli</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Neurological Service, San Camillo de' Lellis General Hospital, Rieti, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neurological Section, Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention (SMDN), Sulmona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goldstein</LastName><ForeName>Joshua N</ForeName><Initials>JN</Initials><AffiliationInfo><Affiliation>Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schreuder</LastName><ForeName>Floris H B M</ForeName><Initials>FH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tetri</LastName><ForeName>Sami</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tatlisumak</LastName><ForeName>Turgut</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Neurology, Royal Melbourne Hospital, Parkville, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Nieuwenhuizen</LastName><ForeName>Koen M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, Rudolf Magnus Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dequatre-Ponchelle</LastName><ForeName>Nelly</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Lille Nord de France (UDSL), Lille University Hospital Center, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee-Archer</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Austin Hospital, Heidelberg, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horstmann</LastName><ForeName>Solveig</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>Duncan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pomero</LastName><ForeName>Fulvio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Santa Croce e Carle Hospital, Cuneo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masotti</LastName><ForeName>Luca</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Internal Medicine, Cecina Hospital, Cecina, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lerpiniere</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Godoy</LastName><ForeName>Daniel Agustin</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Neurointensive Care Unit, Pasteur Sanatorium, Catamarca, Argentina.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Intensive Care Unit, San Juan Bautista Hospital, Catamarca, Argentina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cohen</LastName><ForeName>Abigail S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Department of Neurology, Massachusetts General Hospital, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houben</LastName><ForeName>Rik</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Al-Shahi Salman</LastName><ForeName>Rustam</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pennati</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Internal Medicine, Cecina Hospital, Cecina, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fenoglio</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Santa Croce e Carle Hospital, Cuneo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Werring</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>University College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Veltkamp</LastName><ForeName>Roland</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Heidelberg, Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wood</LastName><ForeName>Edith</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Greater Manchester Neurosciences Centre, Salford Royal National Health Service Foundation Trust, Salford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dewey</LastName><ForeName>Helen M</ForeName><Initials>HM</Initials><AffiliationInfo><Affiliation>Department of Neurology, Austin Hospital, Heidelberg, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cordonnier</LastName><ForeName>Charlotte</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Lille Nord de France (UDSL), Lille University Hospital Center, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klijn</LastName><ForeName>Catharina J M</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Department of Neurology and Neurosurgery, Rudolf Magnus Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meligeni</LastName><ForeName>Fabrizio</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Medical Emergency, San Camillo de' Lellis General Hospital, Rieti, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davis</LastName><ForeName>Stephen M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Department of Neurology, Royal Melbourne Hospital, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine and Florey Institute, University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huhtakangas</LastName><ForeName>Juha</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Oulu University Hospital, Oulu, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Staals</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Maastricht University Medical Center, Maastricht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosand</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Massachusetts General Hospital, Boston, MA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meretoja</LastName><ForeName>Atte</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Royal Melbourne Hospital, Parkville, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine and Florey Institute, University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0900428</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 NS059727</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>G1002605</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>05</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann Neurol</MedlineTA><NlmUniqueID>7707449</NlmUniqueID><ISSNLinking>0364-5134</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000925">Anticoagulants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000933">Antifibrinolytic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001779">Blood Coagulation Factors</NameOfSubstance></Chemical><Chemical><RegistryNumber>12001-79-5</RegistryNumber><NameOfSubstance UI="D014812">Vitamin K</NameOfSubstance></Chemical><Chemical><RegistryNumber>37224-63-8</RegistryNumber><NameOfSubstance UI="C025667">prothrombin complex 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Factors</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002543" MajorTopicYN="N">Cerebral Hemorrhage</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010949" MajorTopicYN="Y">Plasma</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012042" MajorTopicYN="Y">Registries</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014812" MajorTopicYN="N">Vitamin K</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="N">antagonists & inhibitors</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4654243</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>12</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>03</Month><Day>26</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>03</Month><Day>27</Day></PubMedPubDate><PubMedPubDate 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