Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.
Identifieur interne : 001F53 ( PubMed/Corpus ); précédent : 001F52; suivant : 001F54Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.
Auteurs : Rajat Kumar ; Fumihiko Kimura ; Kwang Woo Ahn ; Zhen-Huan Hu ; Yachiyo Kuwatsuka ; John P. Klein ; Marcelo Pasquini ; Koichi Miyamura ; Koji Kato ; Ayami Yoshimi ; Yoshihiro Inamoto ; Tatsuo Ichinohe ; William Allen Wood ; Baldeep Wirk ; Matthew Seftel ; Philip Rowlings ; David I. Marks ; Kirk R. Schultz ; Vikas Gupta ; Laurence Dedeken ; Biju George ; Jean-Yves Cahn ; Jeff Szer ; Jong Wook Lee ; Aloysius Y L. Ho ; Anders Fasth ; Theresa Hahn ; Nandita Khera ; Jignesh Dalal ; Carmem Bonfim ; Mahmoud Aljurf ; Yoshiko Atsuta ; Wael SaberSource :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1523-6536 ] ; 2016.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Anemia, Aplastic (mortality), Anemia, Aplastic (therapy), Bone Marrow Transplantation, Child, Child, Preschool, Female, Follow-Up Studies, Graft Rejection (mortality), Humans, Infant, Japan, Male, Middle Aged, Peripheral Blood Stem Cell Transplantation, Retrospective Studies, Siblings, Socioeconomic Factors.
- MESH :
- mortality : Anemia, Aplastic, Graft Rejection.
- therapy : Anemia, Aplastic.
- Adolescent, Adult, Aged, Bone Marrow Transplantation, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Infant, Japan, Male, Middle Aged, Peripheral Blood Stem Cell Transplantation, Retrospective Studies, Siblings, Socioeconomic Factors.
Abstract
Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared with mobilized peripheral blood stem cells (PBSCs). We hypothesized that this recommendation may not apply to those regions where patients present later in their disease course, with heavier transfusion load and with higher graft failure rates. Patients with SAA who received HSCT from an HLA-matched sibling donor from 1995 to 2009 and reported to the Center for International Blood and Marrow Transplant Research or the Japan Society for Hematopoietic Cell Transplantation were analyzed. The study population was categorized by gross national income per capita and region/countries into 4 groups. Groups analyzed were high-income countries (HIC), which were further divided into United States-Canada (n = 486) and other HIC (n = 1264); upper middle income (UMIC) (n = 482); and combined lower-middle, low-income countries (LM-LIC) (n = 142). In multivariate analysis, overall survival (OS) was highest with BM as graft source in HIC compared with PBSCs in all countries or BM in UMIC or LM-LIC (P < .001). There was no significant difference in OS between BM and PBSCs in UMIC (P = .32) or LM-LIC (P = .23). In LM-LIC the 28-day neutrophil engraftment was higher with PBSCs compared with BM (97% versus 77%, P = .002). Chronic graft-versus-host disease was significantly higher with PBSCs in all groups. Whereas BM should definitely be the preferred graft source for HLA-matched sibling HSCT in SAA, PBSCs may be an acceptable alternative in countries with limited resources when treating patients at high risk of graft failure and infective complications.
DOI: 10.1016/j.bbmt.2016.01.012
PubMed: 26797402
Links to Exploration step
pubmed:26797402Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.</title><author><name sortKey="Kumar, Rajat" sort="Kumar, Rajat" uniqKey="Kumar R" first="Rajat" last="Kumar">Rajat Kumar</name><affiliation><nlm:affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: rkumar@cancercare.mb.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Kimura, Fumihiko" sort="Kimura, Fumihiko" uniqKey="Kimura F" first="Fumihiko" last="Kimura">Fumihiko Kimura</name><affiliation><nlm:affiliation>Division of Hematology, National Defense Medical College, Tokorozawa, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Kuwatsuka, Yachiyo" sort="Kuwatsuka, Yachiyo" uniqKey="Kuwatsuka Y" first="Yachiyo" last="Kuwatsuka">Yachiyo Kuwatsuka</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P" last="Klein">John P. Klein</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Pasquini, Marcelo" sort="Pasquini, Marcelo" uniqKey="Pasquini M" first="Marcelo" last="Pasquini">Marcelo Pasquini</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Miyamura, Koichi" sort="Miyamura, Koichi" uniqKey="Miyamura K" first="Koichi" last="Miyamura">Koichi Miyamura</name><affiliation><nlm:affiliation>Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Kato, Koji" sort="Kato, Koji" uniqKey="Kato K" first="Koji" last="Kato">Koji Kato</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Yoshimi, Ayami" sort="Yoshimi, Ayami" uniqKey="Yoshimi A" first="Ayami" last="Yoshimi">Ayami Yoshimi</name><affiliation><nlm:affiliation>Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation><nlm:affiliation>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ichinohe, Tatsuo" sort="Ichinohe, Tatsuo" uniqKey="Ichinohe T" first="Tatsuo" last="Ichinohe">Tatsuo Ichinohe</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Wood, William Allen" sort="Wood, William Allen" uniqKey="Wood W" first="William Allen" last="Wood">William Allen Wood</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.</nlm:affiliation></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation><nlm:affiliation>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation><nlm:affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rowlings, Philip" sort="Rowlings, Philip" uniqKey="Rowlings P" first="Philip" last="Rowlings">Philip Rowlings</name><affiliation><nlm:affiliation>Calvary Mater Newcastle, HAPS-Pathology North, University of Newcastle, Callaghan, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name><affiliation><nlm:affiliation>Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Schultz, Kirk R" sort="Schultz, Kirk R" uniqKey="Schultz K" first="Kirk R" last="Schultz">Kirk R. Schultz</name><affiliation><nlm:affiliation>BC Children's Hospital and Child and Family Research Institute, Vancouver, British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation><nlm:affiliation>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Dedeken, Laurence" sort="Dedeken, Laurence" uniqKey="Dedeken L" first="Laurence" last="Dedeken">Laurence Dedeken</name><affiliation><nlm:affiliation>Department of Hematology-Oncology, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="George, Biju" sort="George, Biju" uniqKey="George B" first="Biju" last="George">Biju George</name><affiliation><nlm:affiliation>Christian Medical College, Vellore, India.</nlm:affiliation></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:affiliation>Department of Hematology, University Hospital, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name><affiliation><nlm:affiliation>Department Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jong Wook" sort="Lee, Jong Wook" uniqKey="Lee J" first="Jong Wook" last="Lee">Jong Wook Lee</name><affiliation><nlm:affiliation>BMT Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Ho, Aloysius Y L" sort="Ho, Aloysius Y L" uniqKey="Ho A" first="Aloysius Y L" last="Ho">Aloysius Y L. Ho</name><affiliation><nlm:affiliation>Singapore General Hospital, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Fasth, Anders" sort="Fasth, Anders" uniqKey="Fasth A" first="Anders" last="Fasth">Anders Fasth</name><affiliation><nlm:affiliation>Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Hahn, Theresa" sort="Hahn, Theresa" uniqKey="Hahn T" first="Theresa" last="Hahn">Theresa Hahn</name><affiliation><nlm:affiliation>Roswell Park Cancer Institute, Buffalo, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Khera, Nandita" sort="Khera, Nandita" uniqKey="Khera N" first="Nandita" last="Khera">Nandita Khera</name><affiliation><nlm:affiliation>Department of Hematology/Oncology, Mayo Clinic, Phoenix, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Dalal, Jignesh" sort="Dalal, Jignesh" uniqKey="Dalal J" first="Jignesh" last="Dalal">Jignesh Dalal</name><affiliation><nlm:affiliation>Rainbow Babies & Children's Hospital/Case Western Reserve University, Cleveland, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Bonfim, Carmem" sort="Bonfim, Carmem" uniqKey="Bonfim C" first="Carmem" last="Bonfim">Carmem Bonfim</name><affiliation><nlm:affiliation>Hospital de Clinicas, Federal University of Parana, Curitiba, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name><affiliation><nlm:affiliation>Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Atsuta, Yoshiko" sort="Atsuta, Yoshiko" uniqKey="Atsuta Y" first="Yoshiko" last="Atsuta">Yoshiko Atsuta</name><affiliation><nlm:affiliation>Japanese Data Center for Hematopoietic Cell Transplantation and Nagoya University Graduate School of Medicine, Nagoya, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26797402</idno><idno type="pmid">26797402</idno><idno type="doi">10.1016/j.bbmt.2016.01.012</idno><idno type="wicri:Area/PubMed/Corpus">001F53</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.</title><author><name sortKey="Kumar, Rajat" sort="Kumar, Rajat" uniqKey="Kumar R" first="Rajat" last="Kumar">Rajat Kumar</name><affiliation><nlm:affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: rkumar@cancercare.mb.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Kimura, Fumihiko" sort="Kimura, Fumihiko" uniqKey="Kimura F" first="Fumihiko" last="Kimura">Fumihiko Kimura</name><affiliation><nlm:affiliation>Division of Hematology, National Defense Medical College, Tokorozawa, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ahn, Kwang Woo" sort="Ahn, Kwang Woo" uniqKey="Ahn K" first="Kwang Woo" last="Ahn">Kwang Woo Ahn</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Hu, Zhen Huan" sort="Hu, Zhen Huan" uniqKey="Hu Z" first="Zhen-Huan" last="Hu">Zhen-Huan Hu</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Kuwatsuka, Yachiyo" sort="Kuwatsuka, Yachiyo" uniqKey="Kuwatsuka Y" first="Yachiyo" last="Kuwatsuka">Yachiyo Kuwatsuka</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Klein, John P" sort="Klein, John P" uniqKey="Klein J" first="John P" last="Klein">John P. Klein</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Pasquini, Marcelo" sort="Pasquini, Marcelo" uniqKey="Pasquini M" first="Marcelo" last="Pasquini">Marcelo Pasquini</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author><author><name sortKey="Miyamura, Koichi" sort="Miyamura, Koichi" uniqKey="Miyamura K" first="Koichi" last="Miyamura">Koichi Miyamura</name><affiliation><nlm:affiliation>Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Kato, Koji" sort="Kato, Koji" uniqKey="Kato K" first="Koji" last="Kato">Koji Kato</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Yoshimi, Ayami" sort="Yoshimi, Ayami" uniqKey="Yoshimi A" first="Ayami" last="Yoshimi">Ayami Yoshimi</name><affiliation><nlm:affiliation>Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Inamoto, Yoshihiro" sort="Inamoto, Yoshihiro" uniqKey="Inamoto Y" first="Yoshihiro" last="Inamoto">Yoshihiro Inamoto</name><affiliation><nlm:affiliation>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Ichinohe, Tatsuo" sort="Ichinohe, Tatsuo" uniqKey="Ichinohe T" first="Tatsuo" last="Ichinohe">Tatsuo Ichinohe</name><affiliation><nlm:affiliation>Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Wood, William Allen" sort="Wood, William Allen" uniqKey="Wood W" first="William Allen" last="Wood">William Allen Wood</name><affiliation><nlm:affiliation>Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.</nlm:affiliation></affiliation></author><author><name sortKey="Wirk, Baldeep" sort="Wirk, Baldeep" uniqKey="Wirk B" first="Baldeep" last="Wirk">Baldeep Wirk</name><affiliation><nlm:affiliation>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, Washington.</nlm:affiliation></affiliation></author><author><name sortKey="Seftel, Matthew" sort="Seftel, Matthew" uniqKey="Seftel M" first="Matthew" last="Seftel">Matthew Seftel</name><affiliation><nlm:affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Rowlings, Philip" sort="Rowlings, Philip" uniqKey="Rowlings P" first="Philip" last="Rowlings">Philip Rowlings</name><affiliation><nlm:affiliation>Calvary Mater Newcastle, HAPS-Pathology North, University of Newcastle, Callaghan, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Marks, David I" sort="Marks, David I" uniqKey="Marks D" first="David I" last="Marks">David I. Marks</name><affiliation><nlm:affiliation>Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Schultz, Kirk R" sort="Schultz, Kirk R" uniqKey="Schultz K" first="Kirk R" last="Schultz">Kirk R. Schultz</name><affiliation><nlm:affiliation>BC Children's Hospital and Child and Family Research Institute, Vancouver, British Columbia, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gupta, Vikas" sort="Gupta, Vikas" uniqKey="Gupta V" first="Vikas" last="Gupta">Vikas Gupta</name><affiliation><nlm:affiliation>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Dedeken, Laurence" sort="Dedeken, Laurence" uniqKey="Dedeken L" first="Laurence" last="Dedeken">Laurence Dedeken</name><affiliation><nlm:affiliation>Department of Hematology-Oncology, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium.</nlm:affiliation></affiliation></author><author><name sortKey="George, Biju" sort="George, Biju" uniqKey="George B" first="Biju" last="George">Biju George</name><affiliation><nlm:affiliation>Christian Medical College, Vellore, India.</nlm:affiliation></affiliation></author><author><name sortKey="Cahn, Jean Yves" sort="Cahn, Jean Yves" uniqKey="Cahn J" first="Jean-Yves" last="Cahn">Jean-Yves Cahn</name><affiliation><nlm:affiliation>Department of Hematology, University Hospital, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Szer, Jeff" sort="Szer, Jeff" uniqKey="Szer J" first="Jeff" last="Szer">Jeff Szer</name><affiliation><nlm:affiliation>Department Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Jong Wook" sort="Lee, Jong Wook" uniqKey="Lee J" first="Jong Wook" last="Lee">Jong Wook Lee</name><affiliation><nlm:affiliation>BMT Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.</nlm:affiliation></affiliation></author><author><name sortKey="Ho, Aloysius Y L" sort="Ho, Aloysius Y L" uniqKey="Ho A" first="Aloysius Y L" last="Ho">Aloysius Y L. Ho</name><affiliation><nlm:affiliation>Singapore General Hospital, Singapore, Singapore.</nlm:affiliation></affiliation></author><author><name sortKey="Fasth, Anders" sort="Fasth, Anders" uniqKey="Fasth A" first="Anders" last="Fasth">Anders Fasth</name><affiliation><nlm:affiliation>Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Hahn, Theresa" sort="Hahn, Theresa" uniqKey="Hahn T" first="Theresa" last="Hahn">Theresa Hahn</name><affiliation><nlm:affiliation>Roswell Park Cancer Institute, Buffalo, New York.</nlm:affiliation></affiliation></author><author><name sortKey="Khera, Nandita" sort="Khera, Nandita" uniqKey="Khera N" first="Nandita" last="Khera">Nandita Khera</name><affiliation><nlm:affiliation>Department of Hematology/Oncology, Mayo Clinic, Phoenix, Arizona.</nlm:affiliation></affiliation></author><author><name sortKey="Dalal, Jignesh" sort="Dalal, Jignesh" uniqKey="Dalal J" first="Jignesh" last="Dalal">Jignesh Dalal</name><affiliation><nlm:affiliation>Rainbow Babies & Children's Hospital/Case Western Reserve University, Cleveland, Ohio.</nlm:affiliation></affiliation></author><author><name sortKey="Bonfim, Carmem" sort="Bonfim, Carmem" uniqKey="Bonfim C" first="Carmem" last="Bonfim">Carmem Bonfim</name><affiliation><nlm:affiliation>Hospital de Clinicas, Federal University of Parana, Curitiba, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Aljurf, Mahmoud" sort="Aljurf, Mahmoud" uniqKey="Aljurf M" first="Mahmoud" last="Aljurf">Mahmoud Aljurf</name><affiliation><nlm:affiliation>Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Atsuta, Yoshiko" sort="Atsuta, Yoshiko" uniqKey="Atsuta Y" first="Yoshiko" last="Atsuta">Yoshiko Atsuta</name><affiliation><nlm:affiliation>Japanese Data Center for Hematopoietic Cell Transplantation and Nagoya University Graduate School of Medicine, Nagoya, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Saber, Wael" sort="Saber, Wael" uniqKey="Saber W" first="Wael" last="Saber">Wael Saber</name><affiliation><nlm:affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="eISSN">1523-6536</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Anemia, Aplastic (mortality)</term><term>Anemia, Aplastic (therapy)</term><term>Bone Marrow Transplantation</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Follow-Up Studies</term><term>Graft Rejection (mortality)</term><term>Humans</term><term>Infant</term><term>Japan</term><term>Male</term><term>Middle Aged</term><term>Peripheral Blood Stem Cell Transplantation</term><term>Retrospective Studies</term><term>Siblings</term><term>Socioeconomic Factors</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Anemia, Aplastic</term><term>Graft Rejection</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Anemia, Aplastic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Bone Marrow Transplantation</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Infant</term><term>Japan</term><term>Male</term><term>Middle Aged</term><term>Peripheral Blood Stem Cell Transplantation</term><term>Retrospective Studies</term><term>Siblings</term><term>Socioeconomic Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared with mobilized peripheral blood stem cells (PBSCs). We hypothesized that this recommendation may not apply to those regions where patients present later in their disease course, with heavier transfusion load and with higher graft failure rates. Patients with SAA who received HSCT from an HLA-matched sibling donor from 1995 to 2009 and reported to the Center for International Blood and Marrow Transplant Research or the Japan Society for Hematopoietic Cell Transplantation were analyzed. The study population was categorized by gross national income per capita and region/countries into 4 groups. Groups analyzed were high-income countries (HIC), which were further divided into United States-Canada (n = 486) and other HIC (n = 1264); upper middle income (UMIC) (n = 482); and combined lower-middle, low-income countries (LM-LIC) (n = 142). In multivariate analysis, overall survival (OS) was highest with BM as graft source in HIC compared with PBSCs in all countries or BM in UMIC or LM-LIC (P < .001). There was no significant difference in OS between BM and PBSCs in UMIC (P = .32) or LM-LIC (P = .23). In LM-LIC the 28-day neutrophil engraftment was higher with PBSCs compared with BM (97% versus 77%, P = .002). Chronic graft-versus-host disease was significantly higher with PBSCs in all groups. Whereas BM should definitely be the preferred graft source for HLA-matched sibling HSCT in SAA, PBSCs may be an acceptable alternative in countries with limited resources when treating patients at high risk of graft failure and infective complications.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26797402</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>08</Day></DateCreated><DateCompleted><Year>2016</Year><Month>12</Month><Day>16</Day></DateCompleted><DateRevised><Year>2017</Year><Month>05</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1523-6536</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>5</Issue><PubDate><Year>2016</Year><Month>May</Month></PubDate></JournalIssue><Title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</Title><ISOAbbreviation>Biol. Blood Marrow Transplant.</ISOAbbreviation></Journal><ArticleTitle>Comparing Outcomes with Bone Marrow or Peripheral Blood Stem Cells as Graft Source for Matched Sibling Transplants in Severe Aplastic Anemia across Different Economic Regions.</ArticleTitle><Pagination><MedlinePgn>932-40</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbmt.2016.01.012</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1083-8791(16)00052-5</ELocationID><Abstract><AbstractText>Bone marrow (BM) is the preferred graft source for hematopoietic stem cell transplantation (HSCT) in severe aplastic anemia (SAA) compared with mobilized peripheral blood stem cells (PBSCs). We hypothesized that this recommendation may not apply to those regions where patients present later in their disease course, with heavier transfusion load and with higher graft failure rates. Patients with SAA who received HSCT from an HLA-matched sibling donor from 1995 to 2009 and reported to the Center for International Blood and Marrow Transplant Research or the Japan Society for Hematopoietic Cell Transplantation were analyzed. The study population was categorized by gross national income per capita and region/countries into 4 groups. Groups analyzed were high-income countries (HIC), which were further divided into United States-Canada (n = 486) and other HIC (n = 1264); upper middle income (UMIC) (n = 482); and combined lower-middle, low-income countries (LM-LIC) (n = 142). In multivariate analysis, overall survival (OS) was highest with BM as graft source in HIC compared with PBSCs in all countries or BM in UMIC or LM-LIC (P < .001). There was no significant difference in OS between BM and PBSCs in UMIC (P = .32) or LM-LIC (P = .23). In LM-LIC the 28-day neutrophil engraftment was higher with PBSCs compared with BM (97% versus 77%, P = .002). Chronic graft-versus-host disease was significantly higher with PBSCs in all groups. Whereas BM should definitely be the preferred graft source for HLA-matched sibling HSCT in SAA, PBSCs may be an acceptable alternative in countries with limited resources when treating patients at high risk of graft failure and infective complications.</AbstractText><CopyrightInformation>Copyright © 2016 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Rajat</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address: rkumar@cancercare.mb.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kimura</LastName><ForeName>Fumihiko</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Division of Hematology, National Defense Medical College, Tokorozawa, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahn</LastName><ForeName>Kwang Woo</ForeName><Initials>KW</Initials><AffiliationInfo><Affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Zhen-Huan</ForeName><Initials>ZH</Initials><AffiliationInfo><Affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuwatsuka</LastName><ForeName>Yachiyo</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin; Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klein</LastName><ForeName>John P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pasquini</LastName><ForeName>Marcelo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyamura</LastName><ForeName>Koichi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kato</LastName><ForeName>Koji</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Hematology and Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoshimi</LastName><ForeName>Ayami</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Inamoto</LastName><ForeName>Yoshihiro</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Division of Hematopoietic Stem Cell Transplantation, National Cancer Center Hospital, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ichinohe</LastName><ForeName>Tatsuo</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wood</LastName><ForeName>William Allen</ForeName><Initials>WA</Initials><Suffix>Jr</Suffix><AffiliationInfo><Affiliation>Division of Hematology/Oncology, Department of Medicine, University of North Carolina, Chapel Hill, North Carolina.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wirk</LastName><ForeName>Baldeep</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Bone Marrow Transplant, Seattle Cancer Care Alliance, Seattle, Washington.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seftel</LastName><ForeName>Matthew</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology and Hematology, CancerCare Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rowlings</LastName><ForeName>Philip</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Calvary Mater Newcastle, HAPS-Pathology North, University of Newcastle, Callaghan, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marks</LastName><ForeName>David I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Pediatric Bone Marrow Transplant, University Hospitals Bristol NHS Trust, Bristol, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schultz</LastName><ForeName>Kirk R</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>BC Children's Hospital and Child and Family Research Institute, Vancouver, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gupta</LastName><ForeName>Vikas</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dedeken</LastName><ForeName>Laurence</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Hematology-Oncology, Hopital Universitaire des Enfants Reine Fabiola, Brussels, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>George</LastName><ForeName>Biju</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Christian Medical College, Vellore, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cahn</LastName><ForeName>Jean-Yves</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Department of Hematology, University Hospital, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Szer</LastName><ForeName>Jeff</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department Clinical Haematology and Bone Marrow Transplantation, Royal Melbourne Hospital, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Jong Wook</ForeName><Initials>JW</Initials><AffiliationInfo><Affiliation>BMT Center, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Aloysius Y L</ForeName><Initials>AY</Initials><AffiliationInfo><Affiliation>Singapore General Hospital, Singapore, Singapore.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fasth</LastName><ForeName>Anders</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pediatrics, University of Gothenburg, Gothenburg, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hahn</LastName><ForeName>Theresa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Roswell Park Cancer Institute, Buffalo, New York.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khera</LastName><ForeName>Nandita</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Hematology/Oncology, Mayo Clinic, Phoenix, Arizona.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dalal</LastName><ForeName>Jignesh</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Rainbow Babies & Children's Hospital/Case Western Reserve University, Cleveland, Ohio.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonfim</LastName><ForeName>Carmem</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Hospital de Clinicas, Federal University of Parana, Curitiba, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aljurf</LastName><ForeName>Mahmoud</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Oncology, King Faisal Specialist Hospital Center & Research, Riyadh, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Atsuta</LastName><ForeName>Yoshiko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Japanese Data Center for Hematopoietic Cell Transplantation and Nagoya University Graduate School of Medicine, Nagoya, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Saber</LastName><ForeName>Wael</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Medicine, Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>U24 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Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006084" MajorTopicYN="N">Graft Rejection</DescriptorName><QualifierName UI="Q000401" MajorTopicYN="Y">mortality</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007564" MajorTopicYN="N">Japan</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D036102" MajorTopicYN="Y">Peripheral Blood Stem Cell Transplantation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D035781" MajorTopicYN="Y">Siblings</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012959" MajorTopicYN="N">Socioeconomic Factors</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS767543 [Available on 05/01/17]</OtherID><OtherID Source="NLM">PMC4826285 [Available on 05/01/17]</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Aplastic anemia</Keyword><Keyword MajorTopicYN="N">Economic regions</Keyword><Keyword MajorTopicYN="N">Graft source</Keyword><Keyword MajorTopicYN="N">Hematopoietic cell transplantation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>10</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>01</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>1</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>1</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26797402</ArticleId><ArticleId IdType="pii">S1083-8791(16)00052-5</ArticleId><ArticleId IdType="doi">10.1016/j.bbmt.2016.01.012</ArticleId><ArticleId IdType="pmc">PMC4826285</ArticleId><ArticleId 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