Prognostic factors in stage III-IV adrenocortical carcinomas (ACC): an European Network for the Study of Adrenal Tumor (ENSAT) study.
Identifieur interne : 002838 ( PubMed/Corpus ); précédent : 002837; suivant : 002839Prognostic factors in stage III-IV adrenocortical carcinomas (ACC): an European Network for the Study of Adrenal Tumor (ENSAT) study.
Auteurs : R. Libé ; I. Borget ; C L Ronchi ; B. Zaggia ; M. Kroiss ; T. Kerkhofs ; J. Bertherat ; M. Volante ; M. Quinkler ; O. Chabre ; M. Bala ; A. Tabarin ; F. Beuschlein ; D. Vezzosi ; T. Deutschbein ; F. Borson-Chazot ; I. Hermsen ; A. Stell ; C. Fottner ; S. Leboulleux ; S. Hahner ; M. Mannelli ; A. Berruti ; H. Haak ; M. Terzolo ; M. Fassnacht ; E. BaudinSource :
- Annals of oncology : official journal of the European Society for Medical Oncology [ 1569-8041 ] ; 2015.
English descriptors
- KwdEn :
- Adrenal Cortex Neoplasms (mortality), Adrenal Cortex Neoplasms (pathology), Adrenocortical Carcinoma (mortality), Adrenocortical Carcinoma (pathology), Bone Neoplasms (mortality), Bone Neoplasms (secondary), Europe, Female, Follow-Up Studies, Humans, Liver Neoplasms (mortality), Liver Neoplasms (secondary), Lung Neoplasms (mortality), Lung Neoplasms (secondary), Lymphatic Metastasis, Male, Middle Aged, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Recurrence, Local (mortality), Neoplasm Recurrence, Local (pathology), Neoplasm Staging, Prognosis, Retrospective Studies, Survival Rate.
- MESH :
- geographic : Europe.
- mortality : Adrenal Cortex Neoplasms, Adrenocortical Carcinoma, Bone Neoplasms, Liver Neoplasms, Lung Neoplasms, Neoplasm Recurrence, Local.
- pathology : Adrenal Cortex Neoplasms, Adrenocortical Carcinoma, Neoplasm Recurrence, Local.
- secondary : Bone Neoplasms, Liver Neoplasms, Lung Neoplasms.
- Female, Follow-Up Studies, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Grading, Neoplasm Invasiveness, Neoplasm Staging, Prognosis, Retrospective Studies, Survival Rate.
Abstract
The clinical course of advanced adrenocortical carcinoma (ACC) is heterogeneous. Our study aimed primarily to refine and make headway in the prognostic stratification of advanced ACC.
DOI: 10.1093/annonc/mdv329
PubMed: 26392430
Links to Exploration step
pubmed:26392430Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prognostic factors in stage III-IV adrenocortical carcinomas (ACC): an European Network for the Study of Adrenal Tumor (ENSAT) study.</title><author><name sortKey="Libe, R" sort="Libe, R" uniqKey="Libe R" first="R" last="Libé">R. Libé</name><affiliation><nlm:affiliation>French Adrenal Cancer Network, Institut National du Cancer, Paris.</nlm:affiliation></affiliation></author><author><name sortKey="Borget, I" sort="Borget, I" uniqKey="Borget I" first="I" last="Borget">I. Borget</name><affiliation><nlm:affiliation>Department of Biostatistics and Epidemiology, Gustave Roussy and University Paris-Sud, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ronchi, C L" sort="Ronchi, C L" uniqKey="Ronchi C" first="C L" last="Ronchi">C L Ronchi</name><affiliation><nlm:affiliation>Central Laboratory, Research Unit, University Hospital Wurzburg, Wurzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Zaggia, B" sort="Zaggia, B" uniqKey="Zaggia B" first="B" last="Zaggia">B. Zaggia</name><affiliation><nlm:affiliation>Internal Medicine, San Luigi Hospital, University of Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Kroiss, M" sort="Kroiss, M" uniqKey="Kroiss M" first="M" last="Kroiss">M. Kroiss</name><affiliation><nlm:affiliation>Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kerkhofs, T" sort="Kerkhofs, T" uniqKey="Kerkhofs T" first="T" last="Kerkhofs">T. Kerkhofs</name><affiliation><nlm:affiliation>Internal Medicine, Maxima Medisch Centrum, Eindhoven, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bertherat, J" sort="Bertherat, J" uniqKey="Bertherat J" first="J" last="Bertherat">J. Bertherat</name><affiliation><nlm:affiliation>Endocrinology Unit, Cochin Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Volante, M" sort="Volante, M" uniqKey="Volante M" first="M" last="Volante">M. Volante</name><affiliation><nlm:affiliation>Department of Oncology, University of Turin, San Luigi Hospital, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Quinkler, M" sort="Quinkler, M" uniqKey="Quinkler M" first="M" last="Quinkler">M. Quinkler</name><affiliation><nlm:affiliation>Clinical Endocrinology, Charit Campus Mitte, Charitί University Medicine Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chabre, O" sort="Chabre, O" uniqKey="Chabre O" first="O" last="Chabre">O. Chabre</name><affiliation><nlm:affiliation>Endocrinology Unit, University Hospital of Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bala, M" sort="Bala, M" uniqKey="Bala M" first="M" last="Bala">M. Bala</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tabarin, A" sort="Tabarin, A" uniqKey="Tabarin A" first="A" last="Tabarin">A. Tabarin</name><affiliation><nlm:affiliation>Department of Endocrinology, CHU Bordeaux, University of Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Beuschlein, F" sort="Beuschlein, F" uniqKey="Beuschlein F" first="F" last="Beuschlein">F. Beuschlein</name><affiliation><nlm:affiliation>Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Vezzosi, D" sort="Vezzosi, D" uniqKey="Vezzosi D" first="D" last="Vezzosi">D. Vezzosi</name><affiliation><nlm:affiliation>Department of Endocrinology and Metabolic Diseases, CHU Larrey, Toulouse.</nlm:affiliation></affiliation></author><author><name sortKey="Deutschbein, T" sort="Deutschbein, T" uniqKey="Deutschbein T" first="T" last="Deutschbein">T. Deutschbein</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Borson Chazot, F" sort="Borson Chazot, F" uniqKey="Borson Chazot F" first="F" last="Borson-Chazot">F. Borson-Chazot</name><affiliation><nlm:affiliation>Nuclear Medicine Unit, University of Lyon 1, Hospices Civils de Lyon Bron, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hermsen, I" sort="Hermsen, I" uniqKey="Hermsen I" first="I" last="Hermsen">I. Hermsen</name><affiliation><nlm:affiliation>Internal Medicine, Maxima Medisch Centrum, Eindhoven, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Stell, A" sort="Stell, A" uniqKey="Stell A" first="A" last="Stell">A. Stell</name><affiliation><nlm:affiliation>Melbourne eResearch Group Level 3, Doug McDonell Building, University of Melbourne, Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Fottner, C" sort="Fottner, C" uniqKey="Fottner C" first="C" last="Fottner">C. Fottner</name><affiliation><nlm:affiliation>Department of Medicine 1, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Leboulleux, S" sort="Leboulleux, S" uniqKey="Leboulleux S" first="S" last="Leboulleux">S. Leboulleux</name><affiliation><nlm:affiliation>Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hahner, S" sort="Hahner, S" uniqKey="Hahner S" first="S" last="Hahner">S. Hahner</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mannelli, M" sort="Mannelli, M" uniqKey="Mannelli M" first="M" last="Mannelli">M. Mannelli</name><affiliation><nlm:affiliation>Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Florence.</nlm:affiliation></affiliation></author><author><name sortKey="Berruti, A" sort="Berruti, A" uniqKey="Berruti A" first="A" last="Berruti">A. Berruti</name><affiliation><nlm:affiliation>Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili Hospital, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Haak, H" sort="Haak, H" uniqKey="Haak H" first="H" last="Haak">H. Haak</name><affiliation><nlm:affiliation>Internal Medicine, Maxima Medisch Centrum, Eindhoven, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Terzolo, M" sort="Terzolo, M" uniqKey="Terzolo M" first="M" last="Terzolo">M. Terzolo</name><affiliation><nlm:affiliation>Internal Medicine, San Luigi Hospital, University of Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fassnacht, M" sort="Fassnacht, M" uniqKey="Fassnacht M" first="M" last="Fassnacht">M. Fassnacht</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Baudin, E" sort="Baudin, E" uniqKey="Baudin E" first="E" last="Baudin">E. Baudin</name><affiliation><nlm:affiliation>Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave Roussy, Villejuif, France eric.baudin@gustaveroussy.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26392430</idno><idno type="pmid">26392430</idno><idno type="doi">10.1093/annonc/mdv329</idno><idno type="wicri:Area/PubMed/Corpus">002838</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002838</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prognostic factors in stage III-IV adrenocortical carcinomas (ACC): an European Network for the Study of Adrenal Tumor (ENSAT) study.</title><author><name sortKey="Libe, R" sort="Libe, R" uniqKey="Libe R" first="R" last="Libé">R. Libé</name><affiliation><nlm:affiliation>French Adrenal Cancer Network, Institut National du Cancer, Paris.</nlm:affiliation></affiliation></author><author><name sortKey="Borget, I" sort="Borget, I" uniqKey="Borget I" first="I" last="Borget">I. Borget</name><affiliation><nlm:affiliation>Department of Biostatistics and Epidemiology, Gustave Roussy and University Paris-Sud, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ronchi, C L" sort="Ronchi, C L" uniqKey="Ronchi C" first="C L" last="Ronchi">C L Ronchi</name><affiliation><nlm:affiliation>Central Laboratory, Research Unit, University Hospital Wurzburg, Wurzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Zaggia, B" sort="Zaggia, B" uniqKey="Zaggia B" first="B" last="Zaggia">B. Zaggia</name><affiliation><nlm:affiliation>Internal Medicine, San Luigi Hospital, University of Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Kroiss, M" sort="Kroiss, M" uniqKey="Kroiss M" first="M" last="Kroiss">M. Kroiss</name><affiliation><nlm:affiliation>Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kerkhofs, T" sort="Kerkhofs, T" uniqKey="Kerkhofs T" first="T" last="Kerkhofs">T. Kerkhofs</name><affiliation><nlm:affiliation>Internal Medicine, Maxima Medisch Centrum, Eindhoven, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Bertherat, J" sort="Bertherat, J" uniqKey="Bertherat J" first="J" last="Bertherat">J. Bertherat</name><affiliation><nlm:affiliation>Endocrinology Unit, Cochin Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Volante, M" sort="Volante, M" uniqKey="Volante M" first="M" last="Volante">M. Volante</name><affiliation><nlm:affiliation>Department of Oncology, University of Turin, San Luigi Hospital, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Quinkler, M" sort="Quinkler, M" uniqKey="Quinkler M" first="M" last="Quinkler">M. Quinkler</name><affiliation><nlm:affiliation>Clinical Endocrinology, Charit Campus Mitte, Charitί University Medicine Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chabre, O" sort="Chabre, O" uniqKey="Chabre O" first="O" last="Chabre">O. Chabre</name><affiliation><nlm:affiliation>Endocrinology Unit, University Hospital of Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bala, M" sort="Bala, M" uniqKey="Bala M" first="M" last="Bala">M. Bala</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tabarin, A" sort="Tabarin, A" uniqKey="Tabarin A" first="A" last="Tabarin">A. Tabarin</name><affiliation><nlm:affiliation>Department of Endocrinology, CHU Bordeaux, University of Bordeaux, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Beuschlein, F" sort="Beuschlein, F" uniqKey="Beuschlein F" first="F" last="Beuschlein">F. Beuschlein</name><affiliation><nlm:affiliation>Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Vezzosi, D" sort="Vezzosi, D" uniqKey="Vezzosi D" first="D" last="Vezzosi">D. Vezzosi</name><affiliation><nlm:affiliation>Department of Endocrinology and Metabolic Diseases, CHU Larrey, Toulouse.</nlm:affiliation></affiliation></author><author><name sortKey="Deutschbein, T" sort="Deutschbein, T" uniqKey="Deutschbein T" first="T" last="Deutschbein">T. Deutschbein</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Borson Chazot, F" sort="Borson Chazot, F" uniqKey="Borson Chazot F" first="F" last="Borson-Chazot">F. Borson-Chazot</name><affiliation><nlm:affiliation>Nuclear Medicine Unit, University of Lyon 1, Hospices Civils de Lyon Bron, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hermsen, I" sort="Hermsen, I" uniqKey="Hermsen I" first="I" last="Hermsen">I. Hermsen</name><affiliation><nlm:affiliation>Internal Medicine, Maxima Medisch Centrum, Eindhoven, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Stell, A" sort="Stell, A" uniqKey="Stell A" first="A" last="Stell">A. Stell</name><affiliation><nlm:affiliation>Melbourne eResearch Group Level 3, Doug McDonell Building, University of Melbourne, Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Fottner, C" sort="Fottner, C" uniqKey="Fottner C" first="C" last="Fottner">C. Fottner</name><affiliation><nlm:affiliation>Department of Medicine 1, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Leboulleux, S" sort="Leboulleux, S" uniqKey="Leboulleux S" first="S" last="Leboulleux">S. Leboulleux</name><affiliation><nlm:affiliation>Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hahner, S" sort="Hahner, S" uniqKey="Hahner S" first="S" last="Hahner">S. Hahner</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mannelli, M" sort="Mannelli, M" uniqKey="Mannelli M" first="M" last="Mannelli">M. Mannelli</name><affiliation><nlm:affiliation>Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Florence.</nlm:affiliation></affiliation></author><author><name sortKey="Berruti, A" sort="Berruti, A" uniqKey="Berruti A" first="A" last="Berruti">A. Berruti</name><affiliation><nlm:affiliation>Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili Hospital, Brescia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Haak, H" sort="Haak, H" uniqKey="Haak H" first="H" last="Haak">H. Haak</name><affiliation><nlm:affiliation>Internal Medicine, Maxima Medisch Centrum, Eindhoven, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Terzolo, M" sort="Terzolo, M" uniqKey="Terzolo M" first="M" last="Terzolo">M. Terzolo</name><affiliation><nlm:affiliation>Internal Medicine, San Luigi Hospital, University of Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fassnacht, M" sort="Fassnacht, M" uniqKey="Fassnacht M" first="M" last="Fassnacht">M. Fassnacht</name><affiliation><nlm:affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Baudin, E" sort="Baudin, E" uniqKey="Baudin E" first="E" last="Baudin">E. Baudin</name><affiliation><nlm:affiliation>Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave Roussy, Villejuif, France eric.baudin@gustaveroussy.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Annals of oncology : official journal of the European Society for Medical Oncology</title><idno type="eISSN">1569-8041</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Neoplasms (mortality)</term><term>Adrenal Cortex Neoplasms (pathology)</term><term>Adrenocortical Carcinoma (mortality)</term><term>Adrenocortical Carcinoma (pathology)</term><term>Bone Neoplasms (mortality)</term><term>Bone Neoplasms (secondary)</term><term>Europe</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Liver Neoplasms (mortality)</term><term>Liver Neoplasms (secondary)</term><term>Lung Neoplasms (mortality)</term><term>Lung Neoplasms (secondary)</term><term>Lymphatic Metastasis</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Grading</term><term>Neoplasm Invasiveness</term><term>Neoplasm Recurrence, Local (mortality)</term><term>Neoplasm Recurrence, Local (pathology)</term><term>Neoplasm Staging</term><term>Prognosis</term><term>Retrospective Studies</term><term>Survival Rate</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Adrenal Cortex Neoplasms</term><term>Adrenocortical Carcinoma</term><term>Bone Neoplasms</term><term>Liver Neoplasms</term><term>Lung Neoplasms</term><term>Neoplasm Recurrence, Local</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Adrenal Cortex Neoplasms</term><term>Adrenocortical Carcinoma</term><term>Neoplasm Recurrence, Local</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Bone Neoplasms</term><term>Liver Neoplasms</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Lymphatic Metastasis</term><term>Male</term><term>Middle Aged</term><term>Neoplasm Grading</term><term>Neoplasm Invasiveness</term><term>Neoplasm Staging</term><term>Prognosis</term><term>Retrospective Studies</term><term>Survival Rate</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinical course of advanced adrenocortical carcinoma (ACC) is heterogeneous. Our study aimed primarily to refine and make headway in the prognostic stratification of advanced ACC.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26392430</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>22</Day></DateCreated><DateCompleted><Year>2016</Year><Month>07</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>10</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1569-8041</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>10</Issue><PubDate><Year>2015</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Annals of oncology : official journal of the European Society for Medical Oncology</Title><ISOAbbreviation>Ann. Oncol.</ISOAbbreviation></Journal><ArticleTitle>Prognostic factors in stage III-IV adrenocortical carcinomas (ACC): an European Network for the Study of Adrenal Tumor (ENSAT) study.</ArticleTitle><Pagination><MedlinePgn>2119-25</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/annonc/mdv329</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The clinical course of advanced adrenocortical carcinoma (ACC) is heterogeneous. Our study aimed primarily to refine and make headway in the prognostic stratification of advanced ACC.</AbstractText><AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Patients with advanced ENSAT ACC (stage III or stage IV) at diagnosis registered between 2000 and 2009 in the ENSAT database were enrolled. The primary end point was overall survival (OS). Parameters of potential prognostic relevance were selected. Univariate and multivariate analyses were carried out: model 1 'before surgery'; model 2 'post-surgery'.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Four hundred and forty-four patients with advanced ENSAT ACC (stage III: 210; stage IV: 234) were analyzed. After a median follow-up of 55.2 months, the median OS was 24 months. A modified ENSAT (mENSAT) classification was validated: stage III (invasion of surrounding tissues/organs or the vena renalis/cava) and stage IVa, IVb, IVc (2, 3 or >3 metastatic organs, including N, respectively). Two- or 5-year OS was 73%, 46%, 26% and 15% or 50%, 15%, 14% and 2% for stages III, IVa, IVb and IVc, respectively. In the multivariate analysis, mENSAT stages (stages IVa, IVb, or IVc, respectively) were significantly correlated with OS (P < 0.0001), as well as additional parameters: age ≥ 50 years (P < 0.0001), tumor- or hormone-related symptoms (P = 0.01 and 0.03, respectively) in model 1 but also the R status (P = 0.001) and Grade (Weiss >6 and/or Ki67 ≥ 20%, P = 0.06) in model 2.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The mENSAT classification and GRAS parameters (Grade, R status, Age and Symptoms) were found to best stratify the prognosis of patients with advanced ACC.</AbstractText><CopyrightInformation>© The Author 2015. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Libé</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>French Adrenal Cancer Network, Institut National du Cancer, Paris.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borget</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Biostatistics and Epidemiology, Gustave Roussy and University Paris-Sud, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ronchi</LastName><ForeName>C L</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>Central Laboratory, Research Unit, University Hospital Wurzburg, Wurzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaggia</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Internal Medicine, San Luigi Hospital, University of Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kroiss</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Comprehensive Cancer Center Mainfranken, University of Würzburg, Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kerkhofs</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Internal Medicine, Maxima Medisch Centrum, Eindhoven, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertherat</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Endocrinology Unit, Cochin Hospital, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Volante</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Oncology, University of Turin, San Luigi Hospital, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quinkler</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Clinical Endocrinology, Charit Campus Mitte, Charitί University Medicine Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chabre</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Endocrinology Unit, University Hospital of Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bala</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tabarin</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Endocrinology, CHU Bordeaux, University of Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beuschlein</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians-Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vezzosi</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Endocrinology and Metabolic Diseases, CHU Larrey, Toulouse.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deutschbein</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borson-Chazot</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Nuclear Medicine Unit, University of Lyon 1, Hospices Civils de Lyon Bron, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hermsen</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Internal Medicine, Maxima Medisch Centrum, Eindhoven, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stell</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Melbourne eResearch Group Level 3, Doug McDonell Building, University of Melbourne, Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fottner</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Medicine 1, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leboulleux</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave Roussy, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hahner</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mannelli</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Florence.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berruti</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili Hospital, Brescia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haak</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Internal Medicine, Maxima Medisch Centrum, Eindhoven, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Terzolo</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Internal Medicine, San Luigi Hospital, University of Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fassnacht</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine I, Endocrine and Diabetes Unit, University Hospital Würzburg, University of Würzburg, Würzburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baudin</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave Roussy, Villejuif, France eric.baudin@gustaveroussy.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>ENSAT network</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ann Oncol</MedlineTA><NlmUniqueID>9007735</NlmUniqueID><ISSNLinking>0923-7534</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000306" MajorTopicYN="N">Adrenal Cortex Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018268" MajorTopicYN="N">Adrenocortical Carcinoma</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001859" MajorTopicYN="N">Bone Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000556" MajorTopicYN="Y">secondary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005060" MajorTopicYN="N" Type="Geographic">Europe</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008113" MajorTopicYN="N">Liver Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000556" MajorTopicYN="Y">secondary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008175" MajorTopicYN="N">Lung Neoplasms</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000556" MajorTopicYN="Y">secondary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008207" MajorTopicYN="N">Lymphatic Metastasis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D060787" MajorTopicYN="N">Neoplasm Grading</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009361" MajorTopicYN="N">Neoplasm Invasiveness</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009364" MajorTopicYN="N">Neoplasm Recurrence, Local</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009367" MajorTopicYN="N">Neoplasm Staging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">ENSAT</Keyword><Keyword MajorTopicYN="N">GRAS</Keyword><Keyword MajorTopicYN="N">adrenocortical carcinoma</Keyword><Keyword MajorTopicYN="N">prognostic factors</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>9</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>9</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26392430</ArticleId><ArticleId IdType="pii">mdv329</ArticleId><ArticleId IdType="doi">10.1093/annonc/mdv329</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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