IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.
Identifieur interne : 002B51 ( PubMed/Corpus ); précédent : 002B50; suivant : 002B52IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.
Auteurs : Michele W L. Teng ; Edward P. Bowman ; Joshua J. Mcelwee ; Mark J. Smyth ; Jean-Laurent Casanova ; Andrea M. Cooper ; Daniel J. CuaSource :
- Nature medicine [ 1546-170X ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , antagonists & inhibitors : Interleukin-12, Interleukin-23.
- immunology : Inflammation.
- chemical , metabolism : Interleukin-12, Interleukin-23.
- pathology : Inflammation.
- Animals, Humans, Immunity, Immunologic Surveillance, Molecular Targeted Therapy.
Abstract
The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell-mediated responses in inflammation for more than a decade after it was first identified. Discovery of the cytokine IL-23, which shares a common p40 subunit with IL-12, prompted efforts to clarify the relative contribution of these two cytokines in immune regulation. Ustekinumab, a therapeutic agent targeting both cytokines, was recently approved to treat psoriasis and psoriatic arthritis, and related agents are in clinical testing for a variety of inflammatory disorders. Here we discuss the therapeutic rationale for targeting these cytokines, the unintended consequences for host defense and tumor surveillance and potential ways in which these therapies can be applied to treat additional immune disorders.
DOI: 10.1038/nm.3895
PubMed: 26121196
Links to Exploration step
pubmed:26121196Le document en format XML
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Bowman</name><affiliation><nlm:affiliation>Merck Research Laboratories, Palo Alto, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcelwee, Joshua J" sort="Mcelwee, Joshua J" uniqKey="Mcelwee J" first="Joshua J" last="Mcelwee">Joshua J. Mcelwee</name><affiliation><nlm:affiliation>Merck Research Laboratories, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation><nlm:affiliation>1] Cancer Immunoregulation and Immunotherapy and Immunology in Cancer and Infection Laboratories, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. [2] School of Medicine, University of Queensland, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation><nlm:affiliation>1] St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA. [2] Howard Hughes Medical Institute, New York, New York, USA. [3] Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Paris, France. [4] Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, Paris, France. [5] Paris Descartes University, Imagine Institute, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Andrea M" sort="Cooper, Andrea M" uniqKey="Cooper A" first="Andrea M" last="Cooper">Andrea M. Cooper</name><affiliation><nlm:affiliation>Trudeau Institute, Inc., Saranac Lake, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cua, Daniel J" sort="Cua, Daniel J" uniqKey="Cua D" first="Daniel J" last="Cua">Daniel J. Cua</name><affiliation><nlm:affiliation>Merck Research Laboratories, Palo Alto, California, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26121196</idno><idno type="pmid">26121196</idno><idno type="doi">10.1038/nm.3895</idno><idno type="wicri:Area/PubMed/Corpus">002B51</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002B51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.</title><author><name sortKey="Teng, Michele W L" sort="Teng, Michele W L" uniqKey="Teng M" first="Michele W L" last="Teng">Michele W L. Teng</name><affiliation><nlm:affiliation>1] Cancer Immunoregulation and Immunotherapy and Immunology in Cancer and Infection Laboratories, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. [2] School of Medicine, University of Queensland, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bowman, Edward P" sort="Bowman, Edward P" uniqKey="Bowman E" first="Edward P" last="Bowman">Edward P. Bowman</name><affiliation><nlm:affiliation>Merck Research Laboratories, Palo Alto, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcelwee, Joshua J" sort="Mcelwee, Joshua J" uniqKey="Mcelwee J" first="Joshua J" last="Mcelwee">Joshua J. Mcelwee</name><affiliation><nlm:affiliation>Merck Research Laboratories, Boston, Massachusetts, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name><affiliation><nlm:affiliation>1] Cancer Immunoregulation and Immunotherapy and Immunology in Cancer and Infection Laboratories, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. [2] School of Medicine, University of Queensland, Herston, Queensland, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Casanova, Jean Laurent" sort="Casanova, Jean Laurent" uniqKey="Casanova J" first="Jean-Laurent" last="Casanova">Jean-Laurent Casanova</name><affiliation><nlm:affiliation>1] St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA. [2] Howard Hughes Medical Institute, New York, New York, USA. [3] Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Paris, France. [4] Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, Paris, France. [5] Paris Descartes University, Imagine Institute, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Andrea M" sort="Cooper, Andrea M" uniqKey="Cooper A" first="Andrea M" last="Cooper">Andrea M. Cooper</name><affiliation><nlm:affiliation>Trudeau Institute, Inc., Saranac Lake, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cua, Daniel J" sort="Cua, Daniel J" uniqKey="Cua D" first="Daniel J" last="Cua">Daniel J. Cua</name><affiliation><nlm:affiliation>Merck Research Laboratories, Palo Alto, California, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nature medicine</title><idno type="eISSN">1546-170X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Immunity</term><term>Immunologic Surveillance</term><term>Inflammation (immunology)</term><term>Inflammation (pathology)</term><term>Interleukin-12 (antagonists & inhibitors)</term><term>Interleukin-12 (metabolism)</term><term>Interleukin-23 (antagonists & inhibitors)</term><term>Interleukin-23 (metabolism)</term><term>Molecular Targeted Therapy</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Interleukin-12</term><term>Interleukin-23</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Interleukin-12</term><term>Interleukin-23</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Immunity</term><term>Immunologic Surveillance</term><term>Molecular Targeted Therapy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell-mediated responses in inflammation for more than a decade after it was first identified. Discovery of the cytokine IL-23, which shares a common p40 subunit with IL-12, prompted efforts to clarify the relative contribution of these two cytokines in immune regulation. Ustekinumab, a therapeutic agent targeting both cytokines, was recently approved to treat psoriasis and psoriatic arthritis, and related agents are in clinical testing for a variety of inflammatory disorders. Here we discuss the therapeutic rationale for targeting these cytokines, the unintended consequences for host defense and tumor surveillance and potential ways in which these therapies can be applied to treat additional immune disorders.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26121196</PMID><DateCreated><Year>2015</Year><Month>07</Month><Day>08</Day></DateCreated><DateCompleted><Year>2015</Year><Month>09</Month><Day>28</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1546-170X</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>7</Issue><PubDate><Year>2015</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Nature medicine</Title><ISOAbbreviation>Nat. Med.</ISOAbbreviation></Journal><ArticleTitle>IL-12 and IL-23 cytokines: from discovery to targeted therapies for immune-mediated inflammatory diseases.</ArticleTitle><Pagination><MedlinePgn>719-29</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/nm.3895</ELocationID><Abstract><AbstractText>The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell-mediated responses in inflammation for more than a decade after it was first identified. Discovery of the cytokine IL-23, which shares a common p40 subunit with IL-12, prompted efforts to clarify the relative contribution of these two cytokines in immune regulation. Ustekinumab, a therapeutic agent targeting both cytokines, was recently approved to treat psoriasis and psoriatic arthritis, and related agents are in clinical testing for a variety of inflammatory disorders. Here we discuss the therapeutic rationale for targeting these cytokines, the unintended consequences for host defense and tumor surveillance and potential ways in which these therapies can be applied to treat additional immune disorders.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Teng</LastName><ForeName>Michele W L</ForeName><Initials>MW</Initials><Identifier Source="ORCID">0000000318869145</Identifier><AffiliationInfo><Affiliation>1] Cancer Immunoregulation and Immunotherapy and Immunology in Cancer and Infection Laboratories, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. [2] School of Medicine, University of Queensland, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bowman</LastName><ForeName>Edward P</ForeName><Initials>EP</Initials><AffiliationInfo><Affiliation>Merck Research Laboratories, Palo Alto, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McElwee</LastName><ForeName>Joshua J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Merck Research Laboratories, Boston, Massachusetts, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smyth</LastName><ForeName>Mark J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>1] Cancer Immunoregulation and Immunotherapy and Immunology in Cancer and Infection Laboratories, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. [2] School of Medicine, University of Queensland, Herston, Queensland, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casanova</LastName><ForeName>Jean-Laurent</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>1] St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York, USA. [2] Howard Hughes Medical Institute, New York, New York, USA. [3] Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM, Paris, France. [4] Pediatric Hematology and Immunology Unit, Necker Hospital for Sick Children, Paris, France. [5] Paris Descartes University, Imagine Institute, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>Andrea M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Trudeau Institute, Inc., Saranac Lake, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cua</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Merck Research Laboratories, Palo Alto, California, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United 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PubStatus="accepted"><Year>2015</Year><Month>05</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>6</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>6</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>9</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26121196</ArticleId><ArticleId IdType="pii">nm.3895</ArticleId><ArticleId IdType="doi">10.1038/nm.3895</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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