AustralieFrV1, PubMed, Corpus, bibRecord, 001D74

Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts.

Identifieur interne : 001D74 ( PubMed/Corpus ); précédent : 001D73; suivant : 001D75

Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts.

Auteurs : David Morse ; Wesley Webster ; Ming Kalanon ; Gordon Langsley ; Geoffrey I. Mcfadden

Source :

PloS one [ 1932-6203 ] ; 2016.

RBID : pubmed:27348424

English descriptors

KwdEn :
- Cloning, Molecular, Plasmodium falciparum (genetics), Plasmodium falciparum (metabolism), Protein Transport, Proteomics (methods), Protozoan Proteins (genetics), Protozoan Proteins (metabolism), Recombinant Fusion Proteins (genetics), Recombinant Fusion Proteins (metabolism), Schizonts (metabolism), rab1 GTP-Binding Proteins (genetics), rab1 GTP-Binding Proteins (metabolism).
MESH :
- chemical , genetics : Protozoan Proteins, Recombinant Fusion Proteins, rab1 GTP-Binding Proteins.
- genetics : Plasmodium falciparum.
- metabolism : Plasmodium falciparum, Protozoan Proteins, Recombinant Fusion Proteins, Schizonts, rab1 GTP-Binding Proteins.
- methods : Proteomics.
- Cloning, Molecular, Protein Transport.

Abstract

Over-expression of a GFP-PfRab1A fusion protein in Plasmodium falciparum schizonts produces a punctate pattern of fluorescence typical of rhoptries, secretory organelles involved in host cell invasion. The GFP-positive bodies were purified by a combination of differential and density gradient centrifugation and their protein content determined by MS/MS sequencing. Consistent with the GFP rhoptry-like pattern of transgenic parasites, four of the 19 proteins identified have been previously described to be rhoptry-associated and another four are ER or ER-associated proteins. Confirmation that GFP-PfRab1A decorates rhoptries was obtained by its co-localization with Rap1 and Ron4 in late phase schizonts. We conclude that PfRab1A potentially regulates vesicular traffic from the endoplasmic reticulum to the rhoptries in Apicomplexa parasites.

DOI: 10.1371/journal.pone.0158174
PubMed: 27348424

Links to Exploration step

pubmed:27348424

Le document en format XML

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<author><name sortKey="Morse, David" sort="Morse, David" uniqKey="Morse D" first="David" last="Morse">David Morse</name>
<affiliation><nlm:affiliation>School of BioSciences, University of Melbourne, Melbourne, VIC, 3010, Australia.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Webster, Wesley" sort="Webster, Wesley" uniqKey="Webster W" first="Wesley" last="Webster">Wesley Webster</name>
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<author><name sortKey="Kalanon, Ming" sort="Kalanon, Ming" uniqKey="Kalanon M" first="Ming" last="Kalanon">Ming Kalanon</name>
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<author><name sortKey="Langsley, Gordon" sort="Langsley, Gordon" uniqKey="Langsley G" first="Gordon" last="Langsley">Gordon Langsley</name>
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<author><name sortKey="Kalanon, Ming" sort="Kalanon, Ming" uniqKey="Kalanon M" first="Ming" last="Kalanon">Ming Kalanon</name>
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<author><name sortKey="Langsley, Gordon" sort="Langsley, Gordon" uniqKey="Langsley G" first="Gordon" last="Langsley">Gordon Langsley</name>
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<author><name sortKey="Mcfadden, Geoffrey I" sort="Mcfadden, Geoffrey I" uniqKey="Mcfadden G" first="Geoffrey I" last="Mcfadden">Geoffrey I. Mcfadden</name>
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<series><title level="j">PloS one</title>
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<term>Plasmodium falciparum (metabolism)</term>
<term>Protein Transport</term>
<term>Proteomics (methods)</term>
<term>Protozoan Proteins (genetics)</term>
<term>Protozoan Proteins (metabolism)</term>
<term>Recombinant Fusion Proteins (genetics)</term>
<term>Recombinant Fusion Proteins (metabolism)</term>
<term>Schizonts (metabolism)</term>
<term>rab1 GTP-Binding Proteins (genetics)</term>
<term>rab1 GTP-Binding Proteins (metabolism)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protozoan Proteins</term>
<term>Recombinant Fusion Proteins</term>
<term>rab1 GTP-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Plasmodium falciparum</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Plasmodium falciparum</term>
<term>Protozoan Proteins</term>
<term>Recombinant Fusion Proteins</term>
<term>Schizonts</term>
<term>rab1 GTP-Binding Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Proteomics</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Cloning, Molecular</term>
<term>Protein Transport</term>
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<front><div type="abstract" xml:lang="en">Over-expression of a GFP-PfRab1A fusion protein in Plasmodium falciparum schizonts produces a punctate pattern of fluorescence typical of rhoptries, secretory organelles involved in host cell invasion. The GFP-positive bodies were purified by a combination of differential and density gradient centrifugation and their protein content determined by MS/MS sequencing. Consistent with the GFP rhoptry-like pattern of transgenic parasites, four of the 19 proteins identified have been previously described to be rhoptry-associated and another four are ER or ER-associated proteins. Confirmation that GFP-PfRab1A decorates rhoptries was obtained by its co-localization with Rap1 and Ron4 in late phase schizonts. We conclude that PfRab1A potentially regulates vesicular traffic from the endoplasmic reticulum to the rhoptries in Apicomplexa parasites.</div>
</front>
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<MeshHeadingList><MeshHeading><DescriptorName UI="D003001" MajorTopicYN="N">Cloning, Molecular</DescriptorName>
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<MeshHeading><DescriptorName UI="D015800" MajorTopicYN="N">Protozoan Proteins</DescriptorName>
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<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
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<MeshHeading><DescriptorName UI="D052939" MajorTopicYN="N">Schizonts</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020761" MajorTopicYN="N">rab1 GTP-Binding Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
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Serveur d'exploration sur les relations entre la France et l'Australie

Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts.

Plasmodium falciparum Rab1A Localizes to Rhoptries in Schizonts.

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