ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.
Identifieur interne : 001D05 ( PubMed/Corpus ); précédent : 001D04; suivant : 001D06ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.
Auteurs : Anne-Laure Renault ; Fabienne Lesueur ; Yan Coulombe ; Stéphane Gobeil ; Penny Soucy ; Yosr Hamdi ; Sylvie Desjardins ; Florence Le Calvez-Kelm ; Maxime Vallée ; Catherine Voegele ; John L. Hopper ; Irene L. Andrulis ; Melissa C. Southey ; Esther M. John ; Jean-Yves Masson ; Sean V. Tavtigian ; Jacques SimardSource :
- PloS one [ 1932-6203 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Carrier Proteins.
- genetics : Breast Neoplasms.
- methods : Genetic Association Studies.
- Age of Onset, Case-Control Studies, Female, Gene Frequency, Genetic Predisposition to Disease, Germ-Line Mutation, Humans, MCF-7 Cells, Pedigree, Polymorphism, Single Nucleotide, Quebec.
Abstract
Approximately half of the familial aggregation of breast cancer remains unexplained. This proportion is less for early-onset disease where familial aggregation is greater, suggesting that other susceptibility genes remain to be discovered. The majority of known breast cancer susceptibility genes are involved in the DNA double-strand break repair pathway. ABRAXAS is involved in this pathway and mutations in this gene impair BRCA1 recruitment to DNA damage foci and increase cell sensitivity to ionizing radiation. Moreover, a recurrent germline mutation was reported in Finnish high-risk breast cancer families. To determine if ABRAXAS could be a breast cancer susceptibility gene in other populations, we conducted a population-based case-control mutation screening study of the coding exons and exon/intron boundaries of ABRAXAS in the Breast Cancer Family Registry. In addition to the common variant p.Asp373Asn, sixteen distinct rare variants were identified. Although no significant difference in allele frequencies between cases and controls was observed for the identified variants, two variants, p.Gly39Val and p.Thr141Ile, were shown to diminish phosphorylation of gamma-H2AX in MCF7 human breast adenocarcinoma cells, an important biomarker of DNA double-strand breaks. Overall, likely damaging or neutral variants were evenly represented among cases and controls suggesting that rare variants in ABRAXAS may explain only a small proportion of hereditary breast cancer.
DOI: 10.1371/journal.pone.0156820
PubMed: 27270457
Links to Exploration step
pubmed:27270457Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.</title><author><name sortKey="Renault, Anne Laure" sort="Renault, Anne Laure" uniqKey="Renault A" first="Anne-Laure" last="Renault">Anne-Laure Renault</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name><affiliation><nlm:affiliation>INSERM, U900, Mines ParisTech, Institut Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Coulombe, Yan" sort="Coulombe, Yan" uniqKey="Coulombe Y" first="Yan" last="Coulombe">Yan Coulombe</name><affiliation><nlm:affiliation>Genome Stability Laboratory, Centre Hospitalier Universitaire de Québec Research Center, HDQ Pavillon, Oncology Axis, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gobeil, Stephane" sort="Gobeil, Stephane" uniqKey="Gobeil S" first="Stéphane" last="Gobeil">Stéphane Gobeil</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hamdi, Yosr" sort="Hamdi, Yosr" uniqKey="Hamdi Y" first="Yosr" last="Hamdi">Yosr Hamdi</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Desjardins, Sylvie" sort="Desjardins, Sylvie" uniqKey="Desjardins S" first="Sylvie" last="Desjardins">Sylvie Desjardins</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Le Calvez Kelm, Florence" sort="Le Calvez Kelm, Florence" uniqKey="Le Calvez Kelm F" first="Florence" last="Le Calvez-Kelm">Florence Le Calvez-Kelm</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vallee, Maxime" sort="Vallee, Maxime" uniqKey="Vallee M" first="Maxime" last="Vallée">Maxime Vallée</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Voegele, Catherine" sort="Voegele, Catherine" uniqKey="Voegele C" first="Catherine" last="Voegele">Catherine Voegele</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Center for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:affiliation>Cancer Prevention Institute of California, Fremont, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Masson, Jean Yves" sort="Masson, Jean Yves" uniqKey="Masson J" first="Jean-Yves" last="Masson">Jean-Yves Masson</name><affiliation><nlm:affiliation>Genome Stability Laboratory, Centre Hospitalier Universitaire de Québec Research Center, HDQ Pavillon, Oncology Axis, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Tavtigian, Sean V" sort="Tavtigian, Sean V" uniqKey="Tavtigian S" first="Sean V" last="Tavtigian">Sean V. Tavtigian</name><affiliation><nlm:affiliation>Department of Oncological Sciences, University of Utah, Salt Lake City, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27270457</idno><idno type="pmid">27270457</idno><idno type="doi">10.1371/journal.pone.0156820</idno><idno type="wicri:Area/PubMed/Corpus">001D05</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.</title><author><name sortKey="Renault, Anne Laure" sort="Renault, Anne Laure" uniqKey="Renault A" first="Anne-Laure" last="Renault">Anne-Laure Renault</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name><affiliation><nlm:affiliation>INSERM, U900, Mines ParisTech, Institut Curie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Coulombe, Yan" sort="Coulombe, Yan" uniqKey="Coulombe Y" first="Yan" last="Coulombe">Yan Coulombe</name><affiliation><nlm:affiliation>Genome Stability Laboratory, Centre Hospitalier Universitaire de Québec Research Center, HDQ Pavillon, Oncology Axis, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Gobeil, Stephane" sort="Gobeil, Stephane" uniqKey="Gobeil S" first="Stéphane" last="Gobeil">Stéphane Gobeil</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Hamdi, Yosr" sort="Hamdi, Yosr" uniqKey="Hamdi Y" first="Yosr" last="Hamdi">Yosr Hamdi</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Desjardins, Sylvie" sort="Desjardins, Sylvie" uniqKey="Desjardins S" first="Sylvie" last="Desjardins">Sylvie Desjardins</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Le Calvez Kelm, Florence" sort="Le Calvez Kelm, Florence" uniqKey="Le Calvez Kelm F" first="Florence" last="Le Calvez-Kelm">Florence Le Calvez-Kelm</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Vallee, Maxime" sort="Vallee, Maxime" uniqKey="Vallee M" first="Maxime" last="Vallée">Maxime Vallée</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Voegele, Catherine" sort="Voegele, Catherine" uniqKey="Voegele C" first="Catherine" last="Voegele">Catherine Voegele</name><affiliation><nlm:affiliation>Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Center for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name><affiliation><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name><affiliation><nlm:affiliation>Cancer Prevention Institute of California, Fremont, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Masson, Jean Yves" sort="Masson, Jean Yves" uniqKey="Masson J" first="Jean-Yves" last="Masson">Jean-Yves Masson</name><affiliation><nlm:affiliation>Genome Stability Laboratory, Centre Hospitalier Universitaire de Québec Research Center, HDQ Pavillon, Oncology Axis, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Tavtigian, Sean V" sort="Tavtigian, Sean V" uniqKey="Tavtigian S" first="Sean V" last="Tavtigian">Sean V. Tavtigian</name><affiliation><nlm:affiliation>Department of Oncological Sciences, University of Utah, Salt Lake City, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of Onset</term><term>Breast Neoplasms (genetics)</term><term>Carrier Proteins (genetics)</term><term>Case-Control Studies</term><term>Female</term><term>Gene Frequency</term><term>Genetic Association Studies (methods)</term><term>Genetic Predisposition to Disease</term><term>Germ-Line Mutation</term><term>Humans</term><term>MCF-7 Cells</term><term>Pedigree</term><term>Polymorphism, Single Nucleotide</term><term>Quebec</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genetic Association Studies</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age of Onset</term><term>Case-Control Studies</term><term>Female</term><term>Gene Frequency</term><term>Genetic Predisposition to Disease</term><term>Germ-Line Mutation</term><term>Humans</term><term>MCF-7 Cells</term><term>Pedigree</term><term>Polymorphism, Single Nucleotide</term><term>Quebec</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Approximately half of the familial aggregation of breast cancer remains unexplained. This proportion is less for early-onset disease where familial aggregation is greater, suggesting that other susceptibility genes remain to be discovered. The majority of known breast cancer susceptibility genes are involved in the DNA double-strand break repair pathway. ABRAXAS is involved in this pathway and mutations in this gene impair BRCA1 recruitment to DNA damage foci and increase cell sensitivity to ionizing radiation. Moreover, a recurrent germline mutation was reported in Finnish high-risk breast cancer families. To determine if ABRAXAS could be a breast cancer susceptibility gene in other populations, we conducted a population-based case-control mutation screening study of the coding exons and exon/intron boundaries of ABRAXAS in the Breast Cancer Family Registry. In addition to the common variant p.Asp373Asn, sixteen distinct rare variants were identified. Although no significant difference in allele frequencies between cases and controls was observed for the identified variants, two variants, p.Gly39Val and p.Thr141Ile, were shown to diminish phosphorylation of gamma-H2AX in MCF7 human breast adenocarcinoma cells, an important biomarker of DNA double-strand breaks. Overall, likely damaging or neutral variants were evenly represented among cases and controls suggesting that rare variants in ABRAXAS may explain only a small proportion of hereditary breast cancer.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27270457</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>09</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>18</Day></DateCompleted><DateRevised><Year>2017</Year><Month>07</Month><Day>18</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>6</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>ABRAXAS (FAM175A) and Breast Cancer Susceptibility: No Evidence of Association in the Breast Cancer Family Registry.</ArticleTitle><Pagination><MedlinePgn>e0156820</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0156820</ELocationID><Abstract><AbstractText>Approximately half of the familial aggregation of breast cancer remains unexplained. This proportion is less for early-onset disease where familial aggregation is greater, suggesting that other susceptibility genes remain to be discovered. The majority of known breast cancer susceptibility genes are involved in the DNA double-strand break repair pathway. ABRAXAS is involved in this pathway and mutations in this gene impair BRCA1 recruitment to DNA damage foci and increase cell sensitivity to ionizing radiation. Moreover, a recurrent germline mutation was reported in Finnish high-risk breast cancer families. To determine if ABRAXAS could be a breast cancer susceptibility gene in other populations, we conducted a population-based case-control mutation screening study of the coding exons and exon/intron boundaries of ABRAXAS in the Breast Cancer Family Registry. In addition to the common variant p.Asp373Asn, sixteen distinct rare variants were identified. Although no significant difference in allele frequencies between cases and controls was observed for the identified variants, two variants, p.Gly39Val and p.Thr141Ile, were shown to diminish phosphorylation of gamma-H2AX in MCF7 human breast adenocarcinoma cells, an important biomarker of DNA double-strand breaks. Overall, likely damaging or neutral variants were evenly represented among cases and controls suggesting that rare variants in ABRAXAS may explain only a small proportion of hereditary breast cancer.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Renault</LastName><ForeName>Anne-Laure</ForeName><Initials>AL</Initials><AffiliationInfo><Affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lesueur</LastName><ForeName>Fabienne</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>INSERM, U900, Mines ParisTech, Institut Curie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coulombe</LastName><ForeName>Yan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Genome Stability Laboratory, Centre Hospitalier Universitaire de Québec Research Center, HDQ Pavillon, Oncology Axis, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gobeil</LastName><ForeName>Stéphane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soucy</LastName><ForeName>Penny</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hamdi</LastName><ForeName>Yosr</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Desjardins</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Calvez-Kelm</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vallée</LastName><ForeName>Maxime</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voegele</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Breast Cancer Family Registry</CollectiveName></Author><Author ValidYN="Y"><LastName>Hopper</LastName><ForeName>John L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Center for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Andrulis</LastName><ForeName>Irene L</ForeName><Initials>IL</Initials><AffiliationInfo><Affiliation>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Southey</LastName><ForeName>Melissa C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, The University of Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>John</LastName><ForeName>Esther M</ForeName><Initials>EM</Initials><AffiliationInfo><Affiliation>Cancer Prevention Institute of California, Fremont, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Stanford University School of Medicine and Stanford Cancer Institute, Stanford, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Masson</LastName><ForeName>Jean-Yves</ForeName><Initials>JY</Initials><AffiliationInfo><Affiliation>Genome Stability Laboratory, Centre Hospitalier Universitaire de Québec Research Center, HDQ Pavillon, Oncology Axis, Quebec, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tavtigian</LastName><ForeName>Sean V</ForeName><Initials>SV</Initials><AffiliationInfo><Affiliation>Department of Oncological Sciences, University of Utah, Salt Lake City, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Huntsman Cancer Institute, University of Utah, Salt Lake City, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simard</LastName><ForeName>Jacques</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, Quebec, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>06</Month><Day>07</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002352">Carrier Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C520310">FAM175A protein, human</NameOfSubstance></Chemical></ChemicalList><SupplMeshList><SupplMeshName Type="Disease" UI="C562840">Breast Cancer, Familial</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2007 Feb;39(2):165-7</RefSource><PMID Version="1">17200668</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nucleic 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