A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.
Identifieur interne : 002055 ( PubMed/Corpus ); précédent : 002054; suivant : 002056A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.
Auteurs : Ruth C. Travis ; Paul N. Appleby ; Richard M. Martin ; Jeff M P. Holly ; Demetrius Albanes ; Amanda Black ; H B As Bueno-De-Mesquita ; June M. Chan ; Chu Chen ; Maria-Dolores Chirlaque ; Michael B. Cook ; Mélanie Deschasaux ; Jenny L. Donovan ; Luigi Ferrucci ; Pilar Galan ; Graham G. Giles ; Edward L. Giovannucci ; Marc J. Gunter ; Laurel A. Habel ; Freddie C. Hamdy ; Kathy J. Helzlsouer ; Serge Hercberg ; Robert N. Hoover ; Joseph A M J L. Janssen ; Rudolf Kaaks ; Tatsuhiko Kubo ; Loic Le Marchand ; E Jeffrey Metter ; Kazuya Mikami ; Joan K. Morris ; David E. Neal ; Marian L. Neuhouser ; Kotaro Ozasa ; Domenico Palli ; Elizabeth A. Platz ; Michael Pollak ; Alison J. Price ; Monique J. Roobol ; Catherine Schaefer ; Jeannette M. Schenk ; Gianluca Severi ; Meir J. Stampfer ; P R Stattin ; Akiko Tamakoshi ; Catherine M. Tangen ; Mathilde Touvier ; Nicholas J. Wald ; Noel S. Weiss ; Regina G. Ziegler ; Timothy J. Key ; Naomi E. AllenSource :
- Cancer research [ 1538-7445 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Insulin-Like Growth Factor I.
- blood : Prostatic Neoplasms.
- epidemiology : Prostatic Neoplasms.
- Aged, Humans, Male, Middle Aged, Risk Factors.
Abstract
The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development. Cancer Res; 76(8); 2288-300. ©2016 AACR.
DOI: 10.1158/0008-5472.CAN-15-1551
PubMed: 26921328
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pubmed:26921328Le document en format XML
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<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name>
<affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation>
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<author><name sortKey="Appleby, Paul N" sort="Appleby, Paul N" uniqKey="Appleby P" first="Paul N" last="Appleby">Paul N. Appleby</name>
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<author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M" last="Martin">Richard M. Martin</name>
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<author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M P" last="Holly">Jeff M P. Holly</name>
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<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
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<author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name>
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<author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H B As" last="Bueno-De-Mesquita">H B As Bueno-De-Mesquita</name>
<affiliation><nlm:affiliation>Dt. for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, and Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands, and Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation>
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<author><name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M" last="Chan">June M. Chan</name>
<affiliation><nlm:affiliation>Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name>
<affiliation><nlm:affiliation>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
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<author><name sortKey="Chirlaque, Maria Dolores" sort="Chirlaque, Maria Dolores" uniqKey="Chirlaque M" first="Maria-Dolores" last="Chirlaque">Maria-Dolores Chirlaque</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B" last="Cook">Michael B. Cook</name>
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</affiliation>
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<author><name sortKey="Deschasaux, Melanie" sort="Deschasaux, Melanie" uniqKey="Deschasaux M" first="Mélanie" last="Deschasaux">Mélanie Deschasaux</name>
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<author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L" last="Donovan">Jenny L. Donovan</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
<affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation>
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<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name>
<affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name>
<affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Habel, Laurel A" sort="Habel, Laurel A" uniqKey="Habel L" first="Laurel A" last="Habel">Laurel A. Habel</name>
<affiliation><nlm:affiliation>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hamdy, Freddie C" sort="Hamdy, Freddie C" uniqKey="Hamdy F" first="Freddie C" last="Hamdy">Freddie C. Hamdy</name>
<affiliation><nlm:affiliation>Nuffield Department of Surgery, University of Oxford, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name>
<affiliation><nlm:affiliation>The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hercberg, Serge" sort="Hercberg, Serge" uniqKey="Hercberg S" first="Serge" last="Hercberg">Serge Hercberg</name>
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</affiliation>
</author>
<author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Janssen, Joseph A M J L" sort="Janssen, Joseph A M J L" uniqKey="Janssen J" first="Joseph A M J L" last="Janssen">Joseph A M J L. Janssen</name>
<affiliation><nlm:affiliation>Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kubo, Tatsuhiko" sort="Kubo, Tatsuhiko" uniqKey="Kubo T" first="Tatsuhiko" last="Kubo">Tatsuhiko Kubo</name>
<affiliation><nlm:affiliation>University of Occupational and Environmental Health, Kitakyushu, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation><nlm:affiliation>University of Hawaii Cancer Center, Honolulu, HI, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Metter, E Jeffrey" sort="Metter, E Jeffrey" uniqKey="Metter E" first="E Jeffrey" last="Metter">E Jeffrey Metter</name>
<affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mikami, Kazuya" sort="Mikami, Kazuya" uniqKey="Mikami K" first="Kazuya" last="Mikami">Kazuya Mikami</name>
<affiliation><nlm:affiliation>Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Morris, Joan K" sort="Morris, Joan K" uniqKey="Morris J" first="Joan K" last="Morris">Joan K. Morris</name>
<affiliation><nlm:affiliation>Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E" last="Neal">David E. Neal</name>
<affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Neuhouser, Marian L" sort="Neuhouser, Marian L" uniqKey="Neuhouser M" first="Marian L" last="Neuhouser">Marian L. Neuhouser</name>
<affiliation><nlm:affiliation>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ozasa, Kotaro" sort="Ozasa, Kotaro" uniqKey="Ozasa K" first="Kotaro" last="Ozasa">Kotaro Ozasa</name>
<affiliation><nlm:affiliation>Radiation Effects Research Foundation, Hiroshima, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name>
<affiliation><nlm:affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A" last="Platz">Elizabeth A. Platz</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pollak, Michael" sort="Pollak, Michael" uniqKey="Pollak M" first="Michael" last="Pollak">Michael Pollak</name>
<affiliation><nlm:affiliation>Departments of Medicine and Oncology, McGill University, Montreal, QC, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Price, Alison J" sort="Price, Alison J" uniqKey="Price A" first="Alison J" last="Price">Alison J. Price</name>
<affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Roobol, Monique J" sort="Roobol, Monique J" uniqKey="Roobol M" first="Monique J" last="Roobol">Monique J. Roobol</name>
<affiliation><nlm:affiliation>Erasmus MC, Dept of Urology Rotterdam, the Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schaefer, Catherine" sort="Schaefer, Catherine" uniqKey="Schaefer C" first="Catherine" last="Schaefer">Catherine Schaefer</name>
<affiliation><nlm:affiliation>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schenk, Jeannette M" sort="Schenk, Jeannette M" uniqKey="Schenk J" first="Jeannette M" last="Schenk">Jeannette M. Schenk</name>
<affiliation><nlm:affiliation>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stampfer, Meir J" sort="Stampfer, Meir J" uniqKey="Stampfer M" first="Meir J" last="Stampfer">Meir J. Stampfer</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name>
<affiliation><nlm:affiliation>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tamakoshi, Akiko" sort="Tamakoshi, Akiko" uniqKey="Tamakoshi A" first="Akiko" last="Tamakoshi">Akiko Tamakoshi</name>
<affiliation><nlm:affiliation>Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tangen, Catherine M" sort="Tangen, Catherine M" uniqKey="Tangen C" first="Catherine M" last="Tangen">Catherine M. Tangen</name>
<affiliation><nlm:affiliation>SWOG Statistical Center, Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington, Seattle, WA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name>
<affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wald, Nicholas J" sort="Wald, Nicholas J" uniqKey="Wald N" first="Nicholas J" last="Wald">Nicholas J. Wald</name>
<affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Weiss, Noel S" sort="Weiss, Noel S" uniqKey="Weiss N" first="Noel S" last="Weiss">Noel S. Weiss</name>
<affiliation><nlm:affiliation>Human Genetics Foundation, Torino, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G" last="Ziegler">Regina G. Ziegler</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name>
<affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E" last="Allen">Naomi E. Allen</name>
<affiliation><nlm:affiliation>Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.</title>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name>
<affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Appleby, Paul N" sort="Appleby, Paul N" uniqKey="Appleby P" first="Paul N" last="Appleby">Paul N. Appleby</name>
<affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Martin, Richard M" sort="Martin, Richard M" uniqKey="Martin R" first="Richard M" last="Martin">Richard M. Martin</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Holly, Jeff M P" sort="Holly, Jeff M P" uniqKey="Holly J" first="Jeff M P" last="Holly">Jeff M P. Holly</name>
<affiliation><nlm:affiliation>School of Clinical Science, Faculty of Medicine, University of Bristol, Bristol, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Black, Amanda" sort="Black, Amanda" uniqKey="Black A" first="Amanda" last="Black">Amanda Black</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bueno De Mesquita, H B As" sort="Bueno De Mesquita, H B As" uniqKey="Bueno De Mesquita H" first="H B As" last="Bueno-De-Mesquita">H B As Bueno-De-Mesquita</name>
<affiliation><nlm:affiliation>Dt. for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, and Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands, and Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chan, June M" sort="Chan, June M" uniqKey="Chan J" first="June M" last="Chan">June M. Chan</name>
<affiliation><nlm:affiliation>Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chen, Chu" sort="Chen, Chu" uniqKey="Chen C" first="Chu" last="Chen">Chu Chen</name>
<affiliation><nlm:affiliation>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chirlaque, Maria Dolores" sort="Chirlaque, Maria Dolores" uniqKey="Chirlaque M" first="Maria-Dolores" last="Chirlaque">Maria-Dolores Chirlaque</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cook, Michael B" sort="Cook, Michael B" uniqKey="Cook M" first="Michael B" last="Cook">Michael B. Cook</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Deschasaux, Melanie" sort="Deschasaux, Melanie" uniqKey="Deschasaux M" first="Mélanie" last="Deschasaux">Mélanie Deschasaux</name>
<affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Donovan, Jenny L" sort="Donovan, Jenny L" uniqKey="Donovan J" first="Jenny L" last="Donovan">Jenny L. Donovan</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Galan, Pilar" sort="Galan, Pilar" uniqKey="Galan P" first="Pilar" last="Galan">Pilar Galan</name>
<affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation>
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<affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation>
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<author><name sortKey="Giovannucci, Edward L" sort="Giovannucci, Edward L" uniqKey="Giovannucci E" first="Edward L" last="Giovannucci">Edward L. Giovannucci</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</nlm:affiliation>
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<author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name>
<affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</nlm:affiliation>
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</author>
<author><name sortKey="Habel, Laurel A" sort="Habel, Laurel A" uniqKey="Habel L" first="Laurel A" last="Habel">Laurel A. Habel</name>
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<affiliation><nlm:affiliation>Nuffield Department of Surgery, University of Oxford, UK.</nlm:affiliation>
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<author><name sortKey="Helzlsouer, Kathy J" sort="Helzlsouer, Kathy J" uniqKey="Helzlsouer K" first="Kathy J" last="Helzlsouer">Kathy J. Helzlsouer</name>
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</author>
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<affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation>
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</author>
<author><name sortKey="Hoover, Robert N" sort="Hoover, Robert N" uniqKey="Hoover R" first="Robert N" last="Hoover">Robert N. Hoover</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation>
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<affiliation><nlm:affiliation>Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands.</nlm:affiliation>
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<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.</nlm:affiliation>
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</author>
<author><name sortKey="Kubo, Tatsuhiko" sort="Kubo, Tatsuhiko" uniqKey="Kubo T" first="Tatsuhiko" last="Kubo">Tatsuhiko Kubo</name>
<affiliation><nlm:affiliation>University of Occupational and Environmental Health, Kitakyushu, Japan.</nlm:affiliation>
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<author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name>
<affiliation><nlm:affiliation>University of Hawaii Cancer Center, Honolulu, HI, USA.</nlm:affiliation>
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<author><name sortKey="Metter, E Jeffrey" sort="Metter, E Jeffrey" uniqKey="Metter E" first="E Jeffrey" last="Metter">E Jeffrey Metter</name>
<affiliation><nlm:affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</nlm:affiliation>
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<author><name sortKey="Mikami, Kazuya" sort="Mikami, Kazuya" uniqKey="Mikami K" first="Kazuya" last="Mikami">Kazuya Mikami</name>
<affiliation><nlm:affiliation>Kyoto Prefectural University of Medicine, Kyoto, Japan.</nlm:affiliation>
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<author><name sortKey="Morris, Joan K" sort="Morris, Joan K" uniqKey="Morris J" first="Joan K" last="Morris">Joan K. Morris</name>
<affiliation><nlm:affiliation>Wolfson Institute of Preventive Medicine, Queen Mary University of London, Charterhouse Square, London, UK.</nlm:affiliation>
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<author><name sortKey="Neal, David E" sort="Neal, David E" uniqKey="Neal D" first="David E" last="Neal">David E. Neal</name>
<affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, UK.</nlm:affiliation>
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<affiliation><nlm:affiliation>Radiation Effects Research Foundation, Hiroshima, Japan.</nlm:affiliation>
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<author><name sortKey="Palli, Domenico" sort="Palli, Domenico" uniqKey="Palli D" first="Domenico" last="Palli">Domenico Palli</name>
<affiliation><nlm:affiliation>Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute - ISPO, Florence, Italy.</nlm:affiliation>
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<author><name sortKey="Platz, Elizabeth A" sort="Platz, Elizabeth A" uniqKey="Platz E" first="Elizabeth A" last="Platz">Elizabeth A. Platz</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.</nlm:affiliation>
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<author><name sortKey="Pollak, Michael" sort="Pollak, Michael" uniqKey="Pollak M" first="Michael" last="Pollak">Michael Pollak</name>
<affiliation><nlm:affiliation>Departments of Medicine and Oncology, McGill University, Montreal, QC, Canada.</nlm:affiliation>
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<affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation>
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<author><name sortKey="Schaefer, Catherine" sort="Schaefer, Catherine" uniqKey="Schaefer C" first="Catherine" last="Schaefer">Catherine Schaefer</name>
<affiliation><nlm:affiliation>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA.</nlm:affiliation>
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<affiliation><nlm:affiliation>Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</nlm:affiliation>
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<author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name>
<affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</nlm:affiliation>
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<author><name sortKey="Stattin, P R" sort="Stattin, P R" uniqKey="Stattin P" first="P R" last="Stattin">P R Stattin</name>
<affiliation><nlm:affiliation>Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.</nlm:affiliation>
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<author><name sortKey="Tamakoshi, Akiko" sort="Tamakoshi, Akiko" uniqKey="Tamakoshi A" first="Akiko" last="Tamakoshi">Akiko Tamakoshi</name>
<affiliation><nlm:affiliation>Hokkaido University Graduate School of Medicine, Sapporo, Japan.</nlm:affiliation>
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<affiliation><nlm:affiliation>SWOG Statistical Center, Fred Hutchinson Cancer Research Center, and Department of Biostatistics, University of Washington, Seattle, WA, USA.</nlm:affiliation>
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<author><name sortKey="Touvier, Mathilde" sort="Touvier, Mathilde" uniqKey="Touvier M" first="Mathilde" last="Touvier">Mathilde Touvier</name>
<affiliation><nlm:affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, UK.</nlm:affiliation>
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<affiliation><nlm:affiliation>Human Genetics Foundation, Torino, Italy.</nlm:affiliation>
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<author><name sortKey="Ziegler, Regina G" sort="Ziegler, Regina G" uniqKey="Ziegler R" first="Regina G" last="Ziegler">Regina G. Ziegler</name>
<affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</nlm:affiliation>
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<author><name sortKey="Key, Timothy J" sort="Key, Timothy J" uniqKey="Key T" first="Timothy J" last="Key">Timothy J. Key</name>
<affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation>
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<author><name sortKey="Allen, Naomi E" sort="Allen, Naomi E" uniqKey="Allen N" first="Naomi E" last="Allen">Naomi E. Allen</name>
<affiliation><nlm:affiliation>Clinical Trials Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</nlm:affiliation>
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</analytic>
<series><title level="j">Cancer research</title>
<idno type="eISSN">1538-7445</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
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<term>Humans</term>
<term>Insulin-Like Growth Factor I (metabolism)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prostatic Neoplasms (blood)</term>
<term>Prostatic Neoplasms (epidemiology)</term>
<term>Risk Factors</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Insulin-Like Growth Factor I</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Prostatic Neoplasms</term>
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<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
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<front><div type="abstract" xml:lang="en">The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development. Cancer Res; 76(8); 2288-300. ©2016 AACR.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26921328</PMID>
<DateCreated><Year>2016</Year>
<Month>05</Month>
<Day>20</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>02</Month>
<Day>27</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>09</Month>
<Day>22</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1538-7445</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>76</Volume>
<Issue>8</Issue>
<PubDate><Year>2016</Year>
<Month>04</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Cancer research</Title>
<ISOAbbreviation>Cancer Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk.</ArticleTitle>
<Pagination><MedlinePgn>2288-2300</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1158/0008-5472.CAN-15-1551</ELocationID>
<Abstract><AbstractText>The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development. Cancer Res; 76(8); 2288-300. ©2016 AACR.</AbstractText>
<CopyrightInformation>©2016 American Association for Cancer Research.</CopyrightInformation>
</Abstract>
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<ForeName>Ruth C</ForeName>
<Initials>RC</Initials>
<AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</Affiliation>
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<ForeName>Paul N</ForeName>
<Initials>PN</Initials>
<AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.</Affiliation>
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<ForeName>Richard M</ForeName>
<Initials>RM</Initials>
<AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation>
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<AffiliationInfo><Affiliation>Medical Research Council/University of Bristol Integrative Epidemiology Unit, University of Bristol, and National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, UK.</Affiliation>
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<ForeName>Jeff M P</ForeName>
<Initials>JMP</Initials>
<AffiliationInfo><Affiliation>School of Clinical Science, Faculty of Medicine, University of Bristol, Bristol, UK.</Affiliation>
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<Initials>D</Initials>
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<Initials>A</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</Affiliation>
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<Initials>HBA</Initials>
<AffiliationInfo><Affiliation>Dt. for Determinants of Chronic Diseases, National Institute for Public Health and the Environment (RIVM), Bilthoven, and Dt. of Gastroenterology and Hepatology, University Medical Centre, Utrecht, The Netherlands, and Dt. of Social & Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</Affiliation>
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<ForeName>June M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Departments of Epidemiology & Biostatistics and Urology, University of California San Francisco, CA, USA.</Affiliation>
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<ForeName>Chu</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Division of Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.</Affiliation>
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<ForeName>Maria-Dolores</ForeName>
<Initials>MD</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, and CIBER Epidemiología y Salud Pública, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Cook</LastName>
<ForeName>Michael B</ForeName>
<Initials>MB</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</Affiliation>
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<ForeName>Jenny L</ForeName>
<Initials>JL</Initials>
<AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation>
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<AffiliationInfo><Affiliation>Intramural Research Program, National Institute on Aging, Baltimore, MD, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, and Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Victoria, Australia.</Affiliation>
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<Initials>EL</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.</Affiliation>
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<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.</Affiliation>
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<AffiliationInfo><Affiliation>Division of Research, Kaiser Permanente, Northern California, Oakland, California, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Nuffield Department of Surgery, University of Oxford, UK.</Affiliation>
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<Initials>KJ</Initials>
<AffiliationInfo><Affiliation>The Prevention and Research Center, Mercy Medical Center, Baltimore, MD, USA.</Affiliation>
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<AffiliationInfo><Affiliation>Sorbonne Paris Cité Epidemiology and Biostatistics Research Center, Nutritional Epidemiology Research Team, Inserm U1153, Inra U1125, Cnam, University Paris 13, University Paris 5, University Paris 7, F-93017, Bobigny, France.</Affiliation>
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<Initials>RN</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, U.S. National Cancer Institute, Bethesda, MD, USA.</Affiliation>
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<Initials>JAMJL</Initials>
<AffiliationInfo><Affiliation>Erasmus MC, Dept Internal Medicine, Rotterdam, the Netherlands.</Affiliation>
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<Initials>R</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Centre, Heidelberg, Germany.</Affiliation>
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<Initials>T</Initials>
<AffiliationInfo><Affiliation>University of Occupational and Environmental Health, Kitakyushu, Japan.</Affiliation>
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