Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [18F]DPA-714 PET Imaging.
Identifieur interne : 001F70 ( PubMed/Corpus ); précédent : 001F69; suivant : 001F71Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [18F]DPA-714 PET Imaging.
Auteurs : Clément Thomas ; Johnny Vercouillie ; Aurélie Doméné ; Clovis Tauber ; Michael Kassiou ; Denis Guilloteau ; Christophe Destrieux ; Sophie Sérrière ; Sylvie ChalonSource :
- Molecular imaging [ 1536-0121 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Disease Models, Animal, Early Diagnosis, Fluorine Radioisotopes (chemistry), Fluorine Radioisotopes (pharmacology), Humans, Male, Microglia (metabolism), Microglia (pathology), Positron-Emission Tomography (methods), Pyrazoles (chemistry), Pyrimidines (chemistry), Rats, Receptors, GABA (metabolism), Subarachnoid Hemorrhage (diagnostic imaging), Subarachnoid Hemorrhage (metabolism), Subarachnoid Hemorrhage (pathology).
- MESH :
- chemical , chemistry : Fluorine Radioisotopes, Pyrazoles, Pyrimidines.
- chemical , metabolism : Receptors, GABA.
- chemical , pharmacology : Fluorine Radioisotopes.
- diagnostic imaging : Subarachnoid Hemorrhage.
- metabolism : Microglia, Subarachnoid Hemorrhage.
- methods : Positron-Emission Tomography.
- pathology : Microglia, Subarachnoid Hemorrhage.
- Animals, Disease Models, Animal, Early Diagnosis, Humans, Male, Rats.
Abstract
Subarachnoid hemorrhage (SAH) can lead to delayed cerebral ischemia, which increases the rate of morbidity and mortality. The detection of microglial activation may serve as a biomarker for the identification of patients at risk of this deleterious consequence. We assessed this hypothesis in a rat model of SAH in which the exploration of neuroinflammation related to microglial activation was correlated with the degree of bleeding. We used the rat filament model and evaluated (at 48 hours postsurgery) the intensity of neuroinflammation using positron emission tomography (PET) imaging with the 18-kDa translocator protein (TSPO) tracer [(18)F]DPA-714, quantitative autoradiography with [(3)H]PK-11195, and SAH grade by postmortem brain picture. High SAH grades were strongly and positively correlated with in vivo PET imaging of TSPO in the cortex and striatum. In addition, a positive correlation was found in the cortex in TSPO, with densities determined by imaging and autoradiographic approaches. Qualitative immunofluorescence studies indicated that overexpression of TSPO was linked to astrocytic/microglial activation. In this model, PET imaging of TSPO using [(18)F]DPA-714 appeared to be a relevant index of the degree of bleeding, indicating that this imaging method could be used in human patients to improve the management of patients with SAH.
DOI: 10.1177/1536012116639189
PubMed: 27118758
Links to Exploration step
pubmed:27118758Le document en format XML
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Tours, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tauber, Clovis" sort="Tauber, Clovis" uniqKey="Tauber C" first="Clovis" last="Tauber">Clovis Tauber</name><affiliation><nlm:affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kassiou, Michael" sort="Kassiou, Michael" uniqKey="Kassiou M" first="Michael" last="Kassiou">Michael Kassiou</name><affiliation><nlm:affiliation>Faculty of Health Sciences, School of Chemistry, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Guilloteau, Denis" sort="Guilloteau, Denis" uniqKey="Guilloteau D" first="Denis" last="Guilloteau">Denis Guilloteau</name><affiliation><nlm:affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France CHRU de Tours, Tours, France.</nlm:affiliation></affiliation></author><author><name sortKey="Destrieux, Christophe" sort="Destrieux, 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France.</nlm:affiliation></affiliation></author><author><name sortKey="Domene, Aurelie" sort="Domene, Aurelie" uniqKey="Domene A" first="Aurélie" last="Doméné">Aurélie Doméné</name><affiliation><nlm:affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tauber, Clovis" sort="Tauber, Clovis" uniqKey="Tauber C" first="Clovis" last="Tauber">Clovis Tauber</name><affiliation><nlm:affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kassiou, Michael" sort="Kassiou, Michael" uniqKey="Kassiou M" first="Michael" last="Kassiou">Michael Kassiou</name><affiliation><nlm:affiliation>Faculty of Health Sciences, School of Chemistry, University of Sydney, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Guilloteau, Denis" sort="Guilloteau, Denis" uniqKey="Guilloteau D" first="Denis" 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Université François-Rabelais de Tours, Tours, France sylvie.chalon@univ-tours.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Molecular imaging</title><idno type="eISSN">1536-0121</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Early Diagnosis</term><term>Fluorine Radioisotopes (chemistry)</term><term>Fluorine Radioisotopes (pharmacology)</term><term>Humans</term><term>Male</term><term>Microglia (metabolism)</term><term>Microglia (pathology)</term><term>Positron-Emission Tomography (methods)</term><term>Pyrazoles (chemistry)</term><term>Pyrimidines (chemistry)</term><term>Rats</term><term>Receptors, GABA (metabolism)</term><term>Subarachnoid Hemorrhage (diagnostic imaging)</term><term>Subarachnoid Hemorrhage (metabolism)</term><term>Subarachnoid Hemorrhage (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Fluorine Radioisotopes</term><term>Pyrazoles</term><term>Pyrimidines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, GABA</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Fluorine Radioisotopes</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Subarachnoid Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Microglia</term><term>Subarachnoid Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Positron-Emission Tomography</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Microglia</term><term>Subarachnoid Hemorrhage</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Early Diagnosis</term><term>Humans</term><term>Male</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subarachnoid hemorrhage (SAH) can lead to delayed cerebral ischemia, which increases the rate of morbidity and mortality. The detection of microglial activation may serve as a biomarker for the identification of patients at risk of this deleterious consequence. We assessed this hypothesis in a rat model of SAH in which the exploration of neuroinflammation related to microglial activation was correlated with the degree of bleeding. We used the rat filament model and evaluated (at 48 hours postsurgery) the intensity of neuroinflammation using positron emission tomography (PET) imaging with the 18-kDa translocator protein (TSPO) tracer [(18)F]DPA-714, quantitative autoradiography with [(3)H]PK-11195, and SAH grade by postmortem brain picture. High SAH grades were strongly and positively correlated with in vivo PET imaging of TSPO in the cortex and striatum. In addition, a positive correlation was found in the cortex in TSPO, with densities determined by imaging and autoradiographic approaches. Qualitative immunofluorescence studies indicated that overexpression of TSPO was linked to astrocytic/microglial activation. In this model, PET imaging of TSPO using [(18)F]DPA-714 appeared to be a relevant index of the degree of bleeding, indicating that this imaging method could be used in human patients to improve the management of patients with SAH.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27118758</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>27</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>13</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>10</Day></DateRevised><Article PubModel="Electronic-Print"><Journal><ISSN IssnType="Electronic">1536-0121</ISSN><JournalIssue CitedMedium="Internet"><Volume>15</Volume><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>Molecular imaging</Title><ISOAbbreviation>Mol Imaging</ISOAbbreviation></Journal><ArticleTitle>Detection of Neuroinflammation in a Rat Model of Subarachnoid Hemorrhage Using [18F]DPA-714 PET Imaging.</ArticleTitle><ELocationID EIdType="doi" ValidYN="Y">10.1177/1536012116639189</ELocationID><ELocationID EIdType="pii" ValidYN="Y">1536012116639189</ELocationID><Abstract><AbstractText>Subarachnoid hemorrhage (SAH) can lead to delayed cerebral ischemia, which increases the rate of morbidity and mortality. The detection of microglial activation may serve as a biomarker for the identification of patients at risk of this deleterious consequence. We assessed this hypothesis in a rat model of SAH in which the exploration of neuroinflammation related to microglial activation was correlated with the degree of bleeding. We used the rat filament model and evaluated (at 48 hours postsurgery) the intensity of neuroinflammation using positron emission tomography (PET) imaging with the 18-kDa translocator protein (TSPO) tracer [(18)F]DPA-714, quantitative autoradiography with [(3)H]PK-11195, and SAH grade by postmortem brain picture. High SAH grades were strongly and positively correlated with in vivo PET imaging of TSPO in the cortex and striatum. In addition, a positive correlation was found in the cortex in TSPO, with densities determined by imaging and autoradiographic approaches. Qualitative immunofluorescence studies indicated that overexpression of TSPO was linked to astrocytic/microglial activation. In this model, PET imaging of TSPO using [(18)F]DPA-714 appeared to be a relevant index of the degree of bleeding, indicating that this imaging method could be used in human patients to improve the management of patients with SAH.</AbstractText><CopyrightInformation>© The Author(s) 2016.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>Clément</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vercouillie</LastName><ForeName>Johnny</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Doméné</LastName><ForeName>Aurélie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tauber</LastName><ForeName>Clovis</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kassiou</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Faculty of Health Sciences, School of Chemistry, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guilloteau</LastName><ForeName>Denis</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Destrieux</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France CHRU de Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sérrière</LastName><ForeName>Sophie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chalon</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>UMR Inserm U930, Université François-Rabelais de Tours, Tours, France sylvie.chalon@univ-tours.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Imaging</MedlineTA><NlmUniqueID>101120118</NlmUniqueID><ISSNLinking>1535-3508</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C463819">Bzrp protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005462">Fluorine Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C530129">N,N-diethyl-2-(2-(4-(2-fluoroethoxy)phenyl)-5,7-dimethylpyrazolo(1,5-a)pyrimidin-3-yl)acetamide</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011720">Pyrazoles</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011743">Pyrimidines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018079">Receptors, GABA</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Stroke. 1995 Jun;26(6):1086-91; discussion 1091-2</RefSource><PMID Version="1">7762027</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2013;8(2):e56441</RefSource><PMID Version="1">23418569</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Prog Neurobiol. 2006 Dec;80(6):308-22</RefSource><PMID Version="1">17156911</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci Methods. 2008 Jan 30;167(2):327-34</RefSource><PMID Version="1">17870179</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Curr Opin Crit Care. 2002 Apr;8(2):128-33</RefSource><PMID 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MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">PET</Keyword><Keyword MajorTopicYN="Y">SAH</Keyword><Keyword MajorTopicYN="Y">TSPO</Keyword><Keyword MajorTopicYN="Y">animal model</Keyword><Keyword MajorTopicYN="Y">neuroinflammation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>07</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>12</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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