Gas-phase fragmentation of deprotonated tryptophan and its clusters [Trpn -H]- induced by different activation methods.
Identifieur interne : 002A98 ( PubMed/Corpus ); précédent : 002A97; suivant : 002A99Gas-phase fragmentation of deprotonated tryptophan and its clusters [Trpn -H]- induced by different activation methods.
Auteurs : Linda Feketeová ; George N. Khairallah ; Richard A J. O'Hair ; Steen Br Ndsted NielsenSource :
- Rapid communications in mass spectrometry : RCM [ 1097-0231 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Anions, Peptides, Tryptophan.
- chemical : Protons.
- methods : Spectrometry, Mass, Electrospray Ionization.
Abstract
Non-covalent amino acid clusters are the subject of intense research in diverse areas including peptide bond formation studies or the determination of proton affinities or methylating abilities of amino acids. However, most of the research has focused on positive ions and little is known about anionic clusters.
DOI: 10.1002/rcm.7233
PubMed: 26147479
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pubmed:26147479Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gas-phase fragmentation of deprotonated tryptophan and its clusters [Trpn -H]- induced by different activation methods.</title><author><name sortKey="Feketeova, Linda" sort="Feketeova, Linda" uniqKey="Feketeova L" first="Linda" last="Feketeová">Linda Feketeová</name><affiliation><nlm:affiliation>ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, 30 Flemington Road, Parkville, Victoria, 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Khairallah, George N" sort="Khairallah, George N" uniqKey="Khairallah G" first="George N" last="Khairallah">George N. Khairallah</name><affiliation><nlm:affiliation>ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, 30 Flemington Road, Parkville, Victoria, 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="O Hair, Richard A J" sort="O Hair, Richard A J" uniqKey="O Hair R" first="Richard A J" last="O'Hair">Richard A J. O'Hair</name><affiliation><nlm:affiliation>ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, 30 Flemington Road, Parkville, Victoria, 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Nielsen, Steen Br Ndsted" sort="Nielsen, Steen Br Ndsted" uniqKey="Nielsen S" first="Steen Br Ndsted" last="Nielsen">Steen Br Ndsted Nielsen</name><affiliation><nlm:affiliation>Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, Aarhus C, 8000, Denmark.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26147479</idno><idno type="pmid">26147479</idno><idno type="doi">10.1002/rcm.7233</idno><idno type="wicri:Area/PubMed/Corpus">002A98</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A98</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Gas-phase fragmentation of deprotonated tryptophan and its clusters [Trpn -H]- induced by different activation methods.</title><author><name sortKey="Feketeova, Linda" sort="Feketeova, Linda" uniqKey="Feketeova L" first="Linda" last="Feketeová">Linda Feketeová</name><affiliation><nlm:affiliation>ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, 30 Flemington Road, Parkville, Victoria, 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Khairallah, George N" sort="Khairallah, George N" uniqKey="Khairallah G" first="George N" last="Khairallah">George N. Khairallah</name><affiliation><nlm:affiliation>ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, 30 Flemington Road, Parkville, Victoria, 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="O Hair, Richard A J" sort="O Hair, Richard A J" uniqKey="O Hair R" first="Richard A J" last="O'Hair">Richard A J. O'Hair</name><affiliation><nlm:affiliation>ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, 30 Flemington Road, Parkville, Victoria, 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Nielsen, Steen Br Ndsted" sort="Nielsen, Steen Br Ndsted" uniqKey="Nielsen S" first="Steen Br Ndsted" last="Nielsen">Steen Br Ndsted Nielsen</name><affiliation><nlm:affiliation>Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, Aarhus C, 8000, Denmark.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Rapid communications in mass spectrometry : RCM</title><idno type="eISSN">1097-0231</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anions (chemistry)</term><term>Peptides (chemistry)</term><term>Protons</term><term>Spectrometry, Mass, Electrospray Ionization (methods)</term><term>Tryptophan (chemistry)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Anions</term><term>Peptides</term><term>Tryptophan</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Protons</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Spectrometry, Mass, Electrospray Ionization</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non-covalent amino acid clusters are the subject of intense research in diverse areas including peptide bond formation studies or the determination of proton affinities or methylating abilities of amino acids. However, most of the research has focused on positive ions and little is known about anionic clusters.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26147479</PMID><DateCreated><Year>2015</Year><Month>07</Month><Day>07</Day></DateCreated><DateCompleted><Year>2016</Year><Month>01</Month><Day>11</Day></DateCompleted><DateRevised><Year>2015</Year><Month>07</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1097-0231</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>15</Issue><PubDate><Year>2015</Year><Month>Aug</Month><Day>15</Day></PubDate></JournalIssue><Title>Rapid communications in mass spectrometry : RCM</Title><ISOAbbreviation>Rapid Commun. Mass Spectrom.</ISOAbbreviation></Journal><ArticleTitle>Gas-phase fragmentation of deprotonated tryptophan and its clusters [Trpn -H]- induced by different activation methods.</ArticleTitle><Pagination><MedlinePgn>1395-402</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/rcm.7233</ELocationID><Abstract><AbstractText Label="RATIONALE" NlmCategory="BACKGROUND">Non-covalent amino acid clusters are the subject of intense research in diverse areas including peptide bond formation studies or the determination of proton affinities or methylating abilities of amino acids. However, most of the research has focused on positive ions and little is known about anionic clusters.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Fragmentation reactions of deprotonated tryptophan (Trp), [Trp-H](-) and Trp singly deprotonated non-covalently bound clusters [Trp(n) -H](-), n = 2, 3, 4, were investigated using low-energy collision-induced dissociation (CID) with He atoms, high-energy CID with Na atoms, and electron-induced dissociation (EID) with 20-35 eV electrons. Fragmentation of the monomeric Trp anion, where all labile hydrogens were exchanged for deuterium [d(4) -Trp-D](-), was investigated using low-energy CID and EID, in order to shed light on the dissociation mechanisms.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The main fragmentation channel for Trp cluster anions, [Trp(n) -H](-), n >1, is the loss of the neutral monomer. The fragmentation of the deprotonated Trp monomer induced by electrons resembles the fragmentation induced by high-energy collisions through electronic excitation of the parent. However, the excitation must precede in a different way, shown through only monomer loss from larger clusters, n >1, in case of EID, but intracluster chemistry in the case of high-energy CID.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The anion of the indole ring C(8)H(6) N(-) has been identified in the product ion spectra of [Trp(n) -H](-) using all activation methods, thus providing a diagnostic marker ion. No evidence was found for formation of peptide bonds as a route to prebiotic peptides in the fragmentation reactions of these singly deprotonated Trp cluster ions.</AbstractText><CopyrightInformation>Copyright © 2015 John Wiley & Sons, Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Feketeová</LastName><ForeName>Linda</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, 30 Flemington Road, Parkville, Victoria, 3010, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université de Lyon, 69003 Lyon, France; Université Claude Bernard Lyon1; Institut de Physique Nucléaire de Lyon, CNRS/IN2P3, UMR5822, 69622 Villeurbanne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khairallah</LastName><ForeName>George N</ForeName><Initials>GN</Initials><AffiliationInfo><Affiliation>ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, 30 Flemington Road, Parkville, Victoria, 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Hair</LastName><ForeName>Richard A J</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>ARC Centre of Excellence for Free Radical Chemistry and Biotechnology, School of Chemistry and Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, 30 Flemington Road, Parkville, Victoria, 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nielsen</LastName><ForeName>Steen Brøndsted</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Department of Physics and Astronomy, Aarhus University, Ny Munkegade 120, Aarhus C, 8000, Denmark.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Rapid Commun Mass Spectrom</MedlineTA><NlmUniqueID>8802365</NlmUniqueID><ISSNLinking>0951-4198</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000838">Anions</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010455">Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011522">Protons</NameOfSubstance></Chemical><Chemical><RegistryNumber>8DUH1N11BX</RegistryNumber><NameOfSubstance UI="D014364">Tryptophan</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000838" MajorTopicYN="N">Anions</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010455" MajorTopicYN="N">Peptides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011522" MajorTopicYN="Y">Protons</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021241" MajorTopicYN="N">Spectrometry, Mass, Electrospray Ionization</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014364" MajorTopicYN="N">Tryptophan</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>05</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>05</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>7</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>1</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26147479</ArticleId><ArticleId IdType="doi">10.1002/rcm.7233</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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