GWAS for executive function and processing speed suggests involvement of the CADM2 gene.
Identifieur interne : 002328 ( PubMed/Corpus ); précédent : 002327; suivant : 002329GWAS for executive function and processing speed suggests involvement of the CADM2 gene.
Auteurs : C A Ibrahim-Verbaas ; J. Bressler ; S. Debette ; M. Schuur ; A V Smith ; J C Bis ; G. Davies ; S. Trompet ; J A Smith ; C. Wolf ; L B Chibnik ; Y. Liu ; V. Vitart ; M. Kirin ; K. Petrovic ; O. Polasek ; L. Zgaga ; C. Fawns-Ritchie ; P. Hoffmann ; J. Karjalainen ; J. Lahti ; D J Llewellyn ; C O Schmidt ; K A Mather ; V. Chouraki ; Q. Sun ; S M Resnick ; L M Rose ; C. Oldmeadow ; M. Stewart ; B H Smith ; V. Gudnason ; Q. Yang ; S S Mirza ; J W Jukema ; P L Dejager ; T B Harris ; D C Liewald ; N. Amin ; L H Coker ; O. Stegle ; O L Lopez ; R. Schmidt ; A. Teumer ; I. Ford ; N. Karbalai ; J T Becker ; M K Jonsdottir ; R. Au ; Rsn Fehrmann ; S. Herms ; M. Nalls ; W. Zhao ; S T Turner ; K. Yaffe ; K. Lohman ; J C Van Swieten ; Slr Kardia ; D S Knopman ; W M Meeks ; G. Heiss ; E G Holliday ; P W Schofield ; T. Tanaka ; D J Stott ; J. Wang ; P. Ridker ; A J Gow ; A. Pattie ; J M Starr ; L J Hocking ; N J Armstrong ; S. Mclachlan ; J M Shulman ; L C Pilling ; G. Eiriksdottir ; R J Scott ; N A Kochan ; A. Palotie ; Y-C Hsieh ; J G Eriksson ; A. Penman ; R F Gottesman ; B A Oostra ; L. Yu ; A L Destefano ; A. Beiser ; M. Garcia ; J I Rotter ; M M Nöthen ; A. Hofman ; P E Slagboom ; Rgj Westendorp ; B M Buckley ; P A Wolf ; A G Uitterlinden ; B M Psaty ; H J Grabe ; S. Bandinelli ; D I Chasman ; F. Grodstein ; K. R Ikkönen ; J-C Lambert ; D J Porteous ; J F Price ; P S Sachdev ; L. Ferrucci ; J R Attia ; I. Rudan ; C. Hayward ; A F Wright ; J F Wilson ; S. Cichon ; L. Franke ; H. Schmidt ; J. Ding ; Ajm De Craen ; M. Fornage ; D A Bennett ; I J Deary ; M A Ikram ; L J Launer ; A L Fitzpatrick ; S. Seshadri ; C M Van Duijn ; T H MosleySource :
- Molecular psychiatry [ 1476-5578 ] ; 2016.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Cell Adhesion Molecules (genetics), Cell Adhesion Molecules (physiology), Cognition (physiology), Cohort Studies, European Continental Ancestry Group (genetics), Executive Function (physiology), Female, Genetic Association Studies, Genetic Variation (genetics), Genome-Wide Association Study, Genomics, Humans, Introns, Male, Middle Aged, Neuropsychological Tests, Polymorphism, Single Nucleotide, gamma-Aminobutyric Acid.
- MESH :
- chemical , genetics : Cell Adhesion Molecules.
- chemical , physiology : Cell Adhesion Molecules.
- genetics : European Continental Ancestry Group, Genetic Variation.
- physiology : Cognition, Executive Function.
- Aged, Aged, 80 and over, Cohort Studies, Female, Genetic Association Studies, Genome-Wide Association Study, Genomics, Humans, Introns, Male, Middle Aged, Neuropsychological Tests, Polymorphism, Single Nucleotide, gamma-Aminobutyric Acid.
Abstract
To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts. A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10(-8)) and in the joint discovery and replication meta-analysis (P-value=3.28 × 10(-9) after adjustment for age, gender and education) in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. Rs17518584 is located about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, but is within an intron of a variant transcript that includes an alternative first exon. The variant is associated with expression of CADM2 in the cingulate cortex (P-value=4 × 10(-4)). The protein encoded by CADM2 is involved in glutamate signaling (P-value=7.22 × 10(-15)), gamma-aminobutyric acid (GABA) transport (P-value=1.36 × 10(-11)) and neuron cell-cell adhesion (P-value=1.48 × 10(-13)). Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.
DOI: 10.1038/mp.2015.37
PubMed: 25869804
Links to Exploration step
pubmed:25869804Le document en format XML
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Debette</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schuur, M" sort="Schuur, M" uniqKey="Schuur M" first="M" last="Schuur">M. Schuur</name><affiliation><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, A V" sort="Smith, A V" uniqKey="Smith A" first="A V" last="Smith">A V Smith</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Bis, J C" sort="Bis, J C" uniqKey="Bis J" first="J C" last="Bis">J C Bis</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Davies, G" sort="Davies, G" uniqKey="Davies G" first="G" last="Davies">G. Davies</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S" last="Trompet">S. Trompet</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, J A" sort="Smith, J A" uniqKey="Smith J" first="J A" last="Smith">J A Smith</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wolf, C" sort="Wolf, C" uniqKey="Wolf C" first="C" last="Wolf">C. Wolf</name><affiliation><nlm:affiliation>RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chibnik, L B" sort="Chibnik, L B" uniqKey="Chibnik L" first="L B" last="Chibnik">L B Chibnik</name><affiliation><nlm:affiliation>Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y" last="Liu">Y. Liu</name><affiliation><nlm:affiliation>Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vitart, V" sort="Vitart, V" uniqKey="Vitart V" first="V" last="Vitart">V. Vitart</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kirin, M" sort="Kirin, M" uniqKey="Kirin M" first="M" last="Kirin">M. Kirin</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Petrovic, K" sort="Petrovic, K" uniqKey="Petrovic K" first="K" last="Petrovic">K. Petrovic</name><affiliation><nlm:affiliation>Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Polasek, O" sort="Polasek, O" uniqKey="Polasek O" first="O" last="Polasek">O. Polasek</name><affiliation><nlm:affiliation>Department of Public Health, University of Split, Split, Croatia.</nlm:affiliation></affiliation></author><author><name sortKey="Zgaga, L" sort="Zgaga, L" uniqKey="Zgaga L" first="L" last="Zgaga">L. Zgaga</name><affiliation><nlm:affiliation>Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Fawns Ritchie, C" sort="Fawns Ritchie, C" uniqKey="Fawns Ritchie C" first="C" last="Fawns-Ritchie">C. Fawns-Ritchie</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmann, P" sort="Hoffmann, P" uniqKey="Hoffmann P" first="P" last="Hoffmann">P. Hoffmann</name><affiliation><nlm:affiliation>Institute of Neuroscience and Medicine (INM -1), Research Center Juelich, Juelich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Karjalainen, J" sort="Karjalainen, J" uniqKey="Karjalainen J" first="J" last="Karjalainen">J. Karjalainen</name><affiliation><nlm:affiliation>Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Lahti, J" sort="Lahti, J" uniqKey="Lahti J" first="J" last="Lahti">J. Lahti</name><affiliation><nlm:affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Llewellyn, D J" sort="Llewellyn, D J" uniqKey="Llewellyn D" first="D J" last="Llewellyn">D J Llewellyn</name><affiliation><nlm:affiliation>Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, C O" sort="Schmidt, C O" uniqKey="Schmidt C" first="C O" last="Schmidt">C O Schmidt</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mather, K A" sort="Mather, K A" uniqKey="Mather K" first="K A" last="Mather">K A Mather</name><affiliation><nlm:affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chouraki, V" sort="Chouraki, V" uniqKey="Chouraki V" first="V" last="Chouraki">V. Chouraki</name><affiliation><nlm:affiliation>Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Q" sort="Sun, Q" uniqKey="Sun Q" first="Q" last="Sun">Q. Sun</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Resnick, S M" sort="Resnick, S M" uniqKey="Resnick S" first="S M" last="Resnick">S M Resnick</name><affiliation><nlm:affiliation>Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rose, L M" sort="Rose, L M" uniqKey="Rose L" first="L M" last="Rose">L M Rose</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Oldmeadow, C" sort="Oldmeadow, C" uniqKey="Oldmeadow C" first="C" last="Oldmeadow">C. Oldmeadow</name><affiliation><nlm:affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Stewart, M" sort="Stewart, M" uniqKey="Stewart M" first="M" last="Stewart">M. Stewart</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, B H" sort="Smith, B H" uniqKey="Smith B" first="B H" last="Smith">B H Smith</name><affiliation><nlm:affiliation>Medical Research Institute, University of Dundee, Dundee, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V" last="Gudnason">V. Gudnason</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Q" sort="Yang, Q" uniqKey="Yang Q" first="Q" last="Yang">Q. Yang</name><affiliation><nlm:affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mirza, S S" sort="Mirza, S S" uniqKey="Mirza S" first="S S" last="Mirza">S S Mirza</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Jukema, J W" sort="Jukema, J W" uniqKey="Jukema J" first="J W" last="Jukema">J W Jukema</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Dejager, P L" sort="Dejager, P L" uniqKey="Dejager P" first="P L" last="Dejager">P L Dejager</name><affiliation><nlm:affiliation>Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Harris, T B" sort="Harris, T B" uniqKey="Harris T" first="T B" last="Harris">T B Harris</name><affiliation><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liewald, D C" sort="Liewald, D C" uniqKey="Liewald D" first="D C" last="Liewald">D C Liewald</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Amin, N" sort="Amin, N" uniqKey="Amin N" first="N" last="Amin">N. Amin</name><affiliation><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Coker, L H" sort="Coker, L H" uniqKey="Coker L" first="L H" last="Coker">L H Coker</name><affiliation><nlm:affiliation>Division of Public Health Sciences and Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stegle, O" sort="Stegle, O" uniqKey="Stegle O" first="O" last="Stegle">O. Stegle</name><affiliation><nlm:affiliation>Max Planck Institute for Developmental Biology, Max Planck Institute for Intelligent Systems, Tübingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O L" last="Lopez">O L Lopez</name><affiliation><nlm:affiliation>Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, R" sort="Schmidt, R" uniqKey="Schmidt R" first="R" last="Schmidt">R. Schmidt</name><affiliation><nlm:affiliation>Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Teumer, A" sort="Teumer, A" uniqKey="Teumer A" first="A" last="Teumer">A. Teumer</name><affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ford, I" sort="Ford, I" uniqKey="Ford I" first="I" last="Ford">I. Ford</name><affiliation><nlm:affiliation>Robertson Center for biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Karbalai, N" sort="Karbalai, N" uniqKey="Karbalai N" first="N" last="Karbalai">N. Karbalai</name><affiliation><nlm:affiliation>RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, J T" sort="Becker, J T" uniqKey="Becker J" first="J T" last="Becker">J T Becker</name><affiliation><nlm:affiliation>Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jonsdottir, M K" sort="Jonsdottir, M K" uniqKey="Jonsdottir M" first="M K" last="Jonsdottir">M K Jonsdottir</name><affiliation><nlm:affiliation>Landspitali Hospital, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Au, R" sort="Au, R" uniqKey="Au R" first="R" last="Au">R. Au</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fehrmann, Rsn" sort="Fehrmann, Rsn" uniqKey="Fehrmann R" first="Rsn" last="Fehrmann">Rsn Fehrmann</name><affiliation><nlm:affiliation>Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Herms, S" sort="Herms, S" uniqKey="Herms S" first="S" last="Herms">S. Herms</name><affiliation><nlm:affiliation>Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Nalls, M" sort="Nalls, M" uniqKey="Nalls M" first="M" last="Nalls">M. Nalls</name><affiliation><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, W" sort="Zhao, W" uniqKey="Zhao W" first="W" last="Zhao">W. Zhao</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Turner, S T" sort="Turner, S T" uniqKey="Turner S" first="S T" last="Turner">S T Turner</name><affiliation><nlm:affiliation>Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Yaffe, K" sort="Yaffe, K" uniqKey="Yaffe K" first="K" last="Yaffe">K. Yaffe</name><affiliation><nlm:affiliation>Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lohman, K" sort="Lohman, K" uniqKey="Lohman K" first="K" last="Lohman">K. Lohman</name><affiliation><nlm:affiliation>Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Swieten, J C" sort="Van Swieten, J C" uniqKey="Van Swieten J" first="J C" last="Van Swieten">J C Van Swieten</name><affiliation><nlm:affiliation>Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kardia, Slr" sort="Kardia, Slr" uniqKey="Kardia S" first="Slr" last="Kardia">Slr Kardia</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Knopman, D S" sort="Knopman, D S" uniqKey="Knopman D" first="D S" last="Knopman">D S Knopman</name><affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Meeks, W M" sort="Meeks, W M" uniqKey="Meeks W" first="W M" last="Meeks">W M Meeks</name><affiliation><nlm:affiliation>Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Heiss, G" sort="Heiss, G" uniqKey="Heiss G" first="G" last="Heiss">G. Heiss</name><affiliation><nlm:affiliation>Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holliday, E G" sort="Holliday, E G" uniqKey="Holliday E" first="E G" last="Holliday">E G Holliday</name><affiliation><nlm:affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schofield, P W" sort="Schofield, P W" uniqKey="Schofield P" first="P W" last="Schofield">P W Schofield</name><affiliation><nlm:affiliation>School of Medicine and Public Health, Faculty of Health, University of Newcastle, Newcastle, SW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tanaka, T" sort="Tanaka, T" uniqKey="Tanaka T" first="T" last="Tanaka">T. Tanaka</name><affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stott, D J" sort="Stott, D J" uniqKey="Stott D" first="D J" last="Stott">D J Stott</name><affiliation><nlm:affiliation>Department of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, J" sort="Wang, J" uniqKey="Wang J" first="J" last="Wang">J. Wang</name><affiliation><nlm:affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, P" sort="Ridker, P" uniqKey="Ridker P" first="P" last="Ridker">P. Ridker</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gow, A J" sort="Gow, A J" uniqKey="Gow A" first="A J" last="Gow">A J Gow</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pattie, A" sort="Pattie, A" uniqKey="Pattie A" first="A" last="Pattie">A. Pattie</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Starr, J M" sort="Starr, J M" uniqKey="Starr J" first="J M" last="Starr">J M Starr</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hocking, L J" sort="Hocking, L J" uniqKey="Hocking L" first="L J" last="Hocking">L J Hocking</name><affiliation><nlm:affiliation>Division of Applied Medicine, University of Aberdeen, Aberdeen, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Armstrong, N J" sort="Armstrong, N J" uniqKey="Armstrong N" first="N J" last="Armstrong">N J Armstrong</name><affiliation><nlm:affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mclachlan, S" sort="Mclachlan, S" uniqKey="Mclachlan S" first="S" last="Mclachlan">S. Mclachlan</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Shulman, J M" sort="Shulman, J M" uniqKey="Shulman J" first="J M" last="Shulman">J M Shulman</name><affiliation><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pilling, L C" sort="Pilling, L C" uniqKey="Pilling L" first="L C" last="Pilling">L C Pilling</name><affiliation><nlm:affiliation>Epidemiology and Public Health Group, University of Exeter Medical School, Exeter, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Eiriksdottir, G" sort="Eiriksdottir, G" uniqKey="Eiriksdottir G" first="G" last="Eiriksdottir">G. Eiriksdottir</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name><affiliation><nlm:affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kochan, N A" sort="Kochan, N A" uniqKey="Kochan N" first="N A" last="Kochan">N A Kochan</name><affiliation><nlm:affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hsieh, Y C" sort="Hsieh, Y C" uniqKey="Hsieh Y" first="Y-C" last="Hsieh">Y-C Hsieh</name><affiliation><nlm:affiliation>School of Public Health, Taipei Medical University, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Eriksson, J G" sort="Eriksson, J G" uniqKey="Eriksson J" first="J G" last="Eriksson">J G Eriksson</name><affiliation><nlm:affiliation>Folkhälsan Research Centre, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Penman, A" sort="Penman, A" uniqKey="Penman A" first="A" last="Penman">A. Penman</name><affiliation><nlm:affiliation>Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gottesman, R F" sort="Gottesman, R F" uniqKey="Gottesman R" first="R F" last="Gottesman">R F Gottesman</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Oostra, B A" sort="Oostra, B A" uniqKey="Oostra B" first="B A" last="Oostra">B A Oostra</name><affiliation><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Yu, L" sort="Yu, L" uniqKey="Yu L" first="L" last="Yu">L. Yu</name><affiliation><nlm:affiliation>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A L" last="Destefano">A L Destefano</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Beiser, A" sort="Beiser, A" uniqKey="Beiser A" first="A" last="Beiser">A. Beiser</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia, M" sort="Garcia, M" uniqKey="Garcia M" first="M" last="Garcia">M. Garcia</name><affiliation><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rotter, J I" sort="Rotter, J I" uniqKey="Rotter J" first="J I" last="Rotter">J I Rotter</name><affiliation><nlm:affiliation>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nothen, M M" sort="Nothen, M M" uniqKey="Nothen M" first="M M" last="Nöthen">M M Nöthen</name><affiliation><nlm:affiliation>Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hofman, A" sort="Hofman, A" uniqKey="Hofman A" first="A" last="Hofman">A. Hofman</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Slagboom, P E" sort="Slagboom, P E" uniqKey="Slagboom P" first="P E" last="Slagboom">P E Slagboom</name><affiliation><nlm:affiliation>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Westendorp, Rgj" sort="Westendorp, Rgj" uniqKey="Westendorp R" first="Rgj" last="Westendorp">Rgj Westendorp</name><affiliation><nlm:affiliation>Leiden Academy of Vitality and Ageing, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Buckley, B M" sort="Buckley, B M" uniqKey="Buckley B" first="B M" last="Buckley">B M Buckley</name><affiliation><nlm:affiliation>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Wolf, P A" sort="Wolf, P A" uniqKey="Wolf P" first="P A" last="Wolf">P A Wolf</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Uitterlinden, A G" sort="Uitterlinden, A G" uniqKey="Uitterlinden A" first="A G" last="Uitterlinden">A G Uitterlinden</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Psaty, B M" sort="Psaty, B M" uniqKey="Psaty B" first="B M" last="Psaty">B M Psaty</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Grabe, H J" sort="Grabe, H J" uniqKey="Grabe H" first="H J" last="Grabe">H J Grabe</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, Stralsund, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bandinelli, S" sort="Bandinelli, S" uniqKey="Bandinelli S" first="S" last="Bandinelli">S. Bandinelli</name><affiliation><nlm:affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, D I" sort="Chasman, D I" uniqKey="Chasman D" first="D I" last="Chasman">D I Chasman</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Grodstein, F" sort="Grodstein, F" uniqKey="Grodstein F" first="F" last="Grodstein">F. Grodstein</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="R Ikkonen, K" sort="R Ikkonen, K" uniqKey="R Ikkonen K" first="K" last="R Ikkönen">K. R Ikkönen</name><affiliation><nlm:affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Lambert, J C" sort="Lambert, J C" uniqKey="Lambert J" first="J-C" last="Lambert">J-C Lambert</name><affiliation><nlm:affiliation>Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Porteous, D J" sort="Porteous, D J" uniqKey="Porteous D" first="D J" last="Porteous">D J Porteous</name><affiliation><nlm:affiliation>Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Price, J F" sort="Price, J F" uniqKey="Price J" first="J F" last="Price">J F Price</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sachdev, P S" sort="Sachdev, P S" uniqKey="Sachdev P" first="P S" last="Sachdev">P S Sachdev</name><affiliation><nlm:affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrucci, L" sort="Ferrucci, L" uniqKey="Ferrucci L" first="L" last="Ferrucci">L. Ferrucci</name><affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Attia, J R" sort="Attia, J R" uniqKey="Attia J" first="J R" last="Attia">J R Attia</name><affiliation><nlm:affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rudan, I" sort="Rudan, I" uniqKey="Rudan I" first="I" last="Rudan">I. Rudan</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hayward, C" sort="Hayward, C" uniqKey="Hayward C" first="C" last="Hayward">C. Hayward</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, A F" sort="Wright, A F" uniqKey="Wright A" first="A F" last="Wright">A F Wright</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, J F" sort="Wilson, J F" uniqKey="Wilson J" first="J F" last="Wilson">J F Wilson</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cichon, S" sort="Cichon, S" uniqKey="Cichon S" first="S" last="Cichon">S. Cichon</name><affiliation><nlm:affiliation>Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Franke, L" sort="Franke, L" uniqKey="Franke L" first="L" last="Franke">L. Franke</name><affiliation><nlm:affiliation>Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, H" sort="Schmidt, H" uniqKey="Schmidt H" first="H" last="Schmidt">H. Schmidt</name><affiliation><nlm:affiliation>Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Ding, J" sort="Ding, J" uniqKey="Ding J" first="J" last="Ding">J. Ding</name><affiliation><nlm:affiliation>Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="De Craen, Ajm" sort="De Craen, Ajm" uniqKey="De Craen A" first="Ajm" last="De Craen">Ajm De Craen</name><affiliation><nlm:affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Fornage, M" sort="Fornage, M" uniqKey="Fornage M" first="M" last="Fornage">M. 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Bressler</name><affiliation><nlm:affiliation>Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Debette, S" sort="Debette, S" uniqKey="Debette S" first="S" last="Debette">S. Debette</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schuur, M" sort="Schuur, M" uniqKey="Schuur M" first="M" last="Schuur">M. Schuur</name><affiliation><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, A V" sort="Smith, A V" uniqKey="Smith A" first="A V" last="Smith">A V Smith</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Bis, J C" sort="Bis, J C" uniqKey="Bis J" first="J C" last="Bis">J C Bis</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Davies, G" sort="Davies, G" uniqKey="Davies G" first="G" last="Davies">G. Davies</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Trompet, S" sort="Trompet, S" uniqKey="Trompet S" first="S" last="Trompet">S. Trompet</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, J A" sort="Smith, J A" uniqKey="Smith J" first="J A" last="Smith">J A Smith</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wolf, C" sort="Wolf, C" uniqKey="Wolf C" first="C" last="Wolf">C. Wolf</name><affiliation><nlm:affiliation>RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Chibnik, L B" sort="Chibnik, L B" uniqKey="Chibnik L" first="L B" last="Chibnik">L B Chibnik</name><affiliation><nlm:affiliation>Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Y" sort="Liu, Y" uniqKey="Liu Y" first="Y" last="Liu">Y. Liu</name><affiliation><nlm:affiliation>Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vitart, V" sort="Vitart, V" uniqKey="Vitart V" first="V" last="Vitart">V. Vitart</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kirin, M" sort="Kirin, M" uniqKey="Kirin M" first="M" last="Kirin">M. Kirin</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Petrovic, K" sort="Petrovic, K" uniqKey="Petrovic K" first="K" last="Petrovic">K. Petrovic</name><affiliation><nlm:affiliation>Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Polasek, O" sort="Polasek, O" uniqKey="Polasek O" first="O" last="Polasek">O. Polasek</name><affiliation><nlm:affiliation>Department of Public Health, University of Split, Split, Croatia.</nlm:affiliation></affiliation></author><author><name sortKey="Zgaga, L" sort="Zgaga, L" uniqKey="Zgaga L" first="L" last="Zgaga">L. Zgaga</name><affiliation><nlm:affiliation>Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Fawns Ritchie, C" sort="Fawns Ritchie, C" uniqKey="Fawns Ritchie C" first="C" last="Fawns-Ritchie">C. Fawns-Ritchie</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmann, P" sort="Hoffmann, P" uniqKey="Hoffmann P" first="P" last="Hoffmann">P. Hoffmann</name><affiliation><nlm:affiliation>Institute of Neuroscience and Medicine (INM -1), Research Center Juelich, Juelich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Karjalainen, J" sort="Karjalainen, J" uniqKey="Karjalainen J" first="J" last="Karjalainen">J. Karjalainen</name><affiliation><nlm:affiliation>Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Lahti, J" sort="Lahti, J" uniqKey="Lahti J" first="J" last="Lahti">J. Lahti</name><affiliation><nlm:affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Llewellyn, D J" sort="Llewellyn, D J" uniqKey="Llewellyn D" first="D J" last="Llewellyn">D J Llewellyn</name><affiliation><nlm:affiliation>Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, C O" sort="Schmidt, C O" uniqKey="Schmidt C" first="C O" last="Schmidt">C O Schmidt</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mather, K A" sort="Mather, K A" uniqKey="Mather K" first="K A" last="Mather">K A Mather</name><affiliation><nlm:affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chouraki, V" sort="Chouraki, V" uniqKey="Chouraki V" first="V" last="Chouraki">V. Chouraki</name><affiliation><nlm:affiliation>Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Q" sort="Sun, Q" uniqKey="Sun Q" first="Q" last="Sun">Q. Sun</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Resnick, S M" sort="Resnick, S M" uniqKey="Resnick S" first="S M" last="Resnick">S M Resnick</name><affiliation><nlm:affiliation>Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rose, L M" sort="Rose, L M" uniqKey="Rose L" first="L M" last="Rose">L M Rose</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Oldmeadow, C" sort="Oldmeadow, C" uniqKey="Oldmeadow C" first="C" last="Oldmeadow">C. Oldmeadow</name><affiliation><nlm:affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Stewart, M" sort="Stewart, M" uniqKey="Stewart M" first="M" last="Stewart">M. Stewart</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, B H" sort="Smith, B H" uniqKey="Smith B" first="B H" last="Smith">B H Smith</name><affiliation><nlm:affiliation>Medical Research Institute, University of Dundee, Dundee, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Gudnason, V" sort="Gudnason, V" uniqKey="Gudnason V" first="V" last="Gudnason">V. Gudnason</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Q" sort="Yang, Q" uniqKey="Yang Q" first="Q" last="Yang">Q. Yang</name><affiliation><nlm:affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mirza, S S" sort="Mirza, S S" uniqKey="Mirza S" first="S S" last="Mirza">S S Mirza</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Jukema, J W" sort="Jukema, J W" uniqKey="Jukema J" first="J W" last="Jukema">J W Jukema</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Dejager, P L" sort="Dejager, P L" uniqKey="Dejager P" first="P L" last="Dejager">P L Dejager</name><affiliation><nlm:affiliation>Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Harris, T B" sort="Harris, T B" uniqKey="Harris T" first="T B" last="Harris">T B Harris</name><affiliation><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liewald, D C" sort="Liewald, D C" uniqKey="Liewald D" first="D C" last="Liewald">D C Liewald</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Amin, N" sort="Amin, N" uniqKey="Amin N" first="N" last="Amin">N. Amin</name><affiliation><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Coker, L H" sort="Coker, L H" uniqKey="Coker L" first="L H" last="Coker">L H Coker</name><affiliation><nlm:affiliation>Division of Public Health Sciences and Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stegle, O" sort="Stegle, O" uniqKey="Stegle O" first="O" last="Stegle">O. Stegle</name><affiliation><nlm:affiliation>Max Planck Institute for Developmental Biology, Max Planck Institute for Intelligent Systems, Tübingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lopez, O L" sort="Lopez, O L" uniqKey="Lopez O" first="O L" last="Lopez">O L Lopez</name><affiliation><nlm:affiliation>Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, R" sort="Schmidt, R" uniqKey="Schmidt R" first="R" last="Schmidt">R. Schmidt</name><affiliation><nlm:affiliation>Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Teumer, A" sort="Teumer, A" uniqKey="Teumer A" first="A" last="Teumer">A. Teumer</name><affiliation><nlm:affiliation>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ford, I" sort="Ford, I" uniqKey="Ford I" first="I" last="Ford">I. Ford</name><affiliation><nlm:affiliation>Robertson Center for biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Karbalai, N" sort="Karbalai, N" uniqKey="Karbalai N" first="N" last="Karbalai">N. Karbalai</name><affiliation><nlm:affiliation>RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, J T" sort="Becker, J T" uniqKey="Becker J" first="J T" last="Becker">J T Becker</name><affiliation><nlm:affiliation>Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jonsdottir, M K" sort="Jonsdottir, M K" uniqKey="Jonsdottir M" first="M K" last="Jonsdottir">M K Jonsdottir</name><affiliation><nlm:affiliation>Landspitali Hospital, Reykjavik, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Au, R" sort="Au, R" uniqKey="Au R" first="R" last="Au">R. Au</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fehrmann, Rsn" sort="Fehrmann, Rsn" uniqKey="Fehrmann R" first="Rsn" last="Fehrmann">Rsn Fehrmann</name><affiliation><nlm:affiliation>Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Herms, S" sort="Herms, S" uniqKey="Herms S" first="S" last="Herms">S. Herms</name><affiliation><nlm:affiliation>Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Nalls, M" sort="Nalls, M" uniqKey="Nalls M" first="M" last="Nalls">M. Nalls</name><affiliation><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhao, W" sort="Zhao, W" uniqKey="Zhao W" first="W" last="Zhao">W. Zhao</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Turner, S T" sort="Turner, S T" uniqKey="Turner S" first="S T" last="Turner">S T Turner</name><affiliation><nlm:affiliation>Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Yaffe, K" sort="Yaffe, K" uniqKey="Yaffe K" first="K" last="Yaffe">K. Yaffe</name><affiliation><nlm:affiliation>Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lohman, K" sort="Lohman, K" uniqKey="Lohman K" first="K" last="Lohman">K. Lohman</name><affiliation><nlm:affiliation>Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Swieten, J C" sort="Van Swieten, J C" uniqKey="Van Swieten J" first="J C" last="Van Swieten">J C Van Swieten</name><affiliation><nlm:affiliation>Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kardia, Slr" sort="Kardia, Slr" uniqKey="Kardia S" first="Slr" last="Kardia">Slr Kardia</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Knopman, D S" sort="Knopman, D S" uniqKey="Knopman D" first="D S" last="Knopman">D S Knopman</name><affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Meeks, W M" sort="Meeks, W M" uniqKey="Meeks W" first="W M" last="Meeks">W M Meeks</name><affiliation><nlm:affiliation>Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Heiss, G" sort="Heiss, G" uniqKey="Heiss G" first="G" last="Heiss">G. Heiss</name><affiliation><nlm:affiliation>Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holliday, E G" sort="Holliday, E G" uniqKey="Holliday E" first="E G" last="Holliday">E G Holliday</name><affiliation><nlm:affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schofield, P W" sort="Schofield, P W" uniqKey="Schofield P" first="P W" last="Schofield">P W Schofield</name><affiliation><nlm:affiliation>School of Medicine and Public Health, Faculty of Health, University of Newcastle, Newcastle, SW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tanaka, T" sort="Tanaka, T" uniqKey="Tanaka T" first="T" last="Tanaka">T. Tanaka</name><affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stott, D J" sort="Stott, D J" uniqKey="Stott D" first="D J" last="Stott">D J Stott</name><affiliation><nlm:affiliation>Department of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, J" sort="Wang, J" uniqKey="Wang J" first="J" last="Wang">J. Wang</name><affiliation><nlm:affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, P" sort="Ridker, P" uniqKey="Ridker P" first="P" last="Ridker">P. Ridker</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gow, A J" sort="Gow, A J" uniqKey="Gow A" first="A J" last="Gow">A J Gow</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pattie, A" sort="Pattie, A" uniqKey="Pattie A" first="A" last="Pattie">A. Pattie</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Starr, J M" sort="Starr, J M" uniqKey="Starr J" first="J M" last="Starr">J M Starr</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hocking, L J" sort="Hocking, L J" uniqKey="Hocking L" first="L J" last="Hocking">L J Hocking</name><affiliation><nlm:affiliation>Division of Applied Medicine, University of Aberdeen, Aberdeen, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Armstrong, N J" sort="Armstrong, N J" uniqKey="Armstrong N" first="N J" last="Armstrong">N J Armstrong</name><affiliation><nlm:affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mclachlan, S" sort="Mclachlan, S" uniqKey="Mclachlan S" first="S" last="Mclachlan">S. Mclachlan</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Shulman, J M" sort="Shulman, J M" uniqKey="Shulman J" first="J M" last="Shulman">J M Shulman</name><affiliation><nlm:affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pilling, L C" sort="Pilling, L C" uniqKey="Pilling L" first="L C" last="Pilling">L C Pilling</name><affiliation><nlm:affiliation>Epidemiology and Public Health Group, University of Exeter Medical School, Exeter, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Eiriksdottir, G" sort="Eiriksdottir, G" uniqKey="Eiriksdottir G" first="G" last="Eiriksdottir">G. Eiriksdottir</name><affiliation><nlm:affiliation>Icelandic Heart Association, Kopavogur, Iceland.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, R J" sort="Scott, R J" uniqKey="Scott R" first="R J" last="Scott">R J Scott</name><affiliation><nlm:affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kochan, N A" sort="Kochan, N A" uniqKey="Kochan N" first="N A" last="Kochan">N A Kochan</name><affiliation><nlm:affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Palotie, A" sort="Palotie, A" uniqKey="Palotie A" first="A" last="Palotie">A. Palotie</name><affiliation><nlm:affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hsieh, Y C" sort="Hsieh, Y C" uniqKey="Hsieh Y" first="Y-C" last="Hsieh">Y-C Hsieh</name><affiliation><nlm:affiliation>School of Public Health, Taipei Medical University, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Eriksson, J G" sort="Eriksson, J G" uniqKey="Eriksson J" first="J G" last="Eriksson">J G Eriksson</name><affiliation><nlm:affiliation>Folkhälsan Research Centre, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Penman, A" sort="Penman, A" uniqKey="Penman A" first="A" last="Penman">A. Penman</name><affiliation><nlm:affiliation>Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gottesman, R F" sort="Gottesman, R F" uniqKey="Gottesman R" first="R F" last="Gottesman">R F Gottesman</name><affiliation><nlm:affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Oostra, B A" sort="Oostra, B A" uniqKey="Oostra B" first="B A" last="Oostra">B A Oostra</name><affiliation><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Yu, L" sort="Yu, L" uniqKey="Yu L" first="L" last="Yu">L. Yu</name><affiliation><nlm:affiliation>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A L" last="Destefano">A L Destefano</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Beiser, A" sort="Beiser, A" uniqKey="Beiser A" first="A" last="Beiser">A. Beiser</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Garcia, M" sort="Garcia, M" uniqKey="Garcia M" first="M" last="Garcia">M. Garcia</name><affiliation><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rotter, J I" sort="Rotter, J I" uniqKey="Rotter J" first="J I" last="Rotter">J I Rotter</name><affiliation><nlm:affiliation>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nothen, M M" sort="Nothen, M M" uniqKey="Nothen M" first="M M" last="Nöthen">M M Nöthen</name><affiliation><nlm:affiliation>Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hofman, A" sort="Hofman, A" uniqKey="Hofman A" first="A" last="Hofman">A. Hofman</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Slagboom, P E" sort="Slagboom, P E" uniqKey="Slagboom P" first="P E" last="Slagboom">P E Slagboom</name><affiliation><nlm:affiliation>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Westendorp, Rgj" sort="Westendorp, Rgj" uniqKey="Westendorp R" first="Rgj" last="Westendorp">Rgj Westendorp</name><affiliation><nlm:affiliation>Leiden Academy of Vitality and Ageing, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Buckley, B M" sort="Buckley, B M" uniqKey="Buckley B" first="B M" last="Buckley">B M Buckley</name><affiliation><nlm:affiliation>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Wolf, P A" sort="Wolf, P A" uniqKey="Wolf P" first="P A" last="Wolf">P A Wolf</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Uitterlinden, A G" sort="Uitterlinden, A G" uniqKey="Uitterlinden A" first="A G" last="Uitterlinden">A G Uitterlinden</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Psaty, B M" sort="Psaty, B M" uniqKey="Psaty B" first="B M" last="Psaty">B M Psaty</name><affiliation><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Grabe, H J" sort="Grabe, H J" uniqKey="Grabe H" first="H J" last="Grabe">H J Grabe</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, Stralsund, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bandinelli, S" sort="Bandinelli, S" uniqKey="Bandinelli S" first="S" last="Bandinelli">S. Bandinelli</name><affiliation><nlm:affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, D I" sort="Chasman, D I" uniqKey="Chasman D" first="D I" last="Chasman">D I Chasman</name><affiliation><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Grodstein, F" sort="Grodstein, F" uniqKey="Grodstein F" first="F" last="Grodstein">F. Grodstein</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="R Ikkonen, K" sort="R Ikkonen, K" uniqKey="R Ikkonen K" first="K" last="R Ikkönen">K. R Ikkönen</name><affiliation><nlm:affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Lambert, J C" sort="Lambert, J C" uniqKey="Lambert J" first="J-C" last="Lambert">J-C Lambert</name><affiliation><nlm:affiliation>Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Porteous, D J" sort="Porteous, D J" uniqKey="Porteous D" first="D J" last="Porteous">D J Porteous</name><affiliation><nlm:affiliation>Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Price, J F" sort="Price, J F" uniqKey="Price J" first="J F" last="Price">J F Price</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sachdev, P S" sort="Sachdev, P S" uniqKey="Sachdev P" first="P S" last="Sachdev">P S Sachdev</name><affiliation><nlm:affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrucci, L" sort="Ferrucci, L" uniqKey="Ferrucci L" first="L" last="Ferrucci">L. Ferrucci</name><affiliation><nlm:affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Attia, J R" sort="Attia, J R" uniqKey="Attia J" first="J R" last="Attia">J R Attia</name><affiliation><nlm:affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rudan, I" sort="Rudan, I" uniqKey="Rudan I" first="I" last="Rudan">I. Rudan</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hayward, C" sort="Hayward, C" uniqKey="Hayward C" first="C" last="Hayward">C. Hayward</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, A F" sort="Wright, A F" uniqKey="Wright A" first="A F" last="Wright">A F Wright</name><affiliation><nlm:affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, J F" sort="Wilson, J F" uniqKey="Wilson J" first="J F" last="Wilson">J F Wilson</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cichon, S" sort="Cichon, S" uniqKey="Cichon S" first="S" last="Cichon">S. Cichon</name><affiliation><nlm:affiliation>Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Franke, L" sort="Franke, L" uniqKey="Franke L" first="L" last="Franke">L. Franke</name><affiliation><nlm:affiliation>Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schmidt, H" sort="Schmidt, H" uniqKey="Schmidt H" first="H" last="Schmidt">H. Schmidt</name><affiliation><nlm:affiliation>Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Ding, J" sort="Ding, J" uniqKey="Ding J" first="J" last="Ding">J. Ding</name><affiliation><nlm:affiliation>Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="De Craen, Ajm" sort="De Craen, Ajm" uniqKey="De Craen A" first="Ajm" last="De Craen">Ajm De Craen</name><affiliation><nlm:affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Fornage, M" sort="Fornage, M" uniqKey="Fornage M" first="M" last="Fornage">M. Fornage</name><affiliation><nlm:affiliation>Institute for Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bennett, D A" sort="Bennett, D A" uniqKey="Bennett D" first="D A" last="Bennett">D A Bennett</name><affiliation><nlm:affiliation>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Deary, I J" sort="Deary, I J" uniqKey="Deary I" first="I J" last="Deary">I J Deary</name><affiliation><nlm:affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ikram, M A" sort="Ikram, M A" uniqKey="Ikram M" first="M A" last="Ikram">M A Ikram</name><affiliation><nlm:affiliation>Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Launer, L J" sort="Launer, L J" uniqKey="Launer L" first="L J" last="Launer">L J Launer</name><affiliation><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fitzpatrick, A L" sort="Fitzpatrick, A L" uniqKey="Fitzpatrick A" first="A L" last="Fitzpatrick">A L Fitzpatrick</name><affiliation><nlm:affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seshadri, S" sort="Seshadri, S" uniqKey="Seshadri S" first="S" last="Seshadri">S. Seshadri</name><affiliation><nlm:affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Van Duijn, C M" sort="Van Duijn, C M" uniqKey="Van Duijn C" first="C M" last="Van Duijn">C M Van Duijn</name><affiliation><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Mosley, T H" sort="Mosley, T H" uniqKey="Mosley T" first="T H" last="Mosley">T H Mosley</name><affiliation><nlm:affiliation>Department of Medicine and Neurology, University of Mississippi Medical Center, Jackson, MS, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Molecular psychiatry</title><idno type="eISSN">1476-5578</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cell Adhesion Molecules (genetics)</term><term>Cell Adhesion Molecules (physiology)</term><term>Cognition (physiology)</term><term>Cohort Studies</term><term>European Continental Ancestry Group (genetics)</term><term>Executive Function (physiology)</term><term>Female</term><term>Genetic Association Studies</term><term>Genetic Variation (genetics)</term><term>Genome-Wide Association Study</term><term>Genomics</term><term>Humans</term><term>Introns</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Polymorphism, Single Nucleotide</term><term>gamma-Aminobutyric Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cell Adhesion Molecules</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Cell Adhesion Molecules</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>European Continental Ancestry Group</term><term>Genetic Variation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cognition</term><term>Executive Function</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Genetic Association Studies</term><term>Genome-Wide Association Study</term><term>Genomics</term><term>Humans</term><term>Introns</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Polymorphism, Single Nucleotide</term><term>gamma-Aminobutyric Acid</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts. A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10(-8)) and in the joint discovery and replication meta-analysis (P-value=3.28 × 10(-9) after adjustment for age, gender and education) in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. Rs17518584 is located about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, but is within an intron of a variant transcript that includes an alternative first exon. The variant is associated with expression of CADM2 in the cingulate cortex (P-value=4 × 10(-4)). The protein encoded by CADM2 is involved in glutamate signaling (P-value=7.22 × 10(-15)), gamma-aminobutyric acid (GABA) transport (P-value=1.36 × 10(-11)) and neuron cell-cell adhesion (P-value=1.48 × 10(-13)). Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25869804</PMID><DateCreated><Year>2016</Year><Month>01</Month><Day>20</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>19</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1476-5578</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>2</Issue><PubDate><Year>2016</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Molecular psychiatry</Title><ISOAbbreviation>Mol. Psychiatry</ISOAbbreviation></Journal><ArticleTitle>GWAS for executive function and processing speed suggests involvement of the CADM2 gene.</ArticleTitle><Pagination><MedlinePgn>189-197</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/mp.2015.37</ELocationID><Abstract><AbstractText>To identify common variants contributing to normal variation in two specific domains of cognitive functioning, we conducted a genome-wide association study (GWAS) of executive functioning and information processing speed in non-demented older adults from the CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology) consortium. Neuropsychological testing was available for 5429-32,070 subjects of European ancestry aged 45 years or older, free of dementia and clinical stroke at the time of cognitive testing from 20 cohorts in the discovery phase. We analyzed performance on the Trail Making Test parts A and B, the Letter Digit Substitution Test (LDST), the Digit Symbol Substitution Task (DSST), semantic and phonemic fluency tests, and the Stroop Color and Word Test. Replication was sought in 1311-21860 subjects from 20 independent cohorts. A significant association was observed in the discovery cohorts for the single-nucleotide polymorphism (SNP) rs17518584 (discovery P-value=3.12 × 10(-8)) and in the joint discovery and replication meta-analysis (P-value=3.28 × 10(-9) after adjustment for age, gender and education) in an intron of the gene cell adhesion molecule 2 (CADM2) for performance on the LDST/DSST. Rs17518584 is located about 170 kb upstream of the transcription start site of the major transcript for the CADM2 gene, but is within an intron of a variant transcript that includes an alternative first exon. The variant is associated with expression of CADM2 in the cingulate cortex (P-value=4 × 10(-4)). The protein encoded by CADM2 is involved in glutamate signaling (P-value=7.22 × 10(-15)), gamma-aminobutyric acid (GABA) transport (P-value=1.36 × 10(-11)) and neuron cell-cell adhesion (P-value=1.48 × 10(-13)). Our findings suggest that genetic variation in the CADM2 gene is associated with individual differences in information processing speed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ibrahim-Verbaas</LastName><ForeName>C A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bressler</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Debette</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institut National de la Santé et de la Recherche Médicale (INSERM), U897, Epidemiology and Biostatistics, University of Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Bordeaux University Hospital, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schuur</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>A V</ForeName><Initials>AV</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, Kopavogur, Iceland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bis</LastName><ForeName>J C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davies</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trompet</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>J A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolf</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chibnik</LastName><ForeName>L B</ForeName><Initials>LB</Initials><AffiliationInfo><Affiliation>Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vitart</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kirin</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Petrovic</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Polasek</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Public Health, University of Split, Split, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zgaga</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fawns-Ritchie</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoffmann</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Neuroscience and Medicine (INM -1), Research Center Juelich, Juelich, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karjalainen</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lahti</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Folkhälsan Research Centre, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Llewellyn</LastName><ForeName>D J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Institute of Biomedical and Clinical Sciences, University of Exeter Medical School, Exeter, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>C O</ForeName><Initials>CO</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mather</LastName><ForeName>K A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chouraki</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Q</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Resnick</LastName><ForeName>S M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Laboratory of Behavioral Neuroscience, National Institute on Aging, NIH, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rose</LastName><ForeName>L M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oldmeadow</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stewart</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>B H</ForeName><Initials>BH</Initials><AffiliationInfo><Affiliation>Medical Research Institute, University of Dundee, Dundee, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gudnason</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, Kopavogur, Iceland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, University of Iceland, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Q</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mirza</LastName><ForeName>S S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jukema</LastName><ForeName>J W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>deJager</LastName><ForeName>P L</ForeName><Initials>PL</Initials><AffiliationInfo><Affiliation>Program in Translational Neuropsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>T B</ForeName><Initials>TB</Initials><AffiliationInfo><Affiliation>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liewald</LastName><ForeName>D C</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychology, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amin</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coker</LastName><ForeName>L H</ForeName><Initials>LH</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences and Neurology, Wake Forest School of Medicine, Winston-Salem, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stegle</LastName><ForeName>O</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Max Planck Institute for Developmental Biology, Max Planck Institute for Intelligent Systems, Tübingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopez</LastName><ForeName>O L</ForeName><Initials>OL</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teumer</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ford</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Robertson Center for biostatistics, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karbalai</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>RG Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becker</LastName><ForeName>J T</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jonsdottir</LastName><ForeName>M K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Landspitali Hospital, Reykjavik, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Au</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fehrmann</LastName><ForeName>Rsn</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herms</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nalls</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>W</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turner</LastName><ForeName>S T</ForeName><Initials>ST</Initials><AffiliationInfo><Affiliation>Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yaffe</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco and San Francisco VA Medical Center, San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lohman</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Swieten</LastName><ForeName>J C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kardia</LastName><ForeName>Slr</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knopman</LastName><ForeName>D S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meeks</LastName><ForeName>W M</ForeName><Initials>WM</Initials><AffiliationInfo><Affiliation>Department of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heiss</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holliday</LastName><ForeName>E G</ForeName><Initials>EG</Initials><AffiliationInfo><Affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schofield</LastName><ForeName>P W</ForeName><Initials>PW</Initials><AffiliationInfo><Affiliation>School of Medicine and Public Health, Faculty of Health, University of Newcastle, Newcastle, SW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stott</LastName><ForeName>D J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ridker</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gow</LastName><ForeName>A J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychology, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pattie</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Starr</LastName><ForeName>J M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Alzheimer Scotland Research Centre, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hocking</LastName><ForeName>L J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Division of Applied Medicine, University of Aberdeen, Aberdeen, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Armstrong</LastName><ForeName>N J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Cancer Research Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Mathematics & Statistics and Prince of Wales Clinical School, University of New South Wales, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McLachlan</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shulman</LastName><ForeName>J M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Neurology, Baylor College of Medicine, Houston, TX, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, The Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pilling</LastName><ForeName>L C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Epidemiology and Public Health Group, University of Exeter Medical School, Exeter, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eiriksdottir</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Icelandic Heart Association, Kopavogur, Iceland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>R J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kochan</LastName><ForeName>N A</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palotie</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hsieh</LastName><ForeName>Y-C</ForeName><Initials>YC</Initials><AffiliationInfo><Affiliation>School of Public Health, Taipei Medical University, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eriksson</LastName><ForeName>J G</ForeName><Initials>JG</Initials><AffiliationInfo><Affiliation>Folkhälsan Research Centre, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>National Institute for Health and Welfare, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Vasa Central Hospital, Vasa, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Penman</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gottesman</LastName><ForeName>R F</ForeName><Initials>RF</Initials><AffiliationInfo><Affiliation>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oostra</LastName><ForeName>B A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DeStefano</LastName><ForeName>A L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beiser</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garcia</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rotter</LastName><ForeName>J I</ForeName><Initials>JI</Initials><AffiliationInfo><Affiliation>Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Genetic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nöthen</LastName><ForeName>M M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofman</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slagboom</LastName><ForeName>P E</ForeName><Initials>PE</Initials><AffiliationInfo><Affiliation>Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westendorp</LastName><ForeName>Rgj</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Leiden Academy of Vitality and Ageing, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Buckley</LastName><ForeName>B M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Department of Pharmacology and Therapeutics, University College Cork, Cork, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolf</LastName><ForeName>P A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uitterlinden</LastName><ForeName>A G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Psaty</LastName><ForeName>B M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Health Services, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Group Health Research Institute, Group Health, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grabe</LastName><ForeName>H J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS-Hospital Stralsund, Stralsund, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bandinelli</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chasman</LastName><ForeName>D I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grodstein</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Räikkönen</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lambert</LastName><ForeName>J-C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Inserm, U1167, Institut Pasteur de Lille, Université Lille-Nord de France, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Porteous</LastName><ForeName>D J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Generation Scotland</CollectiveName></Author><Author ValidYN="Y"><LastName>Price</LastName><ForeName>J F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sachdev</LastName><ForeName>P S</ForeName><Initials>PS</Initials><AffiliationInfo><Affiliation>Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Neuropsychiatric Institute, The Prince of Wales Hospital, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferrucci</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Attia</LastName><ForeName>J R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Hunter Medical Research Institute and Faculty of Health, University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rudan</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hayward</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>A F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>J F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cichon</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Genomics, Life and Brain Research Center, Institute of Human Genetics, University of Bonn, Bonn, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franke</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Genetics, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University and General Hospital of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ding</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Craen</LastName><ForeName>Ajm</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fornage</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Molecular Medicine and Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Bennett</LastName><ForeName>D A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Deary</LastName><ForeName>I J</ForeName><Initials>IJ</Initials><AffiliationInfo><Affiliation>Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Psychology, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Ikram</LastName><ForeName>M A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Launer</LastName><ForeName>L J</ForeName><Initials>LJ</Initials><AffiliationInfo><Affiliation>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Fitzpatrick</LastName><ForeName>A L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Seshadri</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, Boston University School of Medicine, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The National Heart Lung and Blood Institute's Framingham Heart Study, Framingham, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>van Duijn</LastName><ForeName>C M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Mosley</LastName><ForeName>T H</ForeName><Initials>TH</Initials><AffiliationInfo><Affiliation>Department of Medicine and Neurology, University of Mississippi Medical Center, Jackson, MS, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>ETM/55</GrantID><Agency>Chief Scientist Office</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>HL34594</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100012C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA050385</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United 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States</Country></Grant><Grant><GrantID>EY015473</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 HC075150</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HL096917</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100008I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HL054463</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL87660</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100005C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL043851</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL059367</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL087660</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100007C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MD009164</GrantID><Acronym>MD</Acronym><Agency>NIMHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HL054464</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG030146</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA055075</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268200800007C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 HC015103</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>263 MD 821336</GrantID><Acronym>MD</Acronym><Agency>NIMHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CZD/16/6</GrantID><Agency>Chief Scientist Office</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>P01 DK070756</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K25AG41906</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 HC025195</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100009C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>HHSN268201100011I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA87969</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100011C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL086694</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AG027058</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>N01 HC085085</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG017917</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AG033193</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>1R01AG032098-01A1</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AG17917</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL087652</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268200625226C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG004402</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA55075</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA49449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01HG004399</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UL1 TR000124</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 AG062106</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC55222</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MR/K026992/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>U01 CA067262</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>WT089062</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 CA065725</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HL054464</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL093029</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS17950</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100010C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL071917</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85086</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL70825</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA67262</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL105756</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01HG004402</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>263 MD821336</GrantID><Acronym>MD</Acronym><Agency>NIMHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>263 MD9164 13</GrantID><Acronym>MD</Acronym><Agency>NIMHD NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG032098</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 HC085082</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA047988</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HL054457</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85081</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U10 HL054481</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK063491</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HG004728</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100006C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85079</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG008122</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201200036C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 AG010161</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100008C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100012C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG033193</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL087641</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>EY09611</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AG30146</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL054464</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100005I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HL054457</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 AG821336</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 AG062103</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL105756</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL034594</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA134958</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 AG916413</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85086</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY015473</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 AG005133</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01[AG]916413</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NHLBIU01HL080295</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CZD/16/6/4</GrantID><Agency>Chief Scientist Office</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_PC_U127561128</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01AG20098</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA182913</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AG023629</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL080295</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AG15819</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA098233</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85082</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL35464</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY009611</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100007C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL054457</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA047988</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K99 HL098459</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>NS041558</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 HC085084</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG020098</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268200800007C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL080467</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL087652</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85082</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100009C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HL080467</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL070825</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100011C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85083</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100005C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC25195</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HL054481</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268200900020C</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DK063491</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01[AG] 821336</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30AG10161</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL035464</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AG16495</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>G0700704</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>HHSN268201100007I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201200036C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA049449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268200782096C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K99HL098459</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA50385</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85083</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>BB/F019394/1</GrantID><Agency>Biotechnology and Biological Sciences Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01HL103612</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA049449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85079</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100006C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG023629</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 HL087641</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K08AG34290</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG027058</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 HC045133</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85080</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>AG008122</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG004399</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 HC035129</GrantID><Acronym>HC</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA65725</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AG015819</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL120393</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01HC85081</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01HL086694</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AG049505</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>04</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Mol 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