The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood.
Identifieur interne : 002174 ( PubMed/Corpus ); précédent : 002173; suivant : 002175The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood.
Auteurs : T. Mansell ; B. Novakovic ; B. Meyer ; P. Rzehak ; P. Vuillermin ; A-L Ponsonby ; F. Collier ; D. Burgner ; R. Saffery ; J. RyanSource :
- Translational psychiatry [ 2158-3188 ] ; 2016.
English descriptors
- KwdEn :
- Adult, Anxiety (genetics), Anxiety (metabolism), Cohort Studies, DNA Methylation, Depression (genetics), Depression (metabolism), Female, Fetal Blood (metabolism), Humans, Infant, Newborn, Insulin-Like Growth Factor II (genetics), Insulin-Like Growth Factor II (metabolism), Linear Models, Male, Pregnancy, Pregnancy Complications (genetics), Pregnancy Complications (metabolism), Prospective Studies, RNA, Long Noncoding (metabolism), Stress, Psychological (genetics), Stress, Psychological (metabolism).
- MESH :
- chemical , genetics : Insulin-Like Growth Factor II.
- genetics : Anxiety, Depression, Pregnancy Complications, Stress, Psychological.
- metabolism : Anxiety, Depression, Fetal Blood, Insulin-Like Growth Factor II, Pregnancy Complications, RNA, Long Noncoding, Stress, Psychological.
- Adult, Cohort Studies, DNA Methylation, Female, Humans, Infant, Newborn, Linear Models, Male, Pregnancy, Prospective Studies.
Abstract
Compelling evidence suggests that maternal mental health in pregnancy can influence fetal development. The imprinted genes, insulin-like growth factor 2 (IGF2) and H19, are involved in fetal growth and each is regulated by DNA methylation. This study aimed to determine the association between maternal mental well-being during pregnancy and differentially methylated regions (DMRs) of IGF2 (DMR0) and the IGF2/H19 imprinting control region (ICR) in newborn offspring. Maternal depression, anxiety and perceived stress were assessed at 28 weeks of pregnancy in the Barwon Infant Study (n=576). DNA methylation was measured in purified cord blood mononuclear cells using the Sequenom MassArray Platform. Maternal anxiety was associated with a decrease in average ICR methylation (Δ=-2.23%; 95% CI=-3.68 to -0.77%), and across all six of the individual CpG units in anxious compared with non-anxious groups. Birth weight and sex modified the association between prenatal anxiety and infant methylation. When stratified into lower (⩽3530 g) and higher (>3530 g) birth weight groups using the median birth weight, there was a stronger association between anxiety and ICR methylation in the lower birth weight group (Δ=-3.89%; 95% CI=-6.06 to -1.72%), with no association in the higher birth weight group. When stratified by infant sex, there was a stronger association in female infants (Δ=-3.70%; 95% CI=-5.90 to -1.51%) and no association in males. All the linear regression models were adjusted for maternal age, smoking and folate intake. These findings show that maternal anxiety in pregnancy is associated with decreased IGF2/H19 ICR DNA methylation in progeny at birth, particularly in female, low birth weight neonates. ICR methylation may help link poor maternal mental health and adverse birth outcomes, but further investigation is needed.
DOI: 10.1038/tp.2016.32
PubMed: 27023171
Links to Exploration step
pubmed:27023171Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood.</title><author><name sortKey="Mansell, T" sort="Mansell, T" uniqKey="Mansell T" first="T" last="Mansell">T. Mansell</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Novakovic, B" sort="Novakovic, B" uniqKey="Novakovic B" first="B" last="Novakovic">B. Novakovic</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Meyer, B" sort="Meyer, B" uniqKey="Meyer B" first="B" last="Meyer">B. Meyer</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rzehak, P" sort="Rzehak, P" uniqKey="Rzehak P" first="P" last="Rzehak">P. Rzehak</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vuillermin, P" sort="Vuillermin, P" uniqKey="Vuillermin P" first="P" last="Vuillermin">P. Vuillermin</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ponsonby, A L" sort="Ponsonby, A L" uniqKey="Ponsonby A" first="A-L" last="Ponsonby">A-L Ponsonby</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Collier, F" sort="Collier, F" uniqKey="Collier F" first="F" last="Collier">F. Collier</name><affiliation><nlm:affiliation>Child Health Research Unit, Barwon Health, Geelong, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Burgner, D" sort="Burgner, D" uniqKey="Burgner D" first="D" last="Burgner">D. Burgner</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Saffery, R" sort="Saffery, R" uniqKey="Saffery R" first="R" last="Saffery">R. Saffery</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ryan, J" sort="Ryan, J" uniqKey="Ryan J" first="J" last="Ryan">J. Ryan</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27023171</idno><idno type="pmid">27023171</idno><idno type="doi">10.1038/tp.2016.32</idno><idno type="wicri:Area/PubMed/Corpus">002174</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002174</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood.</title><author><name sortKey="Mansell, T" sort="Mansell, T" uniqKey="Mansell T" first="T" last="Mansell">T. Mansell</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Novakovic, B" sort="Novakovic, B" uniqKey="Novakovic B" first="B" last="Novakovic">B. Novakovic</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Meyer, B" sort="Meyer, B" uniqKey="Meyer B" first="B" last="Meyer">B. Meyer</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rzehak, P" sort="Rzehak, P" uniqKey="Rzehak P" first="P" last="Rzehak">P. Rzehak</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vuillermin, P" sort="Vuillermin, P" uniqKey="Vuillermin P" first="P" last="Vuillermin">P. Vuillermin</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ponsonby, A L" sort="Ponsonby, A L" uniqKey="Ponsonby A" first="A-L" last="Ponsonby">A-L Ponsonby</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Collier, F" sort="Collier, F" uniqKey="Collier F" first="F" last="Collier">F. Collier</name><affiliation><nlm:affiliation>Child Health Research Unit, Barwon Health, Geelong, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Burgner, D" sort="Burgner, D" uniqKey="Burgner D" first="D" last="Burgner">D. Burgner</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Saffery, R" sort="Saffery, R" uniqKey="Saffery R" first="R" last="Saffery">R. Saffery</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ryan, J" sort="Ryan, J" uniqKey="Ryan J" first="J" last="Ryan">J. Ryan</name><affiliation><nlm:affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Translational psychiatry</title><idno type="eISSN">2158-3188</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Anxiety (genetics)</term><term>Anxiety (metabolism)</term><term>Cohort Studies</term><term>DNA Methylation</term><term>Depression (genetics)</term><term>Depression (metabolism)</term><term>Female</term><term>Fetal Blood (metabolism)</term><term>Humans</term><term>Infant, Newborn</term><term>Insulin-Like Growth Factor II (genetics)</term><term>Insulin-Like Growth Factor II (metabolism)</term><term>Linear Models</term><term>Male</term><term>Pregnancy</term><term>Pregnancy Complications (genetics)</term><term>Pregnancy Complications (metabolism)</term><term>Prospective Studies</term><term>RNA, Long Noncoding (metabolism)</term><term>Stress, Psychological (genetics)</term><term>Stress, Psychological (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Insulin-Like Growth Factor II</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Anxiety</term><term>Depression</term><term>Pregnancy Complications</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Anxiety</term><term>Depression</term><term>Fetal Blood</term><term>Insulin-Like Growth Factor II</term><term>Pregnancy Complications</term><term>RNA, Long Noncoding</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Cohort Studies</term><term>DNA Methylation</term><term>Female</term><term>Humans</term><term>Infant, Newborn</term><term>Linear Models</term><term>Male</term><term>Pregnancy</term><term>Prospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Compelling evidence suggests that maternal mental health in pregnancy can influence fetal development. The imprinted genes, insulin-like growth factor 2 (IGF2) and H19, are involved in fetal growth and each is regulated by DNA methylation. This study aimed to determine the association between maternal mental well-being during pregnancy and differentially methylated regions (DMRs) of IGF2 (DMR0) and the IGF2/H19 imprinting control region (ICR) in newborn offspring. Maternal depression, anxiety and perceived stress were assessed at 28 weeks of pregnancy in the Barwon Infant Study (n=576). DNA methylation was measured in purified cord blood mononuclear cells using the Sequenom MassArray Platform. Maternal anxiety was associated with a decrease in average ICR methylation (Δ=-2.23%; 95% CI=-3.68 to -0.77%), and across all six of the individual CpG units in anxious compared with non-anxious groups. Birth weight and sex modified the association between prenatal anxiety and infant methylation. When stratified into lower (⩽3530 g) and higher (>3530 g) birth weight groups using the median birth weight, there was a stronger association between anxiety and ICR methylation in the lower birth weight group (Δ=-3.89%; 95% CI=-6.06 to -1.72%), with no association in the higher birth weight group. When stratified by infant sex, there was a stronger association in female infants (Δ=-3.70%; 95% CI=-5.90 to -1.51%) and no association in males. All the linear regression models were adjusted for maternal age, smoking and folate intake. These findings show that maternal anxiety in pregnancy is associated with decreased IGF2/H19 ICR DNA methylation in progeny at birth, particularly in female, low birth weight neonates. ICR methylation may help link poor maternal mental health and adverse birth outcomes, but further investigation is needed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27023171</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>30</Day></DateCreated><DateCompleted><Year>2017</Year><Month>02</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2158-3188</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><PubDate><Year>2016</Year><Month>Mar</Month><Day>29</Day></PubDate></JournalIssue><Title>Translational psychiatry</Title><ISOAbbreviation>Transl Psychiatry</ISOAbbreviation></Journal><ArticleTitle>The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood.</ArticleTitle><Pagination><MedlinePgn>e765</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/tp.2016.32</ELocationID><Abstract><AbstractText>Compelling evidence suggests that maternal mental health in pregnancy can influence fetal development. The imprinted genes, insulin-like growth factor 2 (IGF2) and H19, are involved in fetal growth and each is regulated by DNA methylation. This study aimed to determine the association between maternal mental well-being during pregnancy and differentially methylated regions (DMRs) of IGF2 (DMR0) and the IGF2/H19 imprinting control region (ICR) in newborn offspring. Maternal depression, anxiety and perceived stress were assessed at 28 weeks of pregnancy in the Barwon Infant Study (n=576). DNA methylation was measured in purified cord blood mononuclear cells using the Sequenom MassArray Platform. Maternal anxiety was associated with a decrease in average ICR methylation (Δ=-2.23%; 95% CI=-3.68 to -0.77%), and across all six of the individual CpG units in anxious compared with non-anxious groups. Birth weight and sex modified the association between prenatal anxiety and infant methylation. When stratified into lower (⩽3530 g) and higher (>3530 g) birth weight groups using the median birth weight, there was a stronger association between anxiety and ICR methylation in the lower birth weight group (Δ=-3.89%; 95% CI=-6.06 to -1.72%), with no association in the higher birth weight group. When stratified by infant sex, there was a stronger association in female infants (Δ=-3.70%; 95% CI=-5.90 to -1.51%) and no association in males. All the linear regression models were adjusted for maternal age, smoking and folate intake. These findings show that maternal anxiety in pregnancy is associated with decreased IGF2/H19 ICR DNA methylation in progeny at birth, particularly in female, low birth weight neonates. ICR methylation may help link poor maternal mental health and adverse birth outcomes, but further investigation is needed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mansell</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Novakovic</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rzehak</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Ludwig-Maximilians-University of Munich, Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Centre, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vuillermin</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Child Health Research Unit, Barwon Health, Geelong, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, Deakin University, Geelong, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ponsonby</LastName><ForeName>A-L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Collier</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Child Health Research Unit, Barwon Health, Geelong, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, Deakin University, Geelong, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burgner</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saffery</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ryan</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Cancer & Disease Epigenetics, Murdoch Childrens Research Institute, Royal Childrens Hospital, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Inserm U1061, Hopital La Colombiere, Universite Montpellier, Montpellier, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Preventative Medicine, School of Public Health and Preventative Medicine, Monash University, Prahran, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>BIS investigator team</CollectiveName></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Transl Psychiatry</MedlineTA><NlmUniqueID>101562664</NlmUniqueID><ISSNLinking>2158-3188</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C094335">H19 long non-coding RNA</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C035170">IGF2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D062085">RNA, Long Noncoding</NameOfSubstance></Chemical><Chemical><RegistryNumber>67763-97-7</RegistryNumber><NameOfSubstance UI="D007335">Insulin-Like Growth Factor II</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Clin Epigenetics. 2011 Oct 26;3:2</RefSource><PMID Version="1">22414206</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genet Epigenet. 2014 Sep 14;6:37-44</RefSource><PMID Version="1">25512713</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Health Soc Behav. 1983 Dec;24(4):385-96</RefSource><PMID Version="1">6668417</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Genes 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