Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.
Identifieur interne : 002200 ( PubMed/Corpus ); précédent : 002199; suivant : 002201Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.
Auteurs : Liping Hou ; Urs Heilbronner ; Franziska Degenhardt ; Mazda Adli ; Kazufumi Akiyama ; Nirmala Akula ; Raffaella Ardau ; Bárbara Arias ; Lena Backlund ; Claudio E M. Banzato ; Antoni Benabarre ; Susanne Bengesser ; Abesh Kumar Bhattacharjee ; Joanna M. Biernacka ; Armin Birner ; Clara Brichant-Petitjean ; Elise T. Bui ; Pablo Cervantes ; Guo-Bo Chen ; Hsi-Chung Chen ; Caterina Chillotti ; Sven Cichon ; Scott R. Clark ; Francesc Colom ; David A. Cousins ; Cristiana Cruceanu ; Piotr M. Czerski ; Clarissa R. Dantas ; Alexandre Dayer ; Bruno Étain ; Peter Falkai ; Andreas J. Forstner ; Louise Frisén ; Janice M. Fullerton ; Sébastien Gard ; Julie S. Garnham ; Fernando S. Goes ; Paul Grof ; Oliver Gruber ; Ryota Hashimoto ; Joanna Hauser ; Stefan Herms ; Per Hoffmann ; Andrea Hofmann ; Stephane Jamain ; Esther Jiménez ; Jean-Pierre Kahn ; Layla Kassem ; Sarah Kittel-Schneider ; Sebastian Kliwicki ; Barbara König ; Ichiro Kusumi ; Nina Lackner ; Gonzalo Laje ; Mikael Landén ; Catharina Lavebratt ; Marion Leboyer ; Susan G. Leckband ; Carlos A L Pez Jaramillo ; Glenda Macqueen ; Mirko Manchia ; Lina Martinsson ; Manuel Mattheisen ; Michael J. Mccarthy ; Susan L. Mcelroy ; Marina Mitjans ; Francis M. Mondimore ; Palmiero Monteleone ; Caroline M. Nievergelt ; Markus M. Nöthen ; Urban Ösby ; Norio Ozaki ; Roy H. Perlis ; Andrea Pfennig ; Daniela Reich-Erkelenz ; Guy A. Rouleau ; Peter R. Schofield ; K Oliver Schubert ; Barbara W. Schweizer ; Florian Seemüller ; Giovanni Severino ; Tatyana Shekhtman ; Paul D. Shilling ; Kazutaka Shimoda ; Christian Simhandl ; Claire M. Slaney ; Jordan W. Smoller ; Alessio Squassina ; Thomas Stamm ; Pavla Stopkova ; Sarah K. Tighe ; Alfonso Tortorella ; Gustavo Turecki ; Julia Volkert ; Stephanie Witt ; Adam Wright ; L Trevor Young ; Peter P. Zandi ; James B. Potash ; J Raymond Depaulo ; Michael Bauer ; Eva Z. Reininghaus ; Tomas Novák ; Jean-Michel Aubry ; Mario Maj ; Bernhard T. Baune ; Philip B. Mitchell ; Eduard Vieta ; Mark A. Frye ; Janusz K. Rybakowski ; Po-Hsiu Kuo ; Tadafumi Kato ; Maria Grigoroiu-Serbanescu ; Andreas Reif ; Maria Del Zompo ; Frank Bellivier ; Martin Schalling ; Naomi R. Wray ; John R. Kelsoe ; Martin Alda ; Marcella Rietschel ; Francis J. Mcmahon ; Thomas G. SchulzeSource :
- Lancet (London, England) [ 1474-547X ] ; 2016.
English descriptors
- KwdEn :
- Bipolar Disorder (drug therapy), Bipolar Disorder (genetics), Female, Genetic Variation, Genome-Wide Association Study, Genotype, Glial Cell Line-Derived Neurotrophic Factor Receptors (genetics), Humans, Lithium Compounds (therapeutic use), Male, Middle Aged, Phenotype, Polymorphism, Single Nucleotide (genetics), Prospective Studies, Treatment Outcome.
- MESH :
- chemical , genetics : Glial Cell Line-Derived Neurotrophic Factor Receptors.
- drug therapy : Bipolar Disorder.
- genetics : Bipolar Disorder, Polymorphism, Single Nucleotide.
- chemical , therapeutic use : Lithium Compounds.
- Female, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Male, Middle Aged, Phenotype, Prospective Studies, Treatment Outcome.
Abstract
Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified.
DOI: 10.1016/S0140-6736(16)00143-4
PubMed: 26806518
Links to Exploration step
pubmed:26806518Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.</title><author><name sortKey="Hou, Liping" sort="Hou, Liping" uniqKey="Hou L" first="Liping" last="Hou">Liping Hou</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Heilbronner, Urs" sort="Heilbronner, Urs" uniqKey="Heilbronner U" first="Urs" last="Heilbronner">Urs Heilbronner</name><affiliation><nlm:affiliation>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Adli, Mazda" sort="Adli, Mazda" uniqKey="Adli M" first="Mazda" last="Adli">Mazda Adli</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany; Fliedner Klinik Berlin, Center for Psychiatry, Psychotherapy and Psychosomatic Medicine, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Akiyama, Kazufumi" sort="Akiyama, Kazufumi" uniqKey="Akiyama K" first="Kazufumi" last="Akiyama">Kazufumi Akiyama</name><affiliation><nlm:affiliation>Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Akula, Nirmala" sort="Akula, Nirmala" uniqKey="Akula N" first="Nirmala" last="Akula">Nirmala Akula</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ardau, Raffaella" sort="Ardau, Raffaella" uniqKey="Ardau R" first="Raffaella" last="Ardau">Raffaella Ardau</name><affiliation><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Arias, Barbara" sort="Arias, Barbara" uniqKey="Arias B" first="Bárbara" last="Arias">Bárbara Arias</name><affiliation><nlm:affiliation>Department of Biologia Animal, Unitat d'Antropologia (Dp Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Backlund, Lena" sort="Backlund, Lena" uniqKey="Backlund L" first="Lena" last="Backlund">Lena Backlund</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Banzato, Claudio E M" sort="Banzato, Claudio E M" uniqKey="Banzato C" first="Claudio E M" last="Banzato">Claudio E M. Banzato</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Campinas (Unicamp), Campinas, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Benabarre, Antoni" sort="Benabarre, Antoni" uniqKey="Benabarre A" first="Antoni" last="Benabarre">Antoni Benabarre</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bengesser, Susanne" sort="Bengesser, Susanne" uniqKey="Bengesser S" first="Susanne" last="Bengesser">Susanne Bengesser</name><affiliation><nlm:affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Bhattacharjee, Abesh Kumar" sort="Bhattacharjee, Abesh Kumar" uniqKey="Bhattacharjee A" first="Abesh Kumar" last="Bhattacharjee">Abesh Kumar Bhattacharjee</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M" last="Biernacka">Joanna M. Biernacka</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Birner, Armin" sort="Birner, Armin" uniqKey="Birner A" first="Armin" last="Birner">Armin Birner</name><affiliation><nlm:affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Brichant Petitjean, Clara" sort="Brichant Petitjean, Clara" uniqKey="Brichant Petitjean C" first="Clara" last="Brichant-Petitjean">Clara Brichant-Petitjean</name><affiliation><nlm:affiliation>INSERM UMR-S 1144-Université Paris Diderot Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bui, Elise T" sort="Bui, Elise T" uniqKey="Bui E" first="Elise T" last="Bui">Elise T. Bui</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cervantes, Pablo" sort="Cervantes, Pablo" uniqKey="Cervantes P" first="Pablo" last="Cervantes">Pablo Cervantes</name><affiliation><nlm:affiliation>The Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Guo Bo" sort="Chen, Guo Bo" uniqKey="Chen G" first="Guo-Bo" last="Chen">Guo-Bo Chen</name><affiliation><nlm:affiliation>The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Hsi Chung" sort="Chen, Hsi Chung" uniqKey="Chen H" first="Hsi-Chung" last="Chen">Hsi-Chung Chen</name><affiliation><nlm:affiliation>Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Chillotti, Caterina" sort="Chillotti, Caterina" uniqKey="Chillotti C" first="Caterina" last="Chillotti">Caterina Chillotti</name><affiliation><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Clark, Scott R" sort="Clark, Scott R" uniqKey="Clark S" first="Scott R" last="Clark">Scott R. Clark</name><affiliation><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Colom, Francesc" sort="Colom, Francesc" uniqKey="Colom F" first="Francesc" last="Colom">Francesc Colom</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cousins, David A" sort="Cousins, David A" uniqKey="Cousins D" first="David A" last="Cousins">David A. Cousins</name><affiliation><nlm:affiliation>Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cruceanu, Cristiana" sort="Cruceanu, Cristiana" uniqKey="Cruceanu C" first="Cristiana" last="Cruceanu">Cristiana Cruceanu</name><affiliation><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M" last="Czerski">Piotr M. Czerski</name><affiliation><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Dantas, Clarissa R" sort="Dantas, Clarissa R" uniqKey="Dantas C" first="Clarissa R" last="Dantas">Clarissa R. Dantas</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Campinas (Unicamp), Campinas, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Dayer, Alexandre" sort="Dayer, Alexandre" uniqKey="Dayer A" first="Alexandre" last="Dayer">Alexandre Dayer</name><affiliation><nlm:affiliation>Department of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Étain">Bruno Étain</name><affiliation><nlm:affiliation>Inserm U955, Psychiatrie Translationnelle, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Falkai, Peter" sort="Falkai, Peter" uniqKey="Falkai P" first="Peter" last="Falkai">Peter Falkai</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J" last="Forstner">Andreas J. Forstner</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Frisen, Louise" sort="Frisen, Louise" uniqKey="Frisen L" first="Louise" last="Frisén">Louise Frisén</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Child and Adolescent Psychiatry Research Center, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name><affiliation><nlm:affiliation>Mental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Gard, Sebastien" sort="Gard, Sebastien" uniqKey="Gard S" first="Sébastien" last="Gard">Sébastien Gard</name><affiliation><nlm:affiliation>Pôle de Psychiatrie Générale Universitaire, Centre Hospitalier Charles Perrens, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Garnham, Julie S" sort="Garnham, Julie S" uniqKey="Garnham J" first="Julie S" last="Garnham">Julie S. Garnham</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Goes, Fernando S" sort="Goes, Fernando S" uniqKey="Goes F" first="Fernando S" last="Goes">Fernando S. Goes</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Grof, Paul" sort="Grof, Paul" uniqKey="Grof P" first="Paul" last="Grof">Paul Grof</name><affiliation><nlm:affiliation>Mood Disorders Center of Ottawa, Ottawa, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gruber, Oliver" sort="Gruber, Oliver" uniqKey="Gruber O" first="Oliver" last="Gruber">Oliver Gruber</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hashimoto, Ryota" sort="Hashimoto, Ryota" uniqKey="Hashimoto R" first="Ryota" last="Hashimoto">Ryota Hashimoto</name><affiliation><nlm:affiliation>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name><affiliation><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Hofmann, Andrea" sort="Hofmann, Andrea" uniqKey="Hofmann A" first="Andrea" last="Hofmann">Andrea Hofmann</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stephane" last="Jamain">Stephane Jamain</name><affiliation><nlm:affiliation>Inserm U955, Psychiatrie Translationnelle, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jimenez, Esther" sort="Jimenez, Esther" uniqKey="Jimenez E" first="Esther" last="Jiménez">Esther Jiménez</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Kahn, Jean Pierre" sort="Kahn, Jean Pierre" uniqKey="Kahn J" first="Jean-Pierre" last="Kahn">Jean-Pierre Kahn</name><affiliation><nlm:affiliation>Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy-Laxou-Université de Lorraine, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kassem, Layla" sort="Kassem, Layla" uniqKey="Kassem L" first="Layla" last="Kassem">Layla Kassem</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kliwicki, Sebastian" sort="Kliwicki, Sebastian" uniqKey="Kliwicki S" first="Sebastian" last="Kliwicki">Sebastian Kliwicki</name><affiliation><nlm:affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Konig, Barbara" sort="Konig, Barbara" uniqKey="Konig B" first="Barbara" last="König">Barbara König</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Kusumi, Ichiro" sort="Kusumi, Ichiro" uniqKey="Kusumi I" first="Ichiro" last="Kusumi">Ichiro Kusumi</name><affiliation><nlm:affiliation>Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Lackner, Nina" sort="Lackner, Nina" uniqKey="Lackner N" first="Nina" last="Lackner">Nina Lackner</name><affiliation><nlm:affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Laje, Gonzalo" sort="Laje, Gonzalo" uniqKey="Laje G" first="Gonzalo" last="Laje">Gonzalo Laje</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Landen, Mikael" sort="Landen, Mikael" uniqKey="Landen M" first="Mikael" last="Landén">Mikael Landén</name><affiliation><nlm:affiliation>Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lavebratt, Catharina" sort="Lavebratt, Catharina" uniqKey="Lavebratt C" first="Catharina" last="Lavebratt">Catharina Lavebratt</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation><nlm:affiliation>Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier-Henri Mondor, Pôle de Psychiatrie, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Leckband, Susan G" sort="Leckband, Susan G" uniqKey="Leckband S" first="Susan G" last="Leckband">Susan G. Leckband</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Pharmacy, VA San Diego Healthcare System, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jaramillo, Carlos A L Pez" sort="Jaramillo, Carlos A L Pez" uniqKey="Jaramillo C" first="Carlos A L Pez" last="Jaramillo">Carlos A L Pez Jaramillo</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Antioquia, Medellín, Medellín, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Macqueen, Glenda" sort="Macqueen, Glenda" uniqKey="Macqueen G" first="Glenda" last="Macqueen">Glenda Macqueen</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Calgary, Calgary, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Manchia, Mirko" sort="Manchia, Mirko" uniqKey="Manchia M" first="Mirko" last="Manchia">Mirko Manchia</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Martinsson, Lina" sort="Martinsson, Lina" uniqKey="Martinsson L" first="Lina" last="Martinsson">Lina Martinsson</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Mccarthy, Michael J" sort="Mccarthy, Michael J" uniqKey="Mccarthy M" first="Michael J" last="Mccarthy">Michael J. Mccarthy</name><affiliation><nlm:affiliation>Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcelroy, Susan L" sort="Mcelroy, Susan L" uniqKey="Mcelroy S" first="Susan L" last="Mcelroy">Susan L. Mcelroy</name><affiliation><nlm:affiliation>Department of Psychiatry, Lindner Center of Hope, University of Cincinnati, Mason, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mitjans, Marina" sort="Mitjans, Marina" uniqKey="Mitjans M" first="Marina" last="Mitjans">Marina Mitjans</name><affiliation><nlm:affiliation>Department of Biologia Animal, Unitat d'Antropologia (Dp Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mondimore, Francis M" sort="Mondimore, Francis M" uniqKey="Mondimore F" first="Francis M" last="Mondimore">Francis M. Mondimore</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Monteleone, Palmiero" sort="Monteleone, Palmiero" uniqKey="Monteleone P" first="Palmiero" last="Monteleone">Palmiero Monteleone</name><affiliation><nlm:affiliation>Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy; Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nievergelt, Caroline M" sort="Nievergelt, Caroline M" uniqKey="Nievergelt C" first="Caroline M" last="Nievergelt">Caroline M. Nievergelt</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Osby, Urban" sort="Osby, Urban" uniqKey="Osby U" first="Urban" last="Ösby">Urban Ösby</name><affiliation><nlm:affiliation>Department of Neurobiology, Care sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ozaki, Norio" sort="Ozaki, Norio" uniqKey="Ozaki N" first="Norio" last="Ozaki">Norio Ozaki</name><affiliation><nlm:affiliation>Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Perlis, Roy H" sort="Perlis, Roy H" uniqKey="Perlis R" first="Roy H" last="Perlis">Roy H. Perlis</name><affiliation><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Reich Erkelenz, Daniela" sort="Reich Erkelenz, Daniela" uniqKey="Reich Erkelenz D" first="Daniela" last="Reich-Erkelenz">Daniela Reich-Erkelenz</name><affiliation><nlm:affiliation>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation><nlm:affiliation>Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name><affiliation><nlm:affiliation>Mental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schubert, K Oliver" sort="Schubert, K Oliver" uniqKey="Schubert K" first="K Oliver" last="Schubert">K Oliver Schubert</name><affiliation><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schweizer, Barbara W" sort="Schweizer, Barbara W" uniqKey="Schweizer B" first="Barbara W" last="Schweizer">Barbara W. Schweizer</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seemuller, Florian" sort="Seemuller, Florian" uniqKey="Seemuller F" first="Florian" last="Seemüller">Florian Seemüller</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Severino, Giovanni" sort="Severino, Giovanni" uniqKey="Severino G" first="Giovanni" last="Severino">Giovanni Severino</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Shekhtman, Tatyana" sort="Shekhtman, Tatyana" uniqKey="Shekhtman T" first="Tatyana" last="Shekhtman">Tatyana Shekhtman</name><affiliation><nlm:affiliation>Veterans Administration, San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shilling, Paul D" sort="Shilling, Paul D" uniqKey="Shilling P" first="Paul D" last="Shilling">Paul D. Shilling</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shimoda, Kazutaka" sort="Shimoda, Kazutaka" uniqKey="Shimoda K" first="Kazutaka" last="Shimoda">Kazutaka Shimoda</name><affiliation><nlm:affiliation>Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Simhandl, Christian" sort="Simhandl, Christian" uniqKey="Simhandl C" first="Christian" last="Simhandl">Christian Simhandl</name><affiliation><nlm:affiliation>Bipolar Center Wiener Neustadt, Wiener Neustadt, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Slaney, Claire M" sort="Slaney, Claire M" uniqKey="Slaney C" first="Claire M" last="Slaney">Claire M. Slaney</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Smoller, Jordan W" sort="Smoller, Jordan W" uniqKey="Smoller J" first="Jordan W" last="Smoller">Jordan W. Smoller</name><affiliation><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Squassina, Alessio" sort="Squassina, Alessio" uniqKey="Squassina A" first="Alessio" last="Squassina">Alessio Squassina</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Stamm, Thomas" sort="Stamm, Thomas" uniqKey="Stamm T" first="Thomas" last="Stamm">Thomas Stamm</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Stopkova, Pavla" sort="Stopkova, Pavla" uniqKey="Stopkova P" first="Pavla" last="Stopkova">Pavla Stopkova</name><affiliation><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Tighe, Sarah K" sort="Tighe, Sarah K" uniqKey="Tighe S" first="Sarah K" last="Tighe">Sarah K. Tighe</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Iowa, Iowa City, IA, USA; University of Iowa Carver College of Medicine and University of Iowa College of Public Health, VA Quality Scholars Program, Iowa City VA Hospital, Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tortorella, Alfonso" sort="Tortorella, Alfonso" uniqKey="Tortorella A" first="Alfonso" last="Tortorella">Alfonso Tortorella</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name><affiliation><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Volkert, Julia" sort="Volkert, Julia" uniqKey="Volkert J" first="Julia" last="Volkert">Julia Volkert</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Witt, Stephanie" sort="Witt, Stephanie" uniqKey="Witt S" first="Stephanie" last="Witt">Stephanie Witt</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Young, L Trevor" sort="Young, L Trevor" uniqKey="Young L" first="L Trevor" last="Young">L Trevor Young</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Zandi, Peter P" sort="Zandi, Peter P" uniqKey="Zandi P" first="Peter P" last="Zandi">Peter P. Zandi</name><affiliation><nlm:affiliation>Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Potash, James B" sort="Potash, James B" uniqKey="Potash J" first="James B" last="Potash">James B. Potash</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Iowa, Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Depaulo, J Raymond" sort="Depaulo, J Raymond" uniqKey="Depaulo J" first="J Raymond" last="Depaulo">J Raymond Depaulo</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Reininghaus, Eva Z" sort="Reininghaus, Eva Z" uniqKey="Reininghaus E" first="Eva Z" last="Reininghaus">Eva Z. Reininghaus</name><affiliation><nlm:affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Novak, Tomas" sort="Novak, Tomas" uniqKey="Novak T" first="Tomas" last="Novák">Tomas Novák</name><affiliation><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Aubry, Jean Michel" sort="Aubry, Jean Michel" uniqKey="Aubry J" first="Jean-Michel" last="Aubry">Jean-Michel Aubry</name><affiliation><nlm:affiliation>Department of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Maj, Mario" sort="Maj, Mario" uniqKey="Maj M" first="Mario" last="Maj">Mario Maj</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Baune, Bernhard T" sort="Baune, Bernhard T" uniqKey="Baune B" first="Bernhard T" last="Baune">Bernhard T. Baune</name><affiliation><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name><affiliation><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A" last="Frye">Mark A. Frye</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rybakowski, Janusz K" sort="Rybakowski, Janusz K" uniqKey="Rybakowski J" first="Janusz K" last="Rybakowski">Janusz K. Rybakowski</name><affiliation><nlm:affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Kuo, Po Hsiu" sort="Kuo, Po Hsiu" uniqKey="Kuo P" first="Po-Hsiu" last="Kuo">Po-Hsiu Kuo</name><affiliation><nlm:affiliation>Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Kato, Tadafumi" sort="Kato, Tadafumi" uniqKey="Kato T" first="Tadafumi" last="Kato">Tadafumi Kato</name><affiliation><nlm:affiliation>Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name><affiliation><nlm:affiliation>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Psychiatric Hospital, Bucharest, Romania.</nlm:affiliation></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Del Zompo, Maria" sort="Del Zompo, Maria" uniqKey="Del Zompo M" first="Maria" last="Del Zompo">Maria Del Zompo</name><affiliation><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation><nlm:affiliation>INSERM UMR-S 1144-Université Paris Diderot Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Schalling, Martin" sort="Schalling, Martin" uniqKey="Schalling M" first="Martin" last="Schalling">Martin Schalling</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Wray, Naomi R" sort="Wray, Naomi R" uniqKey="Wray N" first="Naomi R" last="Wray">Naomi R. Wray</name><affiliation><nlm:affiliation>The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kelsoe, John R" sort="Kelsoe, John R" uniqKey="Kelsoe J" first="John R" last="Kelsoe">John R. Kelsoe</name><affiliation><nlm:affiliation>Veterans Administration, San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada; National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmahon, Francis J" sort="Mcmahon, Francis J" uniqKey="Mcmahon F" first="Francis J" last="Mcmahon">Francis J. Mcmahon</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA. Electronic address: mcmahonf@mail.nih.gov.</nlm:affiliation></affiliation></author><author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G" last="Schulze">Thomas G. Schulze</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA; Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: thomas.schulze@med.uni-muenchen.de.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26806518</idno><idno type="pmid">26806518</idno><idno type="doi">10.1016/S0140-6736(16)00143-4</idno><idno type="wicri:Area/PubMed/Corpus">002200</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002200</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.</title><author><name sortKey="Hou, Liping" sort="Hou, Liping" uniqKey="Hou L" first="Liping" last="Hou">Liping Hou</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Heilbronner, Urs" sort="Heilbronner, Urs" uniqKey="Heilbronner U" first="Urs" last="Heilbronner">Urs Heilbronner</name><affiliation><nlm:affiliation>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Adli, Mazda" sort="Adli, Mazda" uniqKey="Adli M" first="Mazda" last="Adli">Mazda Adli</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany; Fliedner Klinik Berlin, Center for Psychiatry, Psychotherapy and Psychosomatic Medicine, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Akiyama, Kazufumi" sort="Akiyama, Kazufumi" uniqKey="Akiyama K" first="Kazufumi" last="Akiyama">Kazufumi Akiyama</name><affiliation><nlm:affiliation>Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Akula, Nirmala" sort="Akula, Nirmala" uniqKey="Akula N" first="Nirmala" last="Akula">Nirmala Akula</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ardau, Raffaella" sort="Ardau, Raffaella" uniqKey="Ardau R" first="Raffaella" last="Ardau">Raffaella Ardau</name><affiliation><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Arias, Barbara" sort="Arias, Barbara" uniqKey="Arias B" first="Bárbara" last="Arias">Bárbara Arias</name><affiliation><nlm:affiliation>Department of Biologia Animal, Unitat d'Antropologia (Dp Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Backlund, Lena" sort="Backlund, Lena" uniqKey="Backlund L" first="Lena" last="Backlund">Lena Backlund</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Banzato, Claudio E M" sort="Banzato, Claudio E M" uniqKey="Banzato C" first="Claudio E M" last="Banzato">Claudio E M. Banzato</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Campinas (Unicamp), Campinas, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Benabarre, Antoni" sort="Benabarre, Antoni" uniqKey="Benabarre A" first="Antoni" last="Benabarre">Antoni Benabarre</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bengesser, Susanne" sort="Bengesser, Susanne" uniqKey="Bengesser S" first="Susanne" last="Bengesser">Susanne Bengesser</name><affiliation><nlm:affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Bhattacharjee, Abesh Kumar" sort="Bhattacharjee, Abesh Kumar" uniqKey="Bhattacharjee A" first="Abesh Kumar" last="Bhattacharjee">Abesh Kumar Bhattacharjee</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Biernacka, Joanna M" sort="Biernacka, Joanna M" uniqKey="Biernacka J" first="Joanna M" last="Biernacka">Joanna M. Biernacka</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Birner, Armin" sort="Birner, Armin" uniqKey="Birner A" first="Armin" last="Birner">Armin Birner</name><affiliation><nlm:affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Brichant Petitjean, Clara" sort="Brichant Petitjean, Clara" uniqKey="Brichant Petitjean C" first="Clara" last="Brichant-Petitjean">Clara Brichant-Petitjean</name><affiliation><nlm:affiliation>INSERM UMR-S 1144-Université Paris Diderot Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bui, Elise T" sort="Bui, Elise T" uniqKey="Bui E" first="Elise T" last="Bui">Elise T. Bui</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cervantes, Pablo" sort="Cervantes, Pablo" uniqKey="Cervantes P" first="Pablo" last="Cervantes">Pablo Cervantes</name><affiliation><nlm:affiliation>The Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Guo Bo" sort="Chen, Guo Bo" uniqKey="Chen G" first="Guo-Bo" last="Chen">Guo-Bo Chen</name><affiliation><nlm:affiliation>The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Hsi Chung" sort="Chen, Hsi Chung" uniqKey="Chen H" first="Hsi-Chung" last="Chen">Hsi-Chung Chen</name><affiliation><nlm:affiliation>Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Chillotti, Caterina" sort="Chillotti, Caterina" uniqKey="Chillotti C" first="Caterina" last="Chillotti">Caterina Chillotti</name><affiliation><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Clark, Scott R" sort="Clark, Scott R" uniqKey="Clark S" first="Scott R" last="Clark">Scott R. Clark</name><affiliation><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Colom, Francesc" sort="Colom, Francesc" uniqKey="Colom F" first="Francesc" last="Colom">Francesc Colom</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cousins, David A" sort="Cousins, David A" uniqKey="Cousins D" first="David A" last="Cousins">David A. Cousins</name><affiliation><nlm:affiliation>Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cruceanu, Cristiana" sort="Cruceanu, Cristiana" uniqKey="Cruceanu C" first="Cristiana" last="Cruceanu">Cristiana Cruceanu</name><affiliation><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M" last="Czerski">Piotr M. Czerski</name><affiliation><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Dantas, Clarissa R" sort="Dantas, Clarissa R" uniqKey="Dantas C" first="Clarissa R" last="Dantas">Clarissa R. Dantas</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Campinas (Unicamp), Campinas, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Dayer, Alexandre" sort="Dayer, Alexandre" uniqKey="Dayer A" first="Alexandre" last="Dayer">Alexandre Dayer</name><affiliation><nlm:affiliation>Department of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Etain, Bruno" sort="Etain, Bruno" uniqKey="Etain B" first="Bruno" last="Étain">Bruno Étain</name><affiliation><nlm:affiliation>Inserm U955, Psychiatrie Translationnelle, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Falkai, Peter" sort="Falkai, Peter" uniqKey="Falkai P" first="Peter" last="Falkai">Peter Falkai</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J" last="Forstner">Andreas J. Forstner</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Frisen, Louise" sort="Frisen, Louise" uniqKey="Frisen L" first="Louise" last="Frisén">Louise Frisén</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Child and Adolescent Psychiatry Research Center, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name><affiliation><nlm:affiliation>Mental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Gard, Sebastien" sort="Gard, Sebastien" uniqKey="Gard S" first="Sébastien" last="Gard">Sébastien Gard</name><affiliation><nlm:affiliation>Pôle de Psychiatrie Générale Universitaire, Centre Hospitalier Charles Perrens, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Garnham, Julie S" sort="Garnham, Julie S" uniqKey="Garnham J" first="Julie S" last="Garnham">Julie S. Garnham</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Goes, Fernando S" sort="Goes, Fernando S" uniqKey="Goes F" first="Fernando S" last="Goes">Fernando S. Goes</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Grof, Paul" sort="Grof, Paul" uniqKey="Grof P" first="Paul" last="Grof">Paul Grof</name><affiliation><nlm:affiliation>Mood Disorders Center of Ottawa, Ottawa, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gruber, Oliver" sort="Gruber, Oliver" uniqKey="Gruber O" first="Oliver" last="Gruber">Oliver Gruber</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hashimoto, Ryota" sort="Hashimoto, Ryota" uniqKey="Hashimoto R" first="Ryota" last="Hashimoto">Ryota Hashimoto</name><affiliation><nlm:affiliation>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name><affiliation><nlm:affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Hofmann, Andrea" sort="Hofmann, Andrea" uniqKey="Hofmann A" first="Andrea" last="Hofmann">Andrea Hofmann</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jamain, Stephane" sort="Jamain, Stephane" uniqKey="Jamain S" first="Stephane" last="Jamain">Stephane Jamain</name><affiliation><nlm:affiliation>Inserm U955, Psychiatrie Translationnelle, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jimenez, Esther" sort="Jimenez, Esther" uniqKey="Jimenez E" first="Esther" last="Jiménez">Esther Jiménez</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Kahn, Jean Pierre" sort="Kahn, Jean Pierre" uniqKey="Kahn J" first="Jean-Pierre" last="Kahn">Jean-Pierre Kahn</name><affiliation><nlm:affiliation>Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy-Laxou-Université de Lorraine, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kassem, Layla" sort="Kassem, Layla" uniqKey="Kassem L" first="Layla" last="Kassem">Layla Kassem</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kliwicki, Sebastian" sort="Kliwicki, Sebastian" uniqKey="Kliwicki S" first="Sebastian" last="Kliwicki">Sebastian Kliwicki</name><affiliation><nlm:affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Konig, Barbara" sort="Konig, Barbara" uniqKey="Konig B" first="Barbara" last="König">Barbara König</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Kusumi, Ichiro" sort="Kusumi, Ichiro" uniqKey="Kusumi I" first="Ichiro" last="Kusumi">Ichiro Kusumi</name><affiliation><nlm:affiliation>Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Lackner, Nina" sort="Lackner, Nina" uniqKey="Lackner N" first="Nina" last="Lackner">Nina Lackner</name><affiliation><nlm:affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Laje, Gonzalo" sort="Laje, Gonzalo" uniqKey="Laje G" first="Gonzalo" last="Laje">Gonzalo Laje</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Landen, Mikael" sort="Landen, Mikael" uniqKey="Landen M" first="Mikael" last="Landén">Mikael Landén</name><affiliation><nlm:affiliation>Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lavebratt, Catharina" sort="Lavebratt, Catharina" uniqKey="Lavebratt C" first="Catharina" last="Lavebratt">Catharina Lavebratt</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Leboyer, Marion" sort="Leboyer, Marion" uniqKey="Leboyer M" first="Marion" last="Leboyer">Marion Leboyer</name><affiliation><nlm:affiliation>Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier-Henri Mondor, Pôle de Psychiatrie, Créteil, France.</nlm:affiliation></affiliation></author><author><name sortKey="Leckband, Susan G" sort="Leckband, Susan G" uniqKey="Leckband S" first="Susan G" last="Leckband">Susan G. Leckband</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Pharmacy, VA San Diego Healthcare System, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jaramillo, Carlos A L Pez" sort="Jaramillo, Carlos A L Pez" uniqKey="Jaramillo C" first="Carlos A L Pez" last="Jaramillo">Carlos A L Pez Jaramillo</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Antioquia, Medellín, Medellín, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Macqueen, Glenda" sort="Macqueen, Glenda" uniqKey="Macqueen G" first="Glenda" last="Macqueen">Glenda Macqueen</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Calgary, Calgary, AB, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Manchia, Mirko" sort="Manchia, Mirko" uniqKey="Manchia M" first="Mirko" last="Manchia">Mirko Manchia</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Martinsson, Lina" sort="Martinsson, Lina" uniqKey="Martinsson L" first="Lina" last="Martinsson">Lina Martinsson</name><affiliation><nlm:affiliation>Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name><affiliation><nlm:affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Mccarthy, Michael J" sort="Mccarthy, Michael J" uniqKey="Mccarthy M" first="Michael J" last="Mccarthy">Michael J. Mccarthy</name><affiliation><nlm:affiliation>Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mcelroy, Susan L" sort="Mcelroy, Susan L" uniqKey="Mcelroy S" first="Susan L" last="Mcelroy">Susan L. Mcelroy</name><affiliation><nlm:affiliation>Department of Psychiatry, Lindner Center of Hope, University of Cincinnati, Mason, OH, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mitjans, Marina" sort="Mitjans, Marina" uniqKey="Mitjans M" first="Marina" last="Mitjans">Marina Mitjans</name><affiliation><nlm:affiliation>Department of Biologia Animal, Unitat d'Antropologia (Dp Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Mondimore, Francis M" sort="Mondimore, Francis M" uniqKey="Mondimore F" first="Francis M" last="Mondimore">Francis M. Mondimore</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Monteleone, Palmiero" sort="Monteleone, Palmiero" uniqKey="Monteleone P" first="Palmiero" last="Monteleone">Palmiero Monteleone</name><affiliation><nlm:affiliation>Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy; Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Nievergelt, Caroline M" sort="Nievergelt, Caroline M" uniqKey="Nievergelt C" first="Caroline M" last="Nievergelt">Caroline M. Nievergelt</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Osby, Urban" sort="Osby, Urban" uniqKey="Osby U" first="Urban" last="Ösby">Urban Ösby</name><affiliation><nlm:affiliation>Department of Neurobiology, Care sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ozaki, Norio" sort="Ozaki, Norio" uniqKey="Ozaki N" first="Norio" last="Ozaki">Norio Ozaki</name><affiliation><nlm:affiliation>Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Perlis, Roy H" sort="Perlis, Roy H" uniqKey="Perlis R" first="Roy H" last="Perlis">Roy H. Perlis</name><affiliation><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Reich Erkelenz, Daniela" sort="Reich Erkelenz, Daniela" uniqKey="Reich Erkelenz D" first="Daniela" last="Reich-Erkelenz">Daniela Reich-Erkelenz</name><affiliation><nlm:affiliation>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation><nlm:affiliation>Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name><affiliation><nlm:affiliation>Mental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schubert, K Oliver" sort="Schubert, K Oliver" uniqKey="Schubert K" first="K Oliver" last="Schubert">K Oliver Schubert</name><affiliation><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Schweizer, Barbara W" sort="Schweizer, Barbara W" uniqKey="Schweizer B" first="Barbara W" last="Schweizer">Barbara W. Schweizer</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Seemuller, Florian" sort="Seemuller, Florian" uniqKey="Seemuller F" first="Florian" last="Seemüller">Florian Seemüller</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Severino, Giovanni" sort="Severino, Giovanni" uniqKey="Severino G" first="Giovanni" last="Severino">Giovanni Severino</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Shekhtman, Tatyana" sort="Shekhtman, Tatyana" uniqKey="Shekhtman T" first="Tatyana" last="Shekhtman">Tatyana Shekhtman</name><affiliation><nlm:affiliation>Veterans Administration, San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shilling, Paul D" sort="Shilling, Paul D" uniqKey="Shilling P" first="Paul D" last="Shilling">Paul D. Shilling</name><affiliation><nlm:affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shimoda, Kazutaka" sort="Shimoda, Kazutaka" uniqKey="Shimoda K" first="Kazutaka" last="Shimoda">Kazutaka Shimoda</name><affiliation><nlm:affiliation>Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Simhandl, Christian" sort="Simhandl, Christian" uniqKey="Simhandl C" first="Christian" last="Simhandl">Christian Simhandl</name><affiliation><nlm:affiliation>Bipolar Center Wiener Neustadt, Wiener Neustadt, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Slaney, Claire M" sort="Slaney, Claire M" uniqKey="Slaney C" first="Claire M" last="Slaney">Claire M. Slaney</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Smoller, Jordan W" sort="Smoller, Jordan W" uniqKey="Smoller J" first="Jordan W" last="Smoller">Jordan W. Smoller</name><affiliation><nlm:affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Squassina, Alessio" sort="Squassina, Alessio" uniqKey="Squassina A" first="Alessio" last="Squassina">Alessio Squassina</name><affiliation><nlm:affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Stamm, Thomas" sort="Stamm, Thomas" uniqKey="Stamm T" first="Thomas" last="Stamm">Thomas Stamm</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Stopkova, Pavla" sort="Stopkova, Pavla" uniqKey="Stopkova P" first="Pavla" last="Stopkova">Pavla Stopkova</name><affiliation><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Tighe, Sarah K" sort="Tighe, Sarah K" uniqKey="Tighe S" first="Sarah K" last="Tighe">Sarah K. Tighe</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Iowa, Iowa City, IA, USA; University of Iowa Carver College of Medicine and University of Iowa College of Public Health, VA Quality Scholars Program, Iowa City VA Hospital, Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tortorella, Alfonso" sort="Tortorella, Alfonso" uniqKey="Tortorella A" first="Alfonso" last="Tortorella">Alfonso Tortorella</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name><affiliation><nlm:affiliation>Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Volkert, Julia" sort="Volkert, Julia" uniqKey="Volkert J" first="Julia" last="Volkert">Julia Volkert</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Witt, Stephanie" sort="Witt, Stephanie" uniqKey="Witt S" first="Stephanie" last="Witt">Stephanie Witt</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Young, L Trevor" sort="Young, L Trevor" uniqKey="Young L" first="L Trevor" last="Young">L Trevor Young</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Zandi, Peter P" sort="Zandi, Peter P" uniqKey="Zandi P" first="Peter P" last="Zandi">Peter P. Zandi</name><affiliation><nlm:affiliation>Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Potash, James B" sort="Potash, James B" uniqKey="Potash J" first="James B" last="Potash">James B. Potash</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Iowa, Iowa City, IA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Depaulo, J Raymond" sort="Depaulo, J Raymond" uniqKey="Depaulo J" first="J Raymond" last="Depaulo">J Raymond Depaulo</name><affiliation><nlm:affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Reininghaus, Eva Z" sort="Reininghaus, Eva Z" uniqKey="Reininghaus E" first="Eva Z" last="Reininghaus">Eva Z. Reininghaus</name><affiliation><nlm:affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Novak, Tomas" sort="Novak, Tomas" uniqKey="Novak T" first="Tomas" last="Novák">Tomas Novák</name><affiliation><nlm:affiliation>National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Aubry, Jean Michel" sort="Aubry, Jean Michel" uniqKey="Aubry J" first="Jean-Michel" last="Aubry">Jean-Michel Aubry</name><affiliation><nlm:affiliation>Department of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Maj, Mario" sort="Maj, Mario" uniqKey="Maj M" first="Mario" last="Maj">Mario Maj</name><affiliation><nlm:affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Baune, Bernhard T" sort="Baune, Bernhard T" uniqKey="Baune B" first="Bernhard T" last="Baune">Bernhard T. Baune</name><affiliation><nlm:affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name><affiliation><nlm:affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vieta, Eduard" sort="Vieta, Eduard" uniqKey="Vieta E" first="Eduard" last="Vieta">Eduard Vieta</name><affiliation><nlm:affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Frye, Mark A" sort="Frye, Mark A" uniqKey="Frye M" first="Mark A" last="Frye">Mark A. Frye</name><affiliation><nlm:affiliation>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rybakowski, Janusz K" sort="Rybakowski, Janusz K" uniqKey="Rybakowski J" first="Janusz K" last="Rybakowski">Janusz K. Rybakowski</name><affiliation><nlm:affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Kuo, Po Hsiu" sort="Kuo, Po Hsiu" uniqKey="Kuo P" first="Po-Hsiu" last="Kuo">Po-Hsiu Kuo</name><affiliation><nlm:affiliation>Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Kato, Tadafumi" sort="Kato, Tadafumi" uniqKey="Kato T" first="Tadafumi" last="Kato">Tadafumi Kato</name><affiliation><nlm:affiliation>Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name><affiliation><nlm:affiliation>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Psychiatric Hospital, Bucharest, Romania.</nlm:affiliation></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation><nlm:affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Del Zompo, Maria" sort="Del Zompo, Maria" uniqKey="Del Zompo M" first="Maria" last="Del Zompo">Maria Del Zompo</name><affiliation><nlm:affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bellivier, Frank" sort="Bellivier, Frank" uniqKey="Bellivier F" first="Frank" last="Bellivier">Frank Bellivier</name><affiliation><nlm:affiliation>INSERM UMR-S 1144-Université Paris Diderot Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Schalling, Martin" sort="Schalling, Martin" uniqKey="Schalling M" first="Martin" last="Schalling">Martin Schalling</name><affiliation><nlm:affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Wray, Naomi R" sort="Wray, Naomi R" uniqKey="Wray N" first="Naomi R" last="Wray">Naomi R. Wray</name><affiliation><nlm:affiliation>The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kelsoe, John R" sort="Kelsoe, John R" uniqKey="Kelsoe J" first="John R" last="Kelsoe">John R. Kelsoe</name><affiliation><nlm:affiliation>Veterans Administration, San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name><affiliation><nlm:affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada; National Institute of Mental Health, Klecany, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Mcmahon, Francis J" sort="Mcmahon, Francis J" uniqKey="Mcmahon F" first="Francis J" last="Mcmahon">Francis J. Mcmahon</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA. Electronic address: mcmahonf@mail.nih.gov.</nlm:affiliation></affiliation></author><author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G" last="Schulze">Thomas G. Schulze</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA; Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: thomas.schulze@med.uni-muenchen.de.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Bipolar Disorder (drug therapy)</term><term>Bipolar Disorder (genetics)</term><term>Female</term><term>Genetic Variation</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Glial Cell Line-Derived Neurotrophic Factor Receptors (genetics)</term><term>Humans</term><term>Lithium Compounds (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Phenotype</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Glial Cell Line-Derived Neurotrophic Factor Receptors</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Bipolar Disorder</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Bipolar Disorder</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Lithium Compounds</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Genetic Variation</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Phenotype</term><term>Prospective Studies</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26806518</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>30</Day></DateCreated><DateCompleted><Year>2016</Year><Month>04</Month><Day>11</Day></DateCompleted><DateRevised><Year>2017</Year><Month>08</Month><Day>06</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1474-547X</ISSN><JournalIssue CitedMedium="Internet"><Volume>387</Volume><Issue>10023</Issue><PubDate><Year>2016</Year><Month>Mar</Month><Day>12</Day></PubDate></JournalIssue><Title>Lancet (London, England)</Title><ISOAbbreviation>Lancet</ISOAbbreviation></Journal><ArticleTitle>Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.</ArticleTitle><Pagination><MedlinePgn>1085-1093</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0140-6736(16)00143-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S0140-6736(16)00143-4</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Lithium is a first-line treatment in bipolar disorder, but individual response is variable. Previous studies have suggested that lithium response is a heritable trait. However, no genetic markers of treatment response have been reproducibly identified.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Here, we report the results of a genome-wide association study of lithium response in 2563 patients collected by 22 participating sites from the International Consortium on Lithium Genetics (ConLiGen). Data from common single nucleotide polymorphisms (SNPs) were tested for association with categorical and continuous ratings of lithium response. Lithium response was measured using a well established scale (Alda scale). Genotyped SNPs were used to generate data at more than 6 million sites, using standard genomic imputation methods. Traits were regressed against genotype dosage. Results were combined across two batches by meta-analysis.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">A single locus of four linked SNPs on chromosome 21 met genome-wide significance criteria for association with lithium response (rs79663003, p=1·37 × 10(-8); rs78015114, p=1·31 × 10(-8); rs74795342, p=3·31 × 10(-9); and rs75222709, p=3·50 × 10(-9)). In an independent, prospective study of 73 patients treated with lithium monotherapy for a period of up to 2 years, carriers of the response-associated alleles had a significantly lower rate of relapse than carriers of the alternate alleles (p=0·03268, hazard ratio 3·8, 95% CI 1·1-13·0).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">The response-associated region contains two genes for long, non-coding RNAs (lncRNAs), AL157359.3 and AL157359.4. LncRNAs are increasingly appreciated as important regulators of gene expression, particularly in the CNS. Confirmed biomarkers of lithium response would constitute an important step forward in the clinical management of bipolar disorder. Further studies are needed to establish the biological context and potential clinical utility of these findings.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">Deutsche Forschungsgemeinschaft, National Institute of Mental Health Intramural Research Program.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>Liping</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heilbronner</LastName><ForeName>Urs</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Degenhardt</LastName><ForeName>Franziska</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adli</LastName><ForeName>Mazda</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany; Fliedner Klinik Berlin, Center for Psychiatry, Psychotherapy and Psychosomatic Medicine, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akiyama</LastName><ForeName>Kazufumi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Biological Psychiatry and Neuroscience, Dokkyo Medical University School of Medicine, Mibu, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Akula</LastName><ForeName>Nirmala</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ardau</LastName><ForeName>Raffaella</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arias</LastName><ForeName>Bárbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Biologia Animal, Unitat d'Antropologia (Dp Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Backlund</LastName><ForeName>Lena</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Banzato</LastName><ForeName>Claudio E M</ForeName><Initials>CEM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Campinas (Unicamp), Campinas, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benabarre</LastName><ForeName>Antoni</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bengesser</LastName><ForeName>Susanne</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bhattacharjee</LastName><ForeName>Abesh Kumar</ForeName><Initials>AK</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biernacka</LastName><ForeName>Joanna M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Birner</LastName><ForeName>Armin</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brichant-Petitjean</LastName><ForeName>Clara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>INSERM UMR-S 1144-Université Paris Diderot Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bui</LastName><ForeName>Elise T</ForeName><Initials>ET</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cervantes</LastName><ForeName>Pablo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>The Neuromodulation Unit, McGill University Health Centre, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Guo-Bo</ForeName><Initials>GB</Initials><AffiliationInfo><Affiliation>The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Hsi-Chung</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Department of Psychiatry & Center of Sleep Disorders, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chillotti</LastName><ForeName>Caterina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cichon</LastName><ForeName>Sven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Scott R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colom</LastName><ForeName>Francesc</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cousins</LastName><ForeName>David A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cruceanu</LastName><ForeName>Cristiana</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Czerski</LastName><ForeName>Piotr M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dantas</LastName><ForeName>Clarissa R</ForeName><Initials>CR</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Campinas (Unicamp), Campinas, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dayer</LastName><ForeName>Alexandre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Étain</LastName><ForeName>Bruno</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Inserm U955, Psychiatrie Translationnelle, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Falkai</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Forstner</LastName><ForeName>Andreas J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frisén</LastName><ForeName>Louise</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Child and Adolescent Psychiatry Research Center, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fullerton</LastName><ForeName>Janice M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Mental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gard</LastName><ForeName>Sébastien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Pôle de Psychiatrie Générale Universitaire, Centre Hospitalier Charles Perrens, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garnham</LastName><ForeName>Julie S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goes</LastName><ForeName>Fernando S</ForeName><Initials>FS</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grof</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Mood Disorders Center of Ottawa, Ottawa, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gruber</LastName><ForeName>Oliver</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hashimoto</LastName><ForeName>Ryota</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hauser</LastName><ForeName>Joanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Psychiatric Genetic Unit, Poznan University of Medical Sciences, Poznan, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herms</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoffmann</LastName><ForeName>Per</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany; Human Genomics Research Group, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofmann</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jamain</LastName><ForeName>Stephane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Inserm U955, Psychiatrie Translationnelle, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiménez</LastName><ForeName>Esther</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kahn</LastName><ForeName>Jean-Pierre</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy-Laxou-Université de Lorraine, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kassem</LastName><ForeName>Layla</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kittel-Schneider</LastName><ForeName>Sarah</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kliwicki</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>König</LastName><ForeName>Barbara</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapeutic Medicine, Landesklinikum Neunkirchen, Neunkirchen, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kusumi</LastName><ForeName>Ichiro</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lackner</LastName><ForeName>Nina</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laje</LastName><ForeName>Gonzalo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Landén</LastName><ForeName>Mikael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the Gothenburg University, Gothenburg, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lavebratt</LastName><ForeName>Catharina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leboyer</LastName><ForeName>Marion</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier-Henri Mondor, Pôle de Psychiatrie, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leckband</LastName><ForeName>Susan G</ForeName><Initials>SG</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden; Department of Pharmacy, VA San Diego Healthcare System, San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jaramillo</LastName><ForeName>Carlos A López</ForeName><Initials>CAL</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Antioquia, Medellín, Medellín, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>MacQueen</LastName><ForeName>Glenda</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Calgary, Calgary, AB, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manchia</LastName><ForeName>Mirko</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martinsson</LastName><ForeName>Lina</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mattheisen</LastName><ForeName>Manuel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biomedicine, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarthy</LastName><ForeName>Michael J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McElroy</LastName><ForeName>Susan L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Lindner Center of Hope, University of Cincinnati, Mason, OH, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitjans</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biologia Animal, Unitat d'Antropologia (Dp Biología Animal), Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mondimore</LastName><ForeName>Francis M</ForeName><Initials>FM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monteleone</LastName><ForeName>Palmiero</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy; Department of Psychiatry, University of Naples SUN, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nievergelt</LastName><ForeName>Caroline M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nöthen</LastName><ForeName>Markus M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ösby</LastName><ForeName>Urban</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, Care sciences, and Society, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ozaki</LastName><ForeName>Norio</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perlis</LastName><ForeName>Roy H</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pfennig</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reich-Erkelenz</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rouleau</LastName><ForeName>Guy A</ForeName><Initials>GA</Initials><AffiliationInfo><Affiliation>Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schofield</LastName><ForeName>Peter R</ForeName><Initials>PR</Initials><AffiliationInfo><Affiliation>Mental Illness Research Theme, Neuroscience Research Australia, Sydney, NSW, Australia; School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schubert</LastName><ForeName>K Oliver</ForeName><Initials>KO</Initials><AffiliationInfo><Affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schweizer</LastName><ForeName>Barbara W</ForeName><Initials>BW</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seemüller</LastName><ForeName>Florian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Severino</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shekhtman</LastName><ForeName>Tatyana</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Veterans Administration, San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shilling</LastName><ForeName>Paul D</ForeName><Initials>PD</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shimoda</LastName><ForeName>Kazutaka</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simhandl</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Bipolar Center Wiener Neustadt, Wiener Neustadt, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slaney</LastName><ForeName>Claire M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smoller</LastName><ForeName>Jordan W</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Squassina</LastName><ForeName>Alessio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stamm</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stopkova</LastName><ForeName>Pavla</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>National Institute of Mental Health, Klecany, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tighe</LastName><ForeName>Sarah K</ForeName><Initials>SK</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Iowa, Iowa City, IA, USA; University of Iowa Carver College of Medicine and University of Iowa College of Public Health, VA Quality Scholars Program, Iowa City VA Hospital, Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tortorella</LastName><ForeName>Alfonso</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turecki</LastName><ForeName>Gustavo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Douglas Mental Health University Institute, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Volkert</LastName><ForeName>Julia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Witt</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>Adam</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>L Trevor</ForeName><Initials>LT</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zandi</LastName><ForeName>Peter P</ForeName><Initials>PP</Initials><AffiliationInfo><Affiliation>Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Potash</LastName><ForeName>James B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Iowa, Iowa City, IA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DePaulo</LastName><ForeName>J Raymond</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauer</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden, Dresden, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reininghaus</LastName><ForeName>Eva Z</ForeName><Initials>EZ</Initials><AffiliationInfo><Affiliation>Neurobiological Background and Anthropometrics in Bipolar Affective Disorder, Department of Psychiatry, Medical University of Graz, Graz, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Novák</LastName><ForeName>Tomas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>National Institute of Mental Health, Klecany, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aubry</LastName><ForeName>Jean-Michel</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Mental Health and Psychiatry, Mood Disorders Unit-Geneva University Hospitals, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maj</LastName><ForeName>Mario</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, University of Naples SUN, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baune</LastName><ForeName>Bernhard T</ForeName><Initials>BT</Initials><AffiliationInfo><Affiliation>Discipline of Psychiatry, University of Adelaide, Adelaide, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mitchell</LastName><ForeName>Philip B</ForeName><Initials>PB</Initials><AffiliationInfo><Affiliation>School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vieta</LastName><ForeName>Eduard</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Frye</LastName><ForeName>Mark A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rybakowski</LastName><ForeName>Janusz K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuo</LastName><ForeName>Po-Hsiu</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kato</LastName><ForeName>Tadafumi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Saitama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grigoroiu-Serbanescu</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Psychiatric Hospital, Bucharest, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reif</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Del Zompo</LastName><ForeName>Maria</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellivier</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM UMR-S 1144-Université Paris Diderot Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F Widal, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schalling</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wray</LastName><ForeName>Naomi R</ForeName><Initials>NR</Initials><AffiliationInfo><Affiliation>The University of Queensland, Queensland Brain Institute, Brisbane, Queensland, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kelsoe</LastName><ForeName>John R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Veterans Administration, San Diego Healthcare System, San Diego, CA, USA; Department of Psychiatry, University of California San Diego, San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alda</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, NS, Canada; National Institute of Mental Health, Klecany, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rietschel</LastName><ForeName>Marcella</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McMahon</LastName><ForeName>Francis J</ForeName><Initials>FJ</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA. Electronic address: mcmahonf@mail.nih.gov.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schulze</LastName><ForeName>Thomas G</ForeName><Initials>TG</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Department of Health & Human Services, Bethesda, MD, USA; Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany; Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA; Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. Electronic address: thomas.schulze@med.uni-muenchen.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT00001174</AccessionNumber></AccessionNumberList></DataBank></DataBankList><GrantList CompleteYN="Y"><Grant><GrantID>Z99 MH999999</GrantID><Agency>Intramural NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH059556</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>64410</GrantID><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant><Grant><GrantID>R01 MH059535</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 MH59545</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 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Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>22</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Lancet</MedlineTA><NlmUniqueID>2985213R</NlmUniqueID><ISSNLinking>0140-6736</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C494990">GFRA2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051097">Glial Cell Line-Derived Neurotrophic Factor Receptors</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018020">Lithium 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Version="1">22820512</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2011 Oct;43(10):977-83</RefSource><PMID Version="1">21926972</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bioinformatics. 2010 Sep 1;26(17):2190-1</RefSource><PMID Version="1">20616382</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bipolar Disord. 2005 Oct;7(5):404-17</RefSource><PMID Version="1">16176433</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Gen Psychiatry. 2000 Feb;57(2):187-90</RefSource><PMID Version="1">10665622</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Affect Disord. 2007 Dec;104(1-3):185-90</RefSource><PMID Version="1">17442400</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pharmacol Biochem Behav. 2014 Aug;123:3-16</RefSource><PMID Version="1">24534415</PMID></CommentsCorrections><CommentsCorrections 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Mar;129(1-3):79-83</RefSource><PMID Version="1">20888048</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuropsychobiology. 2010;62(1):72-8</RefSource><PMID Version="1">20453537</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Gen Psychiatry. 2007 May;64(5):543-52</RefSource><PMID Version="1">17485606</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Hum Genet. 2007 Sep;81(3):559-75</RefSource><PMID Version="1">17701901</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Methods. 2013 Jan;10(1):5-6</RefSource><PMID Version="1">23269371</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Psychiatry. 2015 Jan;172(1):94-5</RefSource><PMID Version="1">25553497</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Psychiatry. 2002 Oct;63(10):942-7</RefSource><PMID Version="1">12416605</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Lancet. 2013 May 11;381(9878):1672-82</RefSource><PMID Version="1">23663953</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D001714" MajorTopicYN="N">Bipolar Disorder</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055106" MajorTopicYN="N">Genome-Wide Association Study</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051097" MajorTopicYN="N">Glial Cell Line-Derived Neurotrophic Factor Receptors</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018020" MajorTopicYN="N">Lithium Compounds</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010641" MajorTopicYN="N">Phenotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS755576 [Available on 03/12/17]</OtherID><OtherID Source="NLM">PMC4814312 [Available on 03/12/17]</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26806518</ArticleId><ArticleId IdType="pii">S0140-6736(16)00143-4</ArticleId><ArticleId IdType="doi">10.1016/S0140-6736(16)00143-4</ArticleId><ArticleId IdType="pmc">PMC4814312</ArticleId><ArticleId IdType="mid">NIHMS755576</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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