Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.
Identifieur interne : 001D14 ( PubMed/Corpus ); précédent : 001D13; suivant : 001D15Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.
Auteurs : Luis M. Corrochano ; Alan Kuo ; Marina Marcet-Houben ; Silvia Polaino ; Asaf Salamov ; José M. Villalobos-Escobedo ; Jane Grimwood ; M Isabel Álvarez ; Javier Avalos ; Diane Bauer ; Ernesto P. Benito ; Isabelle Benoit ; Gertraud Burger ; Lola P. Camino ; David Cánovas ; Enrique Cerdá-Olmedo ; Jan-Fang Cheng ; Angel Domínguez ; Marek Eliáš ; Arturo P. Eslava ; Fabian Glaser ; Gabriel Gutiérrez ; Joseph Heitman ; Bernard Henrissat ; Enrique A. Iturriaga ; B Franz Lang ; José L. Lavín ; Soo Chan Lee ; Wenjun Li ; Erika Lindquist ; Sergio L Pez-García ; Eva M. Luque ; Ana T. Marcos ; Joel Martin ; Kevin Mccluskey ; Humberto R. Medina ; Alejandro Miralles-Durán ; Atsushi Miyazaki ; Elisa Mu Oz-Torres ; José A. Oguiza ; Robin A. Ohm ; María Olmedo ; Margarita Orejas ; Lucila Ortiz-Castellanos ; Antonio G. Pisabarro ; Julio Rodríguez-Romero ; José Ruiz-Herrera ; Rosa Ruiz-Vázquez ; Catalina Sanz ; Wendy Schackwitz ; Mahdi Shahriari ; Ekaterina Shelest ; Fátima Silva-Franco ; Darren Soanes ; Khajamohiddin Syed ; Víctor G. Tagua ; Nicholas J. Talbot ; Michael R. Thon ; Hope Tice ; Ronald P. De Vries ; Ad Wiebenga ; Jagjit S. Yadav ; Edward L. Braun ; Scott E. Baker ; Victoriano Garre ; Jeremy Schmutz ; Benjamin A. Horwitz ; Santiago Torres-Martínez ; Alexander Idnurm ; Alfredo Herrera-Estrella ; Toni Gabald N ; Igor V. GrigorievSource :
- Current biology : CB [ 1879-0445 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- genetics : Mucor, Phycomyces, Signal Transduction.
- radiation effects : Mucor, Phycomyces, Transcription, Genetic.
- Evolution, Molecular, Gene Duplication, Genome, Fungal, Light, Multigene Family, Perception.
Abstract
Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3-6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.
DOI: 10.1016/j.cub.2016.04.038
PubMed: 27238284
Links to Exploration step
pubmed:27238284Le document en format XML
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Electronic address: corrochano@us.es.</nlm:affiliation></affiliation></author><author><name sortKey="Kuo, Alan" sort="Kuo, Alan" uniqKey="Kuo A" first="Alan" last="Kuo">Alan Kuo</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Marcet Houben, Marina" sort="Marcet Houben, Marina" uniqKey="Marcet Houben M" first="Marina" last="Marcet-Houben">Marina Marcet-Houben</name><affiliation><nlm:affiliation>Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Polaino, Silvia" sort="Polaino, Silvia" uniqKey="Polaino S" first="Silvia" last="Polaino">Silvia Polaino</name><affiliation><nlm:affiliation>School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Salamov, Asaf" sort="Salamov, Asaf" uniqKey="Salamov A" first="Asaf" last="Salamov">Asaf Salamov</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Villalobos Escobedo, Jose M" sort="Villalobos Escobedo, Jose M" uniqKey="Villalobos Escobedo J" first="José M" last="Villalobos-Escobedo">José M. Villalobos-Escobedo</name><affiliation><nlm:affiliation>Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México.</nlm:affiliation></affiliation></author><author><name sortKey="Grimwood, Jane" sort="Grimwood, Jane" uniqKey="Grimwood J" first="Jane" last="Grimwood">Jane Grimwood</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA; HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Alvarez, M Isabel" sort="Alvarez, M Isabel" uniqKey="Alvarez M" first="M Isabel" last="Álvarez">M Isabel Álvarez</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Avalos, Javier" sort="Avalos, Javier" uniqKey="Avalos J" first="Javier" last="Avalos">Javier Avalos</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bauer, Diane" sort="Bauer, Diane" uniqKey="Bauer D" first="Diane" last="Bauer">Diane Bauer</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Benito, Ernesto P" sort="Benito, Ernesto P" uniqKey="Benito E" first="Ernesto P" last="Benito">Ernesto P. Benito</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain; Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Benoit, Isabelle" sort="Benoit, Isabelle" uniqKey="Benoit I" first="Isabelle" last="Benoit">Isabelle Benoit</name><affiliation><nlm:affiliation>CBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Burger, Gertraud" sort="Burger, Gertraud" uniqKey="Burger G" first="Gertraud" last="Burger">Gertraud Burger</name><affiliation><nlm:affiliation>Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Camino, Lola P" sort="Camino, Lola P" uniqKey="Camino L" first="Lola P" last="Camino">Lola P. Camino</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Canovas, David" sort="Canovas, David" uniqKey="Canovas D" first="David" last="Cánovas">David Cánovas</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cerda Olmedo, Enrique" sort="Cerda Olmedo, Enrique" uniqKey="Cerda Olmedo E" first="Enrique" last="Cerdá-Olmedo">Enrique Cerdá-Olmedo</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Jan Fang" sort="Cheng, Jan Fang" uniqKey="Cheng J" first="Jan-Fang" last="Cheng">Jan-Fang Cheng</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dominguez, Angel" sort="Dominguez, Angel" uniqKey="Dominguez A" first="Angel" last="Domínguez">Angel Domínguez</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Elias, Marek" sort="Elias, Marek" uniqKey="Elias M" first="Marek" last="Eliáš">Marek Eliáš</name><affiliation><nlm:affiliation>Department of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00 Ostrava, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Eslava, Arturo P" sort="Eslava, Arturo P" uniqKey="Eslava A" first="Arturo P" last="Eslava">Arturo P. Eslava</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Glaser, Fabian" sort="Glaser, Fabian" uniqKey="Glaser F" first="Fabian" last="Glaser">Fabian Glaser</name><affiliation><nlm:affiliation>Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Gutierrez, Gabriel" sort="Gutierrez, Gabriel" uniqKey="Gutierrez G" first="Gabriel" last="Gutiérrez">Gabriel Gutiérrez</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Heitman, Joseph" sort="Heitman, Joseph" uniqKey="Heitman J" first="Joseph" last="Heitman">Joseph Heitman</name><affiliation><nlm:affiliation>Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Henrissat, Bernard" sort="Henrissat, Bernard" uniqKey="Henrissat B" first="Bernard" last="Henrissat">Bernard Henrissat</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique (CNRS), UMR7257, Université Aix-Marseille, 163 Avenue de Luminy, 13288 Marseille, France; Department of Biological Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Iturriaga, Enrique A" sort="Iturriaga, Enrique A" uniqKey="Iturriaga E" first="Enrique A" last="Iturriaga">Enrique A. Iturriaga</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lang, B Franz" sort="Lang, B Franz" uniqKey="Lang B" first="B Franz" last="Lang">B Franz Lang</name><affiliation><nlm:affiliation>Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Lavin, Jose L" sort="Lavin, Jose L" uniqKey="Lavin J" first="José L" last="Lavín">José L. Lavín</name><affiliation><nlm:affiliation>Genome Analysis Platform, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Bizkaia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Soo Chan" sort="Lee, Soo Chan" uniqKey="Lee S" first="Soo Chan" last="Lee">Soo Chan Lee</name><affiliation><nlm:affiliation>Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Wenjun" sort="Li, Wenjun" uniqKey="Li W" first="Wenjun" last="Li">Wenjun Li</name><affiliation><nlm:affiliation>Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lindquist, Erika" sort="Lindquist, Erika" uniqKey="Lindquist E" first="Erika" last="Lindquist">Erika Lindquist</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Garcia, Sergio" sort="L Pez Garcia, Sergio" uniqKey="L Pez Garcia S" first="Sergio" last="L Pez-García">Sergio L Pez-García</name><affiliation><nlm:affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Luque, Eva M" sort="Luque, Eva M" uniqKey="Luque E" first="Eva M" last="Luque">Eva M. Luque</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Marcos, Ana T" sort="Marcos, Ana T" uniqKey="Marcos A" first="Ana T" last="Marcos">Ana T. Marcos</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, Joel" sort="Martin, Joel" uniqKey="Martin J" first="Joel" last="Martin">Joel Martin</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mccluskey, Kevin" sort="Mccluskey, Kevin" uniqKey="Mccluskey K" first="Kevin" last="Mccluskey">Kevin Mccluskey</name><affiliation><nlm:affiliation>Department of Plant Pathology, Kansas State University, 4024 Throckmorton Plant Sciences Center, Manhattan, KS 66506, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Medina, Humberto R" sort="Medina, Humberto R" uniqKey="Medina H" first="Humberto R" last="Medina">Humberto R. Medina</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Miralles Duran, Alejandro" sort="Miralles Duran, Alejandro" uniqKey="Miralles Duran A" first="Alejandro" last="Miralles-Durán">Alejandro Miralles-Durán</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Miyazaki, Atsushi" sort="Miyazaki, Atsushi" uniqKey="Miyazaki A" first="Atsushi" last="Miyazaki">Atsushi Miyazaki</name><affiliation><nlm:affiliation>Department of Biological Sciences, Faculty of Science and Engineering, Ishinomaki Senshu University, Ishinomaki 986-8580, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Mu Oz Torres, Elisa" sort="Mu Oz Torres, Elisa" uniqKey="Mu Oz Torres E" first="Elisa" last="Mu Oz-Torres">Elisa Mu Oz-Torres</name><affiliation><nlm:affiliation>Departamento de Biología Celular y Patología, Facultad de Medicina, Universidad de Salamanca, Avenida Campus Miguel de Unamuno, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Oguiza, Jose A" sort="Oguiza, Jose A" uniqKey="Oguiza J" first="José A" last="Oguiza">José A. Oguiza</name><affiliation><nlm:affiliation>Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ohm, Robin A" sort="Ohm, Robin A" uniqKey="Ohm R" first="Robin A" last="Ohm">Robin A. Ohm</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Olmedo, Maria" sort="Olmedo, Maria" uniqKey="Olmedo M" first="María" last="Olmedo">María Olmedo</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Orejas, Margarita" sort="Orejas, Margarita" uniqKey="Orejas M" first="Margarita" last="Orejas">Margarita Orejas</name><affiliation><nlm:affiliation>Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (IATA-CSIC), Avenida Catedrático Agustín Escardino 7, 46980 Paterna, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ortiz Castellanos, Lucila" sort="Ortiz Castellanos, Lucila" uniqKey="Ortiz Castellanos L" first="Lucila" last="Ortiz-Castellanos">Lucila Ortiz-Castellanos</name><affiliation><nlm:affiliation>Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Pisabarro, Antonio G" sort="Pisabarro, Antonio G" uniqKey="Pisabarro A" first="Antonio G" last="Pisabarro">Antonio G. Pisabarro</name><affiliation><nlm:affiliation>Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez Romero, Julio" sort="Rodriguez Romero, Julio" uniqKey="Rodriguez Romero J" first="Julio" last="Rodríguez-Romero">Julio Rodríguez-Romero</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ruiz Herrera, Jose" sort="Ruiz Herrera, Jose" uniqKey="Ruiz Herrera J" first="José" last="Ruiz-Herrera">José Ruiz-Herrera</name><affiliation><nlm:affiliation>Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Ruiz Vazquez, Rosa" sort="Ruiz Vazquez, Rosa" uniqKey="Ruiz Vazquez R" first="Rosa" last="Ruiz-Vázquez">Rosa Ruiz-Vázquez</name><affiliation><nlm:affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sanz, Catalina" sort="Sanz, Catalina" uniqKey="Sanz C" first="Catalina" last="Sanz">Catalina Sanz</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Schackwitz, Wendy" sort="Schackwitz, Wendy" uniqKey="Schackwitz W" first="Wendy" last="Schackwitz">Wendy Schackwitz</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shahriari, Mahdi" sort="Shahriari, Mahdi" uniqKey="Shahriari M" first="Mahdi" last="Shahriari">Mahdi Shahriari</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Shelest, Ekaterina" sort="Shelest, Ekaterina" uniqKey="Shelest E" first="Ekaterina" last="Shelest">Ekaterina Shelest</name><affiliation><nlm:affiliation>Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute), Beutenbergstrasse 11a, 07745 Jena, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Silva Franco, Fatima" sort="Silva Franco, Fatima" uniqKey="Silva Franco F" first="Fátima" last="Silva-Franco">Fátima Silva-Franco</name><affiliation><nlm:affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Soanes, Darren" sort="Soanes, Darren" uniqKey="Soanes D" first="Darren" last="Soanes">Darren Soanes</name><affiliation><nlm:affiliation>Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Syed, Khajamohiddin" sort="Syed, Khajamohiddin" uniqKey="Syed K" first="Khajamohiddin" last="Syed">Khajamohiddin Syed</name><affiliation><nlm:affiliation>Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tagua, Victor G" sort="Tagua, Victor G" uniqKey="Tagua V" first="Víctor G" last="Tagua">Víctor G. Tagua</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Talbot, Nicholas J" sort="Talbot, Nicholas J" uniqKey="Talbot N" first="Nicholas J" last="Talbot">Nicholas J. Talbot</name><affiliation><nlm:affiliation>Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Thon, Michael R" sort="Thon, Michael R" uniqKey="Thon M" first="Michael R" last="Thon">Michael R. Thon</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain; Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tice, Hope" sort="Tice, Hope" uniqKey="Tice H" first="Hope" last="Tice">Hope Tice</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="De Vries, Ronald P" sort="De Vries, Ronald P" uniqKey="De Vries R" first="Ronald P" last="De Vries">Ronald P. De Vries</name><affiliation><nlm:affiliation>CBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wiebenga, Ad" sort="Wiebenga, Ad" uniqKey="Wiebenga A" first="Ad" last="Wiebenga">Ad Wiebenga</name><affiliation><nlm:affiliation>CBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Yadav, Jagjit S" sort="Yadav, Jagjit S" uniqKey="Yadav J" first="Jagjit S" last="Yadav">Jagjit S. Yadav</name><affiliation><nlm:affiliation>Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Braun, Edward L" sort="Braun, Edward L" uniqKey="Braun E" first="Edward L" last="Braun">Edward L. Braun</name><affiliation><nlm:affiliation>Department of Biology, University of Florida, P.O. Box 118525, Gainesville, FL 32611-8525, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Baker, Scott E" sort="Baker, Scott E" uniqKey="Baker S" first="Scott E" last="Baker">Scott E. Baker</name><affiliation><nlm:affiliation>Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA 99352, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Garre, Victoriano" sort="Garre, Victoriano" uniqKey="Garre V" first="Victoriano" last="Garre">Victoriano Garre</name><affiliation><nlm:affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA; HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Horwitz, Benjamin A" sort="Horwitz, Benjamin A" uniqKey="Horwitz B" first="Benjamin A" last="Horwitz">Benjamin A. Horwitz</name><affiliation><nlm:affiliation>Department of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Torres Martinez, Santiago" sort="Torres Martinez, Santiago" uniqKey="Torres Martinez S" first="Santiago" last="Torres-Martínez">Santiago Torres-Martínez</name><affiliation><nlm:affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Idnurm, Alexander" sort="Idnurm, Alexander" uniqKey="Idnurm A" first="Alexander" last="Idnurm">Alexander Idnurm</name><affiliation><nlm:affiliation>School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA; School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Herrera Estrella, Alfredo" sort="Herrera Estrella, Alfredo" uniqKey="Herrera Estrella A" first="Alfredo" last="Herrera-Estrella">Alfredo Herrera-Estrella</name><affiliation><nlm:affiliation>Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México.</nlm:affiliation></affiliation></author><author><name sortKey="Gabald N, Toni" sort="Gabald N, Toni" uniqKey="Gabald N T" first="Toni" last="Gabald N">Toni Gabald N</name><affiliation><nlm:affiliation>Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Grigoriev, Igor V" sort="Grigoriev, Igor V" uniqKey="Grigoriev I" first="Igor V" last="Grigoriev">Igor V. Grigoriev</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27238284</idno><idno type="pmid">27238284</idno><idno type="doi">10.1016/j.cub.2016.04.038</idno><idno type="wicri:Area/PubMed/Corpus">001D14</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.</title><author><name sortKey="Corrochano, Luis M" sort="Corrochano, Luis M" uniqKey="Corrochano L" first="Luis M" last="Corrochano">Luis M. Corrochano</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain. Electronic address: corrochano@us.es.</nlm:affiliation></affiliation></author><author><name sortKey="Kuo, Alan" sort="Kuo, Alan" uniqKey="Kuo A" first="Alan" last="Kuo">Alan Kuo</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Marcet Houben, Marina" sort="Marcet Houben, Marina" uniqKey="Marcet Houben M" first="Marina" last="Marcet-Houben">Marina Marcet-Houben</name><affiliation><nlm:affiliation>Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Polaino, Silvia" sort="Polaino, Silvia" uniqKey="Polaino S" first="Silvia" last="Polaino">Silvia Polaino</name><affiliation><nlm:affiliation>School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Salamov, Asaf" sort="Salamov, Asaf" uniqKey="Salamov A" first="Asaf" last="Salamov">Asaf Salamov</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Villalobos Escobedo, Jose M" sort="Villalobos Escobedo, Jose M" uniqKey="Villalobos Escobedo J" first="José M" last="Villalobos-Escobedo">José M. Villalobos-Escobedo</name><affiliation><nlm:affiliation>Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México.</nlm:affiliation></affiliation></author><author><name sortKey="Grimwood, Jane" sort="Grimwood, Jane" uniqKey="Grimwood J" first="Jane" last="Grimwood">Jane Grimwood</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA; HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Alvarez, M Isabel" sort="Alvarez, M Isabel" uniqKey="Alvarez M" first="M Isabel" last="Álvarez">M Isabel Álvarez</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Avalos, Javier" sort="Avalos, Javier" uniqKey="Avalos J" first="Javier" last="Avalos">Javier Avalos</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Bauer, Diane" sort="Bauer, Diane" uniqKey="Bauer D" first="Diane" last="Bauer">Diane Bauer</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Benito, Ernesto P" sort="Benito, Ernesto P" uniqKey="Benito E" first="Ernesto P" last="Benito">Ernesto P. Benito</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain; Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Benoit, Isabelle" sort="Benoit, Isabelle" uniqKey="Benoit I" first="Isabelle" last="Benoit">Isabelle Benoit</name><affiliation><nlm:affiliation>CBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Burger, Gertraud" sort="Burger, Gertraud" uniqKey="Burger G" first="Gertraud" last="Burger">Gertraud Burger</name><affiliation><nlm:affiliation>Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Camino, Lola P" sort="Camino, Lola P" uniqKey="Camino L" first="Lola P" last="Camino">Lola P. Camino</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Canovas, David" sort="Canovas, David" uniqKey="Canovas D" first="David" last="Cánovas">David Cánovas</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cerda Olmedo, Enrique" sort="Cerda Olmedo, Enrique" uniqKey="Cerda Olmedo E" first="Enrique" last="Cerdá-Olmedo">Enrique Cerdá-Olmedo</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cheng, Jan Fang" sort="Cheng, Jan Fang" uniqKey="Cheng J" first="Jan-Fang" last="Cheng">Jan-Fang Cheng</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dominguez, Angel" sort="Dominguez, Angel" uniqKey="Dominguez A" first="Angel" last="Domínguez">Angel Domínguez</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Elias, Marek" sort="Elias, Marek" uniqKey="Elias M" first="Marek" last="Eliáš">Marek Eliáš</name><affiliation><nlm:affiliation>Department of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00 Ostrava, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Eslava, Arturo P" sort="Eslava, Arturo P" uniqKey="Eslava A" first="Arturo P" last="Eslava">Arturo P. Eslava</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Glaser, Fabian" sort="Glaser, Fabian" uniqKey="Glaser F" first="Fabian" last="Glaser">Fabian Glaser</name><affiliation><nlm:affiliation>Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Gutierrez, Gabriel" sort="Gutierrez, Gabriel" uniqKey="Gutierrez G" first="Gabriel" last="Gutiérrez">Gabriel Gutiérrez</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Heitman, Joseph" sort="Heitman, Joseph" uniqKey="Heitman J" first="Joseph" last="Heitman">Joseph Heitman</name><affiliation><nlm:affiliation>Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Henrissat, Bernard" sort="Henrissat, Bernard" uniqKey="Henrissat B" first="Bernard" last="Henrissat">Bernard Henrissat</name><affiliation><nlm:affiliation>Centre National de la Recherche Scientifique (CNRS), UMR7257, Université Aix-Marseille, 163 Avenue de Luminy, 13288 Marseille, France; Department of Biological Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.</nlm:affiliation></affiliation></author><author><name sortKey="Iturriaga, Enrique A" sort="Iturriaga, Enrique A" uniqKey="Iturriaga E" first="Enrique A" last="Iturriaga">Enrique A. Iturriaga</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lang, B Franz" sort="Lang, B Franz" uniqKey="Lang B" first="B Franz" last="Lang">B Franz Lang</name><affiliation><nlm:affiliation>Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Lavin, Jose L" sort="Lavin, Jose L" uniqKey="Lavin J" first="José L" last="Lavín">José L. Lavín</name><affiliation><nlm:affiliation>Genome Analysis Platform, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Bizkaia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Lee, Soo Chan" sort="Lee, Soo Chan" uniqKey="Lee S" first="Soo Chan" last="Lee">Soo Chan Lee</name><affiliation><nlm:affiliation>Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Wenjun" sort="Li, Wenjun" uniqKey="Li W" first="Wenjun" last="Li">Wenjun Li</name><affiliation><nlm:affiliation>Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lindquist, Erika" sort="Lindquist, Erika" uniqKey="Lindquist E" first="Erika" last="Lindquist">Erika Lindquist</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="L Pez Garcia, Sergio" sort="L Pez Garcia, Sergio" uniqKey="L Pez Garcia S" first="Sergio" last="L Pez-García">Sergio L Pez-García</name><affiliation><nlm:affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Luque, Eva M" sort="Luque, Eva M" uniqKey="Luque E" first="Eva M" last="Luque">Eva M. Luque</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Marcos, Ana T" sort="Marcos, Ana T" uniqKey="Marcos A" first="Ana T" last="Marcos">Ana T. Marcos</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Martin, Joel" sort="Martin, Joel" uniqKey="Martin J" first="Joel" last="Martin">Joel Martin</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mccluskey, Kevin" sort="Mccluskey, Kevin" uniqKey="Mccluskey K" first="Kevin" last="Mccluskey">Kevin Mccluskey</name><affiliation><nlm:affiliation>Department of Plant Pathology, Kansas State University, 4024 Throckmorton Plant Sciences Center, Manhattan, KS 66506, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Medina, Humberto R" sort="Medina, Humberto R" uniqKey="Medina H" first="Humberto R" last="Medina">Humberto R. Medina</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Miralles Duran, Alejandro" sort="Miralles Duran, Alejandro" uniqKey="Miralles Duran A" first="Alejandro" last="Miralles-Durán">Alejandro Miralles-Durán</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Miyazaki, Atsushi" sort="Miyazaki, Atsushi" uniqKey="Miyazaki A" first="Atsushi" last="Miyazaki">Atsushi Miyazaki</name><affiliation><nlm:affiliation>Department of Biological Sciences, Faculty of Science and Engineering, Ishinomaki Senshu University, Ishinomaki 986-8580, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Mu Oz Torres, Elisa" sort="Mu Oz Torres, Elisa" uniqKey="Mu Oz Torres E" first="Elisa" last="Mu Oz-Torres">Elisa Mu Oz-Torres</name><affiliation><nlm:affiliation>Departamento de Biología Celular y Patología, Facultad de Medicina, Universidad de Salamanca, Avenida Campus Miguel de Unamuno, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Oguiza, Jose A" sort="Oguiza, Jose A" uniqKey="Oguiza J" first="José A" last="Oguiza">José A. Oguiza</name><affiliation><nlm:affiliation>Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ohm, Robin A" sort="Ohm, Robin A" uniqKey="Ohm R" first="Robin A" last="Ohm">Robin A. Ohm</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Olmedo, Maria" sort="Olmedo, Maria" uniqKey="Olmedo M" first="María" last="Olmedo">María Olmedo</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Orejas, Margarita" sort="Orejas, Margarita" uniqKey="Orejas M" first="Margarita" last="Orejas">Margarita Orejas</name><affiliation><nlm:affiliation>Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (IATA-CSIC), Avenida Catedrático Agustín Escardino 7, 46980 Paterna, Valencia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ortiz Castellanos, Lucila" sort="Ortiz Castellanos, Lucila" uniqKey="Ortiz Castellanos L" first="Lucila" last="Ortiz-Castellanos">Lucila Ortiz-Castellanos</name><affiliation><nlm:affiliation>Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Pisabarro, Antonio G" sort="Pisabarro, Antonio G" uniqKey="Pisabarro A" first="Antonio G" last="Pisabarro">Antonio G. Pisabarro</name><affiliation><nlm:affiliation>Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Rodriguez Romero, Julio" sort="Rodriguez Romero, Julio" uniqKey="Rodriguez Romero J" first="Julio" last="Rodríguez-Romero">Julio Rodríguez-Romero</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ruiz Herrera, Jose" sort="Ruiz Herrera, Jose" uniqKey="Ruiz Herrera J" first="José" last="Ruiz-Herrera">José Ruiz-Herrera</name><affiliation><nlm:affiliation>Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.</nlm:affiliation></affiliation></author><author><name sortKey="Ruiz Vazquez, Rosa" sort="Ruiz Vazquez, Rosa" uniqKey="Ruiz Vazquez R" first="Rosa" last="Ruiz-Vázquez">Rosa Ruiz-Vázquez</name><affiliation><nlm:affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sanz, Catalina" sort="Sanz, Catalina" uniqKey="Sanz C" first="Catalina" last="Sanz">Catalina Sanz</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Schackwitz, Wendy" sort="Schackwitz, Wendy" uniqKey="Schackwitz W" first="Wendy" last="Schackwitz">Wendy Schackwitz</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Shahriari, Mahdi" sort="Shahriari, Mahdi" uniqKey="Shahriari M" first="Mahdi" last="Shahriari">Mahdi Shahriari</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Shelest, Ekaterina" sort="Shelest, Ekaterina" uniqKey="Shelest E" first="Ekaterina" last="Shelest">Ekaterina Shelest</name><affiliation><nlm:affiliation>Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute), Beutenbergstrasse 11a, 07745 Jena, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Silva Franco, Fatima" sort="Silva Franco, Fatima" uniqKey="Silva Franco F" first="Fátima" last="Silva-Franco">Fátima Silva-Franco</name><affiliation><nlm:affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Soanes, Darren" sort="Soanes, Darren" uniqKey="Soanes D" first="Darren" last="Soanes">Darren Soanes</name><affiliation><nlm:affiliation>Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Syed, Khajamohiddin" sort="Syed, Khajamohiddin" uniqKey="Syed K" first="Khajamohiddin" last="Syed">Khajamohiddin Syed</name><affiliation><nlm:affiliation>Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tagua, Victor G" sort="Tagua, Victor G" uniqKey="Tagua V" first="Víctor G" last="Tagua">Víctor G. Tagua</name><affiliation><nlm:affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Talbot, Nicholas J" sort="Talbot, Nicholas J" uniqKey="Talbot N" first="Nicholas J" last="Talbot">Nicholas J. Talbot</name><affiliation><nlm:affiliation>Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Thon, Michael R" sort="Thon, Michael R" uniqKey="Thon M" first="Michael R" last="Thon">Michael R. Thon</name><affiliation><nlm:affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain; Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Tice, Hope" sort="Tice, Hope" uniqKey="Tice H" first="Hope" last="Tice">Hope Tice</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author><author><name sortKey="De Vries, Ronald P" sort="De Vries, Ronald P" uniqKey="De Vries R" first="Ronald P" last="De Vries">Ronald P. De Vries</name><affiliation><nlm:affiliation>CBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Wiebenga, Ad" sort="Wiebenga, Ad" uniqKey="Wiebenga A" first="Ad" last="Wiebenga">Ad Wiebenga</name><affiliation><nlm:affiliation>CBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Yadav, Jagjit S" sort="Yadav, Jagjit S" uniqKey="Yadav J" first="Jagjit S" last="Yadav">Jagjit S. Yadav</name><affiliation><nlm:affiliation>Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Braun, Edward L" sort="Braun, Edward L" uniqKey="Braun E" first="Edward L" last="Braun">Edward L. Braun</name><affiliation><nlm:affiliation>Department of Biology, University of Florida, P.O. Box 118525, Gainesville, FL 32611-8525, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Baker, Scott E" sort="Baker, Scott E" uniqKey="Baker S" first="Scott E" last="Baker">Scott E. Baker</name><affiliation><nlm:affiliation>Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA 99352, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Garre, Victoriano" sort="Garre, Victoriano" uniqKey="Garre V" first="Victoriano" last="Garre">Victoriano Garre</name><affiliation><nlm:affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Schmutz, Jeremy" sort="Schmutz, Jeremy" uniqKey="Schmutz J" first="Jeremy" last="Schmutz">Jeremy Schmutz</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA; HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Horwitz, Benjamin A" sort="Horwitz, Benjamin A" uniqKey="Horwitz B" first="Benjamin A" last="Horwitz">Benjamin A. Horwitz</name><affiliation><nlm:affiliation>Department of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel.</nlm:affiliation></affiliation></author><author><name sortKey="Torres Martinez, Santiago" sort="Torres Martinez, Santiago" uniqKey="Torres Martinez S" first="Santiago" last="Torres-Martínez">Santiago Torres-Martínez</name><affiliation><nlm:affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Idnurm, Alexander" sort="Idnurm, Alexander" uniqKey="Idnurm A" first="Alexander" last="Idnurm">Alexander Idnurm</name><affiliation><nlm:affiliation>School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA; School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Herrera Estrella, Alfredo" sort="Herrera Estrella, Alfredo" uniqKey="Herrera Estrella A" first="Alfredo" last="Herrera-Estrella">Alfredo Herrera-Estrella</name><affiliation><nlm:affiliation>Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México.</nlm:affiliation></affiliation></author><author><name sortKey="Gabald N, Toni" sort="Gabald N, Toni" uniqKey="Gabald N T" first="Toni" last="Gabald N">Toni Gabald N</name><affiliation><nlm:affiliation>Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Grigoriev, Igor V" sort="Grigoriev, Igor V" uniqKey="Grigoriev I" first="Igor V" last="Grigoriev">Igor V. Grigoriev</name><affiliation><nlm:affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Current biology : CB</title><idno type="eISSN">1879-0445</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Evolution, Molecular</term><term>Gene Duplication</term><term>Genome, Fungal</term><term>Light</term><term>Mucor (genetics)</term><term>Mucor (radiation effects)</term><term>Multigene Family</term><term>Perception</term><term>Phycomyces (genetics)</term><term>Phycomyces (radiation effects)</term><term>Signal Transduction (genetics)</term><term>Transcription, Genetic (radiation effects)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Mucor</term><term>Phycomyces</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="radiation effects" xml:lang="en"><term>Mucor</term><term>Phycomyces</term><term>Transcription, Genetic</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Evolution, Molecular</term><term>Gene Duplication</term><term>Genome, Fungal</term><term>Light</term><term>Multigene Family</term><term>Perception</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3-6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27238284</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>22</Day></DateCreated><DateCompleted><Year>2017</Year><Month>06</Month><Day>22</Day></DateCompleted><DateRevised><Year>2017</Year><Month>08</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0445</ISSN><JournalIssue CitedMedium="Internet"><Volume>26</Volume><Issue>12</Issue><PubDate><Year>2016</Year><Month>Jun</Month><Day>20</Day></PubDate></JournalIssue><Title>Current biology : CB</Title><ISOAbbreviation>Curr. Biol.</ISOAbbreviation></Journal><ArticleTitle>Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.</ArticleTitle><Pagination><MedlinePgn>1577-1584</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0960-9822(16)30361-X</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cub.2016.04.038</ELocationID><Abstract><AbstractText>Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplication or, most likely, a whole-genome duplication (WGD), which is rarely observed in fungi [3-6]. We show that the genome duplication has expanded gene families, including those involved in signal transduction, and that duplicated genes have specialized, as evidenced by differences in their regulation by light. The transcriptional response to light varies with the developmental stage and is still observed in a photoreceptor mutant of P. blakesleeanus. A phototropic mutant of P. blakesleeanus with a heterozygous mutation in the photoreceptor gene madA demonstrates that photosensor dosage is important for the magnitude of signal transduction. We conclude that the genome duplication provided the means to improve signal transduction for enhanced perception of environmental signals. Our results will help to understand the role of genome dynamics in the evolution of sensory perception in eukaryotes.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Corrochano</LastName><ForeName>Luis M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain. Electronic address: corrochano@us.es.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuo</LastName><ForeName>Alan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marcet-Houben</LastName><ForeName>Marina</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Polaino</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Salamov</LastName><ForeName>Asaf</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villalobos-Escobedo</LastName><ForeName>José M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grimwood</LastName><ForeName>Jane</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA; HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Álvarez</LastName><ForeName>M Isabel</ForeName><Initials>MI</Initials><AffiliationInfo><Affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Avalos</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bauer</LastName><ForeName>Diane</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benito</LastName><ForeName>Ernesto P</ForeName><Initials>EP</Initials><AffiliationInfo><Affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain; Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benoit</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>CBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burger</LastName><ForeName>Gertraud</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Camino</LastName><ForeName>Lola P</ForeName><Initials>LP</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cánovas</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerdá-Olmedo</LastName><ForeName>Enrique</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Jan-Fang</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Domínguez</LastName><ForeName>Angel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eliáš</LastName><ForeName>Marek</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Biology and Ecology, Faculty of Science, University of Ostrava, Chittussiho 10, 710 00 Ostrava, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eslava</LastName><ForeName>Arturo P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glaser</LastName><ForeName>Fabian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion - Israel Institute of Technology, Haifa 3200003, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gutiérrez</LastName><ForeName>Gabriel</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heitman</LastName><ForeName>Joseph</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henrissat</LastName><ForeName>Bernard</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique (CNRS), UMR7257, Université Aix-Marseille, 163 Avenue de Luminy, 13288 Marseille, France; Department of Biological Sciences, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Iturriaga</LastName><ForeName>Enrique A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>B Franz</ForeName><Initials>BF</Initials><AffiliationInfo><Affiliation>Universite de Montreal, Pavillon Roger-Gaudry, Biochimie, CP 6128, Succursale Centre-Ville, Montreal QC, H3C 3J7, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lavín</LastName><ForeName>José L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Genome Analysis Platform, CIC bioGUNE, Bizkaia Technology Park, 48160 Derio, Bizkaia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Soo Chan</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Wenjun</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Molecular Genetics and Microbiology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lindquist</LastName><ForeName>Erika</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>López-García</LastName><ForeName>Sergio</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luque</LastName><ForeName>Eva M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marcos</LastName><ForeName>Ana T</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin</LastName><ForeName>Joel</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCluskey</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Plant Pathology, Kansas State University, 4024 Throckmorton Plant Sciences Center, Manhattan, KS 66506, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Medina</LastName><ForeName>Humberto R</ForeName><Initials>HR</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miralles-Durán</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyazaki</LastName><ForeName>Atsushi</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Biological Sciences, Faculty of Science and Engineering, Ishinomaki Senshu University, Ishinomaki 986-8580, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muñoz-Torres</LastName><ForeName>Elisa</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Departamento de Biología Celular y Patología, Facultad de Medicina, Universidad de Salamanca, Avenida Campus Miguel de Unamuno, 37007 Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oguiza</LastName><ForeName>José A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ohm</LastName><ForeName>Robin A</ForeName><Initials>RA</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olmedo</LastName><ForeName>María</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Orejas</LastName><ForeName>Margarita</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Instituto de Agroquímica y Tecnología de Alimentos, Consejo Superior de Investigaciones Científicas (IATA-CSIC), Avenida Catedrático Agustín Escardino 7, 46980 Paterna, Valencia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ortiz-Castellanos</LastName><ForeName>Lucila</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pisabarro</LastName><ForeName>Antonio G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Department of Agrarian Production, Public University of Navarre, 31006 Pamplona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez-Romero</LastName><ForeName>Julio</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruiz-Herrera</LastName><ForeName>José</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruiz-Vázquez</LastName><ForeName>Rosa</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanz</LastName><ForeName>Catalina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schackwitz</LastName><ForeName>Wendy</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shahriari</LastName><ForeName>Mahdi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shelest</LastName><ForeName>Ekaterina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Leibniz Institute for Natural Product Research and Infection Biology (Hans Knoell Institute), Beutenbergstrasse 11a, 07745 Jena, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silva-Franco</LastName><ForeName>Fátima</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soanes</LastName><ForeName>Darren</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Syed</LastName><ForeName>Khajamohiddin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tagua</LastName><ForeName>Víctor G</ForeName><Initials>VG</Initials><AffiliationInfo><Affiliation>Department of Genetics, University of Seville, Avenida Reina Mercedes s/n, 41012 Seville, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Talbot</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Biosciences, College of Life and Environmental Sciences, University of Exeter, Stocker Road, Exeter EX4 4QD, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thon</LastName><ForeName>Michael R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Departamento de Microbiología y Genética, Universidad de Salamanca, Plaza de los doctores de la Reina s/n, 37007 Salamanca, Spain; Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Río Duero 12, 37185 Salamanca, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tice</LastName><ForeName>Hope</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Vries</LastName><ForeName>Ronald P</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>CBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wiebenga</LastName><ForeName>Ad</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>CBS-KNAW Fungal Biodiversity Centre and Fungal Molecular Physiology, Utrecht University, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yadav</LastName><ForeName>Jagjit S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Department of Environmental Health, University of Cincinnati College of Medicine, 160 Panzeca Way, Cincinnati, OH 45267-0056, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Braun</LastName><ForeName>Edward L</ForeName><Initials>EL</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Florida, P.O. Box 118525, Gainesville, FL 32611-8525, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baker</LastName><ForeName>Scott E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA 99352, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garre</LastName><ForeName>Victoriano</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schmutz</LastName><ForeName>Jeremy</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA; HudsonAlpha Institute of Biotechnology, 601 Genome Way Northwest, Huntsville, AL 35806, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horwitz</LastName><ForeName>Benjamin A</ForeName><Initials>BA</Initials><AffiliationInfo><Affiliation>Department of Biology, Technion - Israel Institute of Technology, Haifa 32000, Israel.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Torres-Martínez</LastName><ForeName>Santiago</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Departamento de Genética y Microbiología, Universidad de Murcia, 30071 Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Idnurm</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Biological Sciences, University of Missouri-Kansas City, 5007 Rockhill Road, Kansas City, MO 64110, USA; School of BioSciences, University of Melbourne, Melbourne, VIC 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Herrera-Estrella</LastName><ForeName>Alfredo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratorio Nacional de Genómica para la Biodiversidad (LANGEBIO), Centro de Investigación y Estudios Avanzados, Kilómetro 9.6 Libramiento Norte, Carretera Irapuato-León, 36821 Irapuato, Guanajuato, México.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gabaldón</LastName><ForeName>Toni</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Centre for Genomic Regulation (CRG), Doctor Aiguader 88, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), Doctor Aiguader 88, 08003 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grigoriev</LastName><ForeName>Igor V</ForeName><Initials>IV</Initials><AffiliationInfo><Affiliation>US Department of Energy Joint Genome Institute, 2800 Mitchell Drive, Walnut Creek, CA 94598, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R01 AI050113</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>05</Month><Day>26</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Curr Biol</MedlineTA><NlmUniqueID>9107782</NlmUniqueID><ISSNLinking>0960-9822</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Mol Cell Biol. 2000 Jan;20(1):352-62</RefSource><PMID Version="1">10594037</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 1997 Jun 12;387(6634):708-13</RefSource><PMID 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Fungal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008027" MajorTopicYN="N">Light</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009089" MajorTopicYN="N">Mucor</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005810" MajorTopicYN="N">Multigene Family</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010465" MajorTopicYN="N">Perception</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010800" MajorTopicYN="N">Phycomyces</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014158" MajorTopicYN="N">Transcription, Genetic</DescriptorName><QualifierName UI="Q000528" MajorTopicYN="N">radiation effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>12</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>03</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>04</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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