Estrogenic effects of Ficus umbellata Vahl. (Moraceae) extracts and their ability to alleviate some menopausal symptoms induced by ovariectomy in Wistar rats.
Identifieur interne : 002306 ( PubMed/Corpus ); précédent : 002305; suivant : 002307Estrogenic effects of Ficus umbellata Vahl. (Moraceae) extracts and their ability to alleviate some menopausal symptoms induced by ovariectomy in Wistar rats.
Auteurs : Stéphane Zingue ; Thomas Michel ; Jules Tchatchou ; Nde Chantal Beatrice Magne ; Evelyn Winter ; André Monchot ; Charline Florence Awounfack ; Sefirin Djiogue ; Colin Clyne ; Xavier Fernandez ; Tânia Beatriz Creczynski-Pasa ; Dieudonné NjamenSource :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Cell Survival (drug effects), Cells, Cultured, Epithelium (drug effects), Estrogens (adverse effects), Estrogens (pharmacology), Estrogens (therapeutic use), Female, Ficus (chemistry), Hot Flashes (drug therapy), Humans, Mammary Glands, Human (drug effects), Menopause (drug effects), Organ Size (drug effects), Ovariectomy (adverse effects), Plant Extracts (adverse effects), Plant Extracts (chemistry), Plant Extracts (pharmacology), Plant Extracts (therapeutic use), Proteins (metabolism), Rats, Rats, Wistar, Receptors, Estrogen (metabolism), Umbelliferones (pharmacology), Uterus (drug effects), Uterus (metabolism), Vagina (drug effects).
- MESH :
- chemical , adverse effects : Estrogens, Plant Extracts.
- adverse effects : Ovariectomy.
- chemistry : Ficus, Plant Extracts.
- drug effects : Cell Survival, Epithelium, Mammary Glands, Human, Menopause, Organ Size, Uterus, Vagina.
- drug therapy : Hot Flashes.
- chemical , metabolism : Proteins, Receptors, Estrogen, Uterus.
- chemical , pharmacology : Estrogens, Plant Extracts, Umbelliferones.
- chemical , therapeutic use : Estrogens, Plant Extracts.
- Animals, Cells, Cultured, Female, Humans, Rats, Rats, Wistar.
Abstract
Ficus umbellata Vahl. (Moraceae) is a medicinal plant used in Cameroon to treat amenorrhea as well as other physiological disorders related to menopause.
DOI: 10.1016/j.jep.2016.01.004
PubMed: 26771069
Links to Exploration step
pubmed:26771069Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Estrogenic effects of Ficus umbellata Vahl. (Moraceae) extracts and their ability to alleviate some menopausal symptoms induced by ovariectomy in Wistar rats.</title><author><name sortKey="Zingue, Stephane" sort="Zingue, Stephane" uniqKey="Zingue S" first="Stéphane" last="Zingue">Stéphane Zingue</name><affiliation><nlm:affiliation>Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Michel, Thomas" sort="Michel, Thomas" uniqKey="Michel T" first="Thomas" last="Michel">Thomas Michel</name><affiliation><nlm:affiliation>Institute of Chemistry of Nice, Faculty of Science, University Nice Sophia-Antipolis, UMR CNRS 7272, Valrose Park, F-06108 Nice Cedex 2, Nice, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tchatchou, Jules" sort="Tchatchou, Jules" uniqKey="Tchatchou J" first="Jules" last="Tchatchou">Jules Tchatchou</name><affiliation><nlm:affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Chantal Beatrice Magne, Nde" sort="Chantal Beatrice Magne, Nde" uniqKey="Chantal Beatrice Magne N" first="Nde" last="Chantal Beatrice Magne">Nde Chantal Beatrice Magne</name><affiliation><nlm:affiliation>Hudson Institute of Medical Research, 27-31 Wright Street Clayton, VIC 3168, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Winter, Evelyn" sort="Winter, Evelyn" uniqKey="Winter E" first="Evelyn" last="Winter">Evelyn Winter</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Catarina, CEP 88040-900 Florianópolis, SC, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Monchot, Andre" sort="Monchot, Andre" uniqKey="Monchot A" first="André" last="Monchot">André Monchot</name><affiliation><nlm:affiliation>Institute of Chemistry of Nice, Faculty of Science, University Nice Sophia-Antipolis, UMR CNRS 7272, Valrose Park, F-06108 Nice Cedex 2, Nice, France.</nlm:affiliation></affiliation></author><author><name sortKey="Awounfack, Charline Florence" sort="Awounfack, Charline Florence" uniqKey="Awounfack C" first="Charline Florence" last="Awounfack">Charline Florence Awounfack</name><affiliation><nlm:affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Djiogue, Sefirin" sort="Djiogue, Sefirin" uniqKey="Djiogue S" first="Sefirin" last="Djiogue">Sefirin Djiogue</name><affiliation><nlm:affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Clyne, Colin" sort="Clyne, Colin" uniqKey="Clyne C" first="Colin" last="Clyne">Colin Clyne</name><affiliation><nlm:affiliation>Hudson Institute of Medical Research, 27-31 Wright Street Clayton, VIC 3168, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez, Xavier" sort="Fernandez, Xavier" uniqKey="Fernandez X" first="Xavier" last="Fernandez">Xavier Fernandez</name><affiliation><nlm:affiliation>Institute of Chemistry of Nice, Faculty of Science, University Nice Sophia-Antipolis, UMR CNRS 7272, Valrose Park, F-06108 Nice Cedex 2, Nice, France.</nlm:affiliation></affiliation></author><author><name sortKey="Creczynski Pasa, Tania Beatriz" sort="Creczynski Pasa, Tania Beatriz" uniqKey="Creczynski Pasa T" first="Tânia Beatriz" last="Creczynski-Pasa">Tânia Beatriz Creczynski-Pasa</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Catarina, CEP 88040-900 Florianópolis, SC, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Njamen, Dieudonne" sort="Njamen, Dieudonne" uniqKey="Njamen D" first="Dieudonné" last="Njamen">Dieudonné Njamen</name><affiliation><nlm:affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. Electronic address: dnjamen@gmail.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26771069</idno><idno type="pmid">26771069</idno><idno type="doi">10.1016/j.jep.2016.01.004</idno><idno type="wicri:Area/PubMed/Corpus">002306</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002306</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Estrogenic effects of Ficus umbellata Vahl. (Moraceae) extracts and their ability to alleviate some menopausal symptoms induced by ovariectomy in Wistar rats.</title><author><name sortKey="Zingue, Stephane" sort="Zingue, Stephane" uniqKey="Zingue S" first="Stéphane" last="Zingue">Stéphane Zingue</name><affiliation><nlm:affiliation>Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Michel, Thomas" sort="Michel, Thomas" uniqKey="Michel T" first="Thomas" last="Michel">Thomas Michel</name><affiliation><nlm:affiliation>Institute of Chemistry of Nice, Faculty of Science, University Nice Sophia-Antipolis, UMR CNRS 7272, Valrose Park, F-06108 Nice Cedex 2, Nice, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tchatchou, Jules" sort="Tchatchou, Jules" uniqKey="Tchatchou J" first="Jules" last="Tchatchou">Jules Tchatchou</name><affiliation><nlm:affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Chantal Beatrice Magne, Nde" sort="Chantal Beatrice Magne, Nde" uniqKey="Chantal Beatrice Magne N" first="Nde" last="Chantal Beatrice Magne">Nde Chantal Beatrice Magne</name><affiliation><nlm:affiliation>Hudson Institute of Medical Research, 27-31 Wright Street Clayton, VIC 3168, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Winter, Evelyn" sort="Winter, Evelyn" uniqKey="Winter E" first="Evelyn" last="Winter">Evelyn Winter</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Catarina, CEP 88040-900 Florianópolis, SC, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Monchot, Andre" sort="Monchot, Andre" uniqKey="Monchot A" first="André" last="Monchot">André Monchot</name><affiliation><nlm:affiliation>Institute of Chemistry of Nice, Faculty of Science, University Nice Sophia-Antipolis, UMR CNRS 7272, Valrose Park, F-06108 Nice Cedex 2, Nice, France.</nlm:affiliation></affiliation></author><author><name sortKey="Awounfack, Charline Florence" sort="Awounfack, Charline Florence" uniqKey="Awounfack C" first="Charline Florence" last="Awounfack">Charline Florence Awounfack</name><affiliation><nlm:affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Djiogue, Sefirin" sort="Djiogue, Sefirin" uniqKey="Djiogue S" first="Sefirin" last="Djiogue">Sefirin Djiogue</name><affiliation><nlm:affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Clyne, Colin" sort="Clyne, Colin" uniqKey="Clyne C" first="Colin" last="Clyne">Colin Clyne</name><affiliation><nlm:affiliation>Hudson Institute of Medical Research, 27-31 Wright Street Clayton, VIC 3168, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez, Xavier" sort="Fernandez, Xavier" uniqKey="Fernandez X" first="Xavier" last="Fernandez">Xavier Fernandez</name><affiliation><nlm:affiliation>Institute of Chemistry of Nice, Faculty of Science, University Nice Sophia-Antipolis, UMR CNRS 7272, Valrose Park, F-06108 Nice Cedex 2, Nice, France.</nlm:affiliation></affiliation></author><author><name sortKey="Creczynski Pasa, Tania Beatriz" sort="Creczynski Pasa, Tania Beatriz" uniqKey="Creczynski Pasa T" first="Tânia Beatriz" last="Creczynski-Pasa">Tânia Beatriz Creczynski-Pasa</name><affiliation><nlm:affiliation>Department of Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Catarina, CEP 88040-900 Florianópolis, SC, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Njamen, Dieudonne" sort="Njamen, Dieudonne" uniqKey="Njamen D" first="Dieudonné" last="Njamen">Dieudonné Njamen</name><affiliation><nlm:affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. Electronic address: dnjamen@gmail.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of ethnopharmacology</title><idno type="eISSN">1872-7573</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Survival (drug effects)</term><term>Cells, Cultured</term><term>Epithelium (drug effects)</term><term>Estrogens (adverse effects)</term><term>Estrogens (pharmacology)</term><term>Estrogens (therapeutic use)</term><term>Female</term><term>Ficus (chemistry)</term><term>Hot Flashes (drug therapy)</term><term>Humans</term><term>Mammary Glands, Human (drug effects)</term><term>Menopause (drug effects)</term><term>Organ Size (drug effects)</term><term>Ovariectomy (adverse effects)</term><term>Plant Extracts (adverse effects)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Plant Extracts (therapeutic use)</term><term>Proteins (metabolism)</term><term>Rats</term><term>Rats, Wistar</term><term>Receptors, Estrogen (metabolism)</term><term>Umbelliferones (pharmacology)</term><term>Uterus (drug effects)</term><term>Uterus (metabolism)</term><term>Vagina (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Estrogens</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Ovariectomy</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Ficus</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term><term>Epithelium</term><term>Mammary Glands, Human</term><term>Menopause</term><term>Organ Size</term><term>Uterus</term><term>Vagina</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hot Flashes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Proteins</term><term>Receptors, Estrogen</term><term>Uterus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Estrogens</term><term>Plant Extracts</term><term>Umbelliferones</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Estrogens</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Female</term><term>Humans</term><term>Rats</term><term>Rats, Wistar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Ficus umbellata Vahl. (Moraceae) is a medicinal plant used in Cameroon to treat amenorrhea as well as other physiological disorders related to menopause.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26771069</PMID><DateCreated><Year>2016</Year><Month>02</Month><Day>09</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>14</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7573</ISSN><JournalIssue CitedMedium="Internet"><Volume>179</Volume><PubDate><Year>2016</Year><Month>Feb</Month><Day>17</Day></PubDate></JournalIssue><Title>Journal of ethnopharmacology</Title><ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation></Journal><ArticleTitle>Estrogenic effects of Ficus umbellata Vahl. (Moraceae) extracts and their ability to alleviate some menopausal symptoms induced by ovariectomy in Wistar rats.</ArticleTitle><Pagination><MedlinePgn>332-44</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2016.01.004</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0378-8741(16)30004-6</ELocationID><Abstract><AbstractText Label="ETHNOPHARMACOLOGICAL RELEVANCE" NlmCategory="BACKGROUND">Ficus umbellata Vahl. (Moraceae) is a medicinal plant used in Cameroon to treat amenorrhea as well as other physiological disorders related to menopause.</AbstractText><AbstractText Label="AIM OF STUDY" NlmCategory="OBJECTIVE">In order to justify scientifically its traditional use, the estrogen-like properties of the aqueous (AE) and methanol (MeOH) extracts of F. umbellata were investigated.</AbstractText><AbstractText Label="MATERIAL AND METHODS" NlmCategory="METHODS">In vitro, the ability of different extracts of F. umbellata to activate estrogen receptors α (ERα) and β (ERβ) in cell-based reporter gene assays using human embryonic kidney (HEK293T) cells transfected with ERs was tested. In vivo, a 3-day uterotrophic assay and the capacity of the extracts to alleviate hot flushes in ovariectomized adult rats were tested. Using a bioassay-guided fractionation the major compound of F. umbellata was isolated and tested in vitro on HEK293T-ERα and ERβ cells.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">AE and MeOH extracts significantly altered ERα as well as ERβ activities. In vivo, both extracts significantly increase the uterine and vaginal epithelium thickness, and uterine total protein levels in a dose dependent manner. Interestingly, both extracts of F. umbellata at the dose of 100 mg/kg BW significantly decreased the total number, average duration as well as frequency of hot flushes in experimental rats compared to age-matched OVX controls. Finally, 7-methylumbelliferone, a coumarin was characterized as the major compound of F. umbellata; however this compound did not transactivate ERα as well ERβ in vitro.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These aforementioned results suggest that F. umbellata extracts as used by the traditional practitioner have estrogen-like effects and may alleviate some menopausal problems such as vaginal dryness and hot flushes.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zingue</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, P.O. Box 55, Maroua, Cameroon; Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michel</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Chemistry of Nice, Faculty of Science, University Nice Sophia-Antipolis, UMR CNRS 7272, Valrose Park, F-06108 Nice Cedex 2, Nice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tchatchou</LastName><ForeName>Jules</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chantal Beatrice Magne</LastName><ForeName>Nde</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Hudson Institute of Medical Research, 27-31 Wright Street Clayton, VIC 3168, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Winter</LastName><ForeName>Evelyn</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Catarina, CEP 88040-900 Florianópolis, SC, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monchot</LastName><ForeName>André</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Chemistry of Nice, Faculty of Science, University Nice Sophia-Antipolis, UMR CNRS 7272, Valrose Park, F-06108 Nice Cedex 2, Nice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Awounfack</LastName><ForeName>Charline Florence</ForeName><Initials>CF</Initials><AffiliationInfo><Affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Djiogue</LastName><ForeName>Sefirin</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clyne</LastName><ForeName>Colin</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hudson Institute of Medical Research, 27-31 Wright Street Clayton, VIC 3168, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Institute of Chemistry of Nice, Faculty of Science, University Nice Sophia-Antipolis, UMR CNRS 7272, Valrose Park, F-06108 Nice Cedex 2, Nice, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Creczynski-Pasa</LastName><ForeName>Tânia Beatriz</ForeName><Initials>TB</Initials><AffiliationInfo><Affiliation>Department of Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Catarina, CEP 88040-900 Florianópolis, SC, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Njamen</LastName><ForeName>Dieudonné</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon. Electronic address: dnjamen@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>J Ethnopharmacol</MedlineTA><NlmUniqueID>7903310</NlmUniqueID><ISSNLinking>0378-8741</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004967">Estrogens</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011506">Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011960">Receptors, Estrogen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014468">Umbelliferones</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004848" MajorTopicYN="N">Epithelium</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004967" MajorTopicYN="N">Estrogens</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D030681" MajorTopicYN="N">Ficus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019584" MajorTopicYN="N">Hot Flashes</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042361" MajorTopicYN="N">Mammary Glands, Human</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008593" MajorTopicYN="N">Menopause</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009929" MajorTopicYN="N">Organ Size</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010052" MajorTopicYN="N">Ovariectomy</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011506" MajorTopicYN="N">Proteins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011960" MajorTopicYN="N">Receptors, Estrogen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014468" MajorTopicYN="N">Umbelliferones</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014599" MajorTopicYN="N">Uterus</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014621" MajorTopicYN="N">Vagina</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Coumarins</Keyword><Keyword MajorTopicYN="N">Ficus umbellata</Keyword><Keyword MajorTopicYN="N">Hot flushes</Keyword><Keyword MajorTopicYN="N">Phytoestrogens</Keyword><Keyword MajorTopicYN="N">Uterotrophic effects</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>09</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>12</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>01</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26771069</ArticleId><ArticleId IdType="pii">S0378-8741(16)30004-6</ArticleId><ArticleId IdType="doi">10.1016/j.jep.2016.01.004</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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