AustralieFrV1, PubMed, Corpus, bibRecord, 002072

The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.

Identifieur interne : 002072 ( PubMed/Corpus ); précédent : 002071; suivant : 002073

The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.

Auteurs : Phillip J. Tully ; Karine Péres ; Claudine Berr ; Christophe Tzourio

Source :

Neurobiology of aging [ 1558-1497 ] ; 2016.

RBID : pubmed:26785975

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Aging (genetics), Apolipoprotein E4 (genetics), Dementia (genetics), Depression (genetics), Female, Genetic Association Studies, Humans, Male, Phenotype, Polymorphism, Genetic (genetics), Predictive Value of Tests, Risk Factors, Sex Characteristics.
MESH :
- chemical , genetics : Apolipoprotein E4.
- genetics : Aging, Dementia, Depression, Polymorphism, Genetic.
- Aged, Aged, 80 and over, Female, Genetic Association Studies, Humans, Male, Phenotype, Predictive Value of Tests, Risk Factors, Sex Characteristics.

Abstract

The apolipoprotein E ε4 allele (APOE4) is an established risk factor for dementia; however, conflicting findings have been reported as to whether this phenotype confers a heightened risk for late onset depression (LOD) independent of dementia. We examined 2242 persons for incident LOD who also underwent genotyping for APOE4. Major LOD was associated with female sex (odds ratio, 3.61; 95% confidence interval, 1.89-6.90). APOE4 was not associated with major LOD regardless of whether dementia was excluded. In conclusion, we showed that the APOE4 phenotype holds no predictive value for major LOD.

DOI: 10.1016/j.neurobiolaging.2015.12.018
PubMed: 26785975

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pubmed:26785975

Le document en format XML

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<author><name sortKey="Tully, Phillip J" sort="Tully, Phillip J" uniqKey="Tully P" first="Phillip J" last="Tully">Phillip J. Tully</name>
<affiliation><nlm:affiliation>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; INSERM, Neuroepidemiology, UMR897, Bordeaux, France. Electronic address: phillip.tully@adelaide.edu.au.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peres, Karine" sort="Peres, Karine" uniqKey="Peres K" first="Karine" last="Péres">Karine Péres</name>
<affiliation><nlm:affiliation>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation>
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<author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name>
<affiliation><nlm:affiliation>INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Université Montpellier 1, Hôpital La Colombière, Montpellier, France.</nlm:affiliation>
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<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
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<term>Dementia (genetics)</term>
<term>Depression (genetics)</term>
<term>Female</term>
<term>Genetic Association Studies</term>
<term>Humans</term>
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<term>Polymorphism, Genetic (genetics)</term>
<term>Predictive Value of Tests</term>
<term>Risk Factors</term>
<term>Sex Characteristics</term>
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</keywords>
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<term>Aged, 80 and over</term>
<term>Female</term>
<term>Genetic Association Studies</term>
<term>Humans</term>
<term>Male</term>
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<front><div type="abstract" xml:lang="en">The apolipoprotein E ε4 allele (APOE4) is an established risk factor for dementia; however, conflicting findings have been reported as to whether this phenotype confers a heightened risk for late onset depression (LOD) independent of dementia. We examined 2242 persons for incident LOD who also underwent genotyping for APOE4. Major LOD was associated with female sex (odds ratio, 3.61; 95% confidence interval, 1.89-6.90). APOE4 was not associated with major LOD regardless of whether dementia was excluded. In conclusion, we showed that the APOE4 phenotype holds no predictive value for major LOD.</div>
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The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.

The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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