Efficacy of Intraoperative Dexmedetomidine Compared with Placebo for Postoperative Pain Management: A Meta-Analysis of Published Studies.
Identifieur interne : 001D52 ( PubMed/Corpus ); précédent : 001D51; suivant : 001D53Efficacy of Intraoperative Dexmedetomidine Compared with Placebo for Postoperative Pain Management: A Meta-Analysis of Published Studies.
Auteurs : Myriam Bellon ; Alix Le Bot ; Daphnée Michelet ; Julie Hilly ; Mathieu Maesani ; Christopher Brasher ; Souhayl DahmaniSource :
- Pain and therapy [ 2193-8237 ] ; 2016.
Abstract
Dexmedetomidine (Dex) has sedative, analgesic, and anesthetic-sparing effects. This meta-analysis examines demonstrated intraoperative and postoperative effects of intraoperative Dex administration during pediatric surgery.
DOI: 10.1007/s40122-016-0045-2
PubMed: 26861737
Links to Exploration step
pubmed:26861737Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of Intraoperative Dexmedetomidine Compared with Placebo for Postoperative Pain Management: A Meta-Analysis of Published Studies.</title><author><name sortKey="Bellon, Myriam" sort="Bellon, Myriam" uniqKey="Bellon M" first="Myriam" last="Bellon">Myriam Bellon</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Le Bot, Alix" sort="Le Bot, Alix" uniqKey="Le Bot A" first="Alix" last="Le Bot">Alix Le Bot</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Michelet, Daphnee" sort="Michelet, Daphnee" uniqKey="Michelet D" first="Daphnée" last="Michelet">Daphnée Michelet</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hilly, Julie" sort="Hilly, Julie" uniqKey="Hilly J" first="Julie" last="Hilly">Julie Hilly</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Maesani, Mathieu" sort="Maesani, Mathieu" uniqKey="Maesani M" first="Mathieu" last="Maesani">Mathieu Maesani</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brasher, Christopher" sort="Brasher, Christopher" uniqKey="Brasher C" first="Christopher" last="Brasher">Christopher Brasher</name><affiliation><nlm:affiliation>Department of Anaesthesia and Pain Management, Royal Children's Hospital, Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Dahmani, Souhayl" sort="Dahmani, Souhayl" uniqKey="Dahmani S" first="Souhayl" last="Dahmani">Souhayl Dahmani</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France. souhayl.dahmani@rdb.aphp.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26861737</idno><idno type="pmid">26861737</idno><idno type="doi">10.1007/s40122-016-0045-2</idno><idno type="wicri:Area/PubMed/Corpus">001D52</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D52</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy of Intraoperative Dexmedetomidine Compared with Placebo for Postoperative Pain Management: A Meta-Analysis of Published Studies.</title><author><name sortKey="Bellon, Myriam" sort="Bellon, Myriam" uniqKey="Bellon M" first="Myriam" last="Bellon">Myriam Bellon</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Le Bot, Alix" sort="Le Bot, Alix" uniqKey="Le Bot A" first="Alix" last="Le Bot">Alix Le Bot</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Michelet, Daphnee" sort="Michelet, Daphnee" uniqKey="Michelet D" first="Daphnée" last="Michelet">Daphnée Michelet</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hilly, Julie" sort="Hilly, Julie" uniqKey="Hilly J" first="Julie" last="Hilly">Julie Hilly</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Maesani, Mathieu" sort="Maesani, Mathieu" uniqKey="Maesani M" first="Mathieu" last="Maesani">Mathieu Maesani</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brasher, Christopher" sort="Brasher, Christopher" uniqKey="Brasher C" first="Christopher" last="Brasher">Christopher Brasher</name><affiliation><nlm:affiliation>Department of Anaesthesia and Pain Management, Royal Children's Hospital, Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Dahmani, Souhayl" sort="Dahmani, Souhayl" uniqKey="Dahmani S" first="Souhayl" last="Dahmani">Souhayl Dahmani</name><affiliation><nlm:affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France. souhayl.dahmani@rdb.aphp.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Pain and therapy</title><idno type="ISSN">2193-8237</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dexmedetomidine (Dex) has sedative, analgesic, and anesthetic-sparing effects. This meta-analysis examines demonstrated intraoperative and postoperative effects of intraoperative Dex administration during pediatric surgery.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">26861737</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>20</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>20</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>20</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">2193-8237</ISSN><JournalIssue CitedMedium="Print"><Volume>5</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Pain and therapy</Title><ISOAbbreviation>Pain Ther</ISOAbbreviation></Journal><ArticleTitle>Efficacy of Intraoperative Dexmedetomidine Compared with Placebo for Postoperative Pain Management: A Meta-Analysis of Published Studies.</ArticleTitle><Pagination><MedlinePgn>63-80</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s40122-016-0045-2</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Dexmedetomidine (Dex) has sedative, analgesic, and anesthetic-sparing effects. This meta-analysis examines demonstrated intraoperative and postoperative effects of intraoperative Dex administration during pediatric surgery.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A search for randomized placebo-controlled trials was conducted to identify clinical trials examining intraoperative Dex use in children, infants, and neonates. Primary outcome was postoperative opioid consumption; secondary outcomes were: postoperative pain intensity and postoperative nausea and vomiting (PONV).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Fourteen randomized controlled trials performed during painful procedures were analyzed. Intraoperative Dex administration was associated with significantly reduced postoperative opioid consumption in the postanesthesia care unit [PACU; risk ratio (RR) = 0.31 (0.17, 0.59), I (2) = 76%, p < 0.0001 and cumulative z score using trial sequential analysis], decreased pain intensity in PACU [standardized mean difference (SMD) = -1.18 (-1.88, -0.48), I (2) = 91%, p < 0.0001] but had no effect upon PONV incidence [RR = 0.67 (0.41, 1.08), I (2) = 0%, p = 0.48]. Subgroup analyses found administering Dex during adenotonsillectomy and using a bolus <0.5 µg/kg (irrespective to the use of a continuous administration) without effects on studies outcomes. Heterogeneity was high among results and a high suspicion of publication bias was present for all analyzed outcomes.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">This meta-analysis shows that intraoperative Dex administration in children reduces postoperative opioids consumption and postoperative pain in PACU. According to our results, optimal bolus dose was found to be ≥0.5 µg/kg. Future studies have to explore this particular point and the postoperative analgesic effects of Dex during longer periods.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bellon</LastName><ForeName>Myriam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paris Diderot University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Bot</LastName><ForeName>Alix</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paris Diderot University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michelet</LastName><ForeName>Daphnée</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paris Diderot University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hilly</LastName><ForeName>Julie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paris Diderot University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maesani</LastName><ForeName>Mathieu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paris Diderot University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brasher</LastName><ForeName>Christopher</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia and Pain Management, Royal Children's Hospital, Melbourne, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paris Diderot University, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dahmani</LastName><ForeName>Souhayl</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia and Intensive Care, Robert Debre University Hospital, Paris, France. souhayl.dahmani@rdb.aphp.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Paris Diderot University, Paris, France. souhayl.dahmani@rdb.aphp.fr.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>DHU PROTECT, INSERM U1141, Robert Debre University Hospital, Paris, France. souhayl.dahmani@rdb.aphp.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>02</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>New Zealand</Country><MedlineTA>Pain Ther</MedlineTA><NlmUniqueID>101634491</NlmUniqueID></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Pain. 2010 Aug;150(2):231-6</RefSource><PMID Version="1">20363075</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Saudi J Anaesth. 2013 Jul;7(3):296-300</RefSource><PMID Version="1">24015133</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2015 Apr 13;10(4):e0123728</RefSource><PMID Version="1">25874562</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Clin Exp Med. 2015 Aug 15;8(8):11881-9</RefSource><PMID Version="1">26550100</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Anaesthesiol. 2015 Feb;32(2):85-7</RefSource><PMID Version="1">25536187</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Yonsei Med J. 2014 Mar;55(2):508-16</RefSource><PMID Version="1">24532525</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Crit Care Med. 2013 Jan;41(1):263-306</RefSource><PMID Version="1">23269131</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Paediatr Anaesth. 2007 Aug;17(8):720-33</RefSource><PMID Version="1">17596217</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Anaesthesiol. 2010 Mar;27(3):247-52</RefSource><PMID Version="1">19952754</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain Med. 2010 Dec;11(12):1819-26</RefSource><PMID Version="1">21040434</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Anaesth. 2015 Aug;115(2):171-82</RefSource><PMID Version="1">26170346</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMJ. 2001 Jul 14;323(7304):101-5</RefSource><PMID Version="1">11451790</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Yonsei Med J. 2014 Jan;55(1):209-15</RefSource><PMID Version="1">24339309</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Paediatr Anaesth. 2013 Feb;23(2):170-9</RefSource><PMID Version="1">23043461</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Paediatr Anaesth. 2005 Dec;15(12):1098-104</RefSource><PMID Version="1">16324031</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Minerva Anestesiol. 2015 Oct;81(10 ):1105-17</RefSource><PMID Version="1">26005187</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Pediatr Otorhinolaryngol. 2012 Jul;76(7):1036-41</RefSource><PMID Version="1">22537843</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Anaesth. 2012 Jan;108(1):116-8</RefSource><PMID Version="1">22021900</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Paediatr Anaesth. 2005 Sep;15(9):762-6</RefSource><PMID Version="1">16101707</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Int J Clin Exp Med. 2015 Jun 15;8(6):8450-71</RefSource><PMID Version="1">26309498</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stat Med. 2000 Nov 30;19(22):3127-31</RefSource><PMID Version="1">11113947</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain Physician. 2011 Mar-Apr;14(2):145-61</RefSource><PMID Version="1">21412369</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anaesth Intensive Care. 2009 Jul;37(4):571-6</RefSource><PMID Version="1">19681413</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2014 Jun 16;9(6):e99718</RefSource><PMID Version="1">24932765</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Front Pharmacol. 2014 May 08;5:108</RefSource><PMID Version="1">24847273</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Can J Anaesth. 2011 Jun;58(6):540-50</RefSource><PMID Version="1">21461792</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Anaesthesiol. 2011 Jan;28(1):3-6</RefSource><PMID Version="1">20881501</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Am J Crit Care. 2010 Jan;19(1):55-61; quiz 62</RefSource><PMID Version="1">20045849</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anesth Analg. 2015 Nov;121(5):1308-15</RefSource><PMID Version="1">26332857</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Clin Epidemiol. 2009 Oct;62(10):e1-34</RefSource><PMID Version="1">19631507</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Pain. 2007 Jan;127(1-2):140-50</RefSource><PMID Version="1">16996689</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Arthroplasty. 2007 Oct;22(7 Suppl 3):12-5</RefSource><PMID Version="1">17919586</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>BMC Med Res Methodol. 2005 Apr 20;5:13</RefSource><PMID Version="1">15840177</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Br J Anaesth. 1997 May;78(5):606-17</RefSource><PMID Version="1">9175983</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stat Med. 2011 Apr 30;30(9):903-21</RefSource><PMID Version="1">21472757</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Anesth Analg. 2010 Oct;111(4):1004-10</RefSource><PMID Version="1">20705788</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Anesth. 2010 Oct;24(5):675-82</RefSource><PMID Version="1">20585813</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Stat Med. 2008 Feb 28;27(5):625-50</RefSource><PMID Version="1">17590884</PMID></CommentsCorrections></CommentsCorrectionsList><OtherID Source="NLM">PMC4912966</OtherID><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Analgesia</Keyword><Keyword MajorTopicYN="N">Children</Keyword><Keyword MajorTopicYN="N">Dexmedetomidine</Keyword><Keyword MajorTopicYN="N">Meta-analysis</Keyword><Keyword MajorTopicYN="N">Postoperative pain</Keyword><Keyword MajorTopicYN="N">Recovery</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>12</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>2</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>2</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>2</Month><Day>11</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26861737</ArticleId><ArticleId IdType="doi">10.1007/s40122-016-0045-2</ArticleId><ArticleId IdType="pii">10.1007/s40122-016-0045-2</ArticleId><ArticleId IdType="pmc">PMC4912966</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D52 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 001D52 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:26861737
|texte= Efficacy of Intraoperative Dexmedetomidine Compared with Placebo for Postoperative Pain Management: A Meta-Analysis of Published Studies.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:26861737" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |