Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts.
Identifieur interne : 002644 ( PubMed/Corpus ); précédent : 002643; suivant : 002645Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts.
Auteurs : Francesca Fasanelli ; Laura Baglietto ; Erica Ponzi ; Florence Guida ; Gianluca Campanella ; Mattias Johansson ; Kjell Grankvist ; Mikael Johansson ; Manuela Bianca Assumma ; Alessio Naccarati ; Marc Chadeau-Hyam ; Ugo Ala ; Christian Faltus ; Rudolf Kaaks ; Angela Risch ; Bianca De Stavola ; Allison Hodge ; Graham G. Giles ; Melissa C. Southey ; Caroline L. Relton ; Philip C. Haycock ; Eiliv Lund ; Silvia Polidoro ; Torkjel M. Sandanger ; Gianluca Severi ; Paolo VineisSource :
- Nature communications [ 2041-1723 ] ; 2015.
English descriptors
- KwdEn :
- MESH :
- genetics : Lung Neoplasms, Smoking.
- physiology : Gene Expression Regulation.
- Adult, Aged, Cohort Studies, CpG Islands, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Odds Ratio.
Abstract
DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case-control pairs in the NOWAC cohort, we observe that the most significant associations with lung cancer risk are for cg05575921 in AHRR (OR for 1 s.d.=0.37, 95% CI: 0.31-0.54, P-value=3.3 × 10(-11)) and cg03636183 in F2RL3 (OR for 1 s.d.=0.40, 95% CI: 0.31-0.56, P-value=3.9 × 10(-10)), previously shown to be strongly hypomethylated in smokers. These associations remain significant after adjustment for smoking and are confirmed in additional 664 case-control pairs tightly matched for smoking from the MCCS, NSHDS and EPIC HD cohorts. The replication and mediation analyses suggest that residual confounding is unlikely to explain the observed associations and that hypomethylation of these CpG sites may mediate the effect of tobacco on lung cancer risk.
DOI: 10.1038/ncomms10192
PubMed: 26667048
Links to Exploration step
pubmed:26667048Le document en format XML
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<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
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<author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name>
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<author><name sortKey="De Stavola, Bianca" sort="De Stavola, Bianca" uniqKey="De Stavola B" first="Bianca" last="De Stavola">Bianca De Stavola</name>
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<author><name sortKey="Hodge, Allison" sort="Hodge, Allison" uniqKey="Hodge A" first="Allison" last="Hodge">Allison Hodge</name>
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<author><name sortKey="Haycock, Philip C" sort="Haycock, Philip C" uniqKey="Haycock P" first="Philip C" last="Haycock">Philip C. Haycock</name>
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<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
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<author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts.</title>
<author><name sortKey="Fasanelli, Francesca" sort="Fasanelli, Francesca" uniqKey="Fasanelli F" first="Francesca" last="Fasanelli">Francesca Fasanelli</name>
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<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation><nlm:affiliation>Inserm (Institut National de la Santé et de la Recherche Médicale), Centre for Research in Epidemiology and Population Health, U1018, Team 9, 114 rue Edouard Vaillant, Villejuif 94805, France.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Ponzi, Erica" sort="Ponzi, Erica" uniqKey="Ponzi E" first="Erica" last="Ponzi">Erica Ponzi</name>
<affiliation><nlm:affiliation>Molecular end Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino 10126, Italy.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Guida, Florence" sort="Guida, Florence" uniqKey="Guida F" first="Florence" last="Guida">Florence Guida</name>
<affiliation><nlm:affiliation>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Campanella, Gianluca" sort="Campanella, Gianluca" uniqKey="Campanella G" first="Gianluca" last="Campanella">Gianluca Campanella</name>
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<author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name>
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</affiliation>
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<author><name sortKey="Johansson, Mikael" sort="Johansson, Mikael" uniqKey="Johansson M" first="Mikael" last="Johansson">Mikael Johansson</name>
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</affiliation>
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<author><name sortKey="Assumma, Manuela Bianca" sort="Assumma, Manuela Bianca" uniqKey="Assumma M" first="Manuela Bianca" last="Assumma">Manuela Bianca Assumma</name>
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</affiliation>
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<author><name sortKey="Naccarati, Alessio" sort="Naccarati, Alessio" uniqKey="Naccarati A" first="Alessio" last="Naccarati">Alessio Naccarati</name>
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</affiliation>
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<author><name sortKey="Chadeau Hyam, Marc" sort="Chadeau Hyam, Marc" uniqKey="Chadeau Hyam M" first="Marc" last="Chadeau-Hyam">Marc Chadeau-Hyam</name>
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</affiliation>
</author>
<author><name sortKey="Ala, Ugo" sort="Ala, Ugo" uniqKey="Ala U" first="Ugo" last="Ala">Ugo Ala</name>
<affiliation><nlm:affiliation>Department of Molecular Biotechnology and Health Sciences, Università di Torino, Torino 10126, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Faltus, Christian" sort="Faltus, Christian" uniqKey="Faltus C" first="Christian" last="Faltus">Christian Faltus</name>
<affiliation><nlm:affiliation>Division of Epigenomics and Cancer Risk Factors, DKFZ-German Cancer Research Center, Heidelberg 69121, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology, DKFZ-German Cancer Research Center, Heidelberg 69121, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name>
<affiliation><nlm:affiliation>Division of Epigenomics and Cancer Risk Factors, DKFZ-German Cancer Research Center, Heidelberg 69121, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Stavola, Bianca" sort="De Stavola, Bianca" uniqKey="De Stavola B" first="Bianca" last="De Stavola">Bianca De Stavola</name>
<affiliation><nlm:affiliation>Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hodge, Allison" sort="Hodge, Allison" uniqKey="Hodge A" first="Allison" last="Hodge">Allison Hodge</name>
<affiliation><nlm:affiliation>Department of Genetic Epidemiology, Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Victoria 3004, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
<affiliation><nlm:affiliation>Department of Genetic Epidemiology, Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Victoria 3004, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name>
<affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, University of Melbourne, Melbourne, Victoria 3010, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Relton, Caroline L" sort="Relton, Caroline L" uniqKey="Relton C" first="Caroline L" last="Relton">Caroline L. Relton</name>
<affiliation><nlm:affiliation>MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Haycock, Philip C" sort="Haycock, Philip C" uniqKey="Haycock P" first="Philip C" last="Haycock">Philip C. Haycock</name>
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</affiliation>
</author>
<author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name>
<affiliation><nlm:affiliation>Department of Community Medicine UiT-The Arctic University of Norway, Tromso 9019, Norway.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Polidoro, Silvia" sort="Polidoro, Silvia" uniqKey="Polidoro S" first="Silvia" last="Polidoro">Silvia Polidoro</name>
<affiliation><nlm:affiliation>Molecular end Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino 10126, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sandanger, Torkjel M" sort="Sandanger, Torkjel M" uniqKey="Sandanger T" first="Torkjel M" last="Sandanger">Torkjel M. Sandanger</name>
<affiliation><nlm:affiliation>Department of Community Medicine UiT-The Arctic University of Norway, Tromso 9019, Norway.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
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</affiliation>
</author>
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</affiliation>
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<term>Gene Expression Regulation (physiology)</term>
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<front><div type="abstract" xml:lang="en">DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case-control pairs in the NOWAC cohort, we observe that the most significant associations with lung cancer risk are for cg05575921 in AHRR (OR for 1 s.d.=0.37, 95% CI: 0.31-0.54, P-value=3.3 × 10(-11)) and cg03636183 in F2RL3 (OR for 1 s.d.=0.40, 95% CI: 0.31-0.56, P-value=3.9 × 10(-10)), previously shown to be strongly hypomethylated in smokers. These associations remain significant after adjustment for smoking and are confirmed in additional 664 case-control pairs tightly matched for smoking from the MCCS, NSHDS and EPIC HD cohorts. The replication and mediation analyses suggest that residual confounding is unlikely to explain the observed associations and that hypomethylation of these CpG sites may mediate the effect of tobacco on lung cancer risk.</div>
</front>
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<ArticleTitle>Hypomethylation of smoking-related genes is associated with future lung cancer in four prospective cohorts.</ArticleTitle>
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<Abstract><AbstractText>DNA hypomethylation in certain genes is associated with tobacco exposure but it is unknown whether these methylation changes translate into increased lung cancer risk. In an epigenome-wide study of DNA from pre-diagnostic blood samples from 132 case-control pairs in the NOWAC cohort, we observe that the most significant associations with lung cancer risk are for cg05575921 in AHRR (OR for 1 s.d.=0.37, 95% CI: 0.31-0.54, P-value=3.3 × 10(-11)) and cg03636183 in F2RL3 (OR for 1 s.d.=0.40, 95% CI: 0.31-0.56, P-value=3.9 × 10(-10)), previously shown to be strongly hypomethylated in smokers. These associations remain significant after adjustment for smoking and are confirmed in additional 664 case-control pairs tightly matched for smoking from the MCCS, NSHDS and EPIC HD cohorts. The replication and mediation analyses suggest that residual confounding is unlikely to explain the observed associations and that hypomethylation of these CpG sites may mediate the effect of tobacco on lung cancer risk.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fasanelli</LastName>
<ForeName>Francesca</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Molecular end Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino 10126, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin, Center for Cancer Prevention, Via Santena 7, Torino 10126, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baglietto</LastName>
<ForeName>Laura</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Inserm (Institut National de la Santé et de la Recherche Médicale), Centre for Research in Epidemiology and Population Health, U1018, Team 9, 114 rue Edouard Vaillant, Villejuif 94805, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Paris-South University, Villejuif 91450, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Genetic Epidemiology, Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Victoria 3004, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>School of Population and Global Health, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria 3010, Australia.</Affiliation>
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<AffiliationInfo><Affiliation>Molecular end Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino 10126, Italy.</Affiliation>
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<Initials>M</Initials>
<AffiliationInfo><Affiliation>Genetic Epidemiology Division, International Agency for Research on Cancer, Lyon 69008, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Biobank Research, Umeå University, Umeå SE-90187, Sweden.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Grankvist</LastName>
<ForeName>Kjell</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Biobank Research, Umeå University, Umeå SE-90187, Sweden.</Affiliation>
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<Author ValidYN="Y"><LastName>Johansson</LastName>
<ForeName>Mikael</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Radiation Sciences, Umeå University, Umeå SE-90187, Sweden.</Affiliation>
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<Author ValidYN="Y"><LastName>Assumma</LastName>
<ForeName>Manuela Bianca</ForeName>
<Initials>MB</Initials>
<AffiliationInfo><Affiliation>Molecular end Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino 10126, Italy.</Affiliation>
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<Initials>A</Initials>
<AffiliationInfo><Affiliation>Molecular end Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino 10126, Italy.</Affiliation>
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<ForeName>Marc</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.</Affiliation>
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<Author ValidYN="Y"><LastName>Ala</LastName>
<ForeName>Ugo</ForeName>
<Initials>U</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Biotechnology and Health Sciences, Università di Torino, Torino 10126, Italy.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Faltus</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Division of Epigenomics and Cancer Risk Factors, DKFZ-German Cancer Research Center, Heidelberg 69121, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Kaaks</LastName>
<ForeName>Rudolf</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Epidemiology, DKFZ-German Cancer Research Center, Heidelberg 69121, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research (DZL), Heidelberg 69120, Germany.</Affiliation>
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<AffiliationInfo><Affiliation>Division of Epigenomics and Cancer Risk Factors, DKFZ-German Cancer Research Center, Heidelberg 69121, Germany.</Affiliation>
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<AffiliationInfo><Affiliation>Translational Lung Research Center Heidelberg, Member of the German Center for Lung Research (DZL), Heidelberg 69120, Germany.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Division of Cancer Research and Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg 5020, Austria.</Affiliation>
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<ForeName>Bianca</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.</Affiliation>
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<Author ValidYN="Y"><LastName>Hodge</LastName>
<ForeName>Allison</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Genetic Epidemiology, Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Victoria 3004, Australia.</Affiliation>
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<Author ValidYN="Y"><LastName>Giles</LastName>
<ForeName>Graham G</ForeName>
<Initials>GG</Initials>
<AffiliationInfo><Affiliation>Department of Genetic Epidemiology, Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Victoria 3004, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>School of Population and Global Health, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria 3010, Australia.</Affiliation>
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<ForeName>Melissa C</ForeName>
<Initials>MC</Initials>
<AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, University of Melbourne, Melbourne, Victoria 3010, Australia.</Affiliation>
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<Author ValidYN="Y"><LastName>Relton</LastName>
<ForeName>Caroline L</ForeName>
<Initials>CL</Initials>
<AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.</Affiliation>
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<ForeName>Philip C</ForeName>
<Initials>PC</Initials>
<AffiliationInfo><Affiliation>MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Lund</LastName>
<ForeName>Eiliv</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Community Medicine UiT-The Arctic University of Norway, Tromso 9019, Norway.</Affiliation>
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<Author ValidYN="Y"><LastName>Polidoro</LastName>
<ForeName>Silvia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Molecular end Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino 10126, Italy.</Affiliation>
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</Author>
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<ForeName>Torkjel M</ForeName>
<Initials>TM</Initials>
<AffiliationInfo><Affiliation>Department of Community Medicine UiT-The Arctic University of Norway, Tromso 9019, Norway.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Gianluca</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Molecular end Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino 10126, Italy.</Affiliation>
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<AffiliationInfo><Affiliation>Inserm (Institut National de la Santé et de la Recherche Médicale), Centre for Research in Epidemiology and Population Health, U1018, Team 9, 114 rue Edouard Vaillant, Villejuif 94805, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Paris-South University, Villejuif 91450, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Department of Genetic Epidemiology, Cancer Epidemiology Centre, Cancer Council of Victoria, Melbourne, Victoria 3004, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>School of Population and Global Health, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria 3010, Australia.</Affiliation>
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<ForeName>Paolo</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Molecular end Epidemiology Unit, HuGeF, Human Genetics Foundation, Torino 10126, Italy.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>MRC-PHE Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Norfolk Place, London W2 1PG, UK.</Affiliation>
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<Country>United Kingdom</Country>
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<Agency>Medical Research Council</Agency>
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<CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>BMC Biotechnol. 2013;13:23</RefSource>
<PMID Version="1">23497093</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Intern Med. 2011 Jun 7;154(11):719-26</RefSource>
<PMID Version="1">21646555</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2013 Mar 1;22(5):843-51</RefSource>
<PMID Version="1">23175441</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2012 Jul 1;21(13):3073-82</RefSource>
<PMID Version="1">22492999</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Scand J Public Health Suppl. 2003;61:18-24</RefSource>
<PMID Version="1">14660243</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Eur Respir J. 2005 Nov;26(5):835-45</RefSource>
<PMID Version="1">16264044</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>JAMA. 1993 Jan 13;269(2):232-6</RefSource>
<PMID Version="1">8417241</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Epigenetics. 2013 Oct 11;5(1):19</RefSource>
<PMID Version="1">24120260</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Clin Epigenetics. 2014 Feb 03;6(1):4</RefSource>
<PMID Version="1">24485148</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>IARC Sci Publ. 2002;156:69-70</RefSource>
<PMID Version="1">12484128</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Carcinogenesis. 2010 Oct;31(10):1703-9</RefSource>
<PMID Version="1">20430846</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Lancet. 2003 Sep 13;362(9387):847-52</RefSource>
<PMID Version="1">13678970</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Epidemiology. 1992 Mar;3(2):143-55</RefSource>
<PMID Version="1">1576220</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 2014 Feb 1;179(3):290-8</RefSource>
<PMID Version="1">24355332</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS Med. 2006 Nov;3(11):e442</RefSource>
<PMID Version="1">17132052</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Epidemiology. 2012 Nov;23(6):900-1</RefSource>
<PMID Version="1">23038113</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Epidemiol. 1997;26 Suppl 1:S6-14</RefSource>
<PMID Version="1">9126529</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2012;13:86</RefSource>
<PMID Version="1">22568884</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genome Biol. 2014;15(12):503</RefSource>
<PMID Version="1">25599564</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Med Genet B Neuropsychiatr Genet. 2012 Mar;159B(2):141-51</RefSource>
<PMID Version="1">22232023</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Epigenetics. 2012 Nov;7(11):1331-8</RefSource>
<PMID Version="1">23070629</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Genome Biol. 2012;13(6):R44</RefSource>
<PMID Version="1">22703947</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Epidemiol. 2010 Dec 15;172(12):1339-48</RefSource>
<PMID Version="1">21036955</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Ann Nutr Metab. 1999;43(4):195-204</RefSource>
<PMID Version="1">10592368</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Environ Health Perspect. 2014 Feb;122(2):131-7</RefSource>
<PMID Version="1">24273234</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Natl Cancer Inst. 2004 Jan 21;96(2):99-106</RefSource>
<PMID Version="1">14734699</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Epidemiol. 2012 Feb;41(1):161-76</RefSource>
<PMID Version="1">22422451</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2015 Apr 15;24(8):2349-59</RefSource>
<PMID Version="1">25556184</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013;8(5):e63812</RefSource>
<PMID Version="1">23691101</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Crit Rev Toxicol. 2012 Nov;42(10):877-89</RefSource>
<PMID Version="1">22989067</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Genomics. 2014;15:151</RefSource>
<PMID Version="1">24559495</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Bioinformatics. 2010;11:587</RefSource>
<PMID Version="1">21118553</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Int J Epidemiol. 2014 Aug;43(4):1215-25</RefSource>
<PMID Version="1">24510982</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Hum Mol Genet. 2014 May 1;23(9):2290-7</RefSource>
<PMID Version="1">24334605</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Am J Respir Crit Care Med. 2002 Nov 1;166(9):1218-24</RefSource>
<PMID Version="1">12403691</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>J Clin Oncol. 2003 Mar 1;21(5):921-6</RefSource>
<PMID Version="1">12610194</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Annu Rev Pharmacol Toxicol. 1995;35:307-40</RefSource>
<PMID Version="1">7598497</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>Med Clin North Am. 1992 Mar;76(2):305-31</RefSource>
<PMID Version="1">1548964</PMID>
</CommentsCorrections>
<CommentsCorrections RefType="Cites"><RefSource>BMC Genomics. 2014;15:51</RefSource>
<PMID Version="1">24447442</PMID>
</CommentsCorrections>
</CommentsCorrectionsList>
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