The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.
Identifieur interne : 002072 ( PubMed/Corpus ); précédent : 002071; suivant : 002073The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.
Auteurs : Phillip J. Tully ; Karine Péres ; Claudine Berr ; Christophe TzourioSource :
- Neurobiology of aging [ 1558-1497 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Apolipoprotein E4.
- genetics : Aging, Dementia, Depression, Polymorphism, Genetic.
- Aged, Aged, 80 and over, Female, Genetic Association Studies, Humans, Male, Phenotype, Predictive Value of Tests, Risk Factors, Sex Characteristics.
Abstract
The apolipoprotein E ε4 allele (APOE4) is an established risk factor for dementia; however, conflicting findings have been reported as to whether this phenotype confers a heightened risk for late onset depression (LOD) independent of dementia. We examined 2242 persons for incident LOD who also underwent genotyping for APOE4. Major LOD was associated with female sex (odds ratio, 3.61; 95% confidence interval, 1.89-6.90). APOE4 was not associated with major LOD regardless of whether dementia was excluded. In conclusion, we showed that the APOE4 phenotype holds no predictive value for major LOD.
DOI: 10.1016/j.neurobiolaging.2015.12.018
PubMed: 26785975
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pubmed:26785975Le document en format XML
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<author><name sortKey="Tully, Phillip J" sort="Tully, Phillip J" uniqKey="Tully P" first="Phillip J" last="Tully">Phillip J. Tully</name>
<affiliation><nlm:affiliation>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; INSERM, Neuroepidemiology, UMR897, Bordeaux, France. Electronic address: phillip.tully@adelaide.edu.au.</nlm:affiliation>
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<author><name sortKey="Peres, Karine" sort="Peres, Karine" uniqKey="Peres K" first="Karine" last="Péres">Karine Péres</name>
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<author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name>
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<term>Dementia (genetics)</term>
<term>Depression (genetics)</term>
<term>Female</term>
<term>Genetic Association Studies</term>
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<term>Polymorphism, Genetic (genetics)</term>
<term>Predictive Value of Tests</term>
<term>Risk Factors</term>
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<term>Female</term>
<term>Genetic Association Studies</term>
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<front><div type="abstract" xml:lang="en">The apolipoprotein E ε4 allele (APOE4) is an established risk factor for dementia; however, conflicting findings have been reported as to whether this phenotype confers a heightened risk for late onset depression (LOD) independent of dementia. We examined 2242 persons for incident LOD who also underwent genotyping for APOE4. Major LOD was associated with female sex (odds ratio, 3.61; 95% confidence interval, 1.89-6.90). APOE4 was not associated with major LOD regardless of whether dementia was excluded. In conclusion, we showed that the APOE4 phenotype holds no predictive value for major LOD.</div>
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