Genetic risk of type 2 diabetes in populations of the African continent: A systematic review and meta-analyses.
Identifieur interne : 002066 ( PubMed/Corpus ); précédent : 002065; suivant : 002067Genetic risk of type 2 diabetes in populations of the African continent: A systematic review and meta-analyses.
Auteurs : Yandiswa Y. Yako ; Magellan Guewo-Fokeng ; Eric V. Balti ; Nabila Bouatia-Naji ; Tandi E. Matsha ; Eugene Sobngwi ; Rajiv T. Erasmus ; Justin B. Echouffo-Tcheugui ; Andre P. KengneSource :
- Diabetes research and clinical practice [ 1872-8227 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical : Genetic Markers.
- epidemiology : Africa, Diabetes Mellitus, Type 2.
- genetics : African Continental Ancestry Group, Diabetes Mellitus, Type 2, Polymorphism, Single Nucleotide.
- Genetic Predisposition to Disease, Humans, Risk Factors.
Abstract
Type 2 diabetes (T2D) is growing faster in Africa than anywhere else, driven by the dual effects of genetic and environmental factors. We conducted a systematic review and meta-analyses of published studies on genetic markers of T2D in populations within Africa.
DOI: 10.1016/j.diabres.2016.01.003
PubMed: 26830076
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Yako</name><affiliation><nlm:affiliation>Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa; Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Guewo Fokeng, Magellan" sort="Guewo Fokeng, Magellan" uniqKey="Guewo Fokeng M" first="Magellan" last="Guewo-Fokeng">Magellan Guewo-Fokeng</name><affiliation><nlm:affiliation>Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Balti, Eric V" sort="Balti, Eric V" uniqKey="Balti E" first="Eric V" last="Balti">Eric V. Balti</name><affiliation><nlm:affiliation>Diabetes Research Center, Faculty of Medicine and Pharmacy, Brussels Free University, Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:affiliation>INSERM UMR970 Paris Cardiovascular Research Center, 56 rue Leblanc F-75015 Paris, France; Paris Descartes University, PRES Paris Sorbonne, 12 rue de l'école de medecine F75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Matsha, Tandi E" sort="Matsha, Tandi E" uniqKey="Matsha T" first="Tandi E" last="Matsha">Tandi E. Matsha</name><affiliation><nlm:affiliation>Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Sobngwi, Eugene" sort="Sobngwi, Eugene" uniqKey="Sobngwi E" first="Eugene" last="Sobngwi">Eugene Sobngwi</name><affiliation><nlm:affiliation>Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Erasmus, Rajiv T" sort="Erasmus, Rajiv T" uniqKey="Erasmus R" first="Rajiv T" last="Erasmus">Rajiv T. Erasmus</name><affiliation><nlm:affiliation>Division of Chemical Pathology, Faculty of Medicine and Health Sciences, National Health Laboratory Service (NHLS), University of Stellenbosch, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Echouffo Tcheugui, Justin B" sort="Echouffo Tcheugui, Justin B" uniqKey="Echouffo Tcheugui J" first="Justin B" last="Echouffo-Tcheugui">Justin B. Echouffo-Tcheugui</name><affiliation><nlm:affiliation>Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Department of Medicine, MedStar Health System, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kengne, Andre P" sort="Kengne, Andre P" uniqKey="Kengne A" first="Andre P" last="Kengne">Andre P. Kengne</name><affiliation><nlm:affiliation>Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa; Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; The George Institute for Global Health, The University of Sydney, Sydney, NSW, Australia. 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Yako</name><affiliation><nlm:affiliation>Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa; Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Guewo Fokeng, Magellan" sort="Guewo Fokeng, Magellan" uniqKey="Guewo Fokeng M" first="Magellan" last="Guewo-Fokeng">Magellan Guewo-Fokeng</name><affiliation><nlm:affiliation>Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Balti, Eric V" sort="Balti, Eric V" uniqKey="Balti E" first="Eric V" last="Balti">Eric V. Balti</name><affiliation><nlm:affiliation>Diabetes Research Center, Faculty of Medicine and Pharmacy, Brussels Free University, Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="Bouatia Naji, Nabila" sort="Bouatia Naji, Nabila" uniqKey="Bouatia Naji N" first="Nabila" last="Bouatia-Naji">Nabila Bouatia-Naji</name><affiliation><nlm:affiliation>INSERM UMR970 Paris Cardiovascular Research Center, 56 rue Leblanc F-75015 Paris, France; Paris Descartes University, PRES Paris Sorbonne, 12 rue de l'école de medecine F75006 Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Matsha, Tandi E" sort="Matsha, Tandi E" uniqKey="Matsha T" first="Tandi E" last="Matsha">Tandi E. Matsha</name><affiliation><nlm:affiliation>Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Sobngwi, Eugene" sort="Sobngwi, Eugene" uniqKey="Sobngwi E" first="Eugene" last="Sobngwi">Eugene Sobngwi</name><affiliation><nlm:affiliation>Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.</nlm:affiliation></affiliation></author><author><name sortKey="Erasmus, Rajiv T" sort="Erasmus, Rajiv T" uniqKey="Erasmus R" first="Rajiv T" last="Erasmus">Rajiv T. Erasmus</name><affiliation><nlm:affiliation>Division of Chemical Pathology, Faculty of Medicine and Health Sciences, National Health Laboratory Service (NHLS), University of Stellenbosch, Cape Town, South Africa.</nlm:affiliation></affiliation></author><author><name sortKey="Echouffo Tcheugui, Justin B" sort="Echouffo Tcheugui, Justin B" uniqKey="Echouffo Tcheugui J" first="Justin B" last="Echouffo-Tcheugui">Justin B. Echouffo-Tcheugui</name><affiliation><nlm:affiliation>Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Department of Medicine, MedStar Health System, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kengne, Andre P" sort="Kengne, Andre P" uniqKey="Kengne A" first="Andre P" last="Kengne">Andre P. Kengne</name><affiliation><nlm:affiliation>Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa; Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; The George Institute for Global Health, The University of Sydney, Sydney, NSW, Australia. Electronic address: andre.kengne@mrc.ac.za.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Diabetes research and clinical practice</title><idno type="eISSN">1872-8227</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa (epidemiology)</term><term>African Continental Ancestry Group (genetics)</term><term>Diabetes Mellitus, Type 2 (epidemiology)</term><term>Diabetes Mellitus, Type 2 (genetics)</term><term>Genetic Markers</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Genetic Markers</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Africa</term><term>Diabetes Mellitus, Type 2</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>African Continental Ancestry Group</term><term>Diabetes Mellitus, Type 2</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Type 2 diabetes (T2D) is growing faster in Africa than anywhere else, driven by the dual effects of genetic and environmental factors. We conducted a systematic review and meta-analyses of published studies on genetic markers of T2D in populations within Africa.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26830076</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>22</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-8227</ISSN><JournalIssue CitedMedium="Internet"><Volume>114</Volume><PubDate><Year>2016</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Diabetes research and clinical practice</Title><ISOAbbreviation>Diabetes Res. Clin. Pract.</ISOAbbreviation></Journal><ArticleTitle>Genetic risk of type 2 diabetes in populations of the African continent: A systematic review and meta-analyses.</ArticleTitle><Pagination><MedlinePgn>136-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.diabres.2016.01.003</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0168-8227(16)00012-7</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Type 2 diabetes (T2D) is growing faster in Africa than anywhere else, driven by the dual effects of genetic and environmental factors. We conducted a systematic review and meta-analyses of published studies on genetic markers of T2D in populations within Africa.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Multiple databases were searched for studies of genetic variants associated with T2D in populations living in Africa. Studies reporting on the association of a genetic marker with T2D or indicators of glycaemia were included. Data were extracted on study design and characteristics, genetic determinants, effect estimates of associations with T2D.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Overall, 100 polymorphisms in 57 genes have been investigated in relation with T2D in populations within Africa, in 60 studies. Almost all studies used the candidate gene approach, with >88% published during 2006-2014 and 70% (42/60) originating from Tunisia and Egypt. Polymorphisms in ACE, AGRP, eNOS, GSTP1, HSP70-2, MC4R, MTHFR, PHLPP, POL1, TCF7L2, and TNF-α gene were found to be associated with T2D, with overlapping effect on various cardiometabolic traits. The polymorphisms investigated in multiple studies mostly had consistent effects across studies, with only modest or no statistical heterogeneity. Effect sizes were modestly significant [e.g., odd ratio 1.49 (95%CI 1.33-1.66) for TCF7L2 (rs7903146)]. Underpowered genome-wide studies revealed no diabetes risk loci specific to African populations.</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">Current evidence on the genetic markers of T2D in African populations mostly originate from North African countries, is overall scanty and largely insufficient to reliably inform the genetic architecture of T2D across Africa.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Yako</LastName><ForeName>Yandiswa Y</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa; Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guewo-Fokeng</LastName><ForeName>Magellan</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balti</LastName><ForeName>Eric V</ForeName><Initials>EV</Initials><AffiliationInfo><Affiliation>Diabetes Research Center, Faculty of Medicine and Pharmacy, Brussels Free University, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouatia-Naji</LastName><ForeName>Nabila</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>INSERM UMR970 Paris Cardiovascular Research Center, 56 rue Leblanc F-75015 Paris, France; Paris Descartes University, PRES Paris Sorbonne, 12 rue de l'école de medecine F75006 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matsha</LastName><ForeName>Tandi E</ForeName><Initials>TE</Initials><AffiliationInfo><Affiliation>Faculty of Health and Wellness Sciences, Cape Peninsula University of Technology, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sobngwi</LastName><ForeName>Eugene</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Erasmus</LastName><ForeName>Rajiv T</ForeName><Initials>RT</Initials><AffiliationInfo><Affiliation>Division of Chemical Pathology, Faculty of Medicine and Health Sciences, National Health Laboratory Service (NHLS), University of Stellenbosch, Cape Town, South Africa.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Echouffo-Tcheugui</LastName><ForeName>Justin B</ForeName><Initials>JB</Initials><AffiliationInfo><Affiliation>Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA; Department of Medicine, MedStar Health System, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kengne</LastName><ForeName>Andre P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa; Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; The George Institute for Global Health, The University of Sydney, Sydney, NSW, Australia. Electronic address: andre.kengne@mrc.ac.za.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Diabetes Res Clin Pract</MedlineTA><NlmUniqueID>8508335</NlmUniqueID><ISSNLinking>0168-8227</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005819">Genetic Markers</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000349" MajorTopicYN="N">Africa</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044383" MajorTopicYN="N">African Continental Ancestry Group</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003924" MajorTopicYN="N">Diabetes Mellitus, Type 2</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005819" MajorTopicYN="N">Genetic Markers</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020022" MajorTopicYN="Y">Genetic Predisposition to Disease</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Africa</Keyword><Keyword MajorTopicYN="N">Genetics</Keyword><Keyword MajorTopicYN="N">Type 2 diabetes</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>04</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>11</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>01</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>2</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26830076</ArticleId><ArticleId IdType="pii">S0168-8227(16)00012-7</ArticleId><ArticleId IdType="doi">10.1016/j.diabres.2016.01.003</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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