The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.
Identifieur interne : 002521 ( PubMed/Corpus ); précédent : 002520; suivant : 002522The Tumor Antigen NY-ESO-1 Mediates Direct Recognition of Melanoma Cells by CD4+ T Cells after Intercellular Antigen Transfer.
Auteurs : Jean Francois Fonteneau ; Fabienne Brilot ; Christian Münz ; Monique GannagéSource :
- Journal of immunology (Baltimore, Md. : 1950) [ 1550-6606 ] ; 2016.
English descriptors
- KwdEn :
- Acetylcysteine (analogs & derivatives), Acetylcysteine (pharmacology), Antigen Presentation (immunology), Antigens, Neoplasm (immunology), Autophagy (immunology), Autophagy-Related Protein 12, CD4-Positive T-Lymphocytes (immunology), CD4-Positive T-Lymphocytes (transplantation), Cell Line, Tumor, Chloroquine (pharmacology), Dendritic Cells (immunology), Endocytosis (immunology), Epitopes, T-Lymphocyte (immunology), Histocompatibility Antigens Class II (immunology), Humans, Immunotherapy, Adoptive, Leupeptins, Lymphocyte Activation (immunology), Lysosomal-Associated Membrane Protein 2 (genetics), Melanoma (immunology), Melanoma (therapy), Membrane Proteins (immunology), RNA Interference, RNA, Small Interfering, Small Ubiquitin-Related Modifier Proteins (genetics).
- MESH :
- chemical , analogs & derivatives : Acetylcysteine.
- chemical , genetics : Lysosomal-Associated Membrane Protein 2, Small Ubiquitin-Related Modifier Proteins.
- chemical , immunology : Antigens, Neoplasm, Epitopes, T-Lymphocyte, Histocompatibility Antigens Class II, Membrane Proteins.
- chemical , pharmacology : Acetylcysteine, Chloroquine.
- immunology : Antigen Presentation, Autophagy, CD4-Positive T-Lymphocytes, Dendritic Cells, Endocytosis, Lymphocyte Activation, Melanoma.
- therapy : Melanoma.
- transplantation : CD4-Positive T-Lymphocytes.
- chemical : Autophagy-Related Protein 12, Cell Line, Tumor, Humans, Immunotherapy, Adoptive, Leupeptins, RNA Interference, RNA, Small Interfering.
Abstract
NY-ESO-1-specific CD4(+) T cells are of interest for immune therapy against tumors, because it has been shown that their transfer into a patient with melanoma resulted in tumor regression. Therefore, we investigated how NY-ESO-1 is processed onto MHC class II molecules for direct CD4(+) T cell recognition of melanoma cells. We could rule out proteasome and autophagy-dependent endogenous Ag processing for MHC class II presentation. In contrast, intercellular Ag transfer, followed by classical MHC class II Ag processing via endocytosis, sensitized neighboring melanoma cells for CD4(+) T cell recognition. However, macroautophagy targeting of NY-ESO-1 enhanced MHC class II presentation. Therefore, both elevated NY-ESO-1 release and macroautophagy targeting could improve melanoma cell recognition by CD4(+) T cells and should be explored during immunotherapy of melanoma.
DOI: 10.4049/jimmunol.1402664
PubMed: 26608910
Links to Exploration step
pubmed:26608910Le document en format XML
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<front><div type="abstract" xml:lang="en">NY-ESO-1-specific CD4(+) T cells are of interest for immune therapy against tumors, because it has been shown that their transfer into a patient with melanoma resulted in tumor regression. Therefore, we investigated how NY-ESO-1 is processed onto MHC class II molecules for direct CD4(+) T cell recognition of melanoma cells. We could rule out proteasome and autophagy-dependent endogenous Ag processing for MHC class II presentation. In contrast, intercellular Ag transfer, followed by classical MHC class II Ag processing via endocytosis, sensitized neighboring melanoma cells for CD4(+) T cell recognition. However, macroautophagy targeting of NY-ESO-1 enhanced MHC class II presentation. Therefore, both elevated NY-ESO-1 release and macroautophagy targeting could improve melanoma cell recognition by CD4(+) T cells and should be explored during immunotherapy of melanoma.</div>
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<MeshHeading><DescriptorName UI="D015496" MajorTopicYN="N">CD4-Positive T-Lymphocytes</DescriptorName>
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<QualifierName UI="Q000637" MajorTopicYN="Y">transplantation</QualifierName>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year>
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<Day>21</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
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<ArticleIdList><ArticleId IdType="pubmed">26608910</ArticleId>
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<ArticleId IdType="doi">10.4049/jimmunol.1402664</ArticleId>
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