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Characteristics of patients making serious inhaler errors with a dry powder inhaler and association with asthma-related events in a primary care setting.

Identifieur interne : 002469 ( PubMed/Corpus ); précédent : 002468; suivant : 002470

Characteristics of patients making serious inhaler errors with a dry powder inhaler and association with asthma-related events in a primary care setting.

Auteurs : Janine A M. Westerik ; Victoria Carter ; Henry Chrystyn ; Anne Burden ; Samantha L. Thompson ; Dermot Ryan ; Kevin Gruffydd-Jones ; John Haughney ; Nicolas Roche ; Federico Lavorini ; Alberto Papi ; Antonio Infantino ; Miguel Roman-Rodriguez ; Sinthia Bosnic-Anticevich ; Karin Lisspers ; Björn St Llberg ; Svein H Egh Henrichsen ; Thys Van Der Molen ; Catherine Hutton ; David B. Price

Source :

RBID : pubmed:26810934

English descriptors

Abstract

Correct inhaler technique is central to effective delivery of asthma therapy. The study aim was to identify factors associated with serious inhaler technique errors and their prevalence among primary care patients with asthma using the Diskus dry powder inhaler (DPI).

DOI: 10.3109/02770903.2015.1099160
PubMed: 26810934

Links to Exploration step

pubmed:26810934

Le document en format XML

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<name sortKey="Bosnic Anticevich, Sinthia" sort="Bosnic Anticevich, Sinthia" uniqKey="Bosnic Anticevich S" first="Sinthia" last="Bosnic-Anticevich">Sinthia Bosnic-Anticevich</name>
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<name sortKey="Papi, Alberto" sort="Papi, Alberto" uniqKey="Papi A" first="Alberto" last="Papi">Alberto Papi</name>
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<name sortKey="Infantino, Antonio" sort="Infantino, Antonio" uniqKey="Infantino A" first="Antonio" last="Infantino">Antonio Infantino</name>
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<name sortKey="Roman Rodriguez, Miguel" sort="Roman Rodriguez, Miguel" uniqKey="Roman Rodriguez M" first="Miguel" last="Roman-Rodriguez">Miguel Roman-Rodriguez</name>
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<nlm:affiliation>k Primary Care Respiratory Research Unit, Instituto de Investigación Sanitaria de Palma IdisPa , Palma de Mallorca , Spain .</nlm:affiliation>
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<name sortKey="Bosnic Anticevich, Sinthia" sort="Bosnic Anticevich, Sinthia" uniqKey="Bosnic Anticevich S" first="Sinthia" last="Bosnic-Anticevich">Sinthia Bosnic-Anticevich</name>
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<nlm:affiliation>l Sydney Medical School and the Woolcock Institute of Medical Research, University of Sydney , Sydney , Australia .</nlm:affiliation>
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<nlm:affiliation>m Department of Public Health and Caring Sciences , Preventive Medicine and Family Medicine, Uppsala University , Uppsala , Sweden .</nlm:affiliation>
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<name sortKey="Henrichsen, Svein H Egh" sort="Henrichsen, Svein H Egh" uniqKey="Henrichsen S" first="Svein H Egh" last="Henrichsen">Svein H Egh Henrichsen</name>
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<nlm:affiliation>n Department of General Medicine , University of Oslo and Langbølgen Legesenter , and.</nlm:affiliation>
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<name sortKey="Van Der Molen, Thys" sort="Van Der Molen, Thys" uniqKey="Van Der Molen T" first="Thys" last="Van Der Molen">Thys Van Der Molen</name>
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<nlm:affiliation>o Department of Primary Care , University of Groningen, University Medical Centre Groningen , Groningen , The Netherlands.</nlm:affiliation>
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<name sortKey="Hutton, Catherine" sort="Hutton, Catherine" uniqKey="Hutton C" first="Catherine" last="Hutton">Catherine Hutton</name>
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<nlm:affiliation>a Research in Real-Life, Ltd , Cambridge , United Kingdom .</nlm:affiliation>
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<name sortKey="Price, David B" sort="Price, David B" uniqKey="Price D" first="David B" last="Price">David B. Price</name>
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<title level="j">The Journal of asthma : official journal of the Association for the Care of Asthma</title>
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<term>Administration, Inhalation</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Asthma (drug therapy)</term>
<term>Body Mass Index</term>
<term>Cross-Sectional Studies</term>
<term>Dry Powder Inhalers (statistics & numerical data)</term>
<term>Educational Status</term>
<term>Equipment Design</term>
<term>Female</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Prevalence</term>
<term>Primary Health Care</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Asthma</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en">
<term>Dry Powder Inhalers</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Administration, Inhalation</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Body Mass Index</term>
<term>Cross-Sectional Studies</term>
<term>Educational Status</term>
<term>Equipment Design</term>
<term>Female</term>
<term>Humans</term>
<term>Logistic Models</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Odds Ratio</term>
<term>Prevalence</term>
<term>Primary Health Care</term>
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<front>
<div type="abstract" xml:lang="en">Correct inhaler technique is central to effective delivery of asthma therapy. The study aim was to identify factors associated with serious inhaler technique errors and their prevalence among primary care patients with asthma using the Diskus dry powder inhaler (DPI).</div>
</front>
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<PMID Version="1">26810934</PMID>
<DateCreated>
<Year>2016</Year>
<Month>03</Month>
<Day>26</Day>
</DateCreated>
<DateCompleted>
<Year>2016</Year>
<Month>08</Month>
<Day>15</Day>
</DateCompleted>
<DateRevised>
<Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
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<Journal>
<ISSN IssnType="Electronic">1532-4303</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>53</Volume>
<Issue>3</Issue>
<PubDate>
<Year>2016</Year>
</PubDate>
</JournalIssue>
<Title>The Journal of asthma : official journal of the Association for the Care of Asthma</Title>
<ISOAbbreviation>J Asthma</ISOAbbreviation>
</Journal>
<ArticleTitle>Characteristics of patients making serious inhaler errors with a dry powder inhaler and association with asthma-related events in a primary care setting.</ArticleTitle>
<Pagination>
<MedlinePgn>321-9</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3109/02770903.2015.1099160</ELocationID>
<Abstract>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Correct inhaler technique is central to effective delivery of asthma therapy. The study aim was to identify factors associated with serious inhaler technique errors and their prevalence among primary care patients with asthma using the Diskus dry powder inhaler (DPI).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">This was a historical, multinational, cross-sectional study (2011-2013) using the iHARP database, an international initiative that includes patient- and healthcare provider-reported questionnaires from eight countries. Patients with asthma were observed for serious inhaler errors by trained healthcare providers as predefined by the iHARP steering committee. Multivariable logistic regression, stepwise reduced, was used to identify clinical characteristics and asthma-related outcomes associated with ≥1 serious errors.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 3681 patients with asthma, 623 (17%) were using a Diskus (mean [SD] age, 51 [14]; 61% women). A total of 341 (55%) patients made ≥1 serious errors. The most common errors were the failure to exhale before inhalation, insufficient breath-hold at the end of inhalation, and inhalation that was not forceful from the start. Factors significantly associated with ≥1 serious errors included asthma-related hospitalization the previous year (odds ratio [OR] 2.07; 95% confidence interval [CI], 1.26-3.40); obesity (OR 1.75; 1.17-2.63); poor asthma control the previous 4 weeks (OR 1.57; 1.04-2.36); female sex (OR 1.51; 1.08-2.10); and no inhaler technique review during the previous year (OR 1.45; 1.04-2.02).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Patients with evidence of poor asthma control should be targeted for a review of their inhaler technique even when using a device thought to have a low error rate.</AbstractText>
</Abstract>
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<Affiliation>a Research in Real-Life, Ltd , Cambridge , United Kingdom .</Affiliation>
</AffiliationInfo>
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<Affiliation>c Inhalation Consultancy, Ltd , Yeadon , Leeds , United Kingdom .</Affiliation>
</AffiliationInfo>
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<Affiliation>e Box Surgery , Box , United Kingdom .</Affiliation>
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<Affiliation>f Academic Primary Care, University of Aberdeen , Aberdeen , United Kingdom .</Affiliation>
</AffiliationInfo>
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<Affiliation>g University Paris Descartes (EA2511), Cochin Hospital Group (AP-HP) , Paris , France .</Affiliation>
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<LastName>Lavorini</LastName>
<ForeName>Federico</ForeName>
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<Affiliation>h Department of Experimental and Clinical Medicine , Careggi University Hospital , Florence , Italy .</Affiliation>
</AffiliationInfo>
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<LastName>Papi</LastName>
<ForeName>Alberto</ForeName>
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<Affiliation>i Department of Medical Sciences , University of Ferrara , Ferrara , Italy .</Affiliation>
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<LastName>Infantino</LastName>
<ForeName>Antonio</ForeName>
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<Affiliation>j Special Interest Respiratory Area, Società Italiana Interdisciplinare per le Cure Primarie , Bari , Italy .</Affiliation>
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<Affiliation>k Primary Care Respiratory Research Unit, Instituto de Investigación Sanitaria de Palma IdisPa , Palma de Mallorca , Spain .</Affiliation>
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<Affiliation>m Department of Public Health and Caring Sciences , Preventive Medicine and Family Medicine, Uppsala University , Uppsala , Sweden .</Affiliation>
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<Keyword MajorTopicYN="N">Asthma therapy</Keyword>
<Keyword MajorTopicYN="N">Diskus inhaler</Keyword>
<Keyword MajorTopicYN="N">cross-sectional</Keyword>
<Keyword MajorTopicYN="N">inhalation devices</Keyword>
<Keyword MajorTopicYN="N">multinational</Keyword>
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