A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.
Identifieur interne : 002410 ( PubMed/Corpus ); précédent : 002409; suivant : 002411A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.
Auteurs : Paul S. De Vries ; Daniel I. Chasman ; Maria Sabater-Lleal ; Ming-Huei Chen ; Jennifer E. Huffman ; Maristella Steri ; Weihong Tang ; Alexander Teumer ; Riccardo E. Marioni ; Vera Grossmann ; Jouke J. Hottenga ; Stella Trompet ; Martina Müller-Nurasyid ; Jing Hua Zhao ; Jennifer A. Brody ; Marcus E. Kleber ; Xiuqing Guo ; Jie Jin Wang ; Paul L. Auer ; John R. Attia ; Lisa R. Yanek ; Tarunveer S. Ahluwalia ; Jari Lahti ; Cristina Venturini ; Toshiko Tanaka ; Lawrence F. Bielak ; Peter K. Joshi ; Ares Rocanin-Arjo ; Ivana Kolcic ; Pau Navarro ; Lynda M. Rose ; Christopher Oldmeadow ; Helene Riess ; Johanna Mazur ; Saonli Basu ; Anuj Goel ; Qiong Yang ; Mohsen Ghanbari ; Gonneke Willemsen ; Ann Rumley ; Edoardo Fiorillo ; Anton J M. De Craen ; Anne Grotevendt ; Robert Scott ; Kent D. Taylor ; Graciela E. Delgado ; Jie Yao ; Annette Kifley ; Charles Kooperberg ; Rehan Qayyum ; Lorna M. Lopez ; Tina L. Berentzen ; Katri R Ikkönen ; Massimo Mangino ; Stefania Bandinelli ; Patricia A. Peyser ; Sarah Wild ; David-Alexandre Trégouët ; Alan F. Wright ; Jonathan Marten ; Tatijana Zemunik ; Alanna C. Morrison ; Bengt Sennblad ; Geoffrey Tofler ; Moniek P M. De Maat ; Eco J C. De Geus ; Gordon D. Lowe ; Magdalena Zoledziewska ; Naveed Sattar ; Harald Binder ; Uwe Völker ; Melanie Waldenberger ; Kay-Tee Khaw ; Barbara Mcknight ; Jie Huang ; Nancy S. Jenny ; Elizabeth G. Holliday ; Lihong Qi ; Mark G. Mcevoy ; Diane M. Becker ; John M. Starr ; Antti-Pekka Sarin ; Pirro G. Hysi ; Dena G. Hernandez ; Min A. Jhun ; Harry Campbell ; Anders Hamsten ; Fernando Rivadeneira ; Wendy L. Mcardle ; P Eline Slagboom ; Tanja Zeller ; Wolfgang Koenig ; Bruce M. Psaty ; Talin Haritunians ; Jingmin Liu ; Aarno Palotie ; André G. Uitterlinden ; David J. Stott ; Albert Hofman ; Oscar H. Franco ; Ozren Polasek ; Igor Rudan ; Pierre-Emmanuel Morange ; James F. Wilson ; Sharon L R. Kardia ; Luigi Ferrucci ; Tim D. Spector ; Johan G. Eriksson ; Torben Hansen ; Ian J. Deary ; Lewis C. Becker ; Rodney J. Scott ; Paul Mitchell ; Winfried M Rz ; Nick J. Wareham ; Annette Peters ; Andreas Greinacher ; Philipp S. Wild ; J Wouter Jukema ; Dorret I. Boomsma ; Caroline Hayward ; Francesco Cucca ; Russell Tracy ; Hugh Watkins ; Alex P. Reiner ; Aaron R. Folsom ; Paul M. Ridker ; Christopher J. O'Donnell ; Nicholas L. Smith ; David P. Strachan ; Abbas DehghanSource :
- Human molecular genetics [ 1460-2083 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Fibrinogen.
- genetics : European Continental Ancestry Group, Fibrinogen.
- Adult, Aged, Aged, 80 and over, Female, Genetic Loci, Genome-Wide Association Study, Humans, INDEL Mutation, Male, Middle Aged, Polymorphism, Single Nucleotide.
Abstract
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
DOI: 10.1093/hmg/ddv454
PubMed: 26561523
Links to Exploration step
pubmed:26561523Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.</title><author><name sortKey="De Vries, Paul S" sort="De Vries, Paul S" uniqKey="De Vries P" first="Paul S" last="De Vries">Paul S. De Vries</name><affiliation><nlm:affiliation>Department of Epidemiology.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name><affiliation><nlm:affiliation>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA, Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E" last="Huffman">Jennifer E. Huffman</name><affiliation><nlm:affiliation>Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Steri, Maristella" sort="Steri, Maristella" uniqKey="Steri M" first="Maristella" last="Steri">Maristella Steri</name><affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name><affiliation><nlm:affiliation>Division of Epidemiology and Community Health and.</nlm:affiliation></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:affiliation>Institute for Community Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Marioni, Riccardo E" sort="Marioni, Riccardo E" uniqKey="Marioni R" first="Riccardo E" last="Marioni">Riccardo E. Marioni</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Centre for Genomic and Experimental Medicine, Queensland Brain Institute, University of Queensland, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Grossmann, Vera" sort="Grossmann, Vera" uniqKey="Grossmann V" first="Vera" last="Grossmann">Vera Grossmann</name><affiliation><nlm:affiliation>Center for Thrombosis and Hemostasis (CTH).</nlm:affiliation></affiliation></author><author><name sortKey="Hottenga, Jouke J" sort="Hottenga, Jouke J" uniqKey="Hottenga J" first="Jouke J" last="Hottenga">Jouke J. Hottenga</name><affiliation><nlm:affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation><nlm:affiliation>Department of Cardiology, Department of Gerontology and Geriatrics and.</nlm:affiliation></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:affiliation>Institute of Genetic Epidemiology, Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany, DZHK (German Centre for Cardiovascular Research) and.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, School of Clinical Medicine and.</nlm:affiliation></affiliation></author><author><name sortKey="Brody, Jennifer A" sort="Brody, Jennifer A" uniqKey="Brody J" first="Jennifer A" last="Brody">Jennifer A. Brody</name><affiliation><nlm:affiliation>Department of Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E" last="Kleber">Marcus E. Kleber</name><affiliation><nlm:affiliation>Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Xiuqing" sort="Guo, Xiuqing" uniqKey="Guo X" first="Xiuqing" last="Guo">Xiuqing Guo</name><affiliation><nlm:affiliation>Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center, Torrance, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation><nlm:affiliation>Department of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Auer, Paul L" sort="Auer, Paul L" uniqKey="Auer P" first="Paul L" last="Auer">Paul L. Auer</name><affiliation><nlm:affiliation>Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Attia, John R" sort="Attia, John R" uniqKey="Attia J" first="John R" last="Attia">John R. Attia</name><affiliation><nlm:affiliation>Public Health Stream and School of Medicine and Public Health and.</nlm:affiliation></affiliation></author><author><name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R" last="Yanek">Lisa R. Yanek</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ahluwalia, Tarunveer S" sort="Ahluwalia, Tarunveer S" uniqKey="Ahluwalia T" first="Tarunveer S" last="Ahluwalia">Tarunveer S. Ahluwalia</name><affiliation><nlm:affiliation>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences and Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, The Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:affiliation>Institute of Behavioural Sciences, Folkhälsan Research Centre, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation><nlm:affiliation>Institute of Opthalmology, UCL, London, UK, Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bielak, Lawrence F" sort="Bielak, Lawrence F" uniqKey="Bielak L" first="Lawrence F" last="Bielak">Lawrence F. Bielak</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K" last="Joshi">Peter K. Joshi</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</nlm:affiliation></affiliation></author><author><name sortKey="Rocanin Arjo, Ares" sort="Rocanin Arjo, Ares" uniqKey="Rocanin Arjo A" first="Ares" last="Rocanin-Arjo">Ares Rocanin-Arjo</name><affiliation><nlm:affiliation>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris F-75013, France, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris F-75013, France, Institute for Cardiometabolism and Nutrition (ICAN), Paris F-75013, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:affiliation>Department of Public Health, Faculty of Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Oldmeadow, Christopher" sort="Oldmeadow, Christopher" uniqKey="Oldmeadow C" first="Christopher" last="Oldmeadow">Christopher Oldmeadow</name><affiliation><nlm:affiliation>Public Health Stream and School of Medicine and Public Health and.</nlm:affiliation></affiliation></author><author><name sortKey="Riess, Helene" sort="Riess, Helene" uniqKey="Riess H" first="Helene" last="Riess">Helene Riess</name><affiliation><nlm:affiliation>Institute of Epidemiology II and.</nlm:affiliation></affiliation></author><author><name sortKey="Mazur, Johanna" sort="Mazur, Johanna" uniqKey="Mazur J" first="Johanna" last="Mazur">Johanna Mazur</name><affiliation><nlm:affiliation>Institute of Medical Biostatistics, Epidemiology and Informatics and.</nlm:affiliation></affiliation></author><author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name><affiliation><nlm:affiliation>Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:affiliation>Cardiovascular Medicine Department/Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:affiliation>Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ghanbari, Mohsen" sort="Ghanbari, Mohsen" uniqKey="Ghanbari M" first="Mohsen" last="Ghanbari">Mohsen Ghanbari</name><affiliation><nlm:affiliation>Department of Epidemiology, Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Fiorillo, Edoardo" sort="Fiorillo, Edoardo" uniqKey="Fiorillo E" first="Edoardo" last="Fiorillo">Edoardo Fiorillo</name><affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J M" last="De Craen">Anton J M. De Craen</name><affiliation><nlm:affiliation>Department of Gerontology and Geriatrics and.</nlm:affiliation></affiliation></author><author><name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name><affiliation><nlm:affiliation>Institute of Clinical Chemistry and Laboratory Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, School of Clinical Medicine and.</nlm:affiliation></affiliation></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D" last="Taylor">Kent D. Taylor</name><affiliation><nlm:affiliation>Institute for Translational Genomics and Population Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Delgado, Graciela E" sort="Delgado, Graciela E" uniqKey="Delgado G" first="Graciela E" last="Delgado">Graciela E. Delgado</name><affiliation><nlm:affiliation>Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Yao, Jie" sort="Yao, Jie" uniqKey="Yao J" first="Jie" last="Yao">Jie Yao</name><affiliation><nlm:affiliation>Institute for Translational Genomics and Population Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Kifley, Annette" sort="Kifley, Annette" uniqKey="Kifley A" first="Annette" last="Kifley">Annette Kifley</name><affiliation><nlm:affiliation>Department of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Qayyum, Rehan" sort="Qayyum, Rehan" uniqKey="Qayyum R" first="Rehan" last="Qayyum">Rehan Qayyum</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland, University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD, Belfield, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Berentzen, Tina L" sort="Berentzen, Tina L" uniqKey="Berentzen T" first="Tina L" last="Berentzen">Tina L. Berentzen</name><affiliation><nlm:affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation><nlm:affiliation>Institute of Behavioural Sciences.</nlm:affiliation></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Peyser, Patricia A" sort="Peyser, Patricia A" uniqKey="Peyser P" first="Patricia A" last="Peyser">Patricia A. Peyser</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wild, Sarah" sort="Wild, Sarah" uniqKey="Wild S" first="Sarah" last="Wild">Sarah Wild</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics.</nlm:affiliation></affiliation></author><author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name><affiliation><nlm:affiliation>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris F-75013, France, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris F-75013, France, Institute for Cardiometabolism and Nutrition (ICAN), Paris F-75013, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Marten, Jonathan" sort="Marten, Jonathan" uniqKey="Marten J" first="Jonathan" last="Marten">Jonathan Marten</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:affiliation>Department of Biology, School of Medicine and.</nlm:affiliation></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C" last="Morrison">Alanna C. Morrison</name><affiliation><nlm:affiliation>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name><affiliation><nlm:affiliation>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Tofler, Geoffrey" sort="Tofler, Geoffrey" uniqKey="Tofler G" first="Geoffrey" last="Tofler">Geoffrey Tofler</name><affiliation><nlm:affiliation>Royal North Shore Hospital, Sydney University, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P M" last="De Maat">Moniek P M. De Maat</name><affiliation><nlm:affiliation>Department of Hematology and.</nlm:affiliation></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name><affiliation><nlm:affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands, EMGO+ institute, VU University & VU Medical Center, Amsterdam.</nlm:affiliation></affiliation></author><author><name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D" last="Lowe">Gordon D. Lowe</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Zoledziewska, Magdalena" sort="Zoledziewska, Magdalena" uniqKey="Zoledziewska M" first="Magdalena" last="Zoledziewska">Magdalena Zoledziewska</name><affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation><nlm:affiliation>Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Binder, Harald" sort="Binder, Harald" uniqKey="Binder H" first="Harald" last="Binder">Harald Binder</name><affiliation><nlm:affiliation>Institute of Medical Biostatistics, Epidemiology and Informatics and.</nlm:affiliation></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics and.</nlm:affiliation></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation><nlm:affiliation>Institute of Epidemiology II and Research Unit of Molecular Epidemiology, Helmholtz ZentrumMünchen - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:affiliation>Clinical Gerontology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:affiliation>Department of Biostatistics.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name><affiliation><nlm:affiliation>Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Jenny, Nancy S" sort="Jenny, Nancy S" uniqKey="Jenny N" first="Nancy S" last="Jenny">Nancy S. Jenny</name><affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine and.</nlm:affiliation></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G" last="Holliday">Elizabeth G. Holliday</name><affiliation><nlm:affiliation>Public Health Stream, Hunter Medical Research Institute, School of Medicine and Public Health and.</nlm:affiliation></affiliation></author><author><name sortKey="Qi, Lihong" sort="Qi, Lihong" uniqKey="Qi L" first="Lihong" last="Qi">Lihong Qi</name><affiliation><nlm:affiliation>Division of Biostatistics, Department of Public Health Sciences, UC Davis, Davis, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcevoy, Mark G" sort="Mcevoy, Mark G" uniqKey="Mcevoy M" first="Mark G" last="Mcevoy">Mark G. Mcevoy</name><affiliation><nlm:affiliation>School of Medicine and Public Health, University of Newcastle, Newcastle, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M" last="Becker">Diane M. Becker</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Alzheimer Scotland Dementia Research Centre and.</nlm:affiliation></affiliation></author><author><name sortKey="Sarin, Antti Pekka" sort="Sarin, Antti Pekka" uniqKey="Sarin A" first="Antti-Pekka" last="Sarin">Antti-Pekka Sarin</name><affiliation><nlm:affiliation>Institute for Molecular Medicine Finland (FIMM) and Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G" last="Hysi">Pirro G. Hysi</name><affiliation><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G" last="Hernandez">Dena G. Hernandez</name><affiliation><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jhun, Min A" sort="Jhun, Min A" uniqKey="Jhun M" first="Min A" last="Jhun">Min A. Jhun</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:affiliation>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</nlm:affiliation></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:affiliation>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and.</nlm:affiliation></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:affiliation>Department of Epidemiology, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P Eline" last="Slagboom">P Eline Slagboom</name><affiliation><nlm:affiliation>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation><nlm:affiliation>Department of General and Interventional Cardiology, University Heart Centre, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:affiliation>German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany, Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm, Germany, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:affiliation>Department of Medicine, Epidemiology, and Health Services and Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation><nlm:affiliation>Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jingmin" sort="Liu, Jingmin" uniqKey="Liu J" first="Jingmin" last="Liu">Jingmin Liu</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:affiliation>Institute for Molecular Medicine Finland (FIMM) and.</nlm:affiliation></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:affiliation>Department of Epidemiology, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:affiliation>Department of Epidemiology.</nlm:affiliation></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><affiliation><nlm:affiliation>Department of Epidemiology.</nlm:affiliation></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:affiliation>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Department of Public Health, Faculty of Medicine, Centre for Global Health, University of Split, Split, Croatia.</nlm:affiliation></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:affiliation>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</nlm:affiliation></affiliation></author><author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name><affiliation><nlm:affiliation>Laboratory of Haematology, La Timone Hospital, Marseille F-13385, France, INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille F-13385, France, Aix-Marseille University, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille F-13385, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</nlm:affiliation></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L R" last="Kardia">Sharon L R. Kardia</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:affiliation>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Folkhälsan Research Centre, Helsinki, Finland, National Institute for Health and Welfare, Helsinki, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:affiliation>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, Lewis C" sort="Becker, Lewis C" uniqKey="Becker L" first="Lewis C" last="Becker">Lewis C. Becker</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><affiliation><nlm:affiliation>Information based Medicine Program, Hunter Medical Research Institute, New Lambton Heights, Australia, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton Heights, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation><nlm:affiliation>Department of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:affiliation>Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Synlab Academy, Synlab Services LLC, Mannheim, Germany, Clinical Institute of Medical, Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J" last="Wareham">Nick J. Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, School of Clinical Medicine and.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:affiliation>Institute of Epidemiology II and DZHK (German Centre for Cardiovascular Research) and.</nlm:affiliation></affiliation></author><author><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><affiliation><nlm:affiliation>Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S" last="Wild">Philipp S. Wild</name><affiliation><nlm:affiliation>Center for Thrombosis and Hemostasis (CTH), Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Mainz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation><nlm:affiliation>Department of Cardiology, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands, Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tracy, Russell" sort="Tracy, Russell" uniqKey="Tracy R" first="Russell" last="Tracy">Russell Tracy</name><affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, Center for Clinical and Translational Sciences, University of Vermont College of Medicine, Colchester, VT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:affiliation>Cardiovascular Medicine Department/Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R" last="Folsom">Aaron R. Folsom</name><affiliation><nlm:affiliation>Division of Epidemiology and Community Health and.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J" last="O'Donnell">Christopher J. O'Donnell</name><affiliation><nlm:affiliation>Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, National Heart, Lung and Blood Institute, Division of Intramural Research, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L" last="Smith">Nicholas L. Smith</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA, Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK, Department of Veterans Affairs, Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA and.</nlm:affiliation></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation><nlm:affiliation>Population Health Research Institute, St George's University of London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:affiliation>Department of Epidemiology, a.dehghan@erasmusmc.nl.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26561523</idno><idno type="pmid">26561523</idno><idno type="doi">10.1093/hmg/ddv454</idno><idno type="wicri:Area/PubMed/Corpus">002410</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002410</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.</title><author><name sortKey="De Vries, Paul S" sort="De Vries, Paul S" uniqKey="De Vries P" first="Paul S" last="De Vries">Paul S. De Vries</name><affiliation><nlm:affiliation>Department of Epidemiology.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sabater Lleal, Maria" sort="Sabater Lleal, Maria" uniqKey="Sabater Lleal M" first="Maria" last="Sabater-Lleal">Maria Sabater-Lleal</name><affiliation><nlm:affiliation>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA, Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huffman, Jennifer E" sort="Huffman, Jennifer E" uniqKey="Huffman J" first="Jennifer E" last="Huffman">Jennifer E. Huffman</name><affiliation><nlm:affiliation>Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Steri, Maristella" sort="Steri, Maristella" uniqKey="Steri M" first="Maristella" last="Steri">Maristella Steri</name><affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Weihong" sort="Tang, Weihong" uniqKey="Tang W" first="Weihong" last="Tang">Weihong Tang</name><affiliation><nlm:affiliation>Division of Epidemiology and Community Health and.</nlm:affiliation></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:affiliation>Institute for Community Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Marioni, Riccardo E" sort="Marioni, Riccardo E" uniqKey="Marioni R" first="Riccardo E" last="Marioni">Riccardo E. Marioni</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Centre for Genomic and Experimental Medicine, Queensland Brain Institute, University of Queensland, Brisbane, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Grossmann, Vera" sort="Grossmann, Vera" uniqKey="Grossmann V" first="Vera" last="Grossmann">Vera Grossmann</name><affiliation><nlm:affiliation>Center for Thrombosis and Hemostasis (CTH).</nlm:affiliation></affiliation></author><author><name sortKey="Hottenga, Jouke J" sort="Hottenga, Jouke J" uniqKey="Hottenga J" first="Jouke J" last="Hottenga">Jouke J. Hottenga</name><affiliation><nlm:affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name><affiliation><nlm:affiliation>Department of Cardiology, Department of Gerontology and Geriatrics and.</nlm:affiliation></affiliation></author><author><name sortKey="Muller Nurasyid, Martina" sort="Muller Nurasyid, Martina" uniqKey="Muller Nurasyid M" first="Martina" last="Müller-Nurasyid">Martina Müller-Nurasyid</name><affiliation><nlm:affiliation>Institute of Genetic Epidemiology, Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany, DZHK (German Centre for Cardiovascular Research) and.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, Jing Hua" sort="Zhao, Jing Hua" uniqKey="Zhao J" first="Jing Hua" last="Zhao">Jing Hua Zhao</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, School of Clinical Medicine and.</nlm:affiliation></affiliation></author><author><name sortKey="Brody, Jennifer A" sort="Brody, Jennifer A" uniqKey="Brody J" first="Jennifer A" last="Brody">Jennifer A. Brody</name><affiliation><nlm:affiliation>Department of Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E" last="Kleber">Marcus E. Kleber</name><affiliation><nlm:affiliation>Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Guo, Xiuqing" sort="Guo, Xiuqing" uniqKey="Guo X" first="Xiuqing" last="Guo">Xiuqing Guo</name><affiliation><nlm:affiliation>Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center, Torrance, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name><affiliation><nlm:affiliation>Department of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Auer, Paul L" sort="Auer, Paul L" uniqKey="Auer P" first="Paul L" last="Auer">Paul L. Auer</name><affiliation><nlm:affiliation>Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Attia, John R" sort="Attia, John R" uniqKey="Attia J" first="John R" last="Attia">John R. Attia</name><affiliation><nlm:affiliation>Public Health Stream and School of Medicine and Public Health and.</nlm:affiliation></affiliation></author><author><name sortKey="Yanek, Lisa R" sort="Yanek, Lisa R" uniqKey="Yanek L" first="Lisa R" last="Yanek">Lisa R. Yanek</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ahluwalia, Tarunveer S" sort="Ahluwalia, Tarunveer S" uniqKey="Ahluwalia T" first="Tarunveer S" last="Ahluwalia">Tarunveer S. Ahluwalia</name><affiliation><nlm:affiliation>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences and Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, The Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Lahti, Jari" sort="Lahti, Jari" uniqKey="Lahti J" first="Jari" last="Lahti">Jari Lahti</name><affiliation><nlm:affiliation>Institute of Behavioural Sciences, Folkhälsan Research Centre, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Venturini, Cristina" sort="Venturini, Cristina" uniqKey="Venturini C" first="Cristina" last="Venturini">Cristina Venturini</name><affiliation><nlm:affiliation>Institute of Opthalmology, UCL, London, UK, Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name><affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bielak, Lawrence F" sort="Bielak, Lawrence F" uniqKey="Bielak L" first="Lawrence F" last="Bielak">Lawrence F. Bielak</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Joshi, Peter K" sort="Joshi, Peter K" uniqKey="Joshi P" first="Peter K" last="Joshi">Peter K. Joshi</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</nlm:affiliation></affiliation></author><author><name sortKey="Rocanin Arjo, Ares" sort="Rocanin Arjo, Ares" uniqKey="Rocanin Arjo A" first="Ares" last="Rocanin-Arjo">Ares Rocanin-Arjo</name><affiliation><nlm:affiliation>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris F-75013, France, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris F-75013, France, Institute for Cardiometabolism and Nutrition (ICAN), Paris F-75013, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kolcic, Ivana" sort="Kolcic, Ivana" uniqKey="Kolcic I" first="Ivana" last="Kolcic">Ivana Kolcic</name><affiliation><nlm:affiliation>Department of Public Health, Faculty of Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Navarro, Pau" sort="Navarro, Pau" uniqKey="Navarro P" first="Pau" last="Navarro">Pau Navarro</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Oldmeadow, Christopher" sort="Oldmeadow, Christopher" uniqKey="Oldmeadow C" first="Christopher" last="Oldmeadow">Christopher Oldmeadow</name><affiliation><nlm:affiliation>Public Health Stream and School of Medicine and Public Health and.</nlm:affiliation></affiliation></author><author><name sortKey="Riess, Helene" sort="Riess, Helene" uniqKey="Riess H" first="Helene" last="Riess">Helene Riess</name><affiliation><nlm:affiliation>Institute of Epidemiology II and.</nlm:affiliation></affiliation></author><author><name sortKey="Mazur, Johanna" sort="Mazur, Johanna" uniqKey="Mazur J" first="Johanna" last="Mazur">Johanna Mazur</name><affiliation><nlm:affiliation>Institute of Medical Biostatistics, Epidemiology and Informatics and.</nlm:affiliation></affiliation></author><author><name sortKey="Basu, Saonli" sort="Basu, Saonli" uniqKey="Basu S" first="Saonli" last="Basu">Saonli Basu</name><affiliation><nlm:affiliation>Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name><affiliation><nlm:affiliation>Cardiovascular Medicine Department/Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name><affiliation><nlm:affiliation>Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ghanbari, Mohsen" sort="Ghanbari, Mohsen" uniqKey="Ghanbari M" first="Mohsen" last="Ghanbari">Mohsen Ghanbari</name><affiliation><nlm:affiliation>Department of Epidemiology, Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Willemsen, Gonneke" sort="Willemsen, Gonneke" uniqKey="Willemsen G" first="Gonneke" last="Willemsen">Gonneke Willemsen</name><affiliation><nlm:affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Rumley, Ann" sort="Rumley, Ann" uniqKey="Rumley A" first="Ann" last="Rumley">Ann Rumley</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Fiorillo, Edoardo" sort="Fiorillo, Edoardo" uniqKey="Fiorillo E" first="Edoardo" last="Fiorillo">Edoardo Fiorillo</name><affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="De Craen, Anton J M" sort="De Craen, Anton J M" uniqKey="De Craen A" first="Anton J M" last="De Craen">Anton J M. De Craen</name><affiliation><nlm:affiliation>Department of Gerontology and Geriatrics and.</nlm:affiliation></affiliation></author><author><name sortKey="Grotevendt, Anne" sort="Grotevendt, Anne" uniqKey="Grotevendt A" first="Anne" last="Grotevendt">Anne Grotevendt</name><affiliation><nlm:affiliation>Institute of Clinical Chemistry and Laboratory Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, School of Clinical Medicine and.</nlm:affiliation></affiliation></author><author><name sortKey="Taylor, Kent D" sort="Taylor, Kent D" uniqKey="Taylor K" first="Kent D" last="Taylor">Kent D. Taylor</name><affiliation><nlm:affiliation>Institute for Translational Genomics and Population Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Delgado, Graciela E" sort="Delgado, Graciela E" uniqKey="Delgado G" first="Graciela E" last="Delgado">Graciela E. Delgado</name><affiliation><nlm:affiliation>Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Yao, Jie" sort="Yao, Jie" uniqKey="Yao J" first="Jie" last="Yao">Jie Yao</name><affiliation><nlm:affiliation>Institute for Translational Genomics and Population Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Kifley, Annette" sort="Kifley, Annette" uniqKey="Kifley A" first="Annette" last="Kifley">Annette Kifley</name><affiliation><nlm:affiliation>Department of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kooperberg, Charles" sort="Kooperberg, Charles" uniqKey="Kooperberg C" first="Charles" last="Kooperberg">Charles Kooperberg</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Qayyum, Rehan" sort="Qayyum, Rehan" uniqKey="Qayyum R" first="Rehan" last="Qayyum">Rehan Qayyum</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lopez, Lorna M" sort="Lopez, Lorna M" uniqKey="Lopez L" first="Lorna M" last="Lopez">Lorna M. Lopez</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland, University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD, Belfield, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Berentzen, Tina L" sort="Berentzen, Tina L" uniqKey="Berentzen T" first="Tina L" last="Berentzen">Tina L. Berentzen</name><affiliation><nlm:affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="R Ikkonen, Katri" sort="R Ikkonen, Katri" uniqKey="R Ikkonen K" first="Katri" last="R Ikkönen">Katri R Ikkönen</name><affiliation><nlm:affiliation>Institute of Behavioural Sciences.</nlm:affiliation></affiliation></author><author><name sortKey="Mangino, Massimo" sort="Mangino, Massimo" uniqKey="Mangino M" first="Massimo" last="Mangino">Massimo Mangino</name><affiliation><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bandinelli, Stefania" sort="Bandinelli, Stefania" uniqKey="Bandinelli S" first="Stefania" last="Bandinelli">Stefania Bandinelli</name><affiliation><nlm:affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Peyser, Patricia A" sort="Peyser, Patricia A" uniqKey="Peyser P" first="Patricia A" last="Peyser">Patricia A. Peyser</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wild, Sarah" sort="Wild, Sarah" uniqKey="Wild S" first="Sarah" last="Wild">Sarah Wild</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics.</nlm:affiliation></affiliation></author><author><name sortKey="Tregouet, David Alexandre" sort="Tregouet, David Alexandre" uniqKey="Tregouet D" first="David-Alexandre" last="Trégouët">David-Alexandre Trégouët</name><affiliation><nlm:affiliation>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris F-75013, France, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris F-75013, France, Institute for Cardiometabolism and Nutrition (ICAN), Paris F-75013, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F" last="Wright">Alan F. Wright</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Marten, Jonathan" sort="Marten, Jonathan" uniqKey="Marten J" first="Jonathan" last="Marten">Jonathan Marten</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name><affiliation><nlm:affiliation>Department of Biology, School of Medicine and.</nlm:affiliation></affiliation></author><author><name sortKey="Morrison, Alanna C" sort="Morrison, Alanna C" uniqKey="Morrison A" first="Alanna C" last="Morrison">Alanna C. Morrison</name><affiliation><nlm:affiliation>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sennblad, Bengt" sort="Sennblad, Bengt" uniqKey="Sennblad B" first="Bengt" last="Sennblad">Bengt Sennblad</name><affiliation><nlm:affiliation>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Tofler, Geoffrey" sort="Tofler, Geoffrey" uniqKey="Tofler G" first="Geoffrey" last="Tofler">Geoffrey Tofler</name><affiliation><nlm:affiliation>Royal North Shore Hospital, Sydney University, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="De Maat, Moniek P M" sort="De Maat, Moniek P M" uniqKey="De Maat M" first="Moniek P M" last="De Maat">Moniek P M. De Maat</name><affiliation><nlm:affiliation>Department of Hematology and.</nlm:affiliation></affiliation></author><author><name sortKey="De Geus, Eco J C" sort="De Geus, Eco J C" uniqKey="De Geus E" first="Eco J C" last="De Geus">Eco J C. De Geus</name><affiliation><nlm:affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands, EMGO+ institute, VU University & VU Medical Center, Amsterdam.</nlm:affiliation></affiliation></author><author><name sortKey="Lowe, Gordon D" sort="Lowe, Gordon D" uniqKey="Lowe G" first="Gordon D" last="Lowe">Gordon D. Lowe</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Zoledziewska, Magdalena" sort="Zoledziewska, Magdalena" uniqKey="Zoledziewska M" first="Magdalena" last="Zoledziewska">Magdalena Zoledziewska</name><affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation><nlm:affiliation>Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Binder, Harald" sort="Binder, Harald" uniqKey="Binder H" first="Harald" last="Binder">Harald Binder</name><affiliation><nlm:affiliation>Institute of Medical Biostatistics, Epidemiology and Informatics and.</nlm:affiliation></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics and.</nlm:affiliation></affiliation></author><author><name sortKey="Waldenberger, Melanie" sort="Waldenberger, Melanie" uniqKey="Waldenberger M" first="Melanie" last="Waldenberger">Melanie Waldenberger</name><affiliation><nlm:affiliation>Institute of Epidemiology II and Research Unit of Molecular Epidemiology, Helmholtz ZentrumMünchen - German Research Center for Environmental Health, Neuherberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:affiliation>Clinical Gerontology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mcknight, Barbara" sort="Mcknight, Barbara" uniqKey="Mcknight B" first="Barbara" last="Mcknight">Barbara Mcknight</name><affiliation><nlm:affiliation>Department of Biostatistics.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Jie" sort="Huang, Jie" uniqKey="Huang J" first="Jie" last="Huang">Jie Huang</name><affiliation><nlm:affiliation>Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Jenny, Nancy S" sort="Jenny, Nancy S" uniqKey="Jenny N" first="Nancy S" last="Jenny">Nancy S. Jenny</name><affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine and.</nlm:affiliation></affiliation></author><author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G" last="Holliday">Elizabeth G. Holliday</name><affiliation><nlm:affiliation>Public Health Stream, Hunter Medical Research Institute, School of Medicine and Public Health and.</nlm:affiliation></affiliation></author><author><name sortKey="Qi, Lihong" sort="Qi, Lihong" uniqKey="Qi L" first="Lihong" last="Qi">Lihong Qi</name><affiliation><nlm:affiliation>Division of Biostatistics, Department of Public Health Sciences, UC Davis, Davis, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcevoy, Mark G" sort="Mcevoy, Mark G" uniqKey="Mcevoy M" first="Mark G" last="Mcevoy">Mark G. Mcevoy</name><affiliation><nlm:affiliation>School of Medicine and Public Health, University of Newcastle, Newcastle, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, Diane M" sort="Becker, Diane M" uniqKey="Becker D" first="Diane M" last="Becker">Diane M. Becker</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Starr, John M" sort="Starr, John M" uniqKey="Starr J" first="John M" last="Starr">John M. Starr</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Alzheimer Scotland Dementia Research Centre and.</nlm:affiliation></affiliation></author><author><name sortKey="Sarin, Antti Pekka" sort="Sarin, Antti Pekka" uniqKey="Sarin A" first="Antti-Pekka" last="Sarin">Antti-Pekka Sarin</name><affiliation><nlm:affiliation>Institute for Molecular Medicine Finland (FIMM) and Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Hysi, Pirro G" sort="Hysi, Pirro G" uniqKey="Hysi P" first="Pirro G" last="Hysi">Pirro G. Hysi</name><affiliation><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hernandez, Dena G" sort="Hernandez, Dena G" uniqKey="Hernandez D" first="Dena G" last="Hernandez">Dena G. Hernandez</name><affiliation><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jhun, Min A" sort="Jhun, Min A" uniqKey="Jhun M" first="Min A" last="Jhun">Min A. Jhun</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name><affiliation><nlm:affiliation>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</nlm:affiliation></affiliation></author><author><name sortKey="Hamsten, Anders" sort="Hamsten, Anders" uniqKey="Hamsten A" first="Anders" last="Hamsten">Anders Hamsten</name><affiliation><nlm:affiliation>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and.</nlm:affiliation></affiliation></author><author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name><affiliation><nlm:affiliation>Department of Epidemiology, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Mcardle, Wendy L" sort="Mcardle, Wendy L" uniqKey="Mcardle W" first="Wendy L" last="Mcardle">Wendy L. Mcardle</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Slagboom, P Eline" sort="Slagboom, P Eline" uniqKey="Slagboom P" first="P Eline" last="Slagboom">P Eline Slagboom</name><affiliation><nlm:affiliation>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Zeller, Tanja" sort="Zeller, Tanja" uniqKey="Zeller T" first="Tanja" last="Zeller">Tanja Zeller</name><affiliation><nlm:affiliation>Department of General and Interventional Cardiology, University Heart Centre, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, Hamburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name><affiliation><nlm:affiliation>German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany, Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm, Germany, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Psaty, Bruce M" sort="Psaty, Bruce M" uniqKey="Psaty B" first="Bruce M" last="Psaty">Bruce M. Psaty</name><affiliation><nlm:affiliation>Department of Medicine, Epidemiology, and Health Services and Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Haritunians, Talin" sort="Haritunians, Talin" uniqKey="Haritunians T" first="Talin" last="Haritunians">Talin Haritunians</name><affiliation><nlm:affiliation>Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jingmin" sort="Liu, Jingmin" uniqKey="Liu J" first="Jingmin" last="Liu">Jingmin Liu</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Palotie, Aarno" sort="Palotie, Aarno" uniqKey="Palotie A" first="Aarno" last="Palotie">Aarno Palotie</name><affiliation><nlm:affiliation>Institute for Molecular Medicine Finland (FIMM) and.</nlm:affiliation></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name><affiliation><nlm:affiliation>Department of Epidemiology, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Stott, David J" sort="Stott, David J" uniqKey="Stott D" first="David J" last="Stott">David J. Stott</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:affiliation>Department of Epidemiology.</nlm:affiliation></affiliation></author><author><name sortKey="Franco, Oscar H" sort="Franco, Oscar H" uniqKey="Franco O" first="Oscar H" last="Franco">Oscar H. Franco</name><affiliation><nlm:affiliation>Department of Epidemiology.</nlm:affiliation></affiliation></author><author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name><affiliation><nlm:affiliation>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Department of Public Health, Faculty of Medicine, Centre for Global Health, University of Split, Split, Croatia.</nlm:affiliation></affiliation></author><author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name><affiliation><nlm:affiliation>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</nlm:affiliation></affiliation></author><author><name sortKey="Morange, Pierre Emmanuel" sort="Morange, Pierre Emmanuel" uniqKey="Morange P" first="Pierre-Emmanuel" last="Morange">Pierre-Emmanuel Morange</name><affiliation><nlm:affiliation>Laboratory of Haematology, La Timone Hospital, Marseille F-13385, France, INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille F-13385, France, Aix-Marseille University, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille F-13385, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F" last="Wilson">James F. Wilson</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</nlm:affiliation></affiliation></author><author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L R" last="Kardia">Sharon L R. Kardia</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation><nlm:affiliation>Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Eriksson, Johan G" sort="Eriksson, Johan G" uniqKey="Eriksson J" first="Johan G" last="Eriksson">Johan G. Eriksson</name><affiliation><nlm:affiliation>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Folkhälsan Research Centre, Helsinki, Finland, National Institute for Health and Welfare, Helsinki, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:affiliation>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences and.</nlm:affiliation></affiliation></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J" last="Deary">Ian J. Deary</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, Lewis C" sort="Becker, Lewis C" uniqKey="Becker L" first="Lewis C" last="Becker">Lewis C. Becker</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J" last="Scott">Rodney J. Scott</name><affiliation><nlm:affiliation>Information based Medicine Program, Hunter Medical Research Institute, New Lambton Heights, Australia, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton Heights, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name><affiliation><nlm:affiliation>Department of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name><affiliation><nlm:affiliation>Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Synlab Academy, Synlab Services LLC, Mannheim, Germany, Clinical Institute of Medical, Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nick J" sort="Wareham, Nick J" uniqKey="Wareham N" first="Nick J" last="Wareham">Nick J. Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, School of Clinical Medicine and.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, Annette" sort="Peters, Annette" uniqKey="Peters A" first="Annette" last="Peters">Annette Peters</name><affiliation><nlm:affiliation>Institute of Epidemiology II and DZHK (German Centre for Cardiovascular Research) and.</nlm:affiliation></affiliation></author><author><name sortKey="Greinacher, Andreas" sort="Greinacher, Andreas" uniqKey="Greinacher A" first="Andreas" last="Greinacher">Andreas Greinacher</name><affiliation><nlm:affiliation>Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wild, Philipp S" sort="Wild, Philipp S" uniqKey="Wild P" first="Philipp S" last="Wild">Philipp S. Wild</name><affiliation><nlm:affiliation>Center for Thrombosis and Hemostasis (CTH), Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Mainz, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J Wouter" last="Jukema">J Wouter Jukema</name><affiliation><nlm:affiliation>Department of Cardiology, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands, Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Boomsma, Dorret I" sort="Boomsma, Dorret I" uniqKey="Boomsma D" first="Dorret I" last="Boomsma">Dorret I. Boomsma</name><affiliation><nlm:affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</nlm:affiliation></affiliation></author><author><name sortKey="Cucca, Francesco" sort="Cucca, Francesco" uniqKey="Cucca F" first="Francesco" last="Cucca">Francesco Cucca</name><affiliation><nlm:affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tracy, Russell" sort="Tracy, Russell" uniqKey="Tracy R" first="Russell" last="Tracy">Russell Tracy</name><affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, Center for Clinical and Translational Sciences, University of Vermont College of Medicine, Colchester, VT, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name><affiliation><nlm:affiliation>Cardiovascular Medicine Department/Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name><affiliation><nlm:affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Folsom, Aaron R" sort="Folsom, Aaron R" uniqKey="Folsom A" first="Aaron R" last="Folsom">Aaron R. Folsom</name><affiliation><nlm:affiliation>Division of Epidemiology and Community Health and.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="O Donnell, Christopher J" sort="O Donnell, Christopher J" uniqKey="O Donnell C" first="Christopher J" last="O'Donnell">Christopher J. O'Donnell</name><affiliation><nlm:affiliation>Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, National Heart, Lung and Blood Institute, Division of Intramural Research, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Nicholas L" sort="Smith, Nicholas L" uniqKey="Smith N" first="Nicholas L" last="Smith">Nicholas L. Smith</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA, Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK, Department of Veterans Affairs, Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA and.</nlm:affiliation></affiliation></author><author><name sortKey="Strachan, David P" sort="Strachan, David P" uniqKey="Strachan D" first="David P" last="Strachan">David P. Strachan</name><affiliation><nlm:affiliation>Population Health Research Institute, St George's University of London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:affiliation>Department of Epidemiology, a.dehghan@erasmusmc.nl.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Human molecular genetics</title><idno type="eISSN">1460-2083</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>European Continental Ancestry Group (genetics)</term><term>Female</term><term>Fibrinogen (analysis)</term><term>Fibrinogen (genetics)</term><term>Genetic Loci</term><term>Genome-Wide Association Study</term><term>Humans</term><term>INDEL Mutation</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Fibrinogen</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>European Continental Ancestry Group</term><term>Fibrinogen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Genetic Loci</term><term>Genome-Wide Association Study</term><term>Humans</term><term>INDEL Mutation</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26561523</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>09</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>17</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1460-2083</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Jan</Month><Day>15</Day></PubDate></JournalIssue><Title>Human molecular genetics</Title><ISOAbbreviation>Hum. Mol. Genet.</ISOAbbreviation></Journal><ArticleTitle>A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration.</ArticleTitle><Pagination><MedlinePgn>358-70</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/hmg/ddv454</ELocationID><Abstract><AbstractText>Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including ∼120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.</AbstractText><CopyrightInformation>© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>de Vries</LastName><ForeName>Paul S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Department of Epidemiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chasman</LastName><ForeName>Daniel I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sabater-Lleal</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Ming-Huei</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA, Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huffman</LastName><ForeName>Jennifer E</ForeName><Initials>JE</Initials><AffiliationInfo><Affiliation>Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steri</LastName><ForeName>Maristella</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Weihong</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Division of Epidemiology and Community Health and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teumer</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marioni</LastName><ForeName>Riccardo E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Centre for Genomic and Experimental Medicine, Queensland Brain Institute, University of Queensland, Brisbane, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grossmann</LastName><ForeName>Vera</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Center for Thrombosis and Hemostasis (CTH).</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hottenga</LastName><ForeName>Jouke J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trompet</LastName><ForeName>Stella</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Department of Gerontology and Geriatrics and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Müller-Nurasyid</LastName><ForeName>Martina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Genetic Epidemiology, Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany, DZHK (German Centre for Cardiovascular Research) and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Jing Hua</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, School of Clinical Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brody</LastName><ForeName>Jennifer A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kleber</LastName><ForeName>Marcus E</ForeName><Initials>ME</Initials><AffiliationInfo><Affiliation>Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guo</LastName><ForeName>Xiuqing</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center, Torrance, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Jie Jin</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Auer</LastName><ForeName>Paul L</ForeName><Initials>PL</Initials><AffiliationInfo><Affiliation>Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Attia</LastName><ForeName>John R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Public Health Stream and School of Medicine and Public Health and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yanek</LastName><ForeName>Lisa R</ForeName><Initials>LR</Initials><AffiliationInfo><Affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahluwalia</LastName><ForeName>Tarunveer S</ForeName><Initials>TS</Initials><AffiliationInfo><Affiliation>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences and Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, The Danish Pediatric Asthma Center, Gentofte Hospital, The Capital Region, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lahti</LastName><ForeName>Jari</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Behavioural Sciences, Folkhälsan Research Centre, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Venturini</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Institute of Opthalmology, UCL, London, UK, Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>Toshiko</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bielak</LastName><ForeName>Lawrence F</ForeName><Initials>LF</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joshi</LastName><ForeName>Peter K</ForeName><Initials>PK</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rocanin-Arjo</LastName><ForeName>Ares</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris F-75013, France, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris F-75013, France, Institute for Cardiometabolism and Nutrition (ICAN), Paris F-75013, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kolcic</LastName><ForeName>Ivana</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Public Health, Faculty of Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Navarro</LastName><ForeName>Pau</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rose</LastName><ForeName>Lynda M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oldmeadow</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Public Health Stream and School of Medicine and Public Health and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riess</LastName><ForeName>Helene</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Epidemiology II and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mazur</LastName><ForeName>Johanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Medical Biostatistics, Epidemiology and Informatics and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Basu</LastName><ForeName>Saonli</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, University of Minnesota, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goel</LastName><ForeName>Anuj</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cardiovascular Medicine Department/Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Qiong</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ghanbari</LastName><ForeName>Mohsen</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willemsen</LastName><ForeName>Gonneke</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rumley</LastName><ForeName>Ann</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiorillo</LastName><ForeName>Edoardo</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Craen</LastName><ForeName>Anton J M</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Gerontology and Geriatrics and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grotevendt</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Clinical Chemistry and Laboratory Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, School of Clinical Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Kent D</ForeName><Initials>KD</Initials><AffiliationInfo><Affiliation>Institute for Translational Genomics and Population Sciences and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delgado</LastName><ForeName>Graciela E</ForeName><Initials>GE</Initials><AffiliationInfo><Affiliation>Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yao</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute for Translational Genomics and Population Sciences and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kifley</LastName><ForeName>Annette</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kooperberg</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qayyum</LastName><ForeName>Rehan</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopez</LastName><ForeName>Lorna M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychiatry, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland, University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD, Belfield, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berentzen</LastName><ForeName>Tina L</ForeName><Initials>TL</Initials><AffiliationInfo><Affiliation>Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Räikkönen</LastName><ForeName>Katri</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute of Behavioural Sciences.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mangino</LastName><ForeName>Massimo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bandinelli</LastName><ForeName>Stefania</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peyser</LastName><ForeName>Patricia A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wild</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trégouët</LastName><ForeName>David-Alexandre</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris F-75013, France, Sorbonne Universités, Université Pierre et Marie Curie (UPMC Univ Paris 06), UMR_S 1166, Team Genomics & Pathophysiology of Cardiovascular Diseases, Paris F-75013, France, Institute for Cardiometabolism and Nutrition (ICAN), Paris F-75013, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>Alan F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marten</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zemunik</LastName><ForeName>Tatijana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Biology, School of Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morrison</LastName><ForeName>Alanna C</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sennblad</LastName><ForeName>Bengt</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tofler</LastName><ForeName>Geoffrey</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Royal North Shore Hospital, Sydney University, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Maat</LastName><ForeName>Moniek P M</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Department of Hematology and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Geus</LastName><ForeName>Eco J C</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands, EMGO+ institute, VU University & VU Medical Center, Amsterdam.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lowe</LastName><ForeName>Gordon D</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zoledziewska</LastName><ForeName>Magdalena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sattar</LastName><ForeName>Naveed</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Binder</LastName><ForeName>Harald</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Medical Biostatistics, Epidemiology and Informatics and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Völker</LastName><ForeName>Uwe</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Interfaculty Institute for Genetics and Functional Genomics and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waldenberger</LastName><ForeName>Melanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Epidemiology II and Research Unit of Molecular Epidemiology, Helmholtz ZentrumMünchen - German Research Center for Environmental Health, Neuherberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khaw</LastName><ForeName>Kay-Tee</ForeName><Initials>KT</Initials><AffiliationInfo><Affiliation>Clinical Gerontology Unit, School of Clinical Medicine, University of Cambridge, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mcknight</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Biostatistics.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Jie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jenny</LastName><ForeName>Nancy S</ForeName><Initials>NS</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holliday</LastName><ForeName>Elizabeth G</ForeName><Initials>EG</Initials><AffiliationInfo><Affiliation>Public Health Stream, Hunter Medical Research Institute, School of Medicine and Public Health and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qi</LastName><ForeName>Lihong</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Division of Biostatistics, Department of Public Health Sciences, UC Davis, Davis, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mcevoy</LastName><ForeName>Mark G</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>School of Medicine and Public Health, University of Newcastle, Newcastle, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becker</LastName><ForeName>Diane M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Starr</LastName><ForeName>John M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Alzheimer Scotland Dementia Research Centre and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sarin</LastName><ForeName>Antti-Pekka</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Institute for Molecular Medicine Finland (FIMM) and Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hysi</LastName><ForeName>Pirro G</ForeName><Initials>PG</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hernandez</LastName><ForeName>Dena G</ForeName><Initials>DG</Initials><AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jhun</LastName><ForeName>Min A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campbell</LastName><ForeName>Harry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamsten</LastName><ForeName>Anders</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Cardiovascular Genetics and Genomics Group, Atherosclerosis Research Unit and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rivadeneira</LastName><ForeName>Fernando</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mcardle</LastName><ForeName>Wendy L</ForeName><Initials>WL</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slagboom</LastName><ForeName>P Eline</ForeName><Initials>PE</Initials><AffiliationInfo><Affiliation>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeller</LastName><ForeName>Tanja</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of General and Interventional Cardiology, University Heart Centre, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, Hamburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koenig</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany, Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm, Germany, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Psaty</LastName><ForeName>Bruce M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Department of Medicine, Epidemiology, and Health Services and Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haritunians</LastName><ForeName>Talin</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Inflammatory Bowel & Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jingmin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palotie</LastName><ForeName>Aarno</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Molecular Medicine Finland (FIMM) and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uitterlinden</LastName><ForeName>André G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Department of Internal Medicine, Erasmus MC, Wytemaweg 80, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stott</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofman</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franco</LastName><ForeName>Oscar H</ForeName><Initials>OH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Polasek</LastName><ForeName>Ozren</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Department of Public Health, Faculty of Medicine, Centre for Global Health, University of Split, Split, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rudan</LastName><ForeName>Igor</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morange</LastName><ForeName>Pierre-Emmanuel</ForeName><Initials>PE</Initials><AffiliationInfo><Affiliation>Laboratory of Haematology, La Timone Hospital, Marseille F-13385, France, INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille F-13385, France, Aix-Marseille University, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis, Marseille F-13385, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>James F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kardia</LastName><ForeName>Sharon L R</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferrucci</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spector</LastName><ForeName>Tim D</ForeName><Initials>TD</Initials><AffiliationInfo><Affiliation>Department of Twin Research and Genetic Epidemiology, Kings College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksson</LastName><ForeName>Johan G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland, Folkhälsan Research Centre, Helsinki, Finland, National Institute for Health and Welfare, Helsinki, Finland, Unit of General Practice, Helsinki University Central Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>Torben</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deary</LastName><ForeName>Ian J</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becker</LastName><ForeName>Lewis C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Rodney J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Information based Medicine Program, Hunter Medical Research Institute, New Lambton Heights, Australia, School of Biomedical Sciences and Pharmacy, University of Newcastle, New Lambton Heights, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Ophthalmology, Centre for Vision Research, Westmead Millennium Institute for Medical Research, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>März</LastName><ForeName>Winfried</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Synlab Academy, Synlab Services LLC, Mannheim, Germany, Clinical Institute of Medical, Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>Nick J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, School of Clinical Medicine and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Annette</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Epidemiology II and DZHK (German Centre for Cardiovascular Research) and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Greinacher</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wild</LastName><ForeName>Philipp S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Center for Thrombosis and Hemostasis (CTH), Preventive Cardiology and Preventive Medicine, Department of Medicine 2, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site RheinMain, Mainz, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jukema</LastName><ForeName>J Wouter</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands, Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boomsma</LastName><ForeName>Dorret I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hayward</LastName><ForeName>Caroline</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cucca</LastName><ForeName>Francesco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionaledelle Ricerche, Monserrato, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tracy</LastName><ForeName>Russell</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Center for Clinical and Translational Sciences, University of Vermont College of Medicine, Colchester, VT, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watkins</LastName><ForeName>Hugh</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Cardiovascular Medicine Department/Radcliffe Department of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reiner</LastName><ForeName>Alex P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Fred Hutchinson Cancer Research Center, Seattle, WA, USA, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Folsom</LastName><ForeName>Aaron R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Division of Epidemiology and Community Health and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ridker</LastName><ForeName>Paul M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Donnell</LastName><ForeName>Christopher J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, USA, National Heart, Lung and Blood Institute, Division of Intramural Research, Cardiology Division, Massachusetts General Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Nicholas L</ForeName><Initials>NL</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA, Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, UK, Department of Veterans Affairs, Office of Research and Development, Seattle Epidemiologic Research and Information Center, Seattle, WA, USA and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strachan</LastName><ForeName>David P</ForeName><Initials>DP</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, St George's University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dehghan</LastName><ForeName>Abbas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, a.dehghan@erasmusmc.nl.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>ETM/55</GrantID><Agency>Chief Scientist Office</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>UL1RR025005</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CZB/4/505</GrantID><Agency>Chief Scientist Office</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G1001799</GrantID><Agency>Medical Research Council</Agency><Country>United 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States</Country></Grant><Grant><GrantID>MR/K026992/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_UU_12015/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 HL119443</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01HG004402</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_U106179471</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>CA047988</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MR/N01104X/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>P30 DK063491</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United 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HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R25CA094880</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NR0224103</GrantID><Acronym>NR</Acronym><Agency>NINR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01D0042157-01A</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HL72518</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA182913</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AG023629</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG033193</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Arthritis Research UK</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>HL100245</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL087652</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL080467</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DK063491</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>S10 OD020069</GrantID><Acronym>OD</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS017950</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U24 MH068457-06</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01DK062418</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>068545/Z/02</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>BB/F019394/1</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>U01HL080295</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01-HG005152</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL103612</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>076113/B/04/Z</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0000934</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01HL120393</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL086694</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MH081802</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>11</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Hum Mol 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RefType="Cites"><RefSource>Nature. 2012 Nov 1;491(7422):56-65</RefSource><PMID Version="1">23128226</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044465" MajorTopicYN="N">European Continental Ancestry Group</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005340" MajorTopicYN="N">Fibrinogen</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056426" MajorTopicYN="Y">Genetic Loci</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055106" MajorTopicYN="N">Genome-Wide Association Study</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054643" MajorTopicYN="N">INDEL Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="Y">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4715256 [Available on 01/15/17]</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate 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