Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.
Identifieur interne : 002C25 ( PubMed/Corpus ); précédent : 002C24; suivant : 002C26Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.
Auteurs : Yugeesh R. Lankadeva ; Lindsea C. Booth ; Junko Kosaka ; Roger G. Evans ; Luc Quintin ; Rinaldo Bellomo ; Clive N. MaySource :
- Critical care medicine [ 1530-0293 ] ; 2015.
English descriptors
- KwdEn :
- Adrenergic alpha-2 Receptor Agonists (pharmacology), Angiotensin II (pharmacology), Animals, Blood Pressure (drug effects), Clonidine (pharmacology), Female, Hypotension (etiology), Hypotension (physiopathology), Kidney (innervation), Phenylephrine (pharmacology), Sepsis (complications), Sepsis (physiopathology), Sheep, Sympathetic Nervous System (drug effects), Sympathetic Nervous System (physiopathology), Vasoconstrictor Agents (pharmacology).
- MESH :
- chemical , pharmacology : Adrenergic alpha-2 Receptor Agonists, Angiotensin II, Clonidine, Phenylephrine, Vasoconstrictor Agents.
- complications : Sepsis.
- drug effects : Blood Pressure, Sympathetic Nervous System.
- etiology : Hypotension.
- innervation : Kidney.
- physiopathology : Hypotension, Sepsis, Sympathetic Nervous System.
- Animals, Female, Sheep.
Abstract
In sepsis, prolonged, sympathetic overstimulation may lead to vasopressor-refractory hypotension. We therefore examined the effects of the α2-adrenergic agonist clonidine on mean arterial pressure, renal sympathetic nerve activity, and pressor responsiveness to phenylephrine and angiotensin II during hypotensive sepsis in conscious sheep.
DOI: 10.1097/CCM.0000000000000963
PubMed: 25860204
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pubmed:25860204Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.</title><author><name sortKey="Lankadeva, Yugeesh R" sort="Lankadeva, Yugeesh R" uniqKey="Lankadeva Y" first="Yugeesh R" last="Lankadeva">Yugeesh R. Lankadeva</name><affiliation><nlm:affiliation>1Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia. 2Department of Physiology, Monash University, VIC, Australia. 3Department of Physiology, University of Lyon, Lyon, France. 4Department of Intensive Care, Austin Health, Heidelberg, VIC, Australia. 5Department of Medicine, Austin Health, Heidelberg, VIC, Australia. 6The Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Booth, Lindsea C" sort="Booth, Lindsea C" uniqKey="Booth L" first="Lindsea C" last="Booth">Lindsea C. Booth</name></author><author><name sortKey="Kosaka, Junko" sort="Kosaka, Junko" uniqKey="Kosaka J" first="Junko" last="Kosaka">Junko Kosaka</name></author><author><name sortKey="Evans, Roger G" sort="Evans, Roger G" uniqKey="Evans R" first="Roger G" last="Evans">Roger G. Evans</name></author><author><name sortKey="Quintin, Luc" sort="Quintin, Luc" uniqKey="Quintin L" first="Luc" last="Quintin">Luc Quintin</name></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name></author><author><name sortKey="May, Clive N" sort="May, Clive N" uniqKey="May C" first="Clive N" last="May">Clive N. May</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25860204</idno><idno type="pmid">25860204</idno><idno type="doi">10.1097/CCM.0000000000000963</idno><idno type="wicri:Area/PubMed/Corpus">002C25</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002C25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.</title><author><name sortKey="Lankadeva, Yugeesh R" sort="Lankadeva, Yugeesh R" uniqKey="Lankadeva Y" first="Yugeesh R" last="Lankadeva">Yugeesh R. Lankadeva</name><affiliation><nlm:affiliation>1Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia. 2Department of Physiology, Monash University, VIC, Australia. 3Department of Physiology, University of Lyon, Lyon, France. 4Department of Intensive Care, Austin Health, Heidelberg, VIC, Australia. 5Department of Medicine, Austin Health, Heidelberg, VIC, Australia. 6The Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Booth, Lindsea C" sort="Booth, Lindsea C" uniqKey="Booth L" first="Lindsea C" last="Booth">Lindsea C. Booth</name></author><author><name sortKey="Kosaka, Junko" sort="Kosaka, Junko" uniqKey="Kosaka J" first="Junko" last="Kosaka">Junko Kosaka</name></author><author><name sortKey="Evans, Roger G" sort="Evans, Roger G" uniqKey="Evans R" first="Roger G" last="Evans">Roger G. Evans</name></author><author><name sortKey="Quintin, Luc" sort="Quintin, Luc" uniqKey="Quintin L" first="Luc" last="Quintin">Luc Quintin</name></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name></author><author><name sortKey="May, Clive N" sort="May, Clive N" uniqKey="May C" first="Clive N" last="May">Clive N. May</name></author></analytic><series><title level="j">Critical care medicine</title><idno type="eISSN">1530-0293</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenergic alpha-2 Receptor Agonists (pharmacology)</term><term>Angiotensin II (pharmacology)</term><term>Animals</term><term>Blood Pressure (drug effects)</term><term>Clonidine (pharmacology)</term><term>Female</term><term>Hypotension (etiology)</term><term>Hypotension (physiopathology)</term><term>Kidney (innervation)</term><term>Phenylephrine (pharmacology)</term><term>Sepsis (complications)</term><term>Sepsis (physiopathology)</term><term>Sheep</term><term>Sympathetic Nervous System (drug effects)</term><term>Sympathetic Nervous System (physiopathology)</term><term>Vasoconstrictor Agents (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Adrenergic alpha-2 Receptor Agonists</term><term>Angiotensin II</term><term>Clonidine</term><term>Phenylephrine</term><term>Vasoconstrictor Agents</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Sepsis</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term><term>Sympathetic Nervous System</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypotension</term></keywords><keywords scheme="MESH" qualifier="innervation" xml:lang="en"><term>Kidney</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Hypotension</term><term>Sepsis</term><term>Sympathetic Nervous System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Sheep</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In sepsis, prolonged, sympathetic overstimulation may lead to vasopressor-refractory hypotension. We therefore examined the effects of the α2-adrenergic agonist clonidine on mean arterial pressure, renal sympathetic nerve activity, and pressor responsiveness to phenylephrine and angiotensin II during hypotensive sepsis in conscious sheep.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25860204</PMID><DateCreated><Year>2015</Year><Month>06</Month><Day>17</Day></DateCreated><DateCompleted><Year>2015</Year><Month>08</Month><Day>26</Day></DateCompleted><DateRevised><Year>2015</Year><Month>06</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1530-0293</ISSN><JournalIssue CitedMedium="Internet"><Volume>43</Volume><Issue>7</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Critical care medicine</Title><ISOAbbreviation>Crit. Care Med.</ISOAbbreviation></Journal><ArticleTitle>Clonidine Restores Pressor Responsiveness to Phenylephrine and Angiotensin II in Ovine Sepsis.</ArticleTitle><Pagination><MedlinePgn>e221-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/CCM.0000000000000963</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">In sepsis, prolonged, sympathetic overstimulation may lead to vasopressor-refractory hypotension. We therefore examined the effects of the α2-adrenergic agonist clonidine on mean arterial pressure, renal sympathetic nerve activity, and pressor responsiveness to phenylephrine and angiotensin II during hypotensive sepsis in conscious sheep.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Interventional study.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Research institute.</AbstractText><AbstractText Label="SUBJECTS" NlmCategory="METHODS">Twelve adult Merino ewes (n = 6 per group).</AbstractText><AbstractText Label="INTERVENTIONS" NlmCategory="METHODS">Sepsis was induced by IV infusion of Escherichia coli for 32 hours. Pressor responses to increasing doses of phenylephrine and angiotensin II were measured at baseline and at 24, 28, and 32 hours of sepsis. Sheep were treated with clonidine (1 μg/kg/hr) or saline-vehicle from 24 to 32 hours of sepsis.</AbstractText><AbstractText Label="MEASUREMENTS AND MAIN RESULTS" NlmCategory="RESULTS">Sepsis was characterized by hypotension (~12 mm Hg), increased heart rate (~80 beats/min), increased renal sympathetic nerve activity (~70%), and blunted pressor responses to phenylephrine and angiotensin II. In vehicle-treated sheep, mean arterial pressure progressively declined from 25 to 32 hours of sepsis (73 ± 3 to 66 ± 3 mm Hg; p = 0.013) while the elevations in heart rate and renal sympathetic nerve activity and reduced pressor responsiveness to vasopressors persisted. Clonidine treatment prevented the further decline in mean arterial pressure, substantially reduced heart rate and renal sympathetic nerve activity and restored pressor responsiveness to both phenylephrine and angiotensin II toward preseptic levels.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Administration of clonidine during hypotensive sepsis reduced renal sympathetic nerve activity, restored vascular sensitivity to both phenylephrine and angiotensin II, and resulted in better preservation of arterial pressure. Considering these findings, a clinical trial for the use of clonidine in the treatment of persistent vasopressor-refractory hypotension in patients with septic shock would be worthwhile.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lankadeva</LastName><ForeName>Yugeesh R</ForeName><Initials>YR</Initials><AffiliationInfo><Affiliation>1Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia. 2Department of Physiology, Monash University, VIC, Australia. 3Department of Physiology, University of Lyon, Lyon, France. 4Department of Intensive Care, Austin Health, Heidelberg, VIC, Australia. 5Department of Medicine, Austin Health, Heidelberg, VIC, Australia. 6The Australian and New Zealand Intensive Care Research Centre, Monash University, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Booth</LastName><ForeName>Lindsea C</ForeName><Initials>LC</Initials></Author><Author ValidYN="Y"><LastName>Kosaka</LastName><ForeName>Junko</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Evans</LastName><ForeName>Roger G</ForeName><Initials>RG</Initials></Author><Author ValidYN="Y"><LastName>Quintin</LastName><ForeName>Luc</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Bellomo</LastName><ForeName>Rinaldo</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>May</LastName><ForeName>Clive N</ForeName><Initials>CN</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Crit Care Med</MedlineTA><NlmUniqueID>0355501</NlmUniqueID><ISSNLinking>0090-3493</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D058647">Adrenergic alpha-2 Receptor Agonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014662">Vasoconstrictor Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>11128-99-7</RegistryNumber><NameOfSubstance UI="D000804">Angiotensin II</NameOfSubstance></Chemical><Chemical><RegistryNumber>1WS297W6MV</RegistryNumber><NameOfSubstance UI="D010656">Phenylephrine</NameOfSubstance></Chemical><Chemical><RegistryNumber>MN3L5RMN02</RegistryNumber><NameOfSubstance UI="D003000">Clonidine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Crit Care Med. 2015 Jul;43(7):1548-50</RefSource><PMID Version="1">26079239</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D058647" MajorTopicYN="N">Adrenergic alpha-2 Receptor Agonists</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000804" MajorTopicYN="N">Angiotensin II</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003000" MajorTopicYN="N">Clonidine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007022" MajorTopicYN="N">Hypotension</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007668" MajorTopicYN="N">Kidney</DescriptorName><QualifierName UI="Q000294" MajorTopicYN="N">innervation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010656" MajorTopicYN="N">Phenylephrine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018805" MajorTopicYN="N">Sepsis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012756" MajorTopicYN="N">Sheep</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013564" MajorTopicYN="N">Sympathetic Nervous System</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014662" MajorTopicYN="N">Vasoconstrictor Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>4</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>4</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>8</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25860204</ArticleId><ArticleId IdType="doi">10.1097/CCM.0000000000000963</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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