EAACI Molecular Allergology User's Guide.
Identifieur interne : 001F12 ( PubMed/Corpus ); précédent : 001F11; suivant : 001F13EAACI Molecular Allergology User's Guide.
Auteurs : P M Matricardi ; J. Kleine-Tebbe ; H J Hoffmann ; R. Valenta ; C. Hilger ; S. Hofmaier ; R C Aalberse ; I. Agache ; R. Asero ; B. Ballmer-Weber ; D. Barber ; K. Beyer ; T. Biedermann ; M B Bil ; S. Blank ; B. Bohle ; P P Bosshard ; H. Breiteneder ; H A Brough ; L. Caraballo ; J C Caubet ; R. Crameri ; J M Davies ; N. Douladiris ; M. Ebisawa ; P A Eigenmann ; M. Fernandez-Rivas ; F. Ferreira ; G. Gadermaier ; M. Glatz ; R G Hamilton ; T. Hawranek ; P. Hellings ; K. Hoffmann-Sommergruber ; T. Jakob ; U. Jappe ; M. Jutel ; S D Kamath ; E F Knol ; P. Korosec ; A. Kuehn ; G. Lack ; A L Lopata ; M. M Kel ; M. Morisset ; V. Niederberger ; A H Nowak-W Grzyn ; N G Papadopoulos ; E A Pastorello ; G. Pauli ; T. Platts-Mills ; D. Posa ; L K Poulsen ; M. Raulf ; J. Sastre ; E. Scala ; J M Schmid ; P. Schmid-Grendelmeier ; M. Van Hage ; R. Van Ree ; S. Vieths ; R. Weber ; M. Wickman ; A. Muraro ; M. OllertSource :
- Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology [ 1399-3038 ] ; 2016.
Abstract
The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.
DOI: 10.1111/pai.12563
PubMed: 27288833
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pubmed:27288833Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">EAACI Molecular Allergology User's Guide.</title><author><name sortKey="Matricardi, P M" sort="Matricardi, P M" uniqKey="Matricardi P" first="P M" last="Matricardi">P M Matricardi</name><affiliation><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kleine Tebbe, J" sort="Kleine Tebbe, J" uniqKey="Kleine Tebbe J" first="J" last="Kleine-Tebbe">J. Kleine-Tebbe</name><affiliation><nlm:affiliation>Allergy & Asthma Center Westend, Outpatient Clinic Ackermann, Hanf, & Kleine-Tebbe, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmann, H J" sort="Hoffmann, H J" uniqKey="Hoffmann H" first="H J" last="Hoffmann">H J Hoffmann</name><affiliation><nlm:affiliation>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Valenta, R" sort="Valenta, R" uniqKey="Valenta R" first="R" last="Valenta">R. Valenta</name><affiliation><nlm:affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Hilger, C" sort="Hilger, C" uniqKey="Hilger C" first="C" last="Hilger">C. Hilger</name><affiliation><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation></affiliation></author><author><name sortKey="Hofmaier, S" sort="Hofmaier, S" uniqKey="Hofmaier S" first="S" last="Hofmaier">S. Hofmaier</name><affiliation><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Aalberse, R C" sort="Aalberse, R C" uniqKey="Aalberse R" first="R C" last="Aalberse">R C Aalberse</name><affiliation><nlm:affiliation>Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Agache, I" sort="Agache, I" uniqKey="Agache I" first="I" last="Agache">I. Agache</name><affiliation><nlm:affiliation>Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania.</nlm:affiliation></affiliation></author><author><name sortKey="Asero, R" sort="Asero, R" uniqKey="Asero R" first="R" last="Asero">R. Asero</name><affiliation><nlm:affiliation>Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ballmer Weber, B" sort="Ballmer Weber, B" uniqKey="Ballmer Weber B" first="B" last="Ballmer-Weber">B. Ballmer-Weber</name><affiliation><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Barber, D" sort="Barber, D" uniqKey="Barber D" first="D" last="Barber">D. Barber</name><affiliation><nlm:affiliation>IMMA-School of Medicine, University CEU San Pablo, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Beyer, K" sort="Beyer, K" uniqKey="Beyer K" first="K" last="Beyer">K. Beyer</name><affiliation><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Biedermann, T" sort="Biedermann, T" uniqKey="Biedermann T" first="T" last="Biedermann">T. Biedermann</name><affiliation><nlm:affiliation>Department of Dermatology and Allergology, Technical University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bil, M B" sort="Bil, M B" uniqKey="Bil M" first="M B" last="Bil">M B Bil</name><affiliation><nlm:affiliation>Allergy Unit, Department of Internal Medicine, University Hospital Ospedali Riuniti di Ancona, Ancona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Blank, S" sort="Blank, S" uniqKey="Blank S" first="S" last="Blank">S. Blank</name><affiliation><nlm:affiliation>Center of Allergy and Environment (ZAUM), Helmholtz Center Munich, Technical University of Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bohle, B" sort="Bohle, B" uniqKey="Bohle B" first="B" last="Bohle">B. Bohle</name><affiliation><nlm:affiliation>Division of Experimental Allergology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Bosshard, P P" sort="Bosshard, P P" uniqKey="Bosshard P" first="P P" last="Bosshard">P P Bosshard</name><affiliation><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Breiteneder, H" sort="Breiteneder, H" uniqKey="Breiteneder H" first="H" last="Breiteneder">H. Breiteneder</name><affiliation><nlm:affiliation>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Brough, H A" sort="Brough, H A" uniqKey="Brough H" first="H A" last="Brough">H A Brough</name><affiliation><nlm:affiliation>Paediatric Allergy, Department of Asthma, Allergy and Respiratory Science, King's College London, Guys' Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Caraballo, L" sort="Caraballo, L" uniqKey="Caraballo L" first="L" last="Caraballo">L. Caraballo</name><affiliation><nlm:affiliation>Institute for Immunological Research, The University of Cartagena, Cartagena de Indias, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Caubet, J C" sort="Caubet, J C" uniqKey="Caubet J" first="J C" last="Caubet">J C Caubet</name><affiliation><nlm:affiliation>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Crameri, R" sort="Crameri, R" uniqKey="Crameri R" first="R" last="Crameri">R. Crameri</name><affiliation><nlm:affiliation>Swiss Institute of Allergy and Asthma Research, University of Zürich, Davos, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Davies, J M" sort="Davies, J M" uniqKey="Davies J" first="J M" last="Davies">J M Davies</name><affiliation><nlm:affiliation>School of Biomedical Sciences, Institute of Biomedical Innovation, Queensland University of Technology, Brisbane, Qld, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Douladiris, N" sort="Douladiris, N" uniqKey="Douladiris N" first="N" last="Douladiris">N. Douladiris</name><affiliation><nlm:affiliation>Allergy Unit, 2nd Paediatric Clinic, National & Kapodistrian University, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Ebisawa, M" sort="Ebisawa, M" uniqKey="Ebisawa M" first="M" last="Ebisawa">M. Ebisawa</name><affiliation><nlm:affiliation>Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Eigenmann, P A" sort="Eigenmann, P A" uniqKey="Eigenmann P" first="P A" last="Eigenmann">P A Eigenmann</name><affiliation><nlm:affiliation>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Rivas, M" sort="Fernandez Rivas, M" uniqKey="Fernandez Rivas M" first="M" last="Fernandez-Rivas">M. Fernandez-Rivas</name><affiliation><nlm:affiliation>Allergy Department, Hospital Clinico San Carlos IdISSC, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ferreira, F" sort="Ferreira, F" uniqKey="Ferreira F" first="F" last="Ferreira">F. Ferreira</name><affiliation><nlm:affiliation>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Gadermaier, G" sort="Gadermaier, G" uniqKey="Gadermaier G" first="G" last="Gadermaier">G. Gadermaier</name><affiliation><nlm:affiliation>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Glatz, M" sort="Glatz, M" uniqKey="Glatz M" first="M" last="Glatz">M. Glatz</name><affiliation><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Hamilton, R G" sort="Hamilton, R G" uniqKey="Hamilton R" first="R G" last="Hamilton">R G Hamilton</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hawranek, T" sort="Hawranek, T" uniqKey="Hawranek T" first="T" last="Hawranek">T. Hawranek</name><affiliation><nlm:affiliation>Department of Dermatology, Paracelsus Private Medical University, Salzburg, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Hellings, P" sort="Hellings, P" uniqKey="Hellings P" first="P" last="Hellings">P. Hellings</name><affiliation><nlm:affiliation>Department of Otorhinolaryngology, Academic Medical Center (AMC), Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmann Sommergruber, K" sort="Hoffmann Sommergruber, K" uniqKey="Hoffmann Sommergruber K" first="K" last="Hoffmann-Sommergruber">K. Hoffmann-Sommergruber</name><affiliation><nlm:affiliation>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Jakob, T" sort="Jakob, T" uniqKey="Jakob T" first="T" last="Jakob">T. Jakob</name><affiliation><nlm:affiliation>Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Justus Liebig University Giessen, Giessen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jappe, U" sort="Jappe, U" uniqKey="Jappe U" first="U" last="Jappe">U. Jappe</name><affiliation><nlm:affiliation>Division of Clinical and Molecular Allergology, Research Centre Borstel, Airway Research Centre North (ARCN), Member of the German Centre for Lung Research (DZL), Borstel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jutel, M" sort="Jutel, M" uniqKey="Jutel M" first="M" last="Jutel">M. Jutel</name><affiliation><nlm:affiliation>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Kamath, S D" sort="Kamath, S D" uniqKey="Kamath S" first="S D" last="Kamath">S D Kamath</name><affiliation><nlm:affiliation>Molecular Allergy Research Laboratory, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville City, Qld, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Knol, E F" sort="Knol, E F" uniqKey="Knol E" first="E F" last="Knol">E F Knol</name><affiliation><nlm:affiliation>Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Korosec, P" sort="Korosec, P" uniqKey="Korosec P" first="P" last="Korosec">P. Korosec</name><affiliation><nlm:affiliation>University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.</nlm:affiliation></affiliation></author><author><name sortKey="Kuehn, A" sort="Kuehn, A" uniqKey="Kuehn A" first="A" last="Kuehn">A. Kuehn</name><affiliation><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation></affiliation></author><author><name sortKey="Lack, G" sort="Lack, G" uniqKey="Lack G" first="G" last="Lack">G. Lack</name><affiliation><nlm:affiliation>King's College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lopata, A L" sort="Lopata, A L" uniqKey="Lopata A" first="A L" last="Lopata">A L Lopata</name><affiliation><nlm:affiliation>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="M Kel, M" sort="M Kel, M" uniqKey="M Kel M" first="M" last="M Kel">M. M Kel</name><affiliation><nlm:affiliation>Skin and Allergy Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Morisset, M" sort="Morisset, M" uniqKey="Morisset M" first="M" last="Morisset">M. Morisset</name><affiliation><nlm:affiliation>National Service of Immuno-Allergology, Centre Hospitalier Luxembourg (CHL), Luxembourg, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Niederberger, V" sort="Niederberger, V" uniqKey="Niederberger V" first="V" last="Niederberger">V. Niederberger</name><affiliation><nlm:affiliation>Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Nowak W Grzyn, A H" sort="Nowak W Grzyn, A H" uniqKey="Nowak W Grzyn A" first="A H" last="Nowak-W Grzyn">A H Nowak-W Grzyn</name><affiliation><nlm:affiliation>Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Papadopoulos, N G" sort="Papadopoulos, N G" uniqKey="Papadopoulos N" first="N G" last="Papadopoulos">N G Papadopoulos</name><affiliation><nlm:affiliation>Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pastorello, E A" sort="Pastorello, E A" uniqKey="Pastorello E" first="E A" last="Pastorello">E A Pastorello</name><affiliation><nlm:affiliation>Unit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Pauli, G" sort="Pauli, G" uniqKey="Pauli G" first="G" last="Pauli">G. Pauli</name><affiliation><nlm:affiliation>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Platts Mills, T" sort="Platts Mills, T" uniqKey="Platts Mills T" first="T" last="Platts-Mills">T. Platts-Mills</name><affiliation><nlm:affiliation>Department of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Posa, D" sort="Posa, D" uniqKey="Posa D" first="D" last="Posa">D. Posa</name><affiliation><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Poulsen, L K" sort="Poulsen, L K" uniqKey="Poulsen L" first="L K" last="Poulsen">L K Poulsen</name><affiliation><nlm:affiliation>Allergy Clinic, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Raulf, M" sort="Raulf, M" uniqKey="Raulf M" first="M" last="Raulf">M. Raulf</name><affiliation><nlm:affiliation>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-University Bochum (IPA), Bochum, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Sastre, J" sort="Sastre, J" uniqKey="Sastre J" first="J" last="Sastre">J. Sastre</name><affiliation><nlm:affiliation>Allergy Division, Fundación Jimenez Díaz, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Scala, E" sort="Scala, E" uniqKey="Scala E" first="E" last="Scala">E. Scala</name><affiliation><nlm:affiliation>Experimental Allergy Unit, IDI-IRCCS, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Schmid, J M" sort="Schmid, J M" uniqKey="Schmid J" first="J M" last="Schmid">J M Schmid</name><affiliation><nlm:affiliation>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Schmid Grendelmeier, P" sort="Schmid Grendelmeier, P" uniqKey="Schmid Grendelmeier P" first="P" last="Schmid-Grendelmeier">P. Schmid-Grendelmeier</name><affiliation><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Van Hage, M" sort="Van Hage, M" uniqKey="Van Hage M" first="M" last="Van Hage">M. Van Hage</name><affiliation><nlm:affiliation>Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Van Ree, R" sort="Van Ree, R" uniqKey="Van Ree R" first="R" last="Van Ree">R. Van Ree</name><affiliation><nlm:affiliation>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vieths, S" sort="Vieths, S" uniqKey="Vieths S" first="S" last="Vieths">S. Vieths</name><affiliation><nlm:affiliation>Department of Allergology, Paul-Ehrlich-Institut, Langen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Weber, R" sort="Weber, R" uniqKey="Weber R" first="R" last="Weber">R. Weber</name><affiliation><nlm:affiliation>School of Medicine, University of Colorado, Denver, CO, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wickman, M" sort="Wickman, M" uniqKey="Wickman M" first="M" last="Wickman">M. Wickman</name><affiliation><nlm:affiliation>Sachs' Children's Hospital, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Muraro, A" sort="Muraro, A" uniqKey="Muraro A" first="A" last="Muraro">A. Muraro</name><affiliation><nlm:affiliation>The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ollert, M" sort="Ollert, M" uniqKey="Ollert M" first="M" last="Ollert">M. Ollert</name><affiliation><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27288833</idno><idno type="pmid">27288833</idno><idno type="doi">10.1111/pai.12563</idno><idno type="wicri:Area/PubMed/Corpus">001F12</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F12</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">EAACI Molecular Allergology User's Guide.</title><author><name sortKey="Matricardi, P M" sort="Matricardi, P M" uniqKey="Matricardi P" first="P M" last="Matricardi">P M Matricardi</name><affiliation><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Kleine Tebbe, J" sort="Kleine Tebbe, J" uniqKey="Kleine Tebbe J" first="J" last="Kleine-Tebbe">J. Kleine-Tebbe</name><affiliation><nlm:affiliation>Allergy & Asthma Center Westend, Outpatient Clinic Ackermann, Hanf, & Kleine-Tebbe, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmann, H J" sort="Hoffmann, H J" uniqKey="Hoffmann H" first="H J" last="Hoffmann">H J Hoffmann</name><affiliation><nlm:affiliation>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Valenta, R" sort="Valenta, R" uniqKey="Valenta R" first="R" last="Valenta">R. Valenta</name><affiliation><nlm:affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Hilger, C" sort="Hilger, C" uniqKey="Hilger C" first="C" last="Hilger">C. Hilger</name><affiliation><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation></affiliation></author><author><name sortKey="Hofmaier, S" sort="Hofmaier, S" uniqKey="Hofmaier S" first="S" last="Hofmaier">S. Hofmaier</name><affiliation><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Aalberse, R C" sort="Aalberse, R C" uniqKey="Aalberse R" first="R C" last="Aalberse">R C Aalberse</name><affiliation><nlm:affiliation>Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Agache, I" sort="Agache, I" uniqKey="Agache I" first="I" last="Agache">I. Agache</name><affiliation><nlm:affiliation>Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania.</nlm:affiliation></affiliation></author><author><name sortKey="Asero, R" sort="Asero, R" uniqKey="Asero R" first="R" last="Asero">R. Asero</name><affiliation><nlm:affiliation>Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ballmer Weber, B" sort="Ballmer Weber, B" uniqKey="Ballmer Weber B" first="B" last="Ballmer-Weber">B. Ballmer-Weber</name><affiliation><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Barber, D" sort="Barber, D" uniqKey="Barber D" first="D" last="Barber">D. Barber</name><affiliation><nlm:affiliation>IMMA-School of Medicine, University CEU San Pablo, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Beyer, K" sort="Beyer, K" uniqKey="Beyer K" first="K" last="Beyer">K. Beyer</name><affiliation><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Biedermann, T" sort="Biedermann, T" uniqKey="Biedermann T" first="T" last="Biedermann">T. Biedermann</name><affiliation><nlm:affiliation>Department of Dermatology and Allergology, Technical University Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bil, M B" sort="Bil, M B" uniqKey="Bil M" first="M B" last="Bil">M B Bil</name><affiliation><nlm:affiliation>Allergy Unit, Department of Internal Medicine, University Hospital Ospedali Riuniti di Ancona, Ancona, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Blank, S" sort="Blank, S" uniqKey="Blank S" first="S" last="Blank">S. Blank</name><affiliation><nlm:affiliation>Center of Allergy and Environment (ZAUM), Helmholtz Center Munich, Technical University of Munich, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bohle, B" sort="Bohle, B" uniqKey="Bohle B" first="B" last="Bohle">B. Bohle</name><affiliation><nlm:affiliation>Division of Experimental Allergology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Bosshard, P P" sort="Bosshard, P P" uniqKey="Bosshard P" first="P P" last="Bosshard">P P Bosshard</name><affiliation><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Breiteneder, H" sort="Breiteneder, H" uniqKey="Breiteneder H" first="H" last="Breiteneder">H. Breiteneder</name><affiliation><nlm:affiliation>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Brough, H A" sort="Brough, H A" uniqKey="Brough H" first="H A" last="Brough">H A Brough</name><affiliation><nlm:affiliation>Paediatric Allergy, Department of Asthma, Allergy and Respiratory Science, King's College London, Guys' Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Caraballo, L" sort="Caraballo, L" uniqKey="Caraballo L" first="L" last="Caraballo">L. Caraballo</name><affiliation><nlm:affiliation>Institute for Immunological Research, The University of Cartagena, Cartagena de Indias, Colombia.</nlm:affiliation></affiliation></author><author><name sortKey="Caubet, J C" sort="Caubet, J C" uniqKey="Caubet J" first="J C" last="Caubet">J C Caubet</name><affiliation><nlm:affiliation>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Crameri, R" sort="Crameri, R" uniqKey="Crameri R" first="R" last="Crameri">R. Crameri</name><affiliation><nlm:affiliation>Swiss Institute of Allergy and Asthma Research, University of Zürich, Davos, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Davies, J M" sort="Davies, J M" uniqKey="Davies J" first="J M" last="Davies">J M Davies</name><affiliation><nlm:affiliation>School of Biomedical Sciences, Institute of Biomedical Innovation, Queensland University of Technology, Brisbane, Qld, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Douladiris, N" sort="Douladiris, N" uniqKey="Douladiris N" first="N" last="Douladiris">N. Douladiris</name><affiliation><nlm:affiliation>Allergy Unit, 2nd Paediatric Clinic, National & Kapodistrian University, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Ebisawa, M" sort="Ebisawa, M" uniqKey="Ebisawa M" first="M" last="Ebisawa">M. Ebisawa</name><affiliation><nlm:affiliation>Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Eigenmann, P A" sort="Eigenmann, P A" uniqKey="Eigenmann P" first="P A" last="Eigenmann">P A Eigenmann</name><affiliation><nlm:affiliation>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Fernandez Rivas, M" sort="Fernandez Rivas, M" uniqKey="Fernandez Rivas M" first="M" last="Fernandez-Rivas">M. Fernandez-Rivas</name><affiliation><nlm:affiliation>Allergy Department, Hospital Clinico San Carlos IdISSC, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ferreira, F" sort="Ferreira, F" uniqKey="Ferreira F" first="F" last="Ferreira">F. Ferreira</name><affiliation><nlm:affiliation>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Gadermaier, G" sort="Gadermaier, G" uniqKey="Gadermaier G" first="G" last="Gadermaier">G. Gadermaier</name><affiliation><nlm:affiliation>Division of Allergy and Immunology, Department of Molecular Biology, University of Salzburg, Salzburg, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Glatz, M" sort="Glatz, M" uniqKey="Glatz M" first="M" last="Glatz">M. Glatz</name><affiliation><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Hamilton, R G" sort="Hamilton, R G" uniqKey="Hamilton R" first="R G" last="Hamilton">R G Hamilton</name><affiliation><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hawranek, T" sort="Hawranek, T" uniqKey="Hawranek T" first="T" last="Hawranek">T. Hawranek</name><affiliation><nlm:affiliation>Department of Dermatology, Paracelsus Private Medical University, Salzburg, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Hellings, P" sort="Hellings, P" uniqKey="Hellings P" first="P" last="Hellings">P. Hellings</name><affiliation><nlm:affiliation>Department of Otorhinolaryngology, Academic Medical Center (AMC), Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmann Sommergruber, K" sort="Hoffmann Sommergruber, K" uniqKey="Hoffmann Sommergruber K" first="K" last="Hoffmann-Sommergruber">K. Hoffmann-Sommergruber</name><affiliation><nlm:affiliation>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Jakob, T" sort="Jakob, T" uniqKey="Jakob T" first="T" last="Jakob">T. Jakob</name><affiliation><nlm:affiliation>Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Justus Liebig University Giessen, Giessen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jappe, U" sort="Jappe, U" uniqKey="Jappe U" first="U" last="Jappe">U. Jappe</name><affiliation><nlm:affiliation>Division of Clinical and Molecular Allergology, Research Centre Borstel, Airway Research Centre North (ARCN), Member of the German Centre for Lung Research (DZL), Borstel, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Jutel, M" sort="Jutel, M" uniqKey="Jutel M" first="M" last="Jutel">M. Jutel</name><affiliation><nlm:affiliation>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Kamath, S D" sort="Kamath, S D" uniqKey="Kamath S" first="S D" last="Kamath">S D Kamath</name><affiliation><nlm:affiliation>Molecular Allergy Research Laboratory, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville City, Qld, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Knol, E F" sort="Knol, E F" uniqKey="Knol E" first="E F" last="Knol">E F Knol</name><affiliation><nlm:affiliation>Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Korosec, P" sort="Korosec, P" uniqKey="Korosec P" first="P" last="Korosec">P. Korosec</name><affiliation><nlm:affiliation>University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.</nlm:affiliation></affiliation></author><author><name sortKey="Kuehn, A" sort="Kuehn, A" uniqKey="Kuehn A" first="A" last="Kuehn">A. Kuehn</name><affiliation><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation></affiliation></author><author><name sortKey="Lack, G" sort="Lack, G" uniqKey="Lack G" first="G" last="Lack">G. Lack</name><affiliation><nlm:affiliation>King's College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lopata, A L" sort="Lopata, A L" uniqKey="Lopata A" first="A L" last="Lopata">A L Lopata</name><affiliation><nlm:affiliation>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="M Kel, M" sort="M Kel, M" uniqKey="M Kel M" first="M" last="M Kel">M. M Kel</name><affiliation><nlm:affiliation>Skin and Allergy Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Morisset, M" sort="Morisset, M" uniqKey="Morisset M" first="M" last="Morisset">M. Morisset</name><affiliation><nlm:affiliation>National Service of Immuno-Allergology, Centre Hospitalier Luxembourg (CHL), Luxembourg, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Niederberger, V" sort="Niederberger, V" uniqKey="Niederberger V" first="V" last="Niederberger">V. Niederberger</name><affiliation><nlm:affiliation>Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Nowak W Grzyn, A H" sort="Nowak W Grzyn, A H" uniqKey="Nowak W Grzyn A" first="A H" last="Nowak-W Grzyn">A H Nowak-W Grzyn</name><affiliation><nlm:affiliation>Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Papadopoulos, N G" sort="Papadopoulos, N G" uniqKey="Papadopoulos N" first="N G" last="Papadopoulos">N G Papadopoulos</name><affiliation><nlm:affiliation>Centre for Paediatrics and Child Health, Institute of Human Development, University of Manchester, Manchester, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pastorello, E A" sort="Pastorello, E A" uniqKey="Pastorello E" first="E A" last="Pastorello">E A Pastorello</name><affiliation><nlm:affiliation>Unit of Allergology and Immunology, Niguarda Ca' Granda Hospital, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Pauli, G" sort="Pauli, G" uniqKey="Pauli G" first="G" last="Pauli">G. Pauli</name><affiliation><nlm:affiliation>Service de Pneumologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.</nlm:affiliation></affiliation></author><author><name sortKey="Platts Mills, T" sort="Platts Mills, T" uniqKey="Platts Mills T" first="T" last="Platts-Mills">T. Platts-Mills</name><affiliation><nlm:affiliation>Department of Microbiology & Immunology, University of Virginia School of Medicine, Charlottesville, VA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Posa, D" sort="Posa, D" uniqKey="Posa D" first="D" last="Posa">D. Posa</name><affiliation><nlm:affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Poulsen, L K" sort="Poulsen, L K" uniqKey="Poulsen L" first="L K" last="Poulsen">L K Poulsen</name><affiliation><nlm:affiliation>Allergy Clinic, Copenhagen University Hospital, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Raulf, M" sort="Raulf, M" uniqKey="Raulf M" first="M" last="Raulf">M. Raulf</name><affiliation><nlm:affiliation>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-University Bochum (IPA), Bochum, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Sastre, J" sort="Sastre, J" uniqKey="Sastre J" first="J" last="Sastre">J. Sastre</name><affiliation><nlm:affiliation>Allergy Division, Fundación Jimenez Díaz, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Scala, E" sort="Scala, E" uniqKey="Scala E" first="E" last="Scala">E. Scala</name><affiliation><nlm:affiliation>Experimental Allergy Unit, IDI-IRCCS, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Schmid, J M" sort="Schmid, J M" uniqKey="Schmid J" first="J M" last="Schmid">J M Schmid</name><affiliation><nlm:affiliation>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Schmid Grendelmeier, P" sort="Schmid Grendelmeier, P" uniqKey="Schmid Grendelmeier P" first="P" last="Schmid-Grendelmeier">P. Schmid-Grendelmeier</name><affiliation><nlm:affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Van Hage, M" sort="Van Hage, M" uniqKey="Van Hage M" first="M" last="Van Hage">M. Van Hage</name><affiliation><nlm:affiliation>Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Van Ree, R" sort="Van Ree, R" uniqKey="Van Ree R" first="R" last="Van Ree">R. Van Ree</name><affiliation><nlm:affiliation>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Vieths, S" sort="Vieths, S" uniqKey="Vieths S" first="S" last="Vieths">S. Vieths</name><affiliation><nlm:affiliation>Department of Allergology, Paul-Ehrlich-Institut, Langen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Weber, R" sort="Weber, R" uniqKey="Weber R" first="R" last="Weber">R. Weber</name><affiliation><nlm:affiliation>School of Medicine, University of Colorado, Denver, CO, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wickman, M" sort="Wickman, M" uniqKey="Wickman M" first="M" last="Wickman">M. Wickman</name><affiliation><nlm:affiliation>Sachs' Children's Hospital, Karolinska Institutet, Stockholm, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Muraro, A" sort="Muraro, A" uniqKey="Muraro A" first="A" last="Muraro">A. Muraro</name><affiliation><nlm:affiliation>The Referral Centre for Food Allergy Diagnosis and Treatment Veneto Region, Department of Mother and Child Health, University of Padua, Padua, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ollert, M" sort="Ollert, M" uniqKey="Ollert M" first="M" last="Ollert">M. Ollert</name><affiliation><nlm:affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology</title><idno type="eISSN">1399-3038</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27288833</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>12</Day></DateCreated><DateRevised><Year>2016</Year><Month>06</Month><Day>12</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1399-3038</ISSN><JournalIssue CitedMedium="Internet"><Volume>27 Suppl 23</Volume><PubDate><Year>2016</Year><Month>May</Month></PubDate></JournalIssue><Title>Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology</Title><ISOAbbreviation>Pediatr Allergy Immunol</ISOAbbreviation></Journal><ArticleTitle>EAACI Molecular Allergology User's Guide.</ArticleTitle><Pagination><MedlinePgn>1-250</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/pai.12563</ELocationID><Abstract><AbstractText>The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.</AbstractText><CopyrightInformation>© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Matricardi</LastName><ForeName>P M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kleine-Tebbe</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Allergy & Asthma Center Westend, Outpatient Clinic Ackermann, Hanf, & Kleine-Tebbe, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoffmann</LastName><ForeName>H J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Valenta</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hilger</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofmaier</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aalberse</LastName><ForeName>R C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Sanquin Research, Department of Immunopathology, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agache</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Allergy and Clinical Immunology, Faculty of Medicine, Transylvania University of Brasov, Brasov, Romania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asero</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Ambulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ballmer-Weber</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barber</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>IMMA-School of Medicine, University CEU San Pablo, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beyer</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Biedermann</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Allergology, Technical University Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bilò</LastName><ForeName>M B</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Allergy Unit, Department of Internal Medicine, University Hospital Ospedali Riuniti di Ancona, Ancona, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blank</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Center of Allergy and Environment (ZAUM), Helmholtz Center Munich, Technical University of Munich, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bohle</LastName><ForeName>B</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Division of Experimental Allergology, Department of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bosshard</LastName><ForeName>P P</ForeName><Initials>PP</Initials><AffiliationInfo><Affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Breiteneder</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brough</LastName><ForeName>H A</ForeName><Initials>HA</Initials><AffiliationInfo><Affiliation>Paediatric Allergy, Department of Asthma, Allergy and Respiratory Science, King's College London, Guys' Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caraballo</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute for Immunological Research, The University of Cartagena, Cartagena de Indias, Colombia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caubet</LastName><ForeName>J C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crameri</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Swiss Institute of Allergy and Asthma Research, University of Zürich, Davos, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davies</LastName><ForeName>J M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>School of Biomedical Sciences, Institute of Biomedical Innovation, Queensland University of Technology, Brisbane, Qld, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Douladiris</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Allergy Unit, 2nd Paediatric Clinic, National & Kapodistrian University, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ebisawa</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Allergy, Clinical Research Center for Allergology and Rheumatology, Sagamihara National Hospital, Kanagawa, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>EIgenmann</LastName><ForeName>P A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Pediatric Allergy Unit, Department of Child and Adolescent, University Hospitals of Geneva, Geneva, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fernandez-Rivas</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Allergy Department, Hospital Clinico San Carlos IdISSC, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferreira</LastName><ForeName>F</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Division of Allergy and Immunology, Department of Molecular Biology, 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USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hawranek</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Dermatology, Paracelsus Private Medical University, Salzburg, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hellings</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, Academic Medical Center (AMC), Amsterdam, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, University Hospitals Leuven, Leuven, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoffmann-Sommergruber</LastName><ForeName>K</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathophysiology and Allergy Research, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jakob</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Dermatology and Allergology, University Medical Center Giessen and Marburg, Justus Liebig University Giessen, Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jappe</LastName><ForeName>U</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Division of Clinical and Molecular Allergology, Research Centre Borstel, Airway Research Centre North (ARCN), Member of the German Centre for Lung Research (DZL), Borstel, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Interdisciplinary Allergy Division, Department of Pneumology, University of Lübeck, Lübeck, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jutel</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamath</LastName><ForeName>S D</ForeName><Initials>SD</Initials><AffiliationInfo><Affiliation>Molecular Allergy Research Laboratory, Centre for Biodiscovery and Molecular Development of Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Townsville City, Qld, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Knol</LastName><ForeName>E F</ForeName><Initials>EF</Initials><AffiliationInfo><Affiliation>Departments of Immunology and Dermatology/Allergology, University Medical Center Utrecht, Utrecht, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Korosec</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>University Clinic of Respiratory and Allergic Diseases, Golnik, Slovenia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuehn</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Infection & Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lack</LastName><ForeName>G</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>King's College London, MRC & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Asthma, Allergy and Lung Biology, Guy's and St Thomas' NHS Foundation Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lopata</LastName><ForeName>A L</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Department of Clinical Immunology, 'ALL-MED' Medical Research Institute, Wrocław Medical University, Wrocław, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mäkelä</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Skin and Allergy Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morisset</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Service of Immuno-Allergology, Centre Hospitalier Luxembourg (CHL), Luxembourg, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Niederberger</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nowak-Węgrzyn</LastName><ForeName>A H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Pediatric Allergy and Immunology, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount 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Immunology, University of Virginia School of Medicine, Charlottesville, VA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Posa</LastName><ForeName>D</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Paediatric Pneumology and Immunology, Charitè Medical University, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Poulsen</LastName><ForeName>L K</ForeName><Initials>LK</Initials><AffiliationInfo><Affiliation>Allergy Clinic, Copenhagen University Hospital, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raulf</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Ruhr-University Bochum (IPA), Bochum, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sastre</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Allergy Division, Fundación Jimenez Díaz, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scala</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Experimental Allergy Unit, IDI-IRCCS, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmid</LastName><ForeName>J M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Respiratory Diseases and Allergy, Institute of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmid-Grendelmeier</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Allergy Unit, Department of Dermatology, University Hospital Zürich, Zürich, Switzerland.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Christine Kühne Center for Allergy Research and Education CK-CARE, Davos, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Hage</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine Solna, Clinical Immunology and Allergy Unit, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Ree</LastName><ForeName>R</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Departments of Experimental Immunology and of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vieths</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Allergology, Paul-Ehrlich-Institut, Langen, 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