Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.
Identifieur interne : 002A66 ( PubMed/Corpus ); précédent : 002A65; suivant : 002A67Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.
Auteurs : S. Gillessen ; A. Omlin ; G. Attard ; J S De Bono ; E. Efstathiou ; K. Fizazi ; S. Halabi ; P S Nelson ; O. Sartor ; M R Smith ; H R Soule ; H. Akaza ; T M Beer ; H. Beltran ; A M Chinnaiyan ; G. Daugaard ; I D Davis ; M. De Santis ; C G Drake ; R A Eeles ; S. Fanti ; M E Gleave ; A. Heidenreich ; M. Hussain ; N D James ; F E Lecouvet ; C J Logothetis ; K. Mastris ; S. Nilsson ; W K Oh ; D. Olmos ; A R Padhani ; C. Parker ; M A Rubin ; J A Schalken ; H I Scher ; A. Sella ; N D Shore ; E J Small ; C N Sternberg ; H. Suzuki ; C J Sweeney ; I F Tannock ; B. TombalSource :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2015.
English descriptors
- KwdEn :
- Adenocarcinoma (pathology), Adenocarcinoma (therapy), Androgen Antagonists (therapeutic use), Antineoplastic Agents (therapeutic use), Antineoplastic Agents, Hormonal (therapeutic use), Bone Density Conservation Agents (therapeutic use), Humans, Male, Orchiectomy, Practice Guidelines as Topic, Prostatectomy, Prostatic Neoplasms (pathology), Prostatic Neoplasms (therapy), Prostatic Neoplasms, Castration-Resistant (pathology), Prostatic Neoplasms, Castration-Resistant (therapy), Radiotherapy, Adjuvant, Taxoids (therapeutic use).
- MESH :
- chemical , therapeutic use : Androgen Antagonists, Antineoplastic Agents, Antineoplastic Agents, Hormonal, Bone Density Conservation Agents, Taxoids.
- pathology : Adenocarcinoma, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant.
- therapy : Adenocarcinoma, Prostatic Neoplasms, Prostatic Neoplasms, Castration-Resistant.
- Humans, Male, Orchiectomy, Practice Guidelines as Topic, Prostatectomy, Radiotherapy, Adjuvant.
Abstract
The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-naïve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection. Management recommendations based on expert opinion, and not based on a critical review of the available evidence, are presented. The various recommendations carried differing degrees of support, as reflected in the wording of the article text and in the detailed voting results recorded in supplementary Material, available at Annals of Oncology online. Detailed decisions on treatment as always will involve consideration of disease extent and location, prior treatments, host factors, patient preferences as well as logistical and economic constraints. Inclusion of men with APC in clinical trials should be encouraged.
DOI: 10.1093/annonc/mdv257
PubMed: 26041764
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pubmed:26041764Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.</title><author><name sortKey="Gillessen, S" sort="Gillessen, S" uniqKey="Gillessen S" first="S" last="Gillessen">S. Gillessen</name><affiliation><nlm:affiliation>Department of Oncology/Haematology, Kantonsspital St Gallen, St Gallen, Switzerland silke.gillessen@kssg.ch.</nlm:affiliation></affiliation></author><author><name sortKey="Omlin, A" sort="Omlin, A" uniqKey="Omlin A" first="A" last="Omlin">A. Omlin</name><affiliation><nlm:affiliation>Department of Oncology/Haematology, Kantonsspital St Gallen, St Gallen, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Attard, G" sort="Attard, G" uniqKey="Attard G" first="G" last="Attard">G. Attard</name><affiliation><nlm:affiliation>Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="De Bono, J S" sort="De Bono, J S" uniqKey="De Bono J" first="J S" last="De Bono">J S De Bono</name><affiliation><nlm:affiliation>Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Efstathiou, E" sort="Efstathiou, E" uniqKey="Efstathiou E" first="E" last="Efstathiou">E. Efstathiou</name><affiliation><nlm:affiliation>Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston Department of Genitourinary Medical Oncology, David H. Koch Centre, The University of Texas M. D. Anderson Cancer Centre, Houston, USA Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Fizazi, K" sort="Fizazi, K" uniqKey="Fizazi K" first="K" last="Fizazi">K. Fizazi</name><affiliation><nlm:affiliation>Department of Cancer Medicine, Institut Gustave Roussy, University of Paris Sud, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Halabi, S" sort="Halabi, S" uniqKey="Halabi S" first="S" last="Halabi">S. Halabi</name><affiliation><nlm:affiliation>Department of Biostatistics and Bioinformatics, Duke University, Durham.</nlm:affiliation></affiliation></author><author><name sortKey="Nelson, P S" sort="Nelson, P S" uniqKey="Nelson P" first="P S" last="Nelson">P S Nelson</name><affiliation><nlm:affiliation>Division of Human Biology, Fred Hutchinson Cancer Research Centre, Seattle.</nlm:affiliation></affiliation></author><author><name sortKey="Sartor, O" sort="Sartor, O" uniqKey="Sartor O" first="O" last="Sartor">O. Sartor</name><affiliation><nlm:affiliation>Tulane Cancer Centre, Tulane University, New Orleans.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, M R" sort="Smith, M R" uniqKey="Smith M" first="M R" last="Smith">M R Smith</name><affiliation><nlm:affiliation>Massachusetts General Hospital Cancer Centre, Boston.</nlm:affiliation></affiliation></author><author><name sortKey="Soule, H R" sort="Soule, H R" uniqKey="Soule H" first="H R" last="Soule">H R Soule</name><affiliation><nlm:affiliation>Prostate Cancer Foundation, Santa Monica, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Akaza, H" sort="Akaza, H" uniqKey="Akaza H" first="H" last="Akaza">H. Akaza</name><affiliation><nlm:affiliation>Research Centre for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Beer, T M" sort="Beer, T M" uniqKey="Beer T" first="T M" last="Beer">T M Beer</name><affiliation><nlm:affiliation>Oregon Health & Science University Knight Cancer Institute, Portland.</nlm:affiliation></affiliation></author><author><name sortKey="Beltran, H" sort="Beltran, H" uniqKey="Beltran H" first="H" last="Beltran">H. Beltran</name><affiliation><nlm:affiliation>Department of Medicine, Weill Cornell Medical College, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Chinnaiyan, A M" sort="Chinnaiyan, A M" uniqKey="Chinnaiyan A" first="A M" last="Chinnaiyan">A M Chinnaiyan</name><affiliation><nlm:affiliation>Michigan Centre for Translational Pathology, Department of Pathology Department of Urology, Comprehensive Cancer Centre Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Daugaard, G" sort="Daugaard, G" uniqKey="Daugaard G" first="G" last="Daugaard">G. Daugaard</name><affiliation><nlm:affiliation>Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Davis, I D" sort="Davis, I D" uniqKey="Davis I" first="I D" last="Davis">I D Davis</name><affiliation><nlm:affiliation>Monash University and Eastern Health, Eastern Health Clinical School, Box Hill, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="De Santis, M" sort="De Santis, M" uniqKey="De Santis M" first="M" last="De Santis">M. De Santis</name><affiliation><nlm:affiliation>Cancer Research Centre, University of Warwick, Warwick, UK Ludwig Boltzmann Institute for Applied Cancer Research, Kaiser Franz Josef-Spital, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Drake, C G" sort="Drake, C G" uniqKey="Drake C" first="C G" last="Drake">C G Drake</name><affiliation><nlm:affiliation>Johns Hopkins Sidney Kimmel Cancer Center and The Brady Urological Institute, Department of Urology, Johns Hopkins University School of Medicine, Baltimore, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Eeles, R A" sort="Eeles, R A" uniqKey="Eeles R" first="R A" last="Eeles">R A Eeles</name><affiliation><nlm:affiliation>The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fanti, S" sort="Fanti, S" uniqKey="Fanti S" first="S" last="Fanti">S. Fanti</name><affiliation><nlm:affiliation>Department of Nuclear Medicine, Policlinico S. Orsola, University of Bologna, Bologna, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gleave, M E" sort="Gleave, M E" uniqKey="Gleave M" first="M E" last="Gleave">M E Gleave</name><affiliation><nlm:affiliation>Urological Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Heidenreich, A" sort="Heidenreich, A" uniqKey="Heidenreich A" first="A" last="Heidenreich">A. Heidenreich</name><affiliation><nlm:affiliation>Klinik und Poliklinik für Urologie, RWTH University Aachen, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hussain, M" sort="Hussain, M" uniqKey="Hussain M" first="M" last="Hussain">M. Hussain</name><affiliation><nlm:affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, USA.</nlm:affiliation></affiliation></author><author><name sortKey="James, N D" sort="James, N D" uniqKey="James N" first="N D" last="James">N D James</name><affiliation><nlm:affiliation>Cancer Research Centre, University of Warwick, Warwick, UK Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lecouvet, F E" sort="Lecouvet, F E" uniqKey="Lecouvet F" first="F E" last="Lecouvet">F E Lecouvet</name><affiliation><nlm:affiliation>Department of Radiology, Centre du Cancer et Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Logothetis, C J" sort="Logothetis, C J" uniqKey="Logothetis C" first="C J" last="Logothetis">C J Logothetis</name><affiliation><nlm:affiliation>Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston Department of Genitourinary Medical Oncology, David H. Koch Centre, The University of Texas M. D. Anderson Cancer Centre, Houston, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mastris, K" sort="Mastris, K" uniqKey="Mastris K" first="K" last="Mastris">K. Mastris</name><affiliation><nlm:affiliation>Europa Uomo Prostate Patients, Clayhall Ilford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nilsson, S" sort="Nilsson, S" uniqKey="Nilsson S" first="S" last="Nilsson">S. Nilsson</name><affiliation><nlm:affiliation>Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Oh, W K" sort="Oh, W K" uniqKey="Oh W" first="W K" last="Oh">W K Oh</name><affiliation><nlm:affiliation>Division of Haematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Olmos, D" sort="Olmos, D" uniqKey="Olmos D" first="D" last="Olmos">D. Olmos</name><affiliation><nlm:affiliation>Prostate Cancer Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid CNIO-IBIMA Genitourinary Cancer Unit, Hospitales Universitarios Virgen de la Victoria y Regional de Málaga, Málaga Centro Integral Oncológico Clara Campal (CIOCC), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Padhani, A R" sort="Padhani, A R" uniqKey="Padhani A" first="A R" last="Padhani">A R Padhani</name><affiliation><nlm:affiliation>Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood.</nlm:affiliation></affiliation></author><author><name sortKey="Parker, C" sort="Parker, C" uniqKey="Parker C" first="C" last="Parker">C. Parker</name><affiliation><nlm:affiliation>Prostate Cancer Targeted Therapy Group, Academic Urology Unit and Department of Diagnostic Radiology, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Rubin, M A" sort="Rubin, M A" uniqKey="Rubin M" first="M A" last="Rubin">M A Rubin</name><affiliation><nlm:affiliation>Institute for Precision Medicine, Meyer Cancer Center, Department of Pathology and Urology, Weill Cornell Medical College and NewYork Presbyterian, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schalken, J A" sort="Schalken, J A" uniqKey="Schalken J" first="J A" last="Schalken">J A Schalken</name><affiliation><nlm:affiliation>Department of Urology, Radboud University, Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Scher, H I" sort="Scher, H I" uniqKey="Scher H" first="H I" last="Scher">H I Scher</name><affiliation><nlm:affiliation>Department of Medicine, Weill Cornell Medical College, New York Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Sella, A" sort="Sella, A" uniqKey="Sella A" first="A" last="Sella">A. Sella</name><affiliation><nlm:affiliation>Department of Oncology, Assaf Harofeh Medical Centre, Tel-Aviv University, Sackler School of Medicine, Zerifin, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Shore, N D" sort="Shore, N D" uniqKey="Shore N" first="N D" last="Shore">N D Shore</name><affiliation><nlm:affiliation>Department of Urology, Carolina Urologic Research Centre, Myrtle Beach.</nlm:affiliation></affiliation></author><author><name sortKey="Small, E J" sort="Small, E J" uniqKey="Small E" first="E J" last="Small">E J Small</name><affiliation><nlm:affiliation>Helen Diller Family Comprehensive Cancer Centre, UCSF, San Francisco, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sternberg, C N" sort="Sternberg, C N" uniqKey="Sternberg C" first="C N" last="Sternberg">C N Sternberg</name><affiliation><nlm:affiliation>Department of Medical Oncology, San Camillo and Forlanini Hospitals, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Suzuki, H" sort="Suzuki, H" uniqKey="Suzuki H" first="H" last="Suzuki">H. Suzuki</name><affiliation><nlm:affiliation>Department of Urology, Toho University Sakura Medical Center, Chiba, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Sweeney, C J" sort="Sweeney, C J" uniqKey="Sweeney C" first="C J" last="Sweeney">C J Sweeney</name><affiliation><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tannock, I F" sort="Tannock, I F" uniqKey="Tannock I" first="I F" last="Tannock">I F Tannock</name><affiliation><nlm:affiliation>Department of Medical Oncology and Haematology, Princess Margaret Cancer Centre, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Tombal, B" sort="Tombal, B" uniqKey="Tombal B" first="B" last="Tombal">B. Tombal</name><affiliation><nlm:affiliation>Service D'Urologie, Institut de Recherche Clinique, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26041764</idno><idno type="pmid">26041764</idno><idno type="doi">10.1093/annonc/mdv257</idno><idno type="wicri:Area/PubMed/Corpus">002A66</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A66</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.</title><author><name sortKey="Gillessen, S" sort="Gillessen, S" uniqKey="Gillessen S" first="S" last="Gillessen">S. Gillessen</name><affiliation><nlm:affiliation>Department of Oncology/Haematology, Kantonsspital St Gallen, St Gallen, Switzerland silke.gillessen@kssg.ch.</nlm:affiliation></affiliation></author><author><name sortKey="Omlin, A" sort="Omlin, A" uniqKey="Omlin A" first="A" last="Omlin">A. Omlin</name><affiliation><nlm:affiliation>Department of Oncology/Haematology, Kantonsspital St Gallen, St Gallen, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Attard, G" sort="Attard, G" uniqKey="Attard G" first="G" last="Attard">G. Attard</name><affiliation><nlm:affiliation>Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="De Bono, J S" sort="De Bono, J S" uniqKey="De Bono J" first="J S" last="De Bono">J S De Bono</name><affiliation><nlm:affiliation>Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Efstathiou, E" sort="Efstathiou, E" uniqKey="Efstathiou E" first="E" last="Efstathiou">E. Efstathiou</name><affiliation><nlm:affiliation>Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston Department of Genitourinary Medical Oncology, David H. Koch Centre, The University of Texas M. D. Anderson Cancer Centre, Houston, USA Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Fizazi, K" sort="Fizazi, K" uniqKey="Fizazi K" first="K" last="Fizazi">K. Fizazi</name><affiliation><nlm:affiliation>Department of Cancer Medicine, Institut Gustave Roussy, University of Paris Sud, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Halabi, S" sort="Halabi, S" uniqKey="Halabi S" first="S" last="Halabi">S. Halabi</name><affiliation><nlm:affiliation>Department of Biostatistics and Bioinformatics, Duke University, Durham.</nlm:affiliation></affiliation></author><author><name sortKey="Nelson, P S" sort="Nelson, P S" uniqKey="Nelson P" first="P S" last="Nelson">P S Nelson</name><affiliation><nlm:affiliation>Division of Human Biology, Fred Hutchinson Cancer Research Centre, Seattle.</nlm:affiliation></affiliation></author><author><name sortKey="Sartor, O" sort="Sartor, O" uniqKey="Sartor O" first="O" last="Sartor">O. Sartor</name><affiliation><nlm:affiliation>Tulane Cancer Centre, Tulane University, New Orleans.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, M R" sort="Smith, M R" uniqKey="Smith M" first="M R" last="Smith">M R Smith</name><affiliation><nlm:affiliation>Massachusetts General Hospital Cancer Centre, Boston.</nlm:affiliation></affiliation></author><author><name sortKey="Soule, H R" sort="Soule, H R" uniqKey="Soule H" first="H R" last="Soule">H R Soule</name><affiliation><nlm:affiliation>Prostate Cancer Foundation, Santa Monica, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Akaza, H" sort="Akaza, H" uniqKey="Akaza H" first="H" last="Akaza">H. Akaza</name><affiliation><nlm:affiliation>Research Centre for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Beer, T M" sort="Beer, T M" uniqKey="Beer T" first="T M" last="Beer">T M Beer</name><affiliation><nlm:affiliation>Oregon Health & Science University Knight Cancer Institute, Portland.</nlm:affiliation></affiliation></author><author><name sortKey="Beltran, H" sort="Beltran, H" uniqKey="Beltran H" first="H" last="Beltran">H. Beltran</name><affiliation><nlm:affiliation>Department of Medicine, Weill Cornell Medical College, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Chinnaiyan, A M" sort="Chinnaiyan, A M" uniqKey="Chinnaiyan A" first="A M" last="Chinnaiyan">A M Chinnaiyan</name><affiliation><nlm:affiliation>Michigan Centre for Translational Pathology, Department of Pathology Department of Urology, Comprehensive Cancer Centre Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Daugaard, G" sort="Daugaard, G" uniqKey="Daugaard G" first="G" last="Daugaard">G. Daugaard</name><affiliation><nlm:affiliation>Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Davis, I D" sort="Davis, I D" uniqKey="Davis I" first="I D" last="Davis">I D Davis</name><affiliation><nlm:affiliation>Monash University and Eastern Health, Eastern Health Clinical School, Box Hill, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="De Santis, M" sort="De Santis, M" uniqKey="De Santis M" first="M" last="De Santis">M. De Santis</name><affiliation><nlm:affiliation>Cancer Research Centre, University of Warwick, Warwick, UK Ludwig Boltzmann Institute for Applied Cancer Research, Kaiser Franz Josef-Spital, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Drake, C G" sort="Drake, C G" uniqKey="Drake C" first="C G" last="Drake">C G Drake</name><affiliation><nlm:affiliation>Johns Hopkins Sidney Kimmel Cancer Center and The Brady Urological Institute, Department of Urology, Johns Hopkins University School of Medicine, Baltimore, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Eeles, R A" sort="Eeles, R A" uniqKey="Eeles R" first="R A" last="Eeles">R A Eeles</name><affiliation><nlm:affiliation>The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fanti, S" sort="Fanti, S" uniqKey="Fanti S" first="S" last="Fanti">S. Fanti</name><affiliation><nlm:affiliation>Department of Nuclear Medicine, Policlinico S. Orsola, University of Bologna, Bologna, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Gleave, M E" sort="Gleave, M E" uniqKey="Gleave M" first="M E" last="Gleave">M E Gleave</name><affiliation><nlm:affiliation>Urological Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Heidenreich, A" sort="Heidenreich, A" uniqKey="Heidenreich A" first="A" last="Heidenreich">A. Heidenreich</name><affiliation><nlm:affiliation>Klinik und Poliklinik für Urologie, RWTH University Aachen, Aachen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hussain, M" sort="Hussain, M" uniqKey="Hussain M" first="M" last="Hussain">M. Hussain</name><affiliation><nlm:affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, USA.</nlm:affiliation></affiliation></author><author><name sortKey="James, N D" sort="James, N D" uniqKey="James N" first="N D" last="James">N D James</name><affiliation><nlm:affiliation>Cancer Research Centre, University of Warwick, Warwick, UK Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham, Birmingham, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lecouvet, F E" sort="Lecouvet, F E" uniqKey="Lecouvet F" first="F E" last="Lecouvet">F E Lecouvet</name><affiliation><nlm:affiliation>Department of Radiology, Centre du Cancer et Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Logothetis, C J" sort="Logothetis, C J" uniqKey="Logothetis C" first="C J" last="Logothetis">C J Logothetis</name><affiliation><nlm:affiliation>Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston Department of Genitourinary Medical Oncology, David H. Koch Centre, The University of Texas M. D. Anderson Cancer Centre, Houston, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mastris, K" sort="Mastris, K" uniqKey="Mastris K" first="K" last="Mastris">K. Mastris</name><affiliation><nlm:affiliation>Europa Uomo Prostate Patients, Clayhall Ilford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nilsson, S" sort="Nilsson, S" uniqKey="Nilsson S" first="S" last="Nilsson">S. Nilsson</name><affiliation><nlm:affiliation>Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Oh, W K" sort="Oh, W K" uniqKey="Oh W" first="W K" last="Oh">W K Oh</name><affiliation><nlm:affiliation>Division of Haematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Olmos, D" sort="Olmos, D" uniqKey="Olmos D" first="D" last="Olmos">D. Olmos</name><affiliation><nlm:affiliation>Prostate Cancer Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid CNIO-IBIMA Genitourinary Cancer Unit, Hospitales Universitarios Virgen de la Victoria y Regional de Málaga, Málaga Centro Integral Oncológico Clara Campal (CIOCC), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Padhani, A R" sort="Padhani, A R" uniqKey="Padhani A" first="A R" last="Padhani">A R Padhani</name><affiliation><nlm:affiliation>Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood.</nlm:affiliation></affiliation></author><author><name sortKey="Parker, C" sort="Parker, C" uniqKey="Parker C" first="C" last="Parker">C. Parker</name><affiliation><nlm:affiliation>Prostate Cancer Targeted Therapy Group, Academic Urology Unit and Department of Diagnostic Radiology, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Rubin, M A" sort="Rubin, M A" uniqKey="Rubin M" first="M A" last="Rubin">M A Rubin</name><affiliation><nlm:affiliation>Institute for Precision Medicine, Meyer Cancer Center, Department of Pathology and Urology, Weill Cornell Medical College and NewYork Presbyterian, New York, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schalken, J A" sort="Schalken, J A" uniqKey="Schalken J" first="J A" last="Schalken">J A Schalken</name><affiliation><nlm:affiliation>Department of Urology, Radboud University, Medical Centre, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Scher, H I" sort="Scher, H I" uniqKey="Scher H" first="H I" last="Scher">H I Scher</name><affiliation><nlm:affiliation>Department of Medicine, Weill Cornell Medical College, New York Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Sella, A" sort="Sella, A" uniqKey="Sella A" first="A" last="Sella">A. Sella</name><affiliation><nlm:affiliation>Department of Oncology, Assaf Harofeh Medical Centre, Tel-Aviv University, Sackler School of Medicine, Zerifin, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Shore, N D" sort="Shore, N D" uniqKey="Shore N" first="N D" last="Shore">N D Shore</name><affiliation><nlm:affiliation>Department of Urology, Carolina Urologic Research Centre, Myrtle Beach.</nlm:affiliation></affiliation></author><author><name sortKey="Small, E J" sort="Small, E J" uniqKey="Small E" first="E J" last="Small">E J Small</name><affiliation><nlm:affiliation>Helen Diller Family Comprehensive Cancer Centre, UCSF, San Francisco, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sternberg, C N" sort="Sternberg, C N" uniqKey="Sternberg C" first="C N" last="Sternberg">C N Sternberg</name><affiliation><nlm:affiliation>Department of Medical Oncology, San Camillo and Forlanini Hospitals, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Suzuki, H" sort="Suzuki, H" uniqKey="Suzuki H" first="H" last="Suzuki">H. Suzuki</name><affiliation><nlm:affiliation>Department of Urology, Toho University Sakura Medical Center, Chiba, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Sweeney, C J" sort="Sweeney, C J" uniqKey="Sweeney C" first="C J" last="Sweeney">C J Sweeney</name><affiliation><nlm:affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tannock, I F" sort="Tannock, I F" uniqKey="Tannock I" first="I F" last="Tannock">I F Tannock</name><affiliation><nlm:affiliation>Department of Medical Oncology and Haematology, Princess Margaret Cancer Centre, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Tombal, B" sort="Tombal, B" uniqKey="Tombal B" first="B" last="Tombal">B. Tombal</name><affiliation><nlm:affiliation>Service D'Urologie, Institut de Recherche Clinique, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma (pathology)</term><term>Adenocarcinoma (therapy)</term><term>Androgen Antagonists (therapeutic use)</term><term>Antineoplastic Agents (therapeutic use)</term><term>Antineoplastic Agents, Hormonal (therapeutic use)</term><term>Bone Density Conservation Agents (therapeutic use)</term><term>Humans</term><term>Male</term><term>Orchiectomy</term><term>Practice Guidelines as Topic</term><term>Prostatectomy</term><term>Prostatic Neoplasms (pathology)</term><term>Prostatic Neoplasms (therapy)</term><term>Prostatic Neoplasms, Castration-Resistant (pathology)</term><term>Prostatic Neoplasms, Castration-Resistant (therapy)</term><term>Radiotherapy, Adjuvant</term><term>Taxoids (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Androgen Antagonists</term><term>Antineoplastic Agents</term><term>Antineoplastic Agents, Hormonal</term><term>Bone Density Conservation Agents</term><term>Taxoids</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adenocarcinoma</term><term>Prostatic Neoplasms</term><term>Prostatic Neoplasms, Castration-Resistant</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Adenocarcinoma</term><term>Prostatic Neoplasms</term><term>Prostatic Neoplasms, Castration-Resistant</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Male</term><term>Orchiectomy</term><term>Practice Guidelines as Topic</term><term>Prostatectomy</term><term>Radiotherapy, Adjuvant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-naïve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection. Management recommendations based on expert opinion, and not based on a critical review of the available evidence, are presented. The various recommendations carried differing degrees of support, as reflected in the wording of the article text and in the detailed voting results recorded in supplementary Material, available at Annals of Oncology online. Detailed decisions on treatment as always will involve consideration of disease extent and location, prior treatments, host factors, patient preferences as well as logistical and economic constraints. Inclusion of men with APC in clinical trials should be encouraged.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26041764</PMID><DateCreated><Year>2015</Year><Month>07</Month><Day>23</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>21</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1569-8041</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>8</Issue><PubDate><Year>2015</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Annals of oncology : official journal of the European Society for Medical Oncology</Title><ISOAbbreviation>Ann. Oncol.</ISOAbbreviation></Journal><ArticleTitle>Management of patients with advanced prostate cancer: recommendations of the St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) 2015.</ArticleTitle><Pagination><MedlinePgn>1589-604</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/annonc/mdv257</ELocationID><Abstract><AbstractText>The first St Gallen Advanced Prostate Cancer Consensus Conference (APCCC) Expert Panel identified and reviewed the available evidence for the ten most important areas of controversy in advanced prostate cancer (APC) management. The successful registration of several drugs for castration-resistant prostate cancer and the recent studies of chemo-hormonal therapy in men with castration-naïve prostate cancer have led to considerable uncertainty as to the best treatment choices, sequence of treatment options and appropriate patient selection. Management recommendations based on expert opinion, and not based on a critical review of the available evidence, are presented. The various recommendations carried differing degrees of support, as reflected in the wording of the article text and in the detailed voting results recorded in supplementary Material, available at Annals of Oncology online. Detailed decisions on treatment as always will involve consideration of disease extent and location, prior treatments, host factors, patient preferences as well as logistical and economic constraints. Inclusion of men with APC in clinical trials should be encouraged.</AbstractText><CopyrightInformation>© The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gillessen</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Oncology/Haematology, Kantonsspital St Gallen, St Gallen, Switzerland silke.gillessen@kssg.ch.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Omlin</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Oncology/Haematology, Kantonsspital St Gallen, St Gallen, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Attard</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Bono</LastName><ForeName>J S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Prostate Cancer Targeted Therapy Group and Drug Development Unit, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Efstathiou</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston Department of Genitourinary Medical Oncology, David H. Koch Centre, The University of Texas M. D. Anderson Cancer Centre, Houston, USA Department of Clinical Therapeutics, Alexandra Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fizazi</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Cancer Medicine, Institut Gustave Roussy, University of Paris Sud, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Halabi</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biostatistics and Bioinformatics, Duke University, Durham.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nelson</LastName><ForeName>P S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Division of Human Biology, Fred Hutchinson Cancer Research Centre, Seattle.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sartor</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Tulane Cancer Centre, Tulane University, New Orleans.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>M R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Massachusetts General Hospital Cancer Centre, Boston.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soule</LastName><ForeName>H R</ForeName><Initials>HR</Initials><AffiliationInfo><Affiliation>Prostate Cancer Foundation, Santa Monica, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akaza</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Research Centre for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beer</LastName><ForeName>T M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Oregon Health & Science University Knight Cancer Institute, Portland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beltran</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Medicine, Weill Cornell Medical College, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chinnaiyan</LastName><ForeName>A M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Michigan Centre for Translational Pathology, Department of Pathology Department of Urology, Comprehensive Cancer Centre Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daugaard</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davis</LastName><ForeName>I D</ForeName><Initials>ID</Initials><AffiliationInfo><Affiliation>Monash University and Eastern Health, Eastern Health Clinical School, Box Hill, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Santis</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Cancer Research Centre, University of Warwick, Warwick, UK Ludwig Boltzmann Institute for Applied Cancer Research, Kaiser Franz Josef-Spital, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Drake</LastName><ForeName>C G</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Johns Hopkins Sidney Kimmel Cancer Center and The Brady Urological Institute, Department of Urology, Johns Hopkins University School of Medicine, Baltimore, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eeles</LastName><ForeName>R A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fanti</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Nuclear Medicine, Policlinico S. Orsola, University of Bologna, Bologna, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gleave</LastName><ForeName>M E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Urological Sciences, Vancouver Prostate Centre, University of British Columbia, Vancouver, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heidenreich</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Klinik und Poliklinik für Urologie, RWTH University Aachen, Aachen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hussain</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Michigan Comprehensive Cancer Center, Ann Arbor, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>James</LastName><ForeName>N D</ForeName><Initials>ND</Initials><AffiliationInfo><Affiliation>Cancer Research Centre, University of Warwick, Warwick, UK Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham, Birmingham, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lecouvet</LastName><ForeName>F E</ForeName><Initials>FE</Initials><AffiliationInfo><Affiliation>Department of Radiology, Centre du Cancer et Institut de Recherche Expérimentale et Clinique (IREC), Cliniques Universitaires Saint Luc, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Logothetis</LastName><ForeName>C J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Department of Genitourinary Medical Oncology, MD Anderson Cancer Centre, Houston Department of Genitourinary Medical Oncology, David H. Koch Centre, The University of Texas M. D. Anderson Cancer Centre, Houston, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mastris</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Europa Uomo Prostate Patients, Clayhall Ilford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nilsson</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oh</LastName><ForeName>W K</ForeName><Initials>WK</Initials><AffiliationInfo><Affiliation>Division of Haematology and Medical Oncology, The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olmos</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Prostate Cancer Clinical Research Unit, Spanish National Cancer Research Centre (CNIO), Madrid CNIO-IBIMA Genitourinary Cancer Unit, Hospitales Universitarios Virgen de la Victoria y Regional de Málaga, Málaga Centro Integral Oncológico Clara Campal (CIOCC), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Padhani</LastName><ForeName>A R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Paul Strickland Scanner Centre, Mount Vernon Cancer Centre, Northwood.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parker</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Prostate Cancer Targeted Therapy Group, Academic Urology Unit and Department of Diagnostic Radiology, The Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rubin</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Institute for Precision Medicine, Meyer Cancer Center, Department of Pathology and Urology, Weill Cornell Medical College and NewYork Presbyterian, New York, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schalken</LastName><ForeName>J A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Urology, Radboud University, Medical Centre, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scher</LastName><ForeName>H I</ForeName><Initials>HI</Initials><AffiliationInfo><Affiliation>Department of Medicine, Weill Cornell Medical College, New York Genitourinary Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sella</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Oncology, Assaf Harofeh Medical Centre, Tel-Aviv University, Sackler School of Medicine, Zerifin, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shore</LastName><ForeName>N D</ForeName><Initials>ND</Initials><AffiliationInfo><Affiliation>Department of Urology, Carolina Urologic Research Centre, Myrtle Beach.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Small</LastName><ForeName>E J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Helen Diller Family Comprehensive Cancer Centre, UCSF, San Francisco, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sternberg</LastName><ForeName>C N</ForeName><Initials>CN</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, San Camillo and Forlanini Hospitals, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suzuki</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Urology, Toho University Sakura Medical Center, Chiba, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sweeney</LastName><ForeName>C J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tannock</LastName><ForeName>I F</ForeName><Initials>IF</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology and Haematology, Princess Margaret Cancer Centre, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tombal</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Service D'Urologie, Institut de Recherche Clinique, Université Catholique de Louvain, Brussels, Belgium.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K24 CA121990</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>PG12-49</GrantID><Agency>Prostate Cancer UK</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016446">Consensus Development Conference</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>06</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Oncol</MedlineTA><NlmUniqueID>9007735</NlmUniqueID><ISSNLinking>0923-7534</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000726">Androgen Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018931">Antineoplastic Agents, Hormonal</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050071">Bone Density Conservation Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D043823">Taxoids</NameOfSubstance></Chemical><Chemical><RegistryNumber>15H5577CQD</RegistryNumber><NameOfSubstance UI="C067311">docetaxel</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>Ann Oncol. 2015 Nov;26(11):2354</RefSource><PMID Version="1">26216387</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>Ann Oncol. 2015 Nov;26(11):2354-5</RefSource><PMID Version="1">26347101</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Urology. 1997 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