Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.
Identifieur interne : 002667 ( PubMed/Corpus ); précédent : 002666; suivant : 002668Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.
Auteurs : Alistair Nichol ; Craig French ; Lorraine Little ; Samir Haddad ; Jeffrey Presneill ; Yaseen Arabi ; Michael Bailey ; D James Cooper ; Jacques Duranteau ; Olivier Huet ; Anne Mak ; Colin Mcarthur ; Ville Pettil ; Markus Skrifvars ; Shirley Vallance ; Dinesh Varma ; Judy Wills ; Rinaldo BellomoSource :
- Lancet (London, England) [ 1474-547X ] ; 2015.
English descriptors
- KwdEn :
- Adult, Australia (epidemiology), Brain Injuries (drug therapy), Brain Injuries (mortality), Double-Blind Method, Erythropoietin (therapeutic use), Europe (epidemiology), Female, Glasgow Outcome Scale, Humans, Incidence, Male, Middle Aged, New Zealand (epidemiology), Saudi Arabia (epidemiology), Treatment Outcome, Venous Thrombosis (epidemiology), Young Adult.
- MESH :
- chemical , therapeutic use : Erythropoietin.
- geographic , epidemiology : Australia, Europe, New Zealand, Saudi Arabia.
- drug therapy : Brain Injuries.
- epidemiology : Venous Thrombosis.
- mortality : Brain Injuries.
- Adult, Double-Blind Method, Female, Glasgow Outcome Scale, Humans, Incidence, Male, Middle Aged, Treatment Outcome, Young Adult.
Abstract
Erythropoietin might have neurocytoprotective effects. In this trial, we studied its effect on neurological recovery, mortality, and venous thrombotic events in patients with traumatic brain injury.
DOI: 10.1016/S0140-6736(15)00386-4
PubMed: 26452709
Links to Exploration step
pubmed:26452709Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.</title><author><name sortKey="Nichol, Alistair" sort="Nichol, Alistair" uniqKey="Nichol A" first="Alistair" last="Nichol">Alistair Nichol</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia; School of Medicine and Medical Sciences, University College Dublin, Dublin Ireland; St Vincent's University Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="French, Craig" sort="French, Craig" uniqKey="French C" first="Craig" last="French">Craig French</name><affiliation><nlm:affiliation>University of Melbourne, Melbourne, VIC, Australia; Western Health, Melbourne, VIC, Australia. Electronic address: craig.french@wh.org.au.</nlm:affiliation></affiliation></author><author><name sortKey="Little, Lorraine" sort="Little, Lorraine" uniqKey="Little L" first="Lorraine" last="Little">Lorraine Little</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Haddad, Samir" sort="Haddad, Samir" uniqKey="Haddad S" first="Samir" last="Haddad">Samir Haddad</name><affiliation><nlm:affiliation>King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Presneill, Jeffrey" sort="Presneill, Jeffrey" uniqKey="Presneill J" first="Jeffrey" last="Presneill">Jeffrey Presneill</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; University of Queensland, Brisbane, QLD, Australia; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Bailey, Michael" sort="Bailey, Michael" uniqKey="Bailey M" first="Michael" last="Bailey">Michael Bailey</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, D James" sort="Cooper, D James" uniqKey="Cooper D" first="D James" last="Cooper">D James Cooper</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Duranteau, Jacques" sort="Duranteau, Jacques" uniqKey="Duranteau J" first="Jacques" last="Duranteau">Jacques Duranteau</name><affiliation><nlm:affiliation>Département d'Anesthésie-Réanimation, Hôpital de Bicêtre, Assistance Publique des Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Huet, Olivier" sort="Huet, Olivier" uniqKey="Huet O" first="Olivier" last="Huet">Olivier Huet</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Department of Anaesthesiology and Intensive Care Medicine, CHU La Cavale Blanche, Brest, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mak, Anne" sort="Mak, Anne" uniqKey="Mak A" first="Anne" last="Mak">Anne Mak</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mcarthur, Colin" sort="Mcarthur, Colin" uniqKey="Mcarthur C" first="Colin" last="Mcarthur">Colin Mcarthur</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Auckland City Hospital, Auckland, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Pettil, Ville" sort="Pettil, Ville" uniqKey="Pettil V" first="Ville" last="Pettil">Ville Pettil</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; University of Helsinki and Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Skrifvars, Markus" sort="Skrifvars, Markus" uniqKey="Skrifvars M" first="Markus" last="Skrifvars">Markus Skrifvars</name><affiliation><nlm:affiliation>University of Helsinki and Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Vallance, Shirley" sort="Vallance, Shirley" uniqKey="Vallance S" first="Shirley" last="Vallance">Shirley Vallance</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Varma, Dinesh" sort="Varma, Dinesh" uniqKey="Varma D" first="Dinesh" last="Varma">Dinesh Varma</name><affiliation><nlm:affiliation>The Alfred, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Wills, Judy" sort="Wills, Judy" uniqKey="Wills J" first="Judy" last="Wills">Judy Wills</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia; Austin Hospital, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26452709</idno><idno type="pmid">26452709</idno><idno type="doi">10.1016/S0140-6736(15)00386-4</idno><idno type="wicri:Area/PubMed/Corpus">002667</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002667</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.</title><author><name sortKey="Nichol, Alistair" sort="Nichol, Alistair" uniqKey="Nichol A" first="Alistair" last="Nichol">Alistair Nichol</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia; School of Medicine and Medical Sciences, University College Dublin, Dublin Ireland; St Vincent's University Hospital, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="French, Craig" sort="French, Craig" uniqKey="French C" first="Craig" last="French">Craig French</name><affiliation><nlm:affiliation>University of Melbourne, Melbourne, VIC, Australia; Western Health, Melbourne, VIC, Australia. Electronic address: craig.french@wh.org.au.</nlm:affiliation></affiliation></author><author><name sortKey="Little, Lorraine" sort="Little, Lorraine" uniqKey="Little L" first="Lorraine" last="Little">Lorraine Little</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Haddad, Samir" sort="Haddad, Samir" uniqKey="Haddad S" first="Samir" last="Haddad">Samir Haddad</name><affiliation><nlm:affiliation>King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Presneill, Jeffrey" sort="Presneill, Jeffrey" uniqKey="Presneill J" first="Jeffrey" last="Presneill">Jeffrey Presneill</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; University of Queensland, Brisbane, QLD, Australia; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Arabi, Yaseen" sort="Arabi, Yaseen" uniqKey="Arabi Y" first="Yaseen" last="Arabi">Yaseen Arabi</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Bailey, Michael" sort="Bailey, Michael" uniqKey="Bailey M" first="Michael" last="Bailey">Michael Bailey</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, D James" sort="Cooper, D James" uniqKey="Cooper D" first="D James" last="Cooper">D James Cooper</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Duranteau, Jacques" sort="Duranteau, Jacques" uniqKey="Duranteau J" first="Jacques" last="Duranteau">Jacques Duranteau</name><affiliation><nlm:affiliation>Département d'Anesthésie-Réanimation, Hôpital de Bicêtre, Assistance Publique des Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Huet, Olivier" sort="Huet, Olivier" uniqKey="Huet O" first="Olivier" last="Huet">Olivier Huet</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Department of Anaesthesiology and Intensive Care Medicine, CHU La Cavale Blanche, Brest, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mak, Anne" sort="Mak, Anne" uniqKey="Mak A" first="Anne" last="Mak">Anne Mak</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mcarthur, Colin" sort="Mcarthur, Colin" uniqKey="Mcarthur C" first="Colin" last="Mcarthur">Colin Mcarthur</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Auckland City Hospital, Auckland, New Zealand.</nlm:affiliation></affiliation></author><author><name sortKey="Pettil, Ville" sort="Pettil, Ville" uniqKey="Pettil V" first="Ville" last="Pettil">Ville Pettil</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; University of Helsinki and Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Skrifvars, Markus" sort="Skrifvars, Markus" uniqKey="Skrifvars M" first="Markus" last="Skrifvars">Markus Skrifvars</name><affiliation><nlm:affiliation>University of Helsinki and Helsinki University Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Vallance, Shirley" sort="Vallance, Shirley" uniqKey="Vallance S" first="Shirley" last="Vallance">Shirley Vallance</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Varma, Dinesh" sort="Varma, Dinesh" uniqKey="Varma D" first="Dinesh" last="Varma">Dinesh Varma</name><affiliation><nlm:affiliation>The Alfred, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Wills, Judy" sort="Wills, Judy" uniqKey="Wills J" first="Judy" last="Wills">Judy Wills</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bellomo, Rinaldo" sort="Bellomo, Rinaldo" uniqKey="Bellomo R" first="Rinaldo" last="Bellomo">Rinaldo Bellomo</name><affiliation><nlm:affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia; Austin Hospital, Melbourne, VIC, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Australia (epidemiology)</term><term>Brain Injuries (drug therapy)</term><term>Brain Injuries (mortality)</term><term>Double-Blind Method</term><term>Erythropoietin (therapeutic use)</term><term>Europe (epidemiology)</term><term>Female</term><term>Glasgow Outcome Scale</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>New Zealand (epidemiology)</term><term>Saudi Arabia (epidemiology)</term><term>Treatment Outcome</term><term>Venous Thrombosis (epidemiology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Erythropoietin</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Australia</term><term>Europe</term><term>New Zealand</term><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Brain Injuries</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Venous Thrombosis</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Brain Injuries</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Female</term><term>Glasgow Outcome Scale</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Treatment Outcome</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Erythropoietin might have neurocytoprotective effects. In this trial, we studied its effect on neurological recovery, mortality, and venous thrombotic events in patients with traumatic brain injury.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26452709</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>07</Day></DateCreated><DateCompleted><Year>2016</Year><Month>01</Month><Day>29</Day></DateCompleted><DateRevised><Year>2016</Year><Month>01</Month><Day>07</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN><JournalIssue CitedMedium="Internet"><Volume>386</Volume><Issue>10012</Issue><PubDate><Year>2015</Year><Month>Dec</Month><Day>19</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.</ArticleTitle><Pagination><MedlinePgn>2499-506</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(15)00386-4</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0140-6736(15)00386-4</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Erythropoietin might have neurocytoprotective effects. In this trial, we studied its effect on neurological recovery, mortality, and venous thrombotic events in patients with traumatic brain injury.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Erythropoietin in Traumatic Brain Injury (EPO-TBI) was a double-blind, placebo-controlled trial undertaken in 29 centres (all university-affiliated teaching hospitals) in seven countries (Australia, New Zealand, France, Germany, Finland, Ireland, and Saudi Arabia). Within 24 h of brain injury, 606 patients were randomly assigned by a concealed web-based computer-generated randomisation schedule to erythropoietin (40,000 units subcutaneously) or placebo (0·9% sodium chloride subcutaneously) once per week for a maximum of three doses. Randomisation was stratified by severity of traumatic brain injury (moderate vs severe) and participating site. With the exception of designated site pharmacists, the site dosing nurses at all sites, and the pharmacists at the central pharmacy in France, all study personnel, patients, and patients' relatives were masked to treatment assignment. The primary outcome, assessed at 6 months by modified intention-to-treat analysis, was improvement in the patients' neurological status, summarised as a reduction in the proportion of patients with an Extended Glasgow Outcome Scale (GOS-E) of 1-4 (death, vegetative state, and severe disability). Two equally spaced preplanned interim analyses were done (after 202 and 404 participants were enrolled). This study is registered with ClinicalTrials.gov, number NCT00987454.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Between May 3, 2010, and Nov 1, 2014, 606 patients were enrolled and randomly assigned to erythropoietin (n=308) or placebo (n=298). Ten of these patients (six in the erythropoietin group and four in the placebo group) were lost to follow up at 6 months; therefore, data for the primary outcome analysis was available for 596 patients (302 in the erythropoietin group and 294 in the placebo group). Compared with placebo, erythropoietin did not reduce the proportion of patients with a GOS-E level of 1-4 (134 [44%] of 302 patients in the erythropoietin group vs 132 [45%] of 294 in the placebo group; relative risk [RR] 0·99 [95% CI 0·83-1·18], p=0·90). In terms of safety, erythropoietin did not significantly affect 6-month mortality versus placebo (32 [11%] of 305 patients had died at 6 months in the erythropoietin group vs 46 [16%] of 297 [16%] in the placebo group; RR 0·68 [95% CI 0·44-1·03], p=0·07) or increase the occurrence of deep venous thrombosis of the lower limbs (48 [16%] of 305 vs 54 [18%] of 298; RR 0·87 [95% CI 0·61-1·24], p=0·44).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Following moderate or severe traumatic brain injury, erythropoietin did not reduce the number of patients with severe neurological dysfunction (GOS-E level 1-4) or increase the incidence of deep venous thrombosis of the lower limbs. The effect of erythropoietin on mortality remains uncertain.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">The National Health and Medical Research Council and the Transport Accident Commission.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nichol</LastName><ForeName>Alistair</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia; School of Medicine and Medical Sciences, University College Dublin, Dublin Ireland; St Vincent's University Hospital, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>French</LastName><ForeName>Craig</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>University of Melbourne, Melbourne, VIC, Australia; Western Health, Melbourne, VIC, Australia. Electronic address: craig.french@wh.org.au.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Little</LastName><ForeName>Lorraine</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haddad</LastName><ForeName>Samir</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Presneill</LastName><ForeName>Jeffrey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; University of Queensland, Brisbane, QLD, Australia; Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arabi</LastName><ForeName>Yaseen</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; King Saud Bin Abdulaziz University for Health Sciences and King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>D James</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duranteau</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Département d'Anesthésie-Réanimation, Hôpital de Bicêtre, Assistance Publique des Hopitaux de Paris, Hôpitaux Universitaires Paris-Sud, Université Paris-Sud, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huet</LastName><ForeName>Olivier</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Department of Anaesthesiology and Intensive Care Medicine, CHU La Cavale Blanche, Brest, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mak</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McArthur</LastName><ForeName>Colin</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; Auckland City Hospital, Auckland, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pettilä</LastName><ForeName>Ville</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; University of Helsinki and Helsinki University Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skrifvars</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>University of Helsinki and Helsinki University Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vallance</LastName><ForeName>Shirley</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Varma</LastName><ForeName>Dinesh</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>The Alfred, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wills</LastName><ForeName>Judy</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; The Alfred, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellomo</LastName><ForeName>Rinaldo</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia; Austin Hospital, Melbourne, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>EPO-TBI Investigators</CollectiveName></Author><Author ValidYN="Y"><CollectiveName>ANZICS Clinical Trials 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|texte= Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.
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Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:26452709" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
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