Longitudinal analysis of the associations between antiretroviral therapy, viraemia and immunosuppression with lipid levels: the D:A:D study.
Identifieur interne : 002459 ( PubMed/Corpus ); précédent : 002458; suivant : 002460Longitudinal analysis of the associations between antiretroviral therapy, viraemia and immunosuppression with lipid levels: the D:A:D study.
Auteurs : David A. Kamara ; Colette Smith ; Lene Ryom ; Peter Reiss ; Martin Rickenbach ; Andrew Phillips ; Amanda Mocroft ; Stephan De Wit ; Matthew Law ; Antonella D'Arminio Monforte ; Francois Dabis ; Christian Pradier ; Jens D. Lundgren ; Caroline SabinSource :
- Antiviral therapy [ 2040-2058 ] ; 2016.
Abstract
Antiretroviral (ART) drugs have been associated with higher triglycerides (TG), higher total cholesterol (TC) and lower high-density lipoprotein cholesterol (HDL-C) levels. Associations between lipid levels with HIV viraemia and immunosuppression in the presence of ART remain unclear.
DOI: 10.3851/IMP3051
PubMed: 27114439
Links to Exploration step
pubmed:27114439Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Longitudinal analysis of the associations between antiretroviral therapy, viraemia and immunosuppression with lipid levels: the D:A:D study.</title>
<author><name sortKey="Kamara, David A" sort="Kamara, David A" uniqKey="Kamara D" first="David A" last="Kamara">David A. Kamara</name>
<affiliation><nlm:affiliation>Research Department of Infection and Population Health, UCL, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Smith, Colette" sort="Smith, Colette" uniqKey="Smith C" first="Colette" last="Smith">Colette Smith</name>
<affiliation><nlm:affiliation>Research Department of Infection and Population Health, UCL, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name>
<affiliation><nlm:affiliation>CHIP, Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
<affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rickenbach, Martin" sort="Rickenbach, Martin" uniqKey="Rickenbach M" first="Martin" last="Rickenbach">Martin Rickenbach</name>
<affiliation><nlm:affiliation>Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name>
<affiliation><nlm:affiliation>Research Department of Infection and Population Health, UCL, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name>
<affiliation><nlm:affiliation>Research Department of Infection and Population Health, UCL, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Wit, Stephan" sort="De Wit, Stephan" uniqKey="De Wit S" first="Stephan" last="De Wit">Stephan De Wit</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, CHU St Pierre Hospital, Brussels, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
<affiliation><nlm:affiliation>The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Monforte, Antonella D Arminio" sort="Monforte, Antonella D Arminio" uniqKey="Monforte A" first="Antonella D'Arminio" last="Monforte">Antonella D'Arminio Monforte</name>
<affiliation><nlm:affiliation>Department of Health Sciences, San Paolo University Hospital, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name>
<affiliation><nlm:affiliation>University of Bordeaux, ISPED, Centre Inserm U0897-Epidemiologie-Biostatistique, Bordeaux, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name>
<affiliation><nlm:affiliation>Department of Public Health, Nice University Hospital, Nice, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D" last="Lundgren">Jens D. Lundgren</name>
<affiliation><nlm:affiliation>CHIP, Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sabin, Caroline" sort="Sabin, Caroline" uniqKey="Sabin C" first="Caroline" last="Sabin">Caroline Sabin</name>
<affiliation><nlm:affiliation>Research Department of Infection and Population Health, UCL, London, UK.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27114439</idno>
<idno type="pmid">27114439</idno>
<idno type="doi">10.3851/IMP3051</idno>
<idno type="wicri:Area/PubMed/Corpus">002459</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002459</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Longitudinal analysis of the associations between antiretroviral therapy, viraemia and immunosuppression with lipid levels: the D:A:D study.</title>
<author><name sortKey="Kamara, David A" sort="Kamara, David A" uniqKey="Kamara D" first="David A" last="Kamara">David A. Kamara</name>
<affiliation><nlm:affiliation>Research Department of Infection and Population Health, UCL, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Smith, Colette" sort="Smith, Colette" uniqKey="Smith C" first="Colette" last="Smith">Colette Smith</name>
<affiliation><nlm:affiliation>Research Department of Infection and Population Health, UCL, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ryom, Lene" sort="Ryom, Lene" uniqKey="Ryom L" first="Lene" last="Ryom">Lene Ryom</name>
<affiliation><nlm:affiliation>CHIP, Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Reiss, Peter" sort="Reiss, Peter" uniqKey="Reiss P" first="Peter" last="Reiss">Peter Reiss</name>
<affiliation><nlm:affiliation>Division of Infectious Diseases, Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rickenbach, Martin" sort="Rickenbach, Martin" uniqKey="Rickenbach M" first="Martin" last="Rickenbach">Martin Rickenbach</name>
<affiliation><nlm:affiliation>Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Phillips, Andrew" sort="Phillips, Andrew" uniqKey="Phillips A" first="Andrew" last="Phillips">Andrew Phillips</name>
<affiliation><nlm:affiliation>Research Department of Infection and Population Health, UCL, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mocroft, Amanda" sort="Mocroft, Amanda" uniqKey="Mocroft A" first="Amanda" last="Mocroft">Amanda Mocroft</name>
<affiliation><nlm:affiliation>Research Department of Infection and Population Health, UCL, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Wit, Stephan" sort="De Wit, Stephan" uniqKey="De Wit S" first="Stephan" last="De Wit">Stephan De Wit</name>
<affiliation><nlm:affiliation>Department of Infectious Diseases, CHU St Pierre Hospital, Brussels, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Law, Matthew" sort="Law, Matthew" uniqKey="Law M" first="Matthew" last="Law">Matthew Law</name>
<affiliation><nlm:affiliation>The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Monforte, Antonella D Arminio" sort="Monforte, Antonella D Arminio" uniqKey="Monforte A" first="Antonella D'Arminio" last="Monforte">Antonella D'Arminio Monforte</name>
<affiliation><nlm:affiliation>Department of Health Sciences, San Paolo University Hospital, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dabis, Francois" sort="Dabis, Francois" uniqKey="Dabis F" first="Francois" last="Dabis">Francois Dabis</name>
<affiliation><nlm:affiliation>University of Bordeaux, ISPED, Centre Inserm U0897-Epidemiologie-Biostatistique, Bordeaux, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pradier, Christian" sort="Pradier, Christian" uniqKey="Pradier C" first="Christian" last="Pradier">Christian Pradier</name>
<affiliation><nlm:affiliation>Department of Public Health, Nice University Hospital, Nice, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lundgren, Jens D" sort="Lundgren, Jens D" uniqKey="Lundgren J" first="Jens D" last="Lundgren">Jens D. Lundgren</name>
<affiliation><nlm:affiliation>CHIP, Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sabin, Caroline" sort="Sabin, Caroline" uniqKey="Sabin C" first="Caroline" last="Sabin">Caroline Sabin</name>
<affiliation><nlm:affiliation>Research Department of Infection and Population Health, UCL, London, UK.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Antiviral therapy</title>
<idno type="eISSN">2040-2058</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Antiretroviral (ART) drugs have been associated with higher triglycerides (TG), higher total cholesterol (TC) and lower high-density lipoprotein cholesterol (HDL-C) levels. Associations between lipid levels with HIV viraemia and immunosuppression in the presence of ART remain unclear.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27114439</PMID>
<DateCreated><Year>2016</Year>
<Month>07</Month>
<Day>12</Day>
</DateCreated>
<DateRevised><Year>2016</Year>
<Month>11</Month>
<Day>17</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2040-2058</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>21</Volume>
<Issue>6</Issue>
<PubDate><Year>2016</Year>
</PubDate>
</JournalIssue>
<Title>Antiviral therapy</Title>
<ISOAbbreviation>Antivir. Ther. (Lond.)</ISOAbbreviation>
</Journal>
<ArticleTitle>Longitudinal analysis of the associations between antiretroviral therapy, viraemia and immunosuppression with lipid levels: the D:A:D study.</ArticleTitle>
<Pagination><MedlinePgn>495-506</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3851/IMP3051</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Antiretroviral (ART) drugs have been associated with higher triglycerides (TG), higher total cholesterol (TC) and lower high-density lipoprotein cholesterol (HDL-C) levels. Associations between lipid levels with HIV viraemia and immunosuppression in the presence of ART remain unclear.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Participants from the D:A:D study with at least one TG/TC/HDL-C measurement were included. Linear mixed effect models were used to determine the association of ART, viral load (VL), nadir and current CD4(+) T-cell count and previous AIDS diagnosis with lipids.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Of 49,717 participants, 90%, 92% and 80% contributed at least one TG/TC/HDL-C measurement (median follow-up 6.8, 6.8 and 5.0 years, respectively). Predicted mean (95% CI) baseline levels for TG, TC and HDL-C (mmol/l), were 2.10 (2.05, 2.14), 4.94 (4.91, 4.98) and 1.08 (1.07, 1.10), respectively. Lopinavir was associated with the worst TG profile, (27.2% higher levels compared to atazanavir; 95% CI 25.2%, 29.2%), and darunavir had a similar profile as atazanavir. The nucleoside pair lamivudine/tenofovir was associated with the most favourable TG profile (-2.8%; -3.5%, -2.0%) compared with emtricitabine/tenofovir, whereas lamivudine/abacavir (+10.2%; +9.3%, +11.2%) and lamivudine/stavudine (+8.0%; +6.9%, +9.0%), were associated with the worst. Raltegravir was associated with lower TG (-5.2%; -6.4%, -3.9%), and nevirapine had a more favourable HDL-C profile (+11.3%; +10.8%, +11.7%) than efavirenz (+5.3%; 5.0%, 5.7%), compared to atazanavir. Higher VLs were associated with lower TG/TC/HDL-C, whereas higher CD4(+) T-cell counts were associated with higher TG/TC/HDL-C.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">TG, TC and HDL-C levels, which generally improved over time, are dependent on ART, viraemia and, to a lesser extent, immunosuppression.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kamara</LastName>
<ForeName>David A</ForeName>
<Initials>DA</Initials>
<AffiliationInfo><Affiliation>Research Department of Infection and Population Health, UCL, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Smith</LastName>
<ForeName>Colette</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Research Department of Infection and Population Health, UCL, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ryom</LastName>
<ForeName>Lene</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>CHIP, Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reiss</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Division of Infectious Diseases, Department of Global Health, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rickenbach</LastName>
<ForeName>Martin</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Institute of Social and Preventive Medicine, University of Lausanne, Lausanne, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Phillips</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Research Department of Infection and Population Health, UCL, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mocroft</LastName>
<ForeName>Amanda</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Research Department of Infection and Population Health, UCL, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>De Wit</LastName>
<ForeName>Stephan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Infectious Diseases, CHU St Pierre Hospital, Brussels, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Law</LastName>
<ForeName>Matthew</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Monforte</LastName>
<ForeName>Antonella d'Arminio</ForeName>
<Initials>AD</Initials>
<AffiliationInfo><Affiliation>Department of Health Sciences, San Paolo University Hospital, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dabis</LastName>
<ForeName>Francois</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>University of Bordeaux, ISPED, Centre Inserm U0897-Epidemiologie-Biostatistique, Bordeaux, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pradier</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Public Health, Nice University Hospital, Nice, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lundgren</LastName>
<ForeName>Jens D</ForeName>
<Initials>JD</Initials>
<AffiliationInfo><Affiliation>CHIP, Department of Infectious Diseases, Section 2100, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sabin</LastName>
<ForeName>Caroline</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Research Department of Infection and Population Health, UCL, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>04</Month>
<Day>26</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Antivir Ther</MedlineTA>
<NlmUniqueID>9815705</NlmUniqueID>
<ISSNLinking>1359-6535</ISSNLinking>
</MedlineJournalInfo>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>02</Month>
<Day>22</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>4</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>4</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>4</Month>
<Day>27</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27114439</ArticleId>
<ArticleId IdType="doi">10.3851/IMP3051</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002459 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 002459 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= PubMed |étape= Corpus |type= RBID |clé= pubmed:27114439 |texte= Longitudinal analysis of the associations between antiretroviral therapy, viraemia and immunosuppression with lipid levels: the D:A:D study. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:27114439" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |