Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
Identifieur interne : 002183 ( PubMed/Corpus ); précédent : 002182; suivant : 002184Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
Auteurs : Sonja I. Berndt ; Nicola J. Camp ; Christine F. Skibola ; Joseph Vijai ; Zhaoming Wang ; Jian Gu ; Alexandra Nieters ; Rachel S. Kelly ; Karin E. Smedby ; Alain Monnereau ; Wendy Cozen ; Angela Cox ; Sophia S. Wang ; Qing Lan ; Lauren R. Teras ; Moara Machado ; Meredith Yeager ; Angela R. Brooks-Wilson ; Patricia Hartge ; Mark P. Purdue ; Brenda M. Birmann ; Claire M. Vajdic ; Pierluigi Cocco ; Yawei Zhang ; Graham G. Giles ; Anne Zeleniuch-Jacquotte ; Charles Lawrence ; Rebecca Montalvan ; Laurie Burdett ; Amy Hutchinson ; Yuanqing Ye ; Timothy G. Call ; Tait D. Shanafelt ; Anne J. Novak ; Neil E. Kay ; Mark Liebow ; Julie M. Cunningham ; Cristine Allmer ; Henrik Hjalgrim ; Hans-Olov Adami ; Mads Melbye ; Bengt Glimelius ; Ellen T. Chang ; Martha Glenn ; Karen Curtin ; Lisa A. Cannon-Albright ; W Ryan Diver ; Brian K. Link ; George J. Weiner ; Lucia Conde ; Paige M. Bracci ; Jacques Riby ; Donna K. Arnett ; Degui Zhi ; Justin M. Leach ; Elizabeth A. Holly ; Rebecca D. Jackson ; Lesley F. Tinker ; Yolanda Benavente ; Núria Sala ; Delphine Casabonne ; Nikolaus Becker ; Paolo Boffetta ; Paul Brennan ; Lenka Foretova ; Marc Maynadie ; James Mckay ; Anthony Staines ; Kari G. Chaffee ; Sara J. Achenbach ; Celine M. Vachon ; Lynn R. Goldin ; Sara S. Strom ; Jose F. Leis ; J Brice Weinberg ; Neil E. Caporaso ; Aaron D. Norman ; Anneclaire J. De Roos ; Lindsay M. Morton ; Richard K. Severson ; Elio Riboli ; Paolo Vineis ; Rudolph Kaaks ; Giovanna Masala ; Elisabete Weiderpass ; María-Dolores Chirlaque ; Roel C H. Vermeulen ; Ruth C. Travis ; Melissa C. Southey ; Roger L. Milne ; Demetrius Albanes ; Jarmo Virtamo ; Stephanie Weinstein ; Jacqueline Clavel ; Tongzhang Zheng ; Theodore R. Holford ; Danylo J. Villano ; Ann Maria ; John J. Spinelli ; Randy D. Gascoyne ; Joseph M. Connors ; Kimberly A. Bertrand ; Edward Giovannucci ; Peter Kraft ; Anne Kricker ; Jenny Turner ; Maria Grazia Ennas ; Giovanni M. Ferri ; Lucia Miligi ; Liming Liang ; Baoshan Ma ; Jinyan Huang ; Simon Crouch ; Ju-Hyun Park ; Nilanjan Chatterjee ; Kari E. North ; John A. Snowden ; Josh Wright ; Joseph F. Fraumeni ; Kenneth Offit ; Xifeng Wu ; Silvia De Sanjose ; James R. Cerhan ; Stephen J. Chanock ; Nathaniel Rothman ; Susan L. SlagerSource :
- Nature communications [ 2041-1723 ] ; 2016.
English descriptors
- KwdEn :
- Adaptor Proteins, Signal Transducing (genetics), Apoptosis Regulatory Proteins (genetics), Bcl-2-Like Protein 11, European Continental Ancestry Group (genetics), Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Leukemia, Lymphocytic, Chronic, B-Cell (genetics), Membrane Proteins (genetics), Polymorphism, Single Nucleotide, Proto-Oncogene Proteins (genetics), Serpins (genetics), T-Box Domain Proteins (genetics).
- MESH :
- chemical , genetics : Adaptor Proteins, Signal Transducing, Apoptosis Regulatory Proteins, Membrane Proteins, Proto-Oncogene Proteins, Serpins, T-Box Domain Proteins.
- chemical : Bcl-2-Like Protein 11.
- genetics : European Continental Ancestry Group, Leukemia, Lymphocytic, Chronic, B-Cell.
- Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide.
Abstract
Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
DOI: 10.1038/ncomms10933
PubMed: 26956414
Links to Exploration step
pubmed:26956414Le document en format XML
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Camp</name><affiliation><nlm:affiliation>Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, Huntsman Cancer Institute and University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Skibola, Christine F" sort="Skibola, Christine F" uniqKey="Skibola C" first="Christine F" last="Skibola">Christine F. Skibola</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gu, Jian" sort="Gu, Jian" uniqKey="Gu J" first="Jian" last="Gu">Jian Gu</name><affiliation><nlm:affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name><affiliation><nlm:affiliation>Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, 79108 Baden-Württemberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kelly, Rachel S" sort="Kelly, Rachel S" uniqKey="Kelly R" first="Rachel S" last="Kelly">Rachel S. Kelly</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smedby, Karin E" sort="Smedby, Karin E" uniqKey="Smedby K" first="Karin E" last="Smedby">Karin E. Smedby</name><affiliation><nlm:affiliation>Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm 17176, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Monnereau, Alain" sort="Monnereau, Alain" uniqKey="Monnereau A" first="Alain" last="Monnereau">Alain Monnereau</name><affiliation><nlm:affiliation>Epidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), F-94807 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Sophia S" sort="Wang, Sophia S" uniqKey="Wang S" first="Sophia S" last="Wang">Sophia S. Wang</name><affiliation><nlm:affiliation>Division of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, California 91030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lan, Qing" sort="Lan, Qing" uniqKey="Lan Q" first="Qing" last="Lan">Qing Lan</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Teras, Lauren R" sort="Teras, Lauren R" uniqKey="Teras L" first="Lauren R" last="Teras">Lauren R. Teras</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Machado, Moara" sort="Machado, Moara" uniqKey="Machado M" first="Moara" last="Machado">Moara Machado</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name><affiliation><nlm:affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Brooks Wilson, Angela R" sort="Brooks Wilson, Angela R" uniqKey="Brooks Wilson A" first="Angela R" last="Brooks-Wilson">Angela R. Brooks-Wilson</name><affiliation><nlm:affiliation>Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</nlm:affiliation></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P" last="Purdue">Mark P. Purdue</name><affiliation><nlm:affiliation>Ontario Health Study, Toronto, Ontario, Canada M5G 0A3.</nlm:affiliation></affiliation></author><author><name sortKey="Birmann, Brenda M" sort="Birmann, Brenda M" uniqKey="Birmann B" first="Brenda M" last="Birmann">Brenda M. Birmann</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vajdic, Claire M" sort="Vajdic, Claire M" uniqKey="Vajdic C" first="Claire M" last="Vajdic">Claire M. Vajdic</name><affiliation><nlm:affiliation>Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name><affiliation><nlm:affiliation>Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, 09042 Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name><affiliation><nlm:affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><affiliation><nlm:affiliation>Department of Population Health, New York University School of Medicine, New York, New York 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lawrence, Charles" sort="Lawrence, Charles" uniqKey="Lawrence C" first="Charles" last="Lawrence">Charles Lawrence</name><affiliation><nlm:affiliation>Westat, Rockville, Maryland 20850, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Montalvan, Rebecca" sort="Montalvan, Rebecca" uniqKey="Montalvan R" first="Rebecca" last="Montalvan">Rebecca Montalvan</name><affiliation><nlm:affiliation>Westat, Rockville, Maryland 20850, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Burdett, Laurie" sort="Burdett, Laurie" uniqKey="Burdett L" first="Laurie" last="Burdett">Laurie Burdett</name><affiliation><nlm:affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hutchinson, Amy" sort="Hutchinson, Amy" uniqKey="Hutchinson A" first="Amy" last="Hutchinson">Amy Hutchinson</name><affiliation><nlm:affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ye, Yuanqing" sort="Ye, Yuanqing" uniqKey="Ye Y" first="Yuanqing" last="Ye">Yuanqing Ye</name><affiliation><nlm:affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Call, Timothy G" sort="Call, Timothy G" uniqKey="Call T" first="Timothy G" last="Call">Timothy G. Call</name><affiliation><nlm:affiliation>Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shanafelt, Tait D" sort="Shanafelt, Tait D" uniqKey="Shanafelt T" first="Tait D" last="Shanafelt">Tait D. Shanafelt</name><affiliation><nlm:affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Novak, Anne J" sort="Novak, Anne J" uniqKey="Novak A" first="Anne J" last="Novak">Anne J. Novak</name><affiliation><nlm:affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kay, Neil E" sort="Kay, Neil E" uniqKey="Kay N" first="Neil E" last="Kay">Neil E. Kay</name><affiliation><nlm:affiliation>Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liebow, Mark" sort="Liebow, Mark" uniqKey="Liebow M" first="Mark" last="Liebow">Mark Liebow</name><affiliation><nlm:affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cunningham, Julie M" sort="Cunningham, Julie M" uniqKey="Cunningham J" first="Julie M" last="Cunningham">Julie M. Cunningham</name><affiliation><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Allmer, Cristine" sort="Allmer, Cristine" uniqKey="Allmer C" first="Cristine" last="Allmer">Cristine Allmer</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hjalgrim, Henrik" sort="Hjalgrim, Henrik" uniqKey="Hjalgrim H" first="Henrik" last="Hjalgrim">Henrik Hjalgrim</name><affiliation><nlm:affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name><affiliation><nlm:affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name><affiliation><nlm:affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, 75105 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Chang, Ellen T" sort="Chang, Ellen T" uniqKey="Chang E" first="Ellen T" last="Chang">Ellen T. Chang</name><affiliation><nlm:affiliation>Center for Epidemiology and Computational Biology, Health Sciences, Exponent, Inc., Menlo Park, California 94025, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Glenn, Martha" sort="Glenn, Martha" uniqKey="Glenn M" first="Martha" last="Glenn">Martha Glenn</name><affiliation><nlm:affiliation>Department of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Curtin, Karen" sort="Curtin, Karen" uniqKey="Curtin K" first="Karen" last="Curtin">Karen Curtin</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cannon Albright, Lisa A" sort="Cannon Albright, Lisa A" uniqKey="Cannon Albright L" first="Lisa A" last="Cannon-Albright">Lisa A. Cannon-Albright</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W Ryan" last="Diver">W Ryan Diver</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Link, Brian K" sort="Link, Brian K" uniqKey="Link B" first="Brian K" last="Link">Brian K. Link</name><affiliation><nlm:affiliation>Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Weiner, George J" sort="Weiner, George J" uniqKey="Weiner G" first="George J" last="Weiner">George J. Weiner</name><affiliation><nlm:affiliation>Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Conde, Lucia" sort="Conde, Lucia" uniqKey="Conde L" first="Lucia" last="Conde">Lucia Conde</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M" last="Bracci">Paige M. Bracci</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Riby, Jacques" sort="Riby, Jacques" uniqKey="Riby J" first="Jacques" last="Riby">Jacques Riby</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Arnett, Donna K" sort="Arnett, Donna K" uniqKey="Arnett D" first="Donna K" last="Arnett">Donna K. Arnett</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhi, Degui" sort="Zhi, Degui" uniqKey="Zhi D" first="Degui" last="Zhi">Degui Zhi</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Leach, Justin M" sort="Leach, Justin M" uniqKey="Leach J" first="Justin M" last="Leach">Justin M. Leach</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A" last="Holly">Elizabeth A. Holly</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D" last="Jackson">Rebecca D. Jackson</name><affiliation><nlm:affiliation>Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, Ohio 43210, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tinker, Lesley F" sort="Tinker, Lesley F" uniqKey="Tinker L" first="Lesley F" last="Tinker">Lesley F. Tinker</name><affiliation><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Benavente, Yolanda" sort="Benavente, Yolanda" uniqKey="Benavente Y" first="Yolanda" last="Benavente">Yolanda Benavente</name><affiliation><nlm:affiliation>Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sala, Nuria" sort="Sala, Nuria" uniqKey="Sala N" first="Núria" last="Sala">Núria Sala</name><affiliation><nlm:affiliation>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Casabonne, Delphine" sort="Casabonne, Delphine" uniqKey="Casabonne D" first="Delphine" last="Casabonne">Delphine Casabonne</name><affiliation><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, 08908L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120 Baden-Württemberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation><nlm:affiliation>The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:affiliation>International Agency for Research on Cancer (IARC), 69372 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation><nlm:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, 656 53 Brno, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadie">Marc Maynadie</name><affiliation><nlm:affiliation>EA 4184, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, 21070 Dijon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:affiliation>International Agency for Research on Cancer (IARC), 69372 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name><affiliation><nlm:affiliation>School of Nursing and Human Sciences, Dublin City University, Dublin 9, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Chaffee, Kari G" sort="Chaffee, Kari G" uniqKey="Chaffee K" first="Kari G" last="Chaffee">Kari G. Chaffee</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Achenbach, Sara J" sort="Achenbach, Sara J" uniqKey="Achenbach S" first="Sara J" last="Achenbach">Sara J. Achenbach</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M" last="Vachon">Celine M. Vachon</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Goldin, Lynn R" sort="Goldin, Lynn R" uniqKey="Goldin L" first="Lynn R" last="Goldin">Lynn R. Goldin</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Strom, Sara S" sort="Strom, Sara S" uniqKey="Strom S" first="Sara S" last="Strom">Sara S. Strom</name><affiliation><nlm:affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Leis, Jose F" sort="Leis, Jose F" uniqKey="Leis J" first="Jose F" last="Leis">Jose F. Leis</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Mayo Clinic, Phoenix, Arizona 85054, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Weinberg, J Brice" sort="Weinberg, J Brice" uniqKey="Weinberg J" first="J Brice" last="Weinberg">J Brice Weinberg</name><affiliation><nlm:affiliation>Department of Medicine, Duke University and VA Medical Centers, Durham, North Carolina 27710, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Norman, Aaron D" sort="Norman, Aaron D" uniqKey="Norman A" first="Aaron D" last="Norman">Aaron D. Norman</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="De Roos, Anneclaire J" sort="De Roos, Anneclaire J" uniqKey="De Roos A" first="Anneclaire J" last="De Roos">Anneclaire J. De Roos</name><affiliation><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M" last="Morton">Lindsay M. Morton</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Severson, Richard K" sort="Severson, Richard K" uniqKey="Severson R" first="Richard K" last="Severson">Richard K. Severson</name><affiliation><nlm:affiliation>Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:affiliation>School of Public Health, Imperial College London, London W2 1PG, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation><nlm:affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kaaks, Rudolph" sort="Kaaks, Rudolph" uniqKey="Kaaks R" first="Rudolph" last="Kaaks">Rudolph Kaaks</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120 Baden-Württemberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Masala, Giovanna" sort="Masala, Giovanna" uniqKey="Masala G" first="Giovanna" last="Masala">Giovanna Masala</name><affiliation><nlm:affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), 50139 Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Chirlaque, Maria Dolores" sort="Chirlaque, Maria Dolores" uniqKey="Chirlaque M" first="María-Dolores" last="Chirlaque">María-Dolores Chirlaque</name><affiliation><nlm:affiliation>CIBER de Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Vermeulen, Roel C H" sort="Vermeulen, Roel C H" uniqKey="Vermeulen R" first="Roel C H" last="Vermeulen">Roel C H. Vermeulen</name><affiliation><nlm:affiliation>Institute for Risk Assessment Sciences, Utrecht University, Utrecht, 3508, TD, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><nlm:affiliation>Chronic Disease Prevention Unit, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Weinstein, Stephanie" sort="Weinstein, Stephanie" uniqKey="Weinstein S" first="Stephanie" last="Weinstein">Stephanie Weinstein</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation><nlm:affiliation>Epidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), F-94807 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Tongzhang" sort="Zheng, Tongzhang" uniqKey="Zheng T" first="Tongzhang" last="Zheng">Tongzhang Zheng</name><affiliation><nlm:affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holford, Theodore R" sort="Holford, Theodore R" uniqKey="Holford T" first="Theodore R" last="Holford">Theodore R. Holford</name><affiliation><nlm:affiliation>Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut 06520, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Villano, Danylo J" sort="Villano, Danylo J" uniqKey="Villano D" first="Danylo J" last="Villano">Danylo J. Villano</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Maria, Ann" sort="Maria, Ann" uniqKey="Maria A" first="Ann" last="Maria">Ann Maria</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J" last="Spinelli">John J. Spinelli</name><affiliation><nlm:affiliation>Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</nlm:affiliation></affiliation></author><author><name sortKey="Gascoyne, Randy D" sort="Gascoyne, Randy D" uniqKey="Gascoyne R" first="Randy D" last="Gascoyne">Randy D. Gascoyne</name><affiliation><nlm:affiliation>Center for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</nlm:affiliation></affiliation></author><author><name sortKey="Connors, Joseph M" sort="Connors, Joseph M" uniqKey="Connors J" first="Joseph M" last="Connors">Joseph M. Connors</name><affiliation><nlm:affiliation>Center for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</nlm:affiliation></affiliation></author><author><name sortKey="Bertrand, Kimberly A" sort="Bertrand, Kimberly A" uniqKey="Bertrand K" first="Kimberly A" last="Bertrand">Kimberly A. Bertrand</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kricker, Anne" sort="Kricker, Anne" uniqKey="Kricker A" first="Anne" last="Kricker">Anne Kricker</name><affiliation><nlm:affiliation>Sydney School of Public Health, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Turner, Jenny" sort="Turner, Jenny" uniqKey="Turner J" first="Jenny" last="Turner">Jenny Turner</name><affiliation><nlm:affiliation>Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ennas, Maria Grazia" sort="Ennas, Maria Grazia" uniqKey="Ennas M" first="Maria Grazia" last="Ennas">Maria Grazia Ennas</name><affiliation><nlm:affiliation>Department of Biomedical Science, University of Cagliari, Monserrato, 09042 Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ferri, Giovanni M" sort="Ferri, Giovanni M" uniqKey="Ferri G" first="Giovanni M" last="Ferri">Giovanni M. Ferri</name><affiliation><nlm:affiliation>Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name><affiliation><nlm:affiliation>Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), 50139 Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Baoshan" sort="Ma, Baoshan" uniqKey="Ma B" first="Baoshan" last="Ma">Baoshan Ma</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Jinyan" sort="Huang, Jinyan" uniqKey="Huang J" first="Jinyan" last="Huang">Jinyan Huang</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Crouch, Simon" sort="Crouch, Simon" uniqKey="Crouch S" first="Simon" last="Crouch">Simon Crouch</name><affiliation><nlm:affiliation>Department of Health Sciences, University of York, York YO10 5DD, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Ju Hyun" sort="Park, Ju Hyun" uniqKey="Park J" first="Ju-Hyun" last="Park">Ju-Hyun Park</name><affiliation><nlm:affiliation>Department of Statistics, Dongguk University, Seoul 100-715, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E" last="North">Kari E. North</name><affiliation><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Snowden, John A" sort="Snowden, John A" uniqKey="Snowden J" first="John A" last="Snowden">John A. Snowden</name><affiliation><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, Josh" sort="Wright, Josh" uniqKey="Wright J" first="Josh" last="Wright">Josh Wright</name><affiliation><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fraumeni, Joseph F" sort="Fraumeni, Joseph F" uniqKey="Fraumeni J" first="Joseph F" last="Fraumeni">Joseph F. Fraumeni</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name><affiliation><nlm:affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjose">Silvia De Sanjose</name><affiliation><nlm:affiliation>Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cerhan, James R" sort="Cerhan, James R" uniqKey="Cerhan J" first="James R" last="Cerhan">James R. Cerhan</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Slager, Susan L" sort="Slager, Susan L" uniqKey="Slager S" first="Susan L" last="Slager">Susan L. Slager</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26956414</idno><idno type="pmid">26956414</idno><idno type="doi">10.1038/ncomms10933</idno><idno type="wicri:Area/PubMed/Corpus">002183</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002183</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.</title><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J" last="Camp">Nicola J. Camp</name><affiliation><nlm:affiliation>Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, Huntsman Cancer Institute and University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Skibola, Christine F" sort="Skibola, Christine F" uniqKey="Skibola C" first="Christine F" last="Skibola">Christine F. Skibola</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gu, Jian" sort="Gu, Jian" uniqKey="Gu J" first="Jian" last="Gu">Jian Gu</name><affiliation><nlm:affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name><affiliation><nlm:affiliation>Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, 79108 Baden-Württemberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kelly, Rachel S" sort="Kelly, Rachel S" uniqKey="Kelly R" first="Rachel S" last="Kelly">Rachel S. Kelly</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Smedby, Karin E" sort="Smedby, Karin E" uniqKey="Smedby K" first="Karin E" last="Smedby">Karin E. Smedby</name><affiliation><nlm:affiliation>Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm 17176, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Monnereau, Alain" sort="Monnereau, Alain" uniqKey="Monnereau A" first="Alain" last="Monnereau">Alain Monnereau</name><affiliation><nlm:affiliation>Epidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), F-94807 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cox, Angela" sort="Cox, Angela" uniqKey="Cox A" first="Angela" last="Cox">Angela Cox</name><affiliation><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Sophia S" sort="Wang, Sophia S" uniqKey="Wang S" first="Sophia S" last="Wang">Sophia S. Wang</name><affiliation><nlm:affiliation>Division of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, California 91030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lan, Qing" sort="Lan, Qing" uniqKey="Lan Q" first="Qing" last="Lan">Qing Lan</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Teras, Lauren R" sort="Teras, Lauren R" uniqKey="Teras L" first="Lauren R" last="Teras">Lauren R. Teras</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Machado, Moara" sort="Machado, Moara" uniqKey="Machado M" first="Moara" last="Machado">Moara Machado</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Yeager, Meredith" sort="Yeager, Meredith" uniqKey="Yeager M" first="Meredith" last="Yeager">Meredith Yeager</name><affiliation><nlm:affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Brooks Wilson, Angela R" sort="Brooks Wilson, Angela R" uniqKey="Brooks Wilson A" first="Angela R" last="Brooks-Wilson">Angela R. Brooks-Wilson</name><affiliation><nlm:affiliation>Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</nlm:affiliation></affiliation></author><author><name sortKey="Hartge, Patricia" sort="Hartge, Patricia" uniqKey="Hartge P" first="Patricia" last="Hartge">Patricia Hartge</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P" last="Purdue">Mark P. Purdue</name><affiliation><nlm:affiliation>Ontario Health Study, Toronto, Ontario, Canada M5G 0A3.</nlm:affiliation></affiliation></author><author><name sortKey="Birmann, Brenda M" sort="Birmann, Brenda M" uniqKey="Birmann B" first="Brenda M" last="Birmann">Brenda M. Birmann</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vajdic, Claire M" sort="Vajdic, Claire M" uniqKey="Vajdic C" first="Claire M" last="Vajdic">Claire M. Vajdic</name><affiliation><nlm:affiliation>Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name><affiliation><nlm:affiliation>Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, 09042 Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name><affiliation><nlm:affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Zeleniuch Jacquotte, Anne" sort="Zeleniuch Jacquotte, Anne" uniqKey="Zeleniuch Jacquotte A" first="Anne" last="Zeleniuch-Jacquotte">Anne Zeleniuch-Jacquotte</name><affiliation><nlm:affiliation>Department of Population Health, New York University School of Medicine, New York, New York 10016, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lawrence, Charles" sort="Lawrence, Charles" uniqKey="Lawrence C" first="Charles" last="Lawrence">Charles Lawrence</name><affiliation><nlm:affiliation>Westat, Rockville, Maryland 20850, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Montalvan, Rebecca" sort="Montalvan, Rebecca" uniqKey="Montalvan R" first="Rebecca" last="Montalvan">Rebecca Montalvan</name><affiliation><nlm:affiliation>Westat, Rockville, Maryland 20850, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Burdett, Laurie" sort="Burdett, Laurie" uniqKey="Burdett L" first="Laurie" last="Burdett">Laurie Burdett</name><affiliation><nlm:affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hutchinson, Amy" sort="Hutchinson, Amy" uniqKey="Hutchinson A" first="Amy" last="Hutchinson">Amy Hutchinson</name><affiliation><nlm:affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ye, Yuanqing" sort="Ye, Yuanqing" uniqKey="Ye Y" first="Yuanqing" last="Ye">Yuanqing Ye</name><affiliation><nlm:affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Call, Timothy G" sort="Call, Timothy G" uniqKey="Call T" first="Timothy G" last="Call">Timothy G. Call</name><affiliation><nlm:affiliation>Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shanafelt, Tait D" sort="Shanafelt, Tait D" uniqKey="Shanafelt T" first="Tait D" last="Shanafelt">Tait D. Shanafelt</name><affiliation><nlm:affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Novak, Anne J" sort="Novak, Anne J" uniqKey="Novak A" first="Anne J" last="Novak">Anne J. Novak</name><affiliation><nlm:affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kay, Neil E" sort="Kay, Neil E" uniqKey="Kay N" first="Neil E" last="Kay">Neil E. Kay</name><affiliation><nlm:affiliation>Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liebow, Mark" sort="Liebow, Mark" uniqKey="Liebow M" first="Mark" last="Liebow">Mark Liebow</name><affiliation><nlm:affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cunningham, Julie M" sort="Cunningham, Julie M" uniqKey="Cunningham J" first="Julie M" last="Cunningham">Julie M. Cunningham</name><affiliation><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Allmer, Cristine" sort="Allmer, Cristine" uniqKey="Allmer C" first="Cristine" last="Allmer">Cristine Allmer</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hjalgrim, Henrik" sort="Hjalgrim, Henrik" uniqKey="Hjalgrim H" first="Henrik" last="Hjalgrim">Henrik Hjalgrim</name><affiliation><nlm:affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Adami, Hans Olov" sort="Adami, Hans Olov" uniqKey="Adami H" first="Hans-Olov" last="Adami">Hans-Olov Adami</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name><affiliation><nlm:affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name><affiliation><nlm:affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, 75105 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Chang, Ellen T" sort="Chang, Ellen T" uniqKey="Chang E" first="Ellen T" last="Chang">Ellen T. Chang</name><affiliation><nlm:affiliation>Center for Epidemiology and Computational Biology, Health Sciences, Exponent, Inc., Menlo Park, California 94025, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Glenn, Martha" sort="Glenn, Martha" uniqKey="Glenn M" first="Martha" last="Glenn">Martha Glenn</name><affiliation><nlm:affiliation>Department of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Curtin, Karen" sort="Curtin, Karen" uniqKey="Curtin K" first="Karen" last="Curtin">Karen Curtin</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Cannon Albright, Lisa A" sort="Cannon Albright, Lisa A" uniqKey="Cannon Albright L" first="Lisa A" last="Cannon-Albright">Lisa A. Cannon-Albright</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W Ryan" last="Diver">W Ryan Diver</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Link, Brian K" sort="Link, Brian K" uniqKey="Link B" first="Brian K" last="Link">Brian K. Link</name><affiliation><nlm:affiliation>Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Weiner, George J" sort="Weiner, George J" uniqKey="Weiner G" first="George J" last="Weiner">George J. Weiner</name><affiliation><nlm:affiliation>Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Conde, Lucia" sort="Conde, Lucia" uniqKey="Conde L" first="Lucia" last="Conde">Lucia Conde</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M" last="Bracci">Paige M. Bracci</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Riby, Jacques" sort="Riby, Jacques" uniqKey="Riby J" first="Jacques" last="Riby">Jacques Riby</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Arnett, Donna K" sort="Arnett, Donna K" uniqKey="Arnett D" first="Donna K" last="Arnett">Donna K. Arnett</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zhi, Degui" sort="Zhi, Degui" uniqKey="Zhi D" first="Degui" last="Zhi">Degui Zhi</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Leach, Justin M" sort="Leach, Justin M" uniqKey="Leach J" first="Justin M" last="Leach">Justin M. Leach</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A" last="Holly">Elizabeth A. Holly</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D" last="Jackson">Rebecca D. Jackson</name><affiliation><nlm:affiliation>Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, Ohio 43210, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tinker, Lesley F" sort="Tinker, Lesley F" uniqKey="Tinker L" first="Lesley F" last="Tinker">Lesley F. Tinker</name><affiliation><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Benavente, Yolanda" sort="Benavente, Yolanda" uniqKey="Benavente Y" first="Yolanda" last="Benavente">Yolanda Benavente</name><affiliation><nlm:affiliation>Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sala, Nuria" sort="Sala, Nuria" uniqKey="Sala N" first="Núria" last="Sala">Núria Sala</name><affiliation><nlm:affiliation>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Casabonne, Delphine" sort="Casabonne, Delphine" uniqKey="Casabonne D" first="Delphine" last="Casabonne">Delphine Casabonne</name><affiliation><nlm:affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, 08908L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Becker, Nikolaus" sort="Becker, Nikolaus" uniqKey="Becker N" first="Nikolaus" last="Becker">Nikolaus Becker</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120 Baden-Württemberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation><nlm:affiliation>The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:affiliation>International Agency for Research on Cancer (IARC), 69372 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation><nlm:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, 656 53 Brno, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadie">Marc Maynadie</name><affiliation><nlm:affiliation>EA 4184, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, 21070 Dijon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:affiliation>International Agency for Research on Cancer (IARC), 69372 Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Staines, Anthony" sort="Staines, Anthony" uniqKey="Staines A" first="Anthony" last="Staines">Anthony Staines</name><affiliation><nlm:affiliation>School of Nursing and Human Sciences, Dublin City University, Dublin 9, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Chaffee, Kari G" sort="Chaffee, Kari G" uniqKey="Chaffee K" first="Kari G" last="Chaffee">Kari G. Chaffee</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Achenbach, Sara J" sort="Achenbach, Sara J" uniqKey="Achenbach S" first="Sara J" last="Achenbach">Sara J. Achenbach</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Vachon, Celine M" sort="Vachon, Celine M" uniqKey="Vachon C" first="Celine M" last="Vachon">Celine M. Vachon</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Goldin, Lynn R" sort="Goldin, Lynn R" uniqKey="Goldin L" first="Lynn R" last="Goldin">Lynn R. Goldin</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Strom, Sara S" sort="Strom, Sara S" uniqKey="Strom S" first="Sara S" last="Strom">Sara S. Strom</name><affiliation><nlm:affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Leis, Jose F" sort="Leis, Jose F" uniqKey="Leis J" first="Jose F" last="Leis">Jose F. Leis</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Mayo Clinic, Phoenix, Arizona 85054, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Weinberg, J Brice" sort="Weinberg, J Brice" uniqKey="Weinberg J" first="J Brice" last="Weinberg">J Brice Weinberg</name><affiliation><nlm:affiliation>Department of Medicine, Duke University and VA Medical Centers, Durham, North Carolina 27710, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Norman, Aaron D" sort="Norman, Aaron D" uniqKey="Norman A" first="Aaron D" last="Norman">Aaron D. Norman</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="De Roos, Anneclaire J" sort="De Roos, Anneclaire J" uniqKey="De Roos A" first="Anneclaire J" last="De Roos">Anneclaire J. De Roos</name><affiliation><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M" last="Morton">Lindsay M. Morton</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Severson, Richard K" sort="Severson, Richard K" uniqKey="Severson R" first="Richard K" last="Severson">Richard K. Severson</name><affiliation><nlm:affiliation>Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:affiliation>School of Public Health, Imperial College London, London W2 1PG, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation><nlm:affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kaaks, Rudolph" sort="Kaaks, Rudolph" uniqKey="Kaaks R" first="Rudolph" last="Kaaks">Rudolph Kaaks</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120 Baden-Württemberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Masala, Giovanna" sort="Masala, Giovanna" uniqKey="Masala G" first="Giovanna" last="Masala">Giovanna Masala</name><affiliation><nlm:affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), 50139 Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Chirlaque, Maria Dolores" sort="Chirlaque, Maria Dolores" uniqKey="Chirlaque M" first="María-Dolores" last="Chirlaque">María-Dolores Chirlaque</name><affiliation><nlm:affiliation>CIBER de Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Vermeulen, Roel C H" sort="Vermeulen, Roel C H" uniqKey="Vermeulen R" first="Roel C H" last="Vermeulen">Roel C H. Vermeulen</name><affiliation><nlm:affiliation>Institute for Risk Assessment Sciences, Utrecht University, Utrecht, 3508, TD, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Virtamo, Jarmo" sort="Virtamo, Jarmo" uniqKey="Virtamo J" first="Jarmo" last="Virtamo">Jarmo Virtamo</name><affiliation><nlm:affiliation>Chronic Disease Prevention Unit, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Weinstein, Stephanie" sort="Weinstein, Stephanie" uniqKey="Weinstein S" first="Stephanie" last="Weinstein">Stephanie Weinstein</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation><nlm:affiliation>Epidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), F-94807 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Tongzhang" sort="Zheng, Tongzhang" uniqKey="Zheng T" first="Tongzhang" last="Zheng">Tongzhang Zheng</name><affiliation><nlm:affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holford, Theodore R" sort="Holford, Theodore R" uniqKey="Holford T" first="Theodore R" last="Holford">Theodore R. Holford</name><affiliation><nlm:affiliation>Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut 06520, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Villano, Danylo J" sort="Villano, Danylo J" uniqKey="Villano D" first="Danylo J" last="Villano">Danylo J. Villano</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Maria, Ann" sort="Maria, Ann" uniqKey="Maria A" first="Ann" last="Maria">Ann Maria</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J" last="Spinelli">John J. Spinelli</name><affiliation><nlm:affiliation>Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</nlm:affiliation></affiliation></author><author><name sortKey="Gascoyne, Randy D" sort="Gascoyne, Randy D" uniqKey="Gascoyne R" first="Randy D" last="Gascoyne">Randy D. Gascoyne</name><affiliation><nlm:affiliation>Center for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</nlm:affiliation></affiliation></author><author><name sortKey="Connors, Joseph M" sort="Connors, Joseph M" uniqKey="Connors J" first="Joseph M" last="Connors">Joseph M. Connors</name><affiliation><nlm:affiliation>Center for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</nlm:affiliation></affiliation></author><author><name sortKey="Bertrand, Kimberly A" sort="Bertrand, Kimberly A" uniqKey="Bertrand K" first="Kimberly A" last="Bertrand">Kimberly A. Bertrand</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kricker, Anne" sort="Kricker, Anne" uniqKey="Kricker A" first="Anne" last="Kricker">Anne Kricker</name><affiliation><nlm:affiliation>Sydney School of Public Health, The University of Sydney, Sydney, New South Wales 2006, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Turner, Jenny" sort="Turner, Jenny" uniqKey="Turner J" first="Jenny" last="Turner">Jenny Turner</name><affiliation><nlm:affiliation>Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ennas, Maria Grazia" sort="Ennas, Maria Grazia" uniqKey="Ennas M" first="Maria Grazia" last="Ennas">Maria Grazia Ennas</name><affiliation><nlm:affiliation>Department of Biomedical Science, University of Cagliari, Monserrato, 09042 Cagliari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ferri, Giovanni M" sort="Ferri, Giovanni M" uniqKey="Ferri G" first="Giovanni M" last="Ferri">Giovanni M. Ferri</name><affiliation><nlm:affiliation>Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name><affiliation><nlm:affiliation>Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), 50139 Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Liang, Liming" sort="Liang, Liming" uniqKey="Liang L" first="Liming" last="Liang">Liming Liang</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ma, Baoshan" sort="Ma, Baoshan" uniqKey="Ma B" first="Baoshan" last="Ma">Baoshan Ma</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Huang, Jinyan" sort="Huang, Jinyan" uniqKey="Huang J" first="Jinyan" last="Huang">Jinyan Huang</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Crouch, Simon" sort="Crouch, Simon" uniqKey="Crouch S" first="Simon" last="Crouch">Simon Crouch</name><affiliation><nlm:affiliation>Department of Health Sciences, University of York, York YO10 5DD, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Park, Ju Hyun" sort="Park, Ju Hyun" uniqKey="Park J" first="Ju-Hyun" last="Park">Ju-Hyun Park</name><affiliation><nlm:affiliation>Department of Statistics, Dongguk University, Seoul 100-715, Republic of Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E" last="North">Kari E. North</name><affiliation><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Snowden, John A" sort="Snowden, John A" uniqKey="Snowden J" first="John A" last="Snowden">John A. Snowden</name><affiliation><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, Josh" sort="Wright, Josh" uniqKey="Wright J" first="Josh" last="Wright">Josh Wright</name><affiliation><nlm:affiliation>Department of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fraumeni, Joseph F" sort="Fraumeni, Joseph F" uniqKey="Fraumeni J" first="Joseph F" last="Fraumeni">Joseph F. Fraumeni</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wu, Xifeng" sort="Wu, Xifeng" uniqKey="Wu X" first="Xifeng" last="Wu">Xifeng Wu</name><affiliation><nlm:affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</nlm:affiliation></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjose">Silvia De Sanjose</name><affiliation><nlm:affiliation>Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cerhan, James R" sort="Cerhan, James R" uniqKey="Cerhan J" first="James R" last="Cerhan">James R. Cerhan</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rothman, Nathaniel" sort="Rothman, Nathaniel" uniqKey="Rothman N" first="Nathaniel" last="Rothman">Nathaniel Rothman</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Slager, Susan L" sort="Slager, Susan L" uniqKey="Slager S" first="Susan L" last="Slager">Susan L. Slager</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptor Proteins, Signal Transducing (genetics)</term><term>Apoptosis Regulatory Proteins (genetics)</term><term>Bcl-2-Like Protein 11</term><term>European Continental Ancestry Group (genetics)</term><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Leukemia, Lymphocytic, Chronic, B-Cell (genetics)</term><term>Membrane Proteins (genetics)</term><term>Polymorphism, Single Nucleotide</term><term>Proto-Oncogene Proteins (genetics)</term><term>Serpins (genetics)</term><term>T-Box Domain Proteins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adaptor Proteins, Signal Transducing</term><term>Apoptosis Regulatory Proteins</term><term>Membrane Proteins</term><term>Proto-Oncogene Proteins</term><term>Serpins</term><term>T-Box Domain Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Bcl-2-Like Protein 11</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>European Continental Ancestry Group</term><term>Leukemia, Lymphocytic, Chronic, B-Cell</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Polymorphism, Single Nucleotide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26956414</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>09</Day></DateCreated><DateCompleted><Year>2016</Year><Month>09</Month><Day>20</Day></DateCompleted><DateRevised><Year>2017</Year><Month>10</Month><Day>27</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><PubDate><Year>2016</Year><Month>Mar</Month><Day>09</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.</ArticleTitle><Pagination><MedlinePgn>10933</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms10933</ELocationID><Abstract><AbstractText>Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P=2.55 × 10(-11)), 6p25.2 (rs73718779, SERPINB6, P=1.97 × 10(-8)) and 3q28 (rs9815073, LPP, P=3.62 × 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P=1.00 × 10(-11)) in the combined analysis. We find suggestive evidence (P<5 × 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P=7.19 × 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P=2.12 × 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Berndt</LastName><ForeName>Sonja I</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Camp</LastName><ForeName>Nicola J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Division of Hematology and Hematologic Malignancies, Department of Internal Medicine, Huntsman Cancer Institute and University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skibola</LastName><ForeName>Christine F</ForeName><Initials>CF</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California 94720, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vijai</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-7933-151X</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zhaoming</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gu</LastName><ForeName>Jian</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nieters</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, 79108 Baden-Württemberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kelly</LastName><ForeName>Rachel S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smedby</LastName><ForeName>Karin E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Department of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm 17176, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monnereau</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Epidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), F-94807 Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Paris Descartes, 75270 Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Registre des hémopathies malignes de la Gironde, Institut Bergonié, 33076 Bordeaux Cedex, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cozen</LastName><ForeName>Wendy</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cox</LastName><ForeName>Angela</ForeName><Initials>A</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5138-1099</Identifier><AffiliationInfo><Affiliation>Department of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Sophia S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Division of Cancer Etiology, City of Hope Beckman Research Institute, Duarte, California 91030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lan</LastName><ForeName>Qing</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teras</LastName><ForeName>Lauren R</ForeName><Initials>LR</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Machado</LastName><ForeName>Moara</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeager</LastName><ForeName>Meredith</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brooks-Wilson</LastName><ForeName>Angela R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada V5A1S6.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartge</LastName><ForeName>Patricia</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Purdue</LastName><ForeName>Mark P</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Ontario Health Study, Toronto, Ontario, Canada M5G 0A3.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Birmann</LastName><ForeName>Brenda M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vajdic</LastName><ForeName>Claire M</ForeName><Initials>CM</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3612-8298</Identifier><AffiliationInfo><Affiliation>Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cocco</LastName><ForeName>Pierluigi</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, 09042 Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yawei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giles</LastName><ForeName>Graham G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeleniuch-Jacquotte</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Population Health, New York University School of Medicine, New York, New York 10016, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Environmental Medicine, New York University School of Medicine, New York, New York 10016, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Perlmutter Cancer Center, NYU Langone Medical Center, New York, New York 10016, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lawrence</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Westat, Rockville, Maryland 20850, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Montalvan</LastName><ForeName>Rebecca</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Westat, Rockville, Maryland 20850, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burdett</LastName><ForeName>Laurie</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hutchinson</LastName><ForeName>Amy</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Gaithersburg, Maryland 20877, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ye</LastName><ForeName>Yuanqing</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Call</LastName><ForeName>Timothy G</ForeName><Initials>TG</Initials><AffiliationInfo><Affiliation>Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shanafelt</LastName><ForeName>Tait D</ForeName><Initials>TD</Initials><AffiliationInfo><Affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Novak</LastName><ForeName>Anne J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kay</LastName><ForeName>Neil E</ForeName><Initials>NE</Initials><AffiliationInfo><Affiliation>Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liebow</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cunningham</LastName><ForeName>Julie M</ForeName><Initials>JM</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-8159-3025</Identifier><AffiliationInfo><Affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allmer</LastName><ForeName>Cristine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hjalgrim</LastName><ForeName>Henrik</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Adami</LastName><ForeName>Hans-Olov</ForeName><Initials>HO</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melbye</LastName><ForeName>Mads</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glimelius</LastName><ForeName>Bengt</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, 75105 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Ellen T</ForeName><Initials>ET</Initials><AffiliationInfo><Affiliation>Center for Epidemiology and Computational Biology, Health Sciences, Exponent, Inc., Menlo Park, California 94025, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glenn</LastName><ForeName>Martha</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Huntsman Cancer Institute, Salt Lake City, Utah 84112, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curtin</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cannon-Albright</LastName><ForeName>Lisa A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah 84108, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>George E. Wahlen Department of Veterans Affairs Medical Center, Salt Lake City, Utah 84148, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diver</LastName><ForeName>W Ryan</ForeName><Initials>WR</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Link</LastName><ForeName>Brian K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiner</LastName><ForeName>George J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conde</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California 94720, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bracci</LastName><ForeName>Paige M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riby</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Environmental Health Sciences, University of California Berkeley School of Public Health, Berkeley, California 94720, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Arnett</LastName><ForeName>Donna K</ForeName><Initials>DK</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhi</LastName><ForeName>Degui</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leach</LastName><ForeName>Justin M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holly</LastName><ForeName>Elizabeth A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>Rebecca D</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, Ohio 43210, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tinker</LastName><ForeName>Lesley F</ForeName><Initials>LF</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benavente</LastName><ForeName>Yolanda</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER de Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sala</LastName><ForeName>Núria</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Translational Research Laboratory, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casabonne</LastName><ForeName>Delphine</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Institut Catala d'Oncologia, IDIBELL, 08908L'Hospitalet de Llobregat, 08908 Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER Epidemiología y Salud Pública (CIBERESP), 28029 Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Becker</LastName><ForeName>Nikolaus</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120 Baden-Württemberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boffetta</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brennan</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer (IARC), 69372 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foretova</LastName><ForeName>Lenka</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute and MF MU, 656 53 Brno, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maynadie</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>EA 4184, Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, 21070 Dijon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McKay</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer (IARC), 69372 Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Staines</LastName><ForeName>Anthony</ForeName><Initials>A</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9161-1357</Identifier><AffiliationInfo><Affiliation>School of Nursing and Human Sciences, Dublin City University, Dublin 9, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chaffee</LastName><ForeName>Kari G</ForeName><Initials>KG</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-7313-1875</Identifier><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Achenbach</LastName><ForeName>Sara J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vachon</LastName><ForeName>Celine M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goldin</LastName><ForeName>Lynn R</ForeName><Initials>LR</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Strom</LastName><ForeName>Sara S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leis</LastName><ForeName>Jose F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Mayo Clinic, Phoenix, Arizona 85054, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weinberg</LastName><ForeName>J Brice</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Department of Medicine, Duke University and VA Medical Centers, Durham, North Carolina 27710, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caporaso</LastName><ForeName>Neil E</ForeName><Initials>NE</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Norman</LastName><ForeName>Aaron D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Roos</LastName><ForeName>Anneclaire J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Environmental and Occupational Health, Drexel University School of Public Health, Philadelphia, Pennsylvania 19104, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morton</LastName><ForeName>Lindsay M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Severson</LastName><ForeName>Richard K</ForeName><Initials>RK</Initials><AffiliationInfo><Affiliation>Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riboli</LastName><ForeName>Elio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>School of Public Health, Imperial College London, London W2 1PG, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vineis</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Human Genetics Foundation, 10126 Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaaks</LastName><ForeName>Rudolph</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, 69120 Baden-Württemberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masala</LastName><ForeName>Giovanna</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute (ISPO), 50139 Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiderpass</LastName><ForeName>Elisabete</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, N-9037 Tromsø, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Research, Cancer Registry of Norway, Institute of Population-Based Cancer Research, N-0304 Oslo, Norway.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Genetic Epidemiology Group, Folkhälsan Research Center, FI-00250 Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chirlaque</LastName><ForeName>María-Dolores</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>CIBER de Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, Murcia Regional Health Authority, E30008 Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vermeulen</LastName><ForeName>Roel C H</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Institute for Risk Assessment Sciences, Utrecht University, Utrecht, 3508, TD, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Travis</LastName><ForeName>Ruth C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Southey</LastName><ForeName>Melissa C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milne</LastName><ForeName>Roger L</ForeName><Initials>RL</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albanes</LastName><ForeName>Demetrius</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Virtamo</LastName><ForeName>Jarmo</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Chronic Disease Prevention Unit, National Institute for Health and Welfare, FI-00271 Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weinstein</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clavel</LastName><ForeName>Jacqueline</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Epidemiology of Childhood and Adolescent Cancers Group, INSERM, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), F-94807 Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Paris Descartes, 75270 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Tongzhang</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holford</LastName><ForeName>Theodore R</ForeName><Initials>TR</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut 06520, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villano</LastName><ForeName>Danylo J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maria</LastName><ForeName>Ann</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spinelli</LastName><ForeName>John J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z3.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gascoyne</LastName><ForeName>Randy D</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>Center for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z3.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Connors</LastName><ForeName>Joseph M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Center for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z3.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertrand</LastName><ForeName>Kimberly A</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giovannucci</LastName><ForeName>Edward</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kraft</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kricker</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Sydney School of Public Health, The University of Sydney, Sydney, New South Wales 2006, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Turner</LastName><ForeName>Jenny</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Faculty of Medicine and Health Sciences, Macquarie University, Sydney, New South Wales 2109, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Histopathology, Douglass Hanly Moir Pathology, Sydney, New South Wales 2113, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ennas</LastName><ForeName>Maria Grazia</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Department of Biomedical Science, University of Cagliari, Monserrato, 09042 Cagliari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferri</LastName><ForeName>Giovanni M</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Interdisciplinary Department of Medicine, University of Bari, 70124 Bari, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miligi</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), 50139 Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liang</LastName><ForeName>Liming</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ma</LastName><ForeName>Baoshan</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>College of Information Science and Technology, Dalian Maritime University, Dalian, Liaoning Province 116026, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Jinyan</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5546-8626</Identifier><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crouch</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Health Sciences, University of York, York YO10 5DD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>Ju-Hyun</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Department of Statistics, Dongguk University, Seoul 100-715, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chatterjee</LastName><ForeName>Nilanjan</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>North</LastName><ForeName>Kari E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snowden</LastName><ForeName>John A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, South Yorkshire S10 2TN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>Josh</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Oncology, University of Sheffield, Sheffield, South Yorkshire S10 1NS, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust, Royal Hallamshire Hospital, Sheffield, South Yorkshire S10 2TN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraumeni</LastName><ForeName>Joseph F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Offit</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Xifeng</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, MD Anderson Cancer Center, Houston, Texas 77030, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Sanjose</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER de Epidemiología y Salud Pública (CIBERESP), 08036 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerhan</LastName><ForeName>James R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chanock</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rothman</LastName><ForeName>Nathaniel</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slager</LastName><ForeName>Susan L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>UL1 TR001070</GrantID><Acronym>TR</Acronym><Agency>NCATS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA167552</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA118444</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 PC067009</GrantID><Acronym>CN</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N02-PC-71105</GrantID><Acronym>PC</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100001I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN261201000034C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R35 CA197449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01-RC-45035</GrantID><Acronym>RC</Acronym><Agency>CCR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN261201000035C</GrantID><Acronym>PC,CA</Acronym><Agency>None</Agency><Country>None</Country></Grant><Grant><GrantID>P30 CA016087</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United 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CA69669-02</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN261201000034C</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA92153</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA167552</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01RC37004</GrantID><Acronym>RC</Acronym><Agency>CCR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100046C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 CA097274</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA049449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100002I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA016359</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN261201000140C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA15083</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA186107</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01CO12400</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 CN045165</GrantID><Acronym>CN</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA049449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA149445</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA134674</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100002C</GrantID><Agency>PHS HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN261201000026C</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P50 CA97274</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100001C</GrantID><Acronym>WH</Acronym><Agency>WHI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100004C</GrantID><Acronym>WH</Acronym><Agency>WHI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA118444</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA042014</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>ES000260</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>30 CA086862</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>CA1046282</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013486">Research Support, U.S. Gov't, Non-P.H.S.</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Commun</MedlineTA><NlmUniqueID>101528555</NlmUniqueID><ISSNLinking>2041-1723</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D048868">Adaptor Proteins, Signal Transducing</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051017">Apoptosis Regulatory Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C447641">BANK1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C000606775">BCL2L11 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000072224">Bcl-2-Like Protein 11</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C434543">CSRNP1 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C491199">EOMES protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008565">Membrane Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011518">Proto-Oncogene Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015843">Serpins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020825">T-Box Domain Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C094472">serpin 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Protein 11</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044465" MajorTopicYN="N">European Continental Ancestry Group</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="N">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055106" MajorTopicYN="Y">Genome-Wide Association Study</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015451" MajorTopicYN="N">Leukemia, Lymphocytic, Chronic, B-Cell</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008565" MajorTopicYN="N">Membrane Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011518" MajorTopicYN="N">Proto-Oncogene Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015843" MajorTopicYN="N">Serpins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020825" MajorTopicYN="N">T-Box Domain Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4786871</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>03</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>02</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>9</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26956414</ArticleId><ArticleId IdType="pii">ncomms10933</ArticleId><ArticleId IdType="doi">10.1038/ncomms10933</ArticleId><ArticleId IdType="pmc">PMC4786871</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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