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Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.

Identifieur interne : 001C55 ( PubMed/Corpus ); précédent : 001C54; suivant : 001C56

Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.

Auteurs : B Rge G. Nordestgaard ; Anne Langsted ; Samia Mora ; Genovefa Kolovou ; Hannsjörg Baum ; Eric Bruckert ; Gerald F. Watts ; Grazyna Sypniewska ; Olov Wiklund ; Jan Borén ; M John Chapman ; Christa Cobbaert ; Olivier S. Descamps ; Arnold Von Eckardstein ; Pia R. Kamstrup ; Kari Pulkki ; Florian Kronenberg ; Alan T. Remaley ; Nader Rifai ; Emilio Ros ; Michel Langlois

Source :

European heart journal [ 1522-9645 ] ; 2016.

RBID : pubmed:27122601

Abstract

To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles.

DOI: 10.1093/eurheartj/ehw152
PubMed: 27122601

Links to Exploration step

pubmed:27122601

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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.</title>
<author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name>
<affiliation><nlm:affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2730 Herlev, Denmark boerge.nordestgaard@regionh.dk.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Langsted, Anne" sort="Langsted, Anne" uniqKey="Langsted A" first="Anne" last="Langsted">Anne Langsted</name>
<affiliation><nlm:affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2730 Herlev, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mora, Samia" sort="Mora, Samia" uniqKey="Mora S" first="Samia" last="Mora">Samia Mora</name>
<affiliation><nlm:affiliation>Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kolovou, Genovefa" sort="Kolovou, Genovefa" uniqKey="Kolovou G" first="Genovefa" last="Kolovou">Genovefa Kolovou</name>
<affiliation><nlm:affiliation>Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Baum, Hannsjorg" sort="Baum, Hannsjorg" uniqKey="Baum H" first="Hannsjörg" last="Baum">Hannsjörg Baum</name>
<affiliation><nlm:affiliation>Institute for Laboratory Medicine, Blutdepot und Krankenhaushygiene, Regionale Kliniken Holding RKH GmbH, Ludwigsburg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bruckert, Eric" sort="Bruckert, Eric" uniqKey="Bruckert E" first="Eric" last="Bruckert">Eric Bruckert</name>
<affiliation><nlm:affiliation>Pitié-Salpetriere University Hospital, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Watts, Gerald F" sort="Watts, Gerald F" uniqKey="Watts G" first="Gerald F" last="Watts">Gerald F. Watts</name>
<affiliation><nlm:affiliation>University of Western Australia, Perth, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sypniewska, Grazyna" sort="Sypniewska, Grazyna" uniqKey="Sypniewska G" first="Grazyna" last="Sypniewska">Grazyna Sypniewska</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, Collegium Medicum, NC University, Bydgoszcz, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wiklund, Olov" sort="Wiklund, Olov" uniqKey="Wiklund O" first="Olov" last="Wiklund">Olov Wiklund</name>
<affiliation><nlm:affiliation>Sahlgrenska University Hospital, Gothenburg, Sweden.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Borén">Jan Borén</name>
<affiliation><nlm:affiliation>Sahlgrenska University Hospital, Gothenburg, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M John" last="Chapman">M John Chapman</name>
<affiliation><nlm:affiliation>INSERM U939, Pitié-Salpetriere University Hospital, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cobbaert, Christa" sort="Cobbaert, Christa" uniqKey="Cobbaert C" first="Christa" last="Cobbaert">Christa Cobbaert</name>
<affiliation><nlm:affiliation>Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Descamps, Olivier S" sort="Descamps, Olivier S" uniqKey="Descamps O" first="Olivier S" last="Descamps">Olivier S. Descamps</name>
<affiliation><nlm:affiliation>Hopital de Jolimont, Haine-Saint-Paul, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Von Eckardstein, Arnold" sort="Von Eckardstein, Arnold" uniqKey="Von Eckardstein A" first="Arnold" last="Von Eckardstein">Arnold Von Eckardstein</name>
<affiliation><nlm:affiliation>Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kamstrup, Pia R" sort="Kamstrup, Pia R" uniqKey="Kamstrup P" first="Pia R" last="Kamstrup">Pia R. Kamstrup</name>
<affiliation><nlm:affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2730 Herlev, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pulkki, Kari" sort="Pulkki, Kari" uniqKey="Pulkki K" first="Kari" last="Pulkki">Kari Pulkki</name>
<affiliation><nlm:affiliation>Department of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name>
<affiliation><nlm:affiliation>Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Remaley, Alan T" sort="Remaley, Alan T" uniqKey="Remaley A" first="Alan T" last="Remaley">Alan T. Remaley</name>
<affiliation><nlm:affiliation>Lipoprotein Metabolism Section, Cardiovascular-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rifai, Nader" sort="Rifai, Nader" uniqKey="Rifai N" first="Nader" last="Rifai">Nader Rifai</name>
<affiliation><nlm:affiliation>Childrens Hospital, Laboratory Medicine, Harvard University, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ros, Emilio" sort="Ros, Emilio" uniqKey="Ros E" first="Emilio" last="Ros">Emilio Ros</name>
<affiliation><nlm:affiliation>Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain Ciber Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Langlois, Michel" sort="Langlois, Michel" uniqKey="Langlois M" first="Michel" last="Langlois">Michel Langlois</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, AZ St-Jan, Brugge, Belgium University of Ghent, Ghent, Belgium.</nlm:affiliation>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.</title>
<author><name sortKey="Nordestgaard, B Rge G" sort="Nordestgaard, B Rge G" uniqKey="Nordestgaard B" first="B Rge G" last="Nordestgaard">B Rge G. Nordestgaard</name>
<affiliation><nlm:affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2730 Herlev, Denmark boerge.nordestgaard@regionh.dk.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Langsted, Anne" sort="Langsted, Anne" uniqKey="Langsted A" first="Anne" last="Langsted">Anne Langsted</name>
<affiliation><nlm:affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2730 Herlev, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mora, Samia" sort="Mora, Samia" uniqKey="Mora S" first="Samia" last="Mora">Samia Mora</name>
<affiliation><nlm:affiliation>Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kolovou, Genovefa" sort="Kolovou, Genovefa" uniqKey="Kolovou G" first="Genovefa" last="Kolovou">Genovefa Kolovou</name>
<affiliation><nlm:affiliation>Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Baum, Hannsjorg" sort="Baum, Hannsjorg" uniqKey="Baum H" first="Hannsjörg" last="Baum">Hannsjörg Baum</name>
<affiliation><nlm:affiliation>Institute for Laboratory Medicine, Blutdepot und Krankenhaushygiene, Regionale Kliniken Holding RKH GmbH, Ludwigsburg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bruckert, Eric" sort="Bruckert, Eric" uniqKey="Bruckert E" first="Eric" last="Bruckert">Eric Bruckert</name>
<affiliation><nlm:affiliation>Pitié-Salpetriere University Hospital, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Watts, Gerald F" sort="Watts, Gerald F" uniqKey="Watts G" first="Gerald F" last="Watts">Gerald F. Watts</name>
<affiliation><nlm:affiliation>University of Western Australia, Perth, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sypniewska, Grazyna" sort="Sypniewska, Grazyna" uniqKey="Sypniewska G" first="Grazyna" last="Sypniewska">Grazyna Sypniewska</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, Collegium Medicum, NC University, Bydgoszcz, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Wiklund, Olov" sort="Wiklund, Olov" uniqKey="Wiklund O" first="Olov" last="Wiklund">Olov Wiklund</name>
<affiliation><nlm:affiliation>Sahlgrenska University Hospital, Gothenburg, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Boren, Jan" sort="Boren, Jan" uniqKey="Boren J" first="Jan" last="Borén">Jan Borén</name>
<affiliation><nlm:affiliation>Sahlgrenska University Hospital, Gothenburg, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chapman, M John" sort="Chapman, M John" uniqKey="Chapman M" first="M John" last="Chapman">M John Chapman</name>
<affiliation><nlm:affiliation>INSERM U939, Pitié-Salpetriere University Hospital, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cobbaert, Christa" sort="Cobbaert, Christa" uniqKey="Cobbaert C" first="Christa" last="Cobbaert">Christa Cobbaert</name>
<affiliation><nlm:affiliation>Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Descamps, Olivier S" sort="Descamps, Olivier S" uniqKey="Descamps O" first="Olivier S" last="Descamps">Olivier S. Descamps</name>
<affiliation><nlm:affiliation>Hopital de Jolimont, Haine-Saint-Paul, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Von Eckardstein, Arnold" sort="Von Eckardstein, Arnold" uniqKey="Von Eckardstein A" first="Arnold" last="Von Eckardstein">Arnold Von Eckardstein</name>
<affiliation><nlm:affiliation>Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kamstrup, Pia R" sort="Kamstrup, Pia R" uniqKey="Kamstrup P" first="Pia R" last="Kamstrup">Pia R. Kamstrup</name>
<affiliation><nlm:affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2730 Herlev, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pulkki, Kari" sort="Pulkki, Kari" uniqKey="Pulkki K" first="Kari" last="Pulkki">Kari Pulkki</name>
<affiliation><nlm:affiliation>Department of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name>
<affiliation><nlm:affiliation>Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Remaley, Alan T" sort="Remaley, Alan T" uniqKey="Remaley A" first="Alan T" last="Remaley">Alan T. Remaley</name>
<affiliation><nlm:affiliation>Lipoprotein Metabolism Section, Cardiovascular-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rifai, Nader" sort="Rifai, Nader" uniqKey="Rifai N" first="Nader" last="Rifai">Nader Rifai</name>
<affiliation><nlm:affiliation>Childrens Hospital, Laboratory Medicine, Harvard University, Boston, MA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ros, Emilio" sort="Ros, Emilio" uniqKey="Ros E" first="Emilio" last="Ros">Emilio Ros</name>
<affiliation><nlm:affiliation>Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain Ciber Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Langlois, Michel" sort="Langlois, Michel" uniqKey="Langlois M" first="Michel" last="Langlois">Michel Langlois</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine, AZ St-Jan, Brugge, Belgium University of Ghent, Ghent, Belgium.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">European heart journal</title>
<idno type="eISSN">1522-9645</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
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<front><div type="abstract" xml:lang="en">To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27122601</PMID>
<DateCreated><Year>2016</Year>
<Month>07</Month>
<Day>02</Day>
</DateCreated>
<DateRevised><Year>2017</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1522-9645</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>37</Volume>
<Issue>25</Issue>
<PubDate><Year>2016</Year>
<Month>Jul</Month>
<Day>01</Day>
</PubDate>
</JournalIssue>
<Title>European heart journal</Title>
<ISOAbbreviation>Eur. Heart J.</ISOAbbreviation>
</Journal>
<ArticleTitle>Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine.</ArticleTitle>
<Pagination><MedlinePgn>1944-58</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1093/eurheartj/ehw152</ELocationID>
<Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">To critically evaluate the clinical implications of the use of non-fasting rather than fasting lipid profiles and to provide guidance for the laboratory reporting of abnormal non-fasting or fasting lipid profiles.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Extensive observational data, in which random non-fasting lipid profiles have been compared with those determined under fasting conditions, indicate that the maximal mean changes at 1-6 h after habitual meals are not clinically significant [+0.3 mmol/L (26 mg/dL) for triglycerides; -0.2 mmol/L (8 mg/dL) for total cholesterol; -0.2 mmol/L (8 mg/dL) for LDL cholesterol; +0.2 mmol/L (8 mg/dL) for calculated remnant cholesterol; -0.2 mmol/L (8 mg/dL) for calculated non-HDL cholesterol]; concentrations of HDL cholesterol, apolipoprotein A1, apolipoprotein B, and lipoprotein(a) are not affected by fasting/non-fasting status. In addition, non-fasting and fasting concentrations vary similarly over time and are comparable in the prediction of cardiovascular disease. To improve patient compliance with lipid testing, we therefore recommend the routine use of non-fasting lipid profiles, while fasting sampling may be considered when non-fasting triglycerides >5 mmol/L (440 mg/dL). For non-fasting samples, laboratory reports should flag abnormal concentrations as triglycerides ≥2 mmol/L (175 mg/dL), total cholesterol ≥5 mmol/L (190 mg/dL), LDL cholesterol ≥3 mmol/L (115 mg/dL), calculated remnant cholesterol ≥0.9 mmol/L (35 mg/dL), calculated non-HDL cholesterol ≥3.9 mmol/L (150 mg/dL), HDL cholesterol ≤1 mmol/L (40 mg/dL), apolipoprotein A1 ≤1.25 g/L (125 mg/dL), apolipoprotein B ≥1.0 g/L (100 mg/dL), and lipoprotein(a) ≥50 mg/dL (80th percentile); for fasting samples, abnormal concentrations correspond to triglycerides ≥1.7 mmol/L (150 mg/dL). Life-threatening concentrations require separate referral when triglycerides >10 mmol/L (880 mg/dL) for the risk of pancreatitis, LDL cholesterol >13 mmol/L (500 mg/dL) for homozygous familial hypercholesterolaemia, LDL cholesterol >5 mmol/L (190 mg/dL) for heterozygous familial hypercholesterolaemia, and lipoprotein(a) >150 mg/dL (99th percentile) for very high cardiovascular risk.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">We recommend that non-fasting blood samples be routinely used for the assessment of plasma lipid profiles. Laboratory reports should flag abnormal values on the basis of desirable concentration cut-points. Non-fasting and fasting measurements should be complementary but not mutually exclusive.</AbstractText>
<CopyrightInformation>© The Author 2016. Published by Oxford University Press on behalf of the European Society of Cardiology.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nordestgaard</LastName>
<ForeName>Børge G</ForeName>
<Initials>BG</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2730 Herlev, Denmark boerge.nordestgaard@regionh.dk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Langsted</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2730 Herlev, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mora</LastName>
<ForeName>Samia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Divisions of Preventive and Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kolovou</LastName>
<ForeName>Genovefa</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Baum</LastName>
<ForeName>Hannsjörg</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Institute for Laboratory Medicine, Blutdepot und Krankenhaushygiene, Regionale Kliniken Holding RKH GmbH, Ludwigsburg, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bruckert</LastName>
<ForeName>Eric</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Pitié-Salpetriere University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Watts</LastName>
<ForeName>Gerald F</ForeName>
<Initials>GF</Initials>
<AffiliationInfo><Affiliation>University of Western Australia, Perth, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sypniewska</LastName>
<ForeName>Grazyna</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine, Collegium Medicum, NC University, Bydgoszcz, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wiklund</LastName>
<ForeName>Olov</ForeName>
<Initials>O</Initials>
<AffiliationInfo><Affiliation>Sahlgrenska University Hospital, Gothenburg, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Borén</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Sahlgrenska University Hospital, Gothenburg, Sweden.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chapman</LastName>
<ForeName>M John</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo><Affiliation>INSERM U939, Pitié-Salpetriere University Hospital, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cobbaert</LastName>
<ForeName>Christa</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Descamps</LastName>
<ForeName>Olivier S</ForeName>
<Initials>OS</Initials>
<AffiliationInfo><Affiliation>Hopital de Jolimont, Haine-Saint-Paul, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>von Eckardstein</LastName>
<ForeName>Arnold</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Institute for Clinical Chemistry, University Hospital Zurich, Zurich, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kamstrup</LastName>
<ForeName>Pia R</ForeName>
<Initials>PR</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, University of Copenhagen, DK-2730 Herlev, Denmark.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pulkki</LastName>
<ForeName>Kari</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Chemistry, University of Eastern Finland, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kronenberg</LastName>
<ForeName>Florian</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Remaley</LastName>
<ForeName>Alan T</ForeName>
<Initials>AT</Initials>
<AffiliationInfo><Affiliation>Lipoprotein Metabolism Section, Cardiovascular-Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rifai</LastName>
<ForeName>Nader</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Childrens Hospital, Laboratory Medicine, Harvard University, Boston, MA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ros</LastName>
<ForeName>Emilio</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Lipid Clinic, Department of Endocrinology and Nutrition, Institut d'Investigacions Biomèdiques August Pi Sunyer, Hospital Clínic, Barcelona, Spain Ciber Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Langlois</LastName>
<ForeName>Michel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Laboratory Medicine, AZ St-Jan, Brugge, Belgium University of Ghent, Ghent, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>European Atherosclerosis Society (EAS) and the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) joint consensus initiative</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>04</Month>
<Day>26</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Eur Heart J</MedlineTA>
<NlmUniqueID>8006263</NlmUniqueID>
<ISSNLinking>0195-668X</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
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<OtherID Source="NLM">PMC4929379</OtherID>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cardiovascular disease</Keyword>
<Keyword MajorTopicYN="N">Lipids</Keyword>
<Keyword MajorTopicYN="N">Lipoproteins</Keyword>
<Keyword MajorTopicYN="N">Normal values</Keyword>
<Keyword MajorTopicYN="N">Reference values</Keyword>
<Keyword MajorTopicYN="N">Stroke</Keyword>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>11</Month>
<Day>01</Day>
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