A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.
Identifieur interne : 002055 ( PubMed/Corpus ); précédent : 002054; suivant : 002056A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.
Auteurs : Ruth C. Travis ; Paul N. Appleby ; Richard M. Martin ; Jeff M P. Holly ; Demetrius Albanes ; Amanda Black ; H B As Bueno-De-Mesquita ; June M. Chan ; Chu Chen ; Maria-Dolores Chirlaque ; Michael B. Cook ; Mélanie Deschasaux ; Jenny L. Donovan ; Luigi Ferrucci ; Pilar Galan ; Graham G. Giles ; Edward L. Giovannucci ; Marc J. Gunter ; Laurel A. Habel ; Freddie C. Hamdy ; Kathy J. Helzlsouer ; Serge Hercberg ; Robert N. Hoover ; Joseph A M J L. Janssen ; Rudolf Kaaks ; Tatsuhiko Kubo ; Loic Le Marchand ; E Jeffrey Metter ; Kazuya Mikami ; Joan K. Morris ; David E. Neal ; Marian L. Neuhouser ; Kotaro Ozasa ; Domenico Palli ; Elizabeth A. Platz ; Michael Pollak ; Alison J. Price ; Monique J. Roobol ; Catherine Schaefer ; Jeannette M. Schenk ; Gianluca Severi ; Meir J. Stampfer ; P R Stattin ; Akiko Tamakoshi ; Catherine M. Tangen ; Mathilde Touvier ; Nicholas J. Wald ; Noel S. Weiss ; Regina G. Ziegler ; Timothy J. Key ; Naomi E. AllenSource :
- Cancer research [ 1538-7445 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Insulin-Like Growth Factor I.
- blood : Prostatic Neoplasms.
- epidemiology : Prostatic Neoplasms.
- Aged, Humans, Male, Middle Aged, Risk Factors.
Abstract
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development. Cancer Res; 76(8); 2288-300. ©2016 AACR.
DOI: 10.1158/0008-5472.CAN-15-1551
PubMed: 26921328
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pubmed:26921328Le document en format XML
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Martin</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M P" last="Holly">Jeff M P. Holly</name><affiliation><nlm:affiliation>School of Clinical Science, Faculty of Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H B As" last="Bueno-De-Mesquita">H B As Bueno-De-Mesquita</name><affiliation><nlm:affiliation>Dt. for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, and Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands, and Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M" last="Chan">June M. Chan</name><affiliation><nlm:affiliation>Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><affiliation><nlm:affiliation>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chirlaque, Maria Dolores" sort="Chirlaque, Maria Dolores" uniqKey="Chirlaque M" first="Maria-Dolores" last="Chirlaque">Maria-Dolores Chirlaque</name><affiliation><nlm:affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B" last="Cook">Michael B. Cook</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Deschasaux, Melanie" sort="Deschasaux, Melanie" uniqKey="Deschasaux M" first="Mélanie" last="Deschasaux">Mélanie Deschasaux</name><affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L" last="Donovan">Jenny L. Donovan</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Habel, Laurel A" sort="Habel, Laurel A" uniqKey="Habel L" first="Laurel A" last="Habel">Laurel A. Habel</name><affiliation><nlm:affiliation>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C" last="Hamdy">Freddie C. Hamdy</name><affiliation><nlm:affiliation>Nuffield Department of Surgery, University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation><nlm:affiliation>The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Janssen, Joseph A M J L" sort="Janssen, Joseph A M J L" uniqKey="Janssen J" first="Joseph A M J L" last="Janssen">Joseph A M J L. Janssen</name><affiliation><nlm:affiliation>Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kubo, Tatsuhiko" sort="Kubo, Tatsuhiko" uniqKey="Kubo T" first="Tatsuhiko" last="Kubo">Tatsuhiko Kubo</name><affiliation><nlm:affiliation>University of Occupational and Environmental Health, Kitakyushu, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:affiliation>University of Hawaii Cancer Center, Honolulu, HI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Metter, E Jeffrey" sort="Metter, E Jeffrey" uniqKey="Metter E" first="E Jeffrey" last="Metter">E Jeffrey Metter</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mikami, Kazuya" sort="Mikami, Kazuya" uniqKey="Mikami K" first="Kazuya" last="Mikami">Kazuya Mikami</name><affiliation><nlm:affiliation>Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Morris, Joan K" sort="Morris, Joan K" uniqKey="Morris J" first="Joan K" last="Morris">Joan K. Morris</name><affiliation><nlm:affiliation>Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E" last="Neal">David E. Neal</name><affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L" last="Neuhouser">Marian L. Neuhouser</name><affiliation><nlm:affiliation>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ozasa, Kotaro" sort="Ozasa, Kotaro" uniqKey="Ozasa K" first="Kotaro" last="Ozasa">Kotaro Ozasa</name><affiliation><nlm:affiliation>Radiation Effects Research Foundation, Hiroshima, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A" last="Platz">Elizabeth A. Platz</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pollak, Michael" sort="Pollak, Michael" uniqKey="Pollak M" first="Michael" last="Pollak">Michael Pollak</name><affiliation><nlm:affiliation>Departments of Medicine and Oncology, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Price, Alison J" sort="Price, Alison J" uniqKey="Price A" first="Alison J" last="Price">Alison J. Price</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Roobol, Monique J" sort="Roobol, Monique J" uniqKey="Roobol M" first="Monique J" last="Roobol">Monique J. Roobol</name><affiliation><nlm:affiliation>Erasmus MC, Dept of Urology Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schaefer, Catherine" sort="Schaefer, Catherine" uniqKey="Schaefer C" first="Catherine" last="Schaefer">Catherine Schaefer</name><affiliation><nlm:affiliation>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schenk, Jeannette M" sort="Schenk, Jeannette M" uniqKey="Schenk J" first="Jeannette M" last="Schenk">Jeannette M. Schenk</name><affiliation><nlm:affiliation>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name><affiliation><nlm:affiliation>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Tamakoshi, Akiko" sort="Tamakoshi, Akiko" uniqKey="Tamakoshi A" first="Akiko" last="Tamakoshi">Akiko Tamakoshi</name><affiliation><nlm:affiliation>Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Tangen, Catherine M" sort="Tangen, Catherine M" uniqKey="Tangen C" first="Catherine M" last="Tangen">Catherine M. Tangen</name><affiliation><nlm:affiliation>SWOG Statistical Center, Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name><affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wald, Nicholas J" sort="Wald, Nicholas J" uniqKey="Wald N" first="Nicholas J" last="Wald">Nicholas J. Wald</name><affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Weiss, Noel S" sort="Weiss, Noel S" uniqKey="Weiss N" first="Noel S" last="Weiss">Noel S. Weiss</name><affiliation><nlm:affiliation>Human Genetics Foundation, Torino, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G" last="Ziegler">Regina G. Ziegler</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E" last="Allen">Naomi E. Allen</name><affiliation><nlm:affiliation>Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26921328</idno><idno type="pmid">26921328</idno><idno type="doi">10.1158/0008-5472.CAN-15-1551</idno><idno type="wicri:Area/PubMed/Corpus">002055</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002055</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.</title><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Appleby, Paul N" sort="Appleby, Paul N" uniqKey="Appleby P" first="Paul N" last="Appleby">Paul N. Appleby</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M" last="Martin">Richard M. Martin</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M P" last="Holly">Jeff M P. Holly</name><affiliation><nlm:affiliation>School of Clinical Science, Faculty of Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H B As" last="Bueno-De-Mesquita">H B As Bueno-De-Mesquita</name><affiliation><nlm:affiliation>Dt. for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, and Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands, and Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M" last="Chan">June M. Chan</name><affiliation><nlm:affiliation>Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name><affiliation><nlm:affiliation>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chirlaque, Maria Dolores" sort="Chirlaque, Maria Dolores" uniqKey="Chirlaque M" first="Maria-Dolores" last="Chirlaque">Maria-Dolores Chirlaque</name><affiliation><nlm:affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B" last="Cook">Michael B. Cook</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Deschasaux, Melanie" sort="Deschasaux, Melanie" uniqKey="Deschasaux M" first="Mélanie" last="Deschasaux">Mélanie Deschasaux</name><affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L" last="Donovan">Jenny L. Donovan</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name><affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Habel, Laurel A" sort="Habel, Laurel A" uniqKey="Habel L" first="Laurel A" last="Habel">Laurel A. Habel</name><affiliation><nlm:affiliation>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C" last="Hamdy">Freddie C. Hamdy</name><affiliation><nlm:affiliation>Nuffield Department of Surgery, University of Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name><affiliation><nlm:affiliation>The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name><affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Janssen, Joseph A M J L" sort="Janssen, Joseph A M J L" uniqKey="Janssen J" first="Joseph A M J L" last="Janssen">Joseph A M J L. Janssen</name><affiliation><nlm:affiliation>Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kubo, Tatsuhiko" sort="Kubo, Tatsuhiko" uniqKey="Kubo T" first="Tatsuhiko" last="Kubo">Tatsuhiko Kubo</name><affiliation><nlm:affiliation>University of Occupational and Environmental Health, Kitakyushu, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:affiliation>University of Hawaii Cancer Center, Honolulu, HI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Metter, E Jeffrey" sort="Metter, E Jeffrey" uniqKey="Metter E" first="E Jeffrey" last="Metter">E Jeffrey Metter</name><affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mikami, Kazuya" sort="Mikami, Kazuya" uniqKey="Mikami K" first="Kazuya" last="Mikami">Kazuya Mikami</name><affiliation><nlm:affiliation>Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Morris, Joan K" sort="Morris, Joan K" uniqKey="Morris J" first="Joan K" last="Morris">Joan K. Morris</name><affiliation><nlm:affiliation>Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E" last="Neal">David E. Neal</name><affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L" last="Neuhouser">Marian L. Neuhouser</name><affiliation><nlm:affiliation>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ozasa, Kotaro" sort="Ozasa, Kotaro" uniqKey="Ozasa K" first="Kotaro" last="Ozasa">Kotaro Ozasa</name><affiliation><nlm:affiliation>Radiation Effects Research Foundation, Hiroshima, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name><affiliation><nlm:affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A" last="Platz">Elizabeth A. Platz</name><affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pollak, Michael" sort="Pollak, Michael" uniqKey="Pollak M" first="Michael" last="Pollak">Michael Pollak</name><affiliation><nlm:affiliation>Departments of Medicine and Oncology, McGill University, Montreal, QC, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Price, Alison J" sort="Price, Alison J" uniqKey="Price A" first="Alison J" last="Price">Alison J. Price</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Roobol, Monique J" sort="Roobol, Monique J" uniqKey="Roobol M" first="Monique J" last="Roobol">Monique J. Roobol</name><affiliation><nlm:affiliation>Erasmus MC, Dept of Urology Rotterdam, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schaefer, Catherine" sort="Schaefer, Catherine" uniqKey="Schaefer C" first="Catherine" last="Schaefer">Catherine Schaefer</name><affiliation><nlm:affiliation>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Schenk, Jeannette M" sort="Schenk, Jeannette M" uniqKey="Schenk J" first="Jeannette M" last="Schenk">Jeannette M. Schenk</name><affiliation><nlm:affiliation>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name><affiliation><nlm:affiliation>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Tamakoshi, Akiko" sort="Tamakoshi, Akiko" uniqKey="Tamakoshi A" first="Akiko" last="Tamakoshi">Akiko Tamakoshi</name><affiliation><nlm:affiliation>Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Tangen, Catherine M" sort="Tangen, Catherine M" uniqKey="Tangen C" first="Catherine M" last="Tangen">Catherine M. Tangen</name><affiliation><nlm:affiliation>SWOG Statistical Center, Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name><affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wald, Nicholas J" sort="Wald, Nicholas J" uniqKey="Wald N" first="Nicholas J" last="Wald">Nicholas J. Wald</name><affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Weiss, Noel S" sort="Weiss, Noel S" uniqKey="Weiss N" first="Noel S" last="Weiss">Noel S. Weiss</name><affiliation><nlm:affiliation>Human Genetics Foundation, Torino, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G" last="Ziegler">Regina G. Ziegler</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E" last="Allen">Naomi E. Allen</name><affiliation><nlm:affiliation>Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cancer research</title><idno type="eISSN">1538-7445</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Humans</term><term>Insulin-Like Growth Factor I (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Prostatic Neoplasms (blood)</term><term>Prostatic Neoplasms (epidemiology)</term><term>Risk Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Insulin-Like Growth Factor I</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Prostatic Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development. Cancer Res; 76(8); 2288-300. ©2016 AACR.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26921328</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>20</Day></DateCreated><DateCompleted><Year>2017</Year><Month>02</Month><Day>27</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-7445</ISSN><JournalIssue CitedMedium="Internet"><Volume>76</Volume><Issue>8</Issue><PubDate><Year>2016</Year><Month>04</Month><Day>15</Day></PubDate></JournalIssue><Title>Cancer research</Title><ISOAbbreviation>Cancer Res.</ISOAbbreviation></Journal><ArticleTitle>A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.</ArticleTitle><Pagination><MedlinePgn>2288-2300</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1158/0008-5472.CAN-15-1551</ELocationID><Abstract><AbstractText>The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development. Cancer Res; 76(8); 2288-300. ©2016 AACR.</AbstractText><CopyrightInformation>©2016 American Association for Cancer Research.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Travis</LastName><ForeName>Ruth C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Appleby</LastName><ForeName>Paul N</ForeName><Initials>PN</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Richard M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, and National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holly</LastName><ForeName>Jeff M P</ForeName><Initials>JMP</Initials><AffiliationInfo><Affiliation>School of Clinical Science, Faculty of Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albanes</LastName><ForeName>Demetrius</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Black</LastName><ForeName>Amanda</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bueno-de-Mesquita</LastName><ForeName>H B As</ForeName><Initials>HBA</Initials><AffiliationInfo><Affiliation>Dt. for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, and Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands, and Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>June M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Chu</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chirlaque</LastName><ForeName>Maria-Dolores</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cook</LastName><ForeName>Michael B</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deschasaux</LastName><ForeName>Mélanie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Donovan</LastName><ForeName>Jenny L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferrucci</LastName><ForeName>Luigi</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Galan</LastName><ForeName>Pilar</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giles</LastName><ForeName>Graham G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giovannucci</LastName><ForeName>Edward L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Nutrition and Department of Medicine, Harvard School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gunter</LastName><ForeName>Marc J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Habel</LastName><ForeName>Laurel A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamdy</LastName><ForeName>Freddie C</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Nuffield Department of Surgery, University of Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helzlsouer</LastName><ForeName>Kathy J</ForeName><Initials>KJ</Initials><AffiliationInfo><Affiliation>The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hercberg</LastName><ForeName>Serge</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoover</LastName><ForeName>Robert N</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Janssen</LastName><ForeName>Joseph A M J L</ForeName><Initials>JAMJL</Initials><AffiliationInfo><Affiliation>Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaaks</LastName><ForeName>Rudolf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kubo</LastName><ForeName>Tatsuhiko</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>University of Occupational and Environmental Health, Kitakyushu, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Marchand</LastName><ForeName>Loic</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>University of Hawaii Cancer Center, Honolulu, HI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Metter</LastName><ForeName>E Jeffrey</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Neurology, University of Tennessee Health Science Center, Memphis, TN.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mikami</LastName><ForeName>Kazuya</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Kyoto Prefectural University of Medicine, Kyoto, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morris</LastName><ForeName>Joan K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neal</LastName><ForeName>David E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Department of Oncology, University of Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Neuhouser</LastName><ForeName>Marian L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ozasa</LastName><ForeName>Kotaro</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Radiation Effects Research Foundation, Hiroshima, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Palli</LastName><ForeName>Domenico</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Platz</LastName><ForeName>Elizabeth A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pollak</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Departments of Medicine and Oncology, McGill University, Montreal, QC, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Price</LastName><ForeName>Alison J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roobol</LastName><ForeName>Monique J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Erasmus MC, Dept of Urology Rotterdam, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schaefer</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schenk</LastName><ForeName>Jeannette M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Epidemiology, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Severi</LastName><ForeName>Gianluca</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Human Genetics Foundation, Torino, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stampfer</LastName><ForeName>Meir J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stattin</LastName><ForeName>Pär</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamakoshi</LastName><ForeName>Akiko</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hokkaido University Graduate School of Medicine, Sapporo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tangen</LastName><ForeName>Catherine M</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>SWOG Statistical Center, Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Touvier</LastName><ForeName>Mathilde</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wald</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Department of Oncology, University of Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiss</LastName><ForeName>Noel S</ForeName><Initials>NS</Initials><AffiliationInfo><Affiliation>Human Genetics Foundation, Torino, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ziegler</LastName><ForeName>Regina G</ForeName><Initials>RG</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Key</LastName><ForeName>Timothy J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Allen</LastName><ForeName>Naomi E</ForeName><Initials>NE</Initials><AffiliationInfo><Affiliation>Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U10 CA037429</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA055075</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UG1 CA189974</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA108964</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA133891</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P01 CA033619</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA182883</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA164973</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R37 CA054281</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>A19169</GrantID><Agency>Cancer Research UK</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D052060">Research Support, N.I.H., Intramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>02</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cancer Res</MedlineTA><NlmUniqueID>2984705R</NlmUniqueID><ISSNLinking>0008-5472</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>67763-96-6</RegistryNumber><NameOfSubstance UI="D007334">Insulin-Like Growth Factor 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Version="1">21047593</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007334" MajorTopicYN="N">Insulin-Like Growth Factor I</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011471" MajorTopicYN="N">Prostatic Neoplasms</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk 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