Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
Identifieur interne : 001C24 ( PubMed/Corpus ); précédent : 001C23; suivant : 001C25Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.
Auteurs : Elena Vigorito ; Karoline B. Kuchenbaecker ; Jonathan Beesley ; Julian Adlard ; Bjarni A. Agnarsson ; Irene L. Andrulis ; Banu K. Arun ; Laure Barjhoux ; Muriel Belotti ; Javier Benitez ; Andreas Berger ; Anders Bojesen ; Bernardo Bonanni ; Carole Brewer ; Trinidad Caldes ; Maria A. Caligo ; Ian Campbell ; Salina B. Chan ; Kathleen B M. Claes ; David E. Cohn ; Jackie Cook ; Mary B. Daly ; Francesca Damiola ; Rosemarie Davidson ; Antoine De Pauw ; Capucine Delnatte ; Orland Diez ; Susan M. Domchek ; Martine Dumont ; Katarzyna Durda ; Bernd Dworniczak ; Douglas F. Easton ; Diana Eccles ; Christina Edwinsdotter Ardnor ; Ros Eeles ; Bent Ejlertsen ; Steve Ellis ; D Gareth Evans ; Lidia Feliubadalo ; Florentia Fostira ; William D. Foulkes ; Eitan Friedman ; Debra Frost ; Pragna Gaddam ; Patricia A. Ganz ; Judy Garber ; Vanesa Garcia-Barberan ; Marion Gauthier-Villars ; Andrea Gehrig ; Anne-Marie Gerdes ; Sophie Giraud ; Andrew K. Godwin ; David E. Goldgar ; Christopher R. Hake ; Thomas V O. Hansen ; Sue Healey ; Shirley Hodgson ; Frans B L. Hogervorst ; Claude Houdayer ; Peter J. Hulick ; Evgeny N. Imyanitov ; Claudine Isaacs ; Louise Izatt ; Angel Izquierdo ; Lauren Jacobs ; Anna Jakubowska ; Ramunas Janavicius ; Katarzyna Jaworska-Bieniek ; Uffe Birk Jensen ; Esther M. John ; Joseph Vijai ; Beth Y. Karlan ; Karin Kast ; Kconfab Investigators ; Sofia Khan ; Ava Kwong ; Yael Laitman ; Jenny Lester ; Fabienne Lesueur ; Annelie Liljegren ; Jan Lubinski ; Phuong L. Mai ; Siranoush Manoukian ; Sylvie Mazoyer ; Alfons Meindl ; Arjen R. Mensenkamp ; Marco Montagna ; Katherine L. Nathanson ; Susan L. Neuhausen ; Heli Nevanlinna ; Dieter Niederacher ; Edith Olah ; Olufunmilayo I. Olopade ; Kai-Ren Ong ; Ana Osorio ; Sue Kyung Park ; Ylva Paulsson-Karlsson ; Inge Sokilde Pedersen ; Bernard Peissel ; Paolo Peterlongo ; Georg Pfeiler ; Catherine M. Phelan ; Marion Piedmonte ; Bruce Poppe ; Miquel Angel Pujana ; Paolo Radice ; Gad Rennert ; Gustavo C. Rodriguez ; Matti A. Rookus ; Eric A. Ross ; Rita Katharina Schmutzler ; Jacques Simard ; Christian F. Singer ; Thomas P. Slavin ; Penny Soucy ; Melissa Southey ; Doris Steinemann ; Dominique Stoppa-Lyonnet ; Grzegorz Sukiennicki ; Christian Sutter ; Csilla I. Szabo ; Muy-Kheng Tea ; Manuel R. Teixeira ; Soo-Hwang Teo ; Mary Beth Terry ; Mads Thomassen ; Maria Grazia Tibiletti ; Laima Tihomirova ; Silvia Tognazzo ; Elizabeth J. Van Rensburg ; Liliana Varesco ; Raymonda Varon-Mateeva ; Athanassios Vratimos ; Jeffrey N. Weitzel ; Lesley Mcguffog ; Judy Kirk ; Amanda Ewart Toland ; Ute Hamann ; Noralane Lindor ; Susan J. Ramus ; Mark H. Greene ; Fergus J. Couch ; Kenneth Offit ; Paul D P. Pharoah ; Georgia Chenevix-Trench ; Antonis C. AntoniouSource :
- PloS one [ 1932-6203 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
Abstract
Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 mutation carriers. Genotype data were available for 15,252 (2,462 ovarian cancer cases) BRCA1 and 8,211 (631 ovarian cancer cases) BRCA2 mutation carriers. Following genotype imputation, ovarian cancer associations were assessed for 4,873 and 5,020 SNPs in BRCA1 and BRCA 2 mutation carriers respectively, within a retrospective cohort analytical framework. In BRCA1 mutation carriers one set of eight correlated candidate causal variants for ovarian cancer risk modification was identified (top SNP rs10124837, HR: 0.73, 95%CI: 0.68 to 0.79, p-value 2× 10-16). These variants were located up to 20 kb upstream of BNC2. In BRCA2 mutation carriers one region, up to 45 kb upstream of BNC2, and containing 100 correlated SNPs was identified as candidate causal (top SNP rs62543585, HR: 0.69, 95%CI: 0.59 to 0.80, p-value 1.0 × 10-6). The candidate causal in BRCA1 mutation carriers did not include the strongest associated variant at this locus in the general population. In sum, we identified a set of candidate causal variants in a region that encompasses the BNC2 transcription start site. The ovarian cancer association at 9p22.2 may be mediated by different variants in BRCA1 mutation carriers and in the general population. Thus, potentially different mechanisms may underlie ovarian cancer risk for mutation carriers and the general population.
DOI: 10.1371/journal.pone.0158801
PubMed: 27463617
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pubmed:27463617Le document en format XML
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<author><name sortKey="Vigorito, Elena" sort="Vigorito, Elena" uniqKey="Vigorito E" first="Elena" last="Vigorito">Elena Vigorito</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
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<author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
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<author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation><nlm:affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029.</nlm:affiliation>
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<author><name sortKey="Adlard, Julian" sort="Adlard, Julian" uniqKey="Adlard J" first="Julian" last="Adlard">Julian Adlard</name>
<affiliation><nlm:affiliation>Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom.</nlm:affiliation>
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<author><name sortKey="Agnarsson, Bjarni A" sort="Agnarsson, Bjarni A" uniqKey="Agnarsson B" first="Bjarni A" last="Agnarsson">Bjarni A. Agnarsson</name>
<affiliation><nlm:affiliation>Department of Pathology, University Hospital (Landspitali) and University of Iceland School of Medicine, Hringbraut, 101 Reykjavik, Iceland.</nlm:affiliation>
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<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name>
<affiliation><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.</nlm:affiliation>
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<author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K" last="Arun">Banu K. Arun</name>
<affiliation><nlm:affiliation>Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, 1515 Pressler Street, CBP 5, Houston, TX, United States of America.</nlm:affiliation>
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<author><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name>
<affiliation><nlm:affiliation>Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.</nlm:affiliation>
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<author><name sortKey="Belotti, Muriel" sort="Belotti, Muriel" uniqKey="Belotti M" first="Muriel" last="Belotti">Muriel Belotti</name>
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<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation><nlm:affiliation>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain, and Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="Berger, Andreas" sort="Berger, Andreas" uniqKey="Berger A" first="Andreas" last="Berger">Andreas Berger</name>
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<author><name sortKey="Bojesen, Anders" sort="Bojesen, Anders" uniqKey="Bojesen A" first="Anders" last="Bojesen">Anders Bojesen</name>
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<author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name>
<affiliation><nlm:affiliation>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), via Ripamonti 435, 20141 Milan, Italy.</nlm:affiliation>
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</author>
<author><name sortKey="Brewer, Carole" sort="Brewer, Carole" uniqKey="Brewer C" first="Carole" last="Brewer">Carole Brewer</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom.</nlm:affiliation>
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<author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name>
<affiliation><nlm:affiliation>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A" last="Caligo">Maria A. Caligo</name>
<affiliation><nlm:affiliation>Section of Genetic Oncology, Dept. of Laboratory Medicine, University and University Hospital of Pisa, Pisa Italy.</nlm:affiliation>
</affiliation>
</author>
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<affiliation><nlm:affiliation>Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC 8006, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chan, Salina B" sort="Chan, Salina B" uniqKey="Chan S" first="Salina B" last="Chan">Salina B. Chan</name>
<affiliation><nlm:affiliation>1600 Divisadero Street, C415, San Francisco, CA 94143-1714, United States of America.</nlm:affiliation>
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<author><name sortKey="Claes, Kathleen B M" sort="Claes, Kathleen B M" uniqKey="Claes K" first="Kathleen B M" last="Claes">Kathleen B M. Claes</name>
<affiliation><nlm:affiliation>Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cohn, David E" sort="Cohn, David E" uniqKey="Cohn D" first="David E" last="Cohn">David E. Cohn</name>
<affiliation><nlm:affiliation>Ohio State University Columbus Cancer Council GYN Oncology, 3651 Ridge Mill Drive, Columbus, OH 43026, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cook, Jackie" sort="Cook, Jackie" uniqKey="Cook J" first="Jackie" last="Cook">Jackie Cook</name>
<affiliation><nlm:affiliation>Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name>
<affiliation><nlm:affiliation>Department of Clinical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, United States of America.</nlm:affiliation>
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<author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name>
<affiliation><nlm:affiliation>Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.</nlm:affiliation>
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<author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pauw, Antoine De" sort="Pauw, Antoine De" uniqKey="Pauw A" first="Antoine De" last="Pauw">Antoine De Pauw</name>
<affiliation><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Delnatte, Capucine" sort="Delnatte, Capucine" uniqKey="Delnatte C" first="Capucine" last="Delnatte">Capucine Delnatte</name>
<affiliation><nlm:affiliation>Unité d'oncogénétique, ICO-Centre René Gauducheau, Boulevard Jacques Monod, 44805 Nantes Saint Herblain Cedex, France.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name>
<affiliation><nlm:affiliation>Oncogenetics Group, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), and Universitat Autònoma, Passeig Vall d'Hebron 119-129, Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name>
<affiliation><nlm:affiliation>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name>
<affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name>
<affiliation><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dworniczak, Bernd" sort="Dworniczak, Bernd" uniqKey="Dworniczak B" first="Bernd" last="Dworniczak">Bernd Dworniczak</name>
<affiliation><nlm:affiliation>Institute of Human Genetics, University of Münster, Münster, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name>
<affiliation><nlm:affiliation>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Edwinsdotter Ardnor, Christina" sort="Edwinsdotter Ardnor, Christina" uniqKey="Edwinsdotter Ardnor C" first="Christina" last="Edwinsdotter Ardnor">Christina Edwinsdotter Ardnor</name>
<affiliation><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name>
<affiliation><nlm:affiliation>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name>
<affiliation><nlm:affiliation>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D Gareth" last="Evans">D Gareth Evans</name>
<affiliation><nlm:affiliation>Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Feliubadalo, Lidia" sort="Feliubadalo, Lidia" uniqKey="Feliubadalo L" first="Lidia" last="Feliubadalo">Lidia Feliubadalo</name>
<affiliation><nlm:affiliation>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, 08908 L'Hospitalet, Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name>
<affiliation><nlm:affiliation>Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D" last="Foulkes">William D. Foulkes</name>
<affiliation><nlm:affiliation>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
<affiliation><nlm:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gaddam, Pragna" sort="Gaddam, Pragna" uniqKey="Gaddam P" first="Pragna" last="Gaddam">Pragna Gaddam</name>
<affiliation><nlm:affiliation>Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A" last="Ganz">Patricia A. Ganz</name>
<affiliation><nlm:affiliation>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA 90095-6900, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name>
<affiliation><nlm:affiliation>Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garcia Barberan, Vanesa" sort="Garcia Barberan, Vanesa" uniqKey="Garcia Barberan V" first="Vanesa" last="Garcia-Barberan">Vanesa Garcia-Barberan</name>
<affiliation><nlm:affiliation>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name>
<affiliation><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gehrig, Andrea" sort="Gehrig, Andrea" uniqKey="Gehrig A" first="Andrea" last="Gehrig">Andrea Gehrig</name>
<affiliation><nlm:affiliation>Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, Rigshospitalet 4062, Blegdamsvej 9, København Ø, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Giraud, Sophie" sort="Giraud, Sophie" uniqKey="Giraud S" first="Sophie" last="Giraud">Sophie Giraud</name>
<affiliation><nlm:affiliation>Service de Génétique Moléculaire et Clinique, Hospices Civils de Lyon, Lyon cedex 04, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name>
<affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS 3040, University of Kansas Medical Center, Kansas City, Kansas, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name>
<affiliation><nlm:affiliation>Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, SOM 4B454, Salt Lake City, UT 84132, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hake, Christopher R" sort="Hake, Christopher R" uniqKey="Hake C" first="Christopher R" last="Hake">Christopher R. Hake</name>
<affiliation><nlm:affiliation>City of Hope Clinical Cancer Genetics Community Research Network, 1500 East Duarte Road, Duarte, CA 91010, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name>
<affiliation><nlm:affiliation>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name>
<affiliation><nlm:affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name>
<affiliation><nlm:affiliation>Medical Genetics Unit, St George's, University of London, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B L" last="Hogervorst">Frans B L. Hogervorst</name>
<affiliation><nlm:affiliation>Family Cancer Clinic, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name>
<affiliation><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hulick, Peter J" sort="Hulick, Peter J" uniqKey="Hulick P" first="Peter J" last="Hulick">Peter J. Hulick</name>
<affiliation><nlm:affiliation>Center for Medical Genetics, NorthShore University Health System, University of Chicago Pritzker School of Medicine, 1000 Central Street, Suite 620, Evanston, IL 60201, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N" last="Imyanitov">Evgeny N. Imyanitov</name>
<affiliation><nlm:affiliation>N.N. Petrov Institute of Oncology, St.-Petersburg 197758, Russia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name>
<affiliation><nlm:affiliation>Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name>
<affiliation><nlm:affiliation>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Izquierdo, Angel" sort="Izquierdo, Angel" uniqKey="Izquierdo A" first="Angel" last="Izquierdo">Angel Izquierdo</name>
<affiliation><nlm:affiliation>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Av. França s/n. 1707 Girona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jacobs, Lauren" sort="Jacobs, Lauren" uniqKey="Jacobs L" first="Lauren" last="Jacobs">Lauren Jacobs</name>
<affiliation><nlm:affiliation>Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name>
<affiliation><nlm:affiliation>Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Santariskiu st., State Research Institute Centre for Innovative medicine, Zygymantu st. 9, Vilnius, Lithuania.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name>
<affiliation><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, Aarhus University Hospital, Brendstrupgaardsvej 21C, Aarhus N, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name>
<affiliation><nlm:affiliation>Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name>
<affiliation><nlm:affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kast, Karin" sort="Kast, Karin" uniqKey="Kast K" first="Karin" last="Kast">Karin Kast</name>
<affiliation><nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name>
<affiliation><nlm:affiliation>Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name>
<affiliation><nlm:affiliation>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700 (Haartmaninkatu 8), 00029 HUS, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name>
<affiliation><nlm:affiliation>The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name>
<affiliation><nlm:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, Israel.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name>
<affiliation><nlm:affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name>
<affiliation><nlm:affiliation>Genetic Epidemiology of Cancer team, Inserm U900, Institut Curie, Mines ParisTech, 26 rue d'Ulm, 75248 Paris cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liljegren, Annelie" sort="Liljegren, Annelie" uniqKey="Liljegren A" first="Annelie" last="Liljegren">Annelie Liljegren</name>
<affiliation><nlm:affiliation>Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L" last="Mai">Phuong L. Mai</name>
<affiliation><nlm:affiliation>Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name>
<affiliation><nlm:affiliation>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name>
<affiliation><nlm:affiliation>Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation><nlm:affiliation>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mensenkamp, Arjen R" sort="Mensenkamp, Arjen R" uniqKey="Mensenkamp A" first="Arjen R" last="Mensenkamp">Arjen R. Mensenkamp</name>
<affiliation><nlm:affiliation>Department of Human Genetics, Radboud university medical centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation><nlm:affiliation>Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name>
<affiliation><nlm:affiliation>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name>
<affiliation><nlm:affiliation>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation><nlm:affiliation>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700 (Haartmaninkatu 8), 00029 HUS, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name>
<affiliation><nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name>
<affiliation><nlm:affiliation>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I" last="Olopade">Olufunmilayo I. Olopade</name>
<affiliation><nlm:affiliation>The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago, IL 60637.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ong, Kai Ren" sort="Ong, Kai Ren" uniqKey="Ong K" first="Kai-Ren" last="Ong">Kai-Ren Ong</name>
<affiliation><nlm:affiliation>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name>
<affiliation><nlm:affiliation>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Park, Sue Kyung" sort="Park, Sue Kyung" uniqKey="Park S" first="Sue Kyung" last="Park">Sue Kyung Park</name>
<affiliation><nlm:affiliation>Department of Preventive Medicine, Seoul National University College of Medicine, Department of Biomedical Science, Seoul National University Graduate School, and Cancer Research Institute, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Paulsson Karlsson, Ylva" sort="Paulsson Karlsson, Ylva" uniqKey="Paulsson Karlsson Y" first="Ylva" last="Paulsson-Karlsson">Ylva Paulsson-Karlsson</name>
<affiliation><nlm:affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pedersen, Inge Sokilde" sort="Pedersen, Inge Sokilde" uniqKey="Pedersen I" first="Inge Sokilde" last="Pedersen">Inge Sokilde Pedersen</name>
<affiliation><nlm:affiliation>Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Reberbansgade 15, Aalborg, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name>
<affiliation><nlm:affiliation>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation><nlm:affiliation>IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, c/o IFOM-IEO campus, via Adamello 16, 20139 Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pfeiler, Georg" sort="Pfeiler, Georg" uniqKey="Pfeiler G" first="Georg" last="Pfeiler">Georg Pfeiler</name>
<affiliation><nlm:affiliation>Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M" last="Phelan">Catherine M. Phelan</name>
<affiliation><nlm:affiliation>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name>
<affiliation><nlm:affiliation>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY 14263, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Poppe, Bruce" sort="Poppe, Bruce" uniqKey="Poppe B" first="Bruce" last="Poppe">Bruce Poppe</name>
<affiliation><nlm:affiliation>Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pujana, Miquel Angel" sort="Pujana, Miquel Angel" uniqKey="Pujana M" first="Miquel Angel" last="Pujana">Miquel Angel Pujana</name>
<affiliation><nlm:affiliation>Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation><nlm:affiliation>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133 Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name>
<affiliation><nlm:affiliation>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, 7 Michal St., Haifa 34362, Israel.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C" last="Rodriguez">Gustavo C. Rodriguez</name>
<affiliation><nlm:affiliation>Division of Gynecologic Oncology, NorthShore University HealthSystem, Univ of Chicago, 2650 Ridge Avenue Suite 1507 Walgreens, Evanston, IL 60201, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ross, Eric A" sort="Ross, Eric A" uniqKey="Ross E" first="Eric A" last="Ross">Eric A. Ross</name>
<affiliation><nlm:affiliation>Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita Katharina" sort="Schmutzler, Rita Katharina" uniqKey="Schmutzler R" first="Rita Katharina" last="Schmutzler">Rita Katharina Schmutzler</name>
<affiliation><nlm:affiliation>Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name>
<affiliation><nlm:affiliation>Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Slavin, Thomas P" sort="Slavin, Thomas P" uniqKey="Slavin T" first="Thomas P" last="Slavin">Thomas P. Slavin</name>
<affiliation><nlm:affiliation>Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name>
<affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name>
<affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Steinemann, Doris" sort="Steinemann, Doris" uniqKey="Steinemann D" first="Doris" last="Steinemann">Doris Steinemann</name>
<affiliation><nlm:affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sukiennicki, Grzegorz" sort="Sukiennicki, Grzegorz" uniqKey="Sukiennicki G" first="Grzegorz" last="Sukiennicki">Grzegorz Sukiennicki</name>
<affiliation><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name>
<affiliation><nlm:affiliation>Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I" last="Szabo">Csilla I. Szabo</name>
<affiliation><nlm:affiliation>National Human Genome Research Institute, National Institutes of Health, Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD 20892-8004, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tea, Muy Kheng" sort="Tea, Muy Kheng" uniqKey="Tea M" first="Muy-Kheng" last="Tea">Muy-Kheng Tea</name>
<affiliation><nlm:affiliation>Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R" last="Teixeira">Manuel R. Teixeira</name>
<affiliation><nlm:affiliation>Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name>
<affiliation><nlm:affiliation>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500 Malaysia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Columbia University, New York, NY, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tibiletti, Maria Grazia" sort="Tibiletti, Maria Grazia" uniqKey="Tibiletti M" first="Maria Grazia" last="Tibiletti">Maria Grazia Tibiletti</name>
<affiliation><nlm:affiliation>UO Anatomia Patologica, Ospedale di Circolo-Università dell'Insubria, Via O.Rossi 9, 21100 Varese, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name>
<affiliation><nlm:affiliation>Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tognazzo, Silvia" sort="Tognazzo, Silvia" uniqKey="Tognazzo S" first="Silvia" last="Tognazzo">Silvia Tognazzo</name>
<affiliation><nlm:affiliation>Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J" last="Van Rensburg">Elizabeth J. Van Rensburg</name>
<affiliation><nlm:affiliation>Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia 0007, South Africa.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Varesco, Liliana" sort="Varesco, Liliana" uniqKey="Varesco L" first="Liliana" last="Varesco">Liliana Varesco</name>
<affiliation><nlm:affiliation>Unit of Hereditary Cancer, Department of Epidemiology, Prevention and Special Functions, IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) AOU San Martino-IST Istituto Nazionale per la Ricerca sul Cancro, largo Rosanna Benzi 10, 16132 Genoa, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Varon Mateeva, Raymonda" sort="Varon Mateeva, Raymonda" uniqKey="Varon Mateeva R" first="Raymonda" last="Varon-Mateeva">Raymonda Varon-Mateeva</name>
<affiliation><nlm:affiliation>Institute of Human Genetics, Campus Virchov Klinikum, Charite Berlin, Berlin, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vratimos, Athanassios" sort="Vratimos, Athanassios" uniqKey="Vratimos A" first="Athanassios" last="Vratimos">Athanassios Vratimos</name>
<affiliation><nlm:affiliation>Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos" Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Weitzel, Jeffrey N" sort="Weitzel, Jeffrey N" uniqKey="Weitzel J" first="Jeffrey N" last="Weitzel">Jeffrey N. Weitzel</name>
<affiliation><nlm:affiliation>Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kirk, Judy" sort="Kirk, Judy" uniqKey="Kirk J" first="Judy" last="Kirk">Judy Kirk</name>
<affiliation><nlm:affiliation>Westmead Hospital, Familial Cancer Service, Hawkesbury Road, P.O. Box 533, Wentworthville, NSW 2145, Australia.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Toland, Amanda Ewart" sort="Toland, Amanda Ewart" uniqKey="Toland A" first="Amanda Ewart" last="Toland">Amanda Ewart Toland</name>
<affiliation><nlm:affiliation>Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, United States of America.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name>
<affiliation><nlm:affiliation>Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Lindor, Noralane" sort="Lindor, Noralane" uniqKey="Lindor N" first="Noralane" last="Lindor">Noralane Lindor</name>
<affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, 13400 E. Scottsdale Blvd., Scottsdale, AZ, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ramus, Susan J" sort="Ramus, Susan J" uniqKey="Ramus S" first="Susan J" last="Ramus">Susan J. Ramus</name>
<affiliation><nlm:affiliation>Department of Preventive Medicine, Keck School of Medicine, University of Southern California, California, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H" last="Greene">Mark H. Greene</name>
<affiliation><nlm:affiliation>Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J" last="Couch">Fergus J. Couch</name>
<affiliation><nlm:affiliation>Department of Laboratory Medicine and Pathology, and Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name>
<affiliation><nlm:affiliation>Clinical Genetics Research Laboratory, Dept. of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Pharoah, Paul D P" sort="Pharoah, Paul D P" uniqKey="Pharoah P" first="Paul D P" last="Pharoah">Paul D P. Pharoah</name>
<affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27463617</idno>
<idno type="pmid">27463617</idno>
<idno type="doi">10.1371/journal.pone.0158801</idno>
<idno type="wicri:Area/PubMed/Corpus">001C24</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C24</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.</title>
<author><name sortKey="Vigorito, Elena" sort="Vigorito, Elena" uniqKey="Vigorito E" first="Elena" last="Vigorito">Elena Vigorito</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
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<author><name sortKey="Kuchenbaecker, Karoline B" sort="Kuchenbaecker, Karoline B" uniqKey="Kuchenbaecker K" first="Karoline B" last="Kuchenbaecker">Karoline B. Kuchenbaecker</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
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<author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name>
<affiliation><nlm:affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029.</nlm:affiliation>
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<author><name sortKey="Adlard, Julian" sort="Adlard, Julian" uniqKey="Adlard J" first="Julian" last="Adlard">Julian Adlard</name>
<affiliation><nlm:affiliation>Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, United Kingdom.</nlm:affiliation>
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<author><name sortKey="Agnarsson, Bjarni A" sort="Agnarsson, Bjarni A" uniqKey="Agnarsson B" first="Bjarni A" last="Agnarsson">Bjarni A. Agnarsson</name>
<affiliation><nlm:affiliation>Department of Pathology, University Hospital (Landspitali) and University of Iceland School of Medicine, Hringbraut, 101 Reykjavik, Iceland.</nlm:affiliation>
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<author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L" last="Andrulis">Irene L. Andrulis</name>
<affiliation><nlm:affiliation>Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.</nlm:affiliation>
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<author><name sortKey="Arun, Banu K" sort="Arun, Banu K" uniqKey="Arun B" first="Banu K" last="Arun">Banu K. Arun</name>
<affiliation><nlm:affiliation>Department of Breast Medical Oncology and Clinical Cancer Genetics Program, University Of Texas MD Anderson Cancer Center, 1515 Pressler Street, CBP 5, Houston, TX, United States of America.</nlm:affiliation>
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<author><name sortKey="Barjhoux, Laure" sort="Barjhoux, Laure" uniqKey="Barjhoux L" first="Laure" last="Barjhoux">Laure Barjhoux</name>
<affiliation><nlm:affiliation>Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.</nlm:affiliation>
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<author><name sortKey="Belotti, Muriel" sort="Belotti, Muriel" uniqKey="Belotti M" first="Muriel" last="Belotti">Muriel Belotti</name>
<affiliation><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benitez">Javier Benitez</name>
<affiliation><nlm:affiliation>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain, and Human Genotyping (CEGEN) Unit, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.</nlm:affiliation>
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<author><name sortKey="Berger, Andreas" sort="Berger, Andreas" uniqKey="Berger A" first="Andreas" last="Berger">Andreas Berger</name>
<affiliation><nlm:affiliation>Dept of OB/GYN, Medical University of Vienna, Vienna, Austria.</nlm:affiliation>
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<author><name sortKey="Bojesen, Anders" sort="Bojesen, Anders" uniqKey="Bojesen A" first="Anders" last="Bojesen">Anders Bojesen</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, Vejle Hospital, Kabbeltoft 25, Vejle, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name>
<affiliation><nlm:affiliation>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), via Ripamonti 435, 20141 Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Brewer, Carole" sort="Brewer, Carole" uniqKey="Brewer C" first="Carole" last="Brewer">Carole Brewer</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name>
<affiliation><nlm:affiliation>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A" last="Caligo">Maria A. Caligo</name>
<affiliation><nlm:affiliation>Section of Genetic Oncology, Dept. of Laboratory Medicine, University and University Hospital of Pisa, Pisa Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Campbell, Ian" sort="Campbell, Ian" uniqKey="Campbell I" first="Ian" last="Campbell">Ian Campbell</name>
<affiliation><nlm:affiliation>Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC 8006, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Chan, Salina B" sort="Chan, Salina B" uniqKey="Chan S" first="Salina B" last="Chan">Salina B. Chan</name>
<affiliation><nlm:affiliation>1600 Divisadero Street, C415, San Francisco, CA 94143-1714, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Claes, Kathleen B M" sort="Claes, Kathleen B M" uniqKey="Claes K" first="Kathleen B M" last="Claes">Kathleen B M. Claes</name>
<affiliation><nlm:affiliation>Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cohn, David E" sort="Cohn, David E" uniqKey="Cohn D" first="David E" last="Cohn">David E. Cohn</name>
<affiliation><nlm:affiliation>Ohio State University Columbus Cancer Council GYN Oncology, 3651 Ridge Mill Drive, Columbus, OH 43026, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cook, Jackie" sort="Cook, Jackie" uniqKey="Cook J" first="Jackie" last="Cook">Jackie Cook</name>
<affiliation><nlm:affiliation>Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B" last="Daly">Mary B. Daly</name>
<affiliation><nlm:affiliation>Department of Clinical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Damiola, Francesca" sort="Damiola, Francesca" uniqKey="Damiola F" first="Francesca" last="Damiola">Francesca Damiola</name>
<affiliation><nlm:affiliation>Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pauw, Antoine De" sort="Pauw, Antoine De" uniqKey="Pauw A" first="Antoine De" last="Pauw">Antoine De Pauw</name>
<affiliation><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Delnatte, Capucine" sort="Delnatte, Capucine" uniqKey="Delnatte C" first="Capucine" last="Delnatte">Capucine Delnatte</name>
<affiliation><nlm:affiliation>Unité d'oncogénétique, ICO-Centre René Gauducheau, Boulevard Jacques Monod, 44805 Nantes Saint Herblain Cedex, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Diez, Orland" sort="Diez, Orland" uniqKey="Diez O" first="Orland" last="Diez">Orland Diez</name>
<affiliation><nlm:affiliation>Oncogenetics Group, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), and Universitat Autònoma, Passeig Vall d'Hebron 119-129, Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M" last="Domchek">Susan M. Domchek</name>
<affiliation><nlm:affiliation>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dumont, Martine" sort="Dumont, Martine" uniqKey="Dumont M" first="Martine" last="Dumont">Martine Dumont</name>
<affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Durda, Katarzyna" sort="Durda, Katarzyna" uniqKey="Durda K" first="Katarzyna" last="Durda">Katarzyna Durda</name>
<affiliation><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dworniczak, Bernd" sort="Dworniczak, Bernd" uniqKey="Dworniczak B" first="Bernd" last="Dworniczak">Bernd Dworniczak</name>
<affiliation><nlm:affiliation>Institute of Human Genetics, University of Münster, Münster, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F" last="Easton">Douglas F. Easton</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name>
<affiliation><nlm:affiliation>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Edwinsdotter Ardnor, Christina" sort="Edwinsdotter Ardnor, Christina" uniqKey="Edwinsdotter Ardnor C" first="Christina" last="Edwinsdotter Ardnor">Christina Edwinsdotter Ardnor</name>
<affiliation><nlm:affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Eeles, Ros" sort="Eeles, Ros" uniqKey="Eeles R" first="Ros" last="Eeles">Ros Eeles</name>
<affiliation><nlm:affiliation>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ejlertsen, Bent" sort="Ejlertsen, Bent" uniqKey="Ejlertsen B" first="Bent" last="Ejlertsen">Bent Ejlertsen</name>
<affiliation><nlm:affiliation>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ellis, Steve" sort="Ellis, Steve" uniqKey="Ellis S" first="Steve" last="Ellis">Steve Ellis</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D Gareth" last="Evans">D Gareth Evans</name>
<affiliation><nlm:affiliation>Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Feliubadalo, Lidia" sort="Feliubadalo, Lidia" uniqKey="Feliubadalo L" first="Lidia" last="Feliubadalo">Lidia Feliubadalo</name>
<affiliation><nlm:affiliation>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, 08908 L'Hospitalet, Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fostira, Florentia" sort="Fostira, Florentia" uniqKey="Fostira F" first="Florentia" last="Fostira">Florentia Fostira</name>
<affiliation><nlm:affiliation>Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D" last="Foulkes">William D. Foulkes</name>
<affiliation><nlm:affiliation>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name>
<affiliation><nlm:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gaddam, Pragna" sort="Gaddam, Pragna" uniqKey="Gaddam P" first="Pragna" last="Gaddam">Pragna Gaddam</name>
<affiliation><nlm:affiliation>Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ganz, Patricia A" sort="Ganz, Patricia A" uniqKey="Ganz P" first="Patricia A" last="Ganz">Patricia A. Ganz</name>
<affiliation><nlm:affiliation>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA 90095-6900, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garber, Judy" sort="Garber, Judy" uniqKey="Garber J" first="Judy" last="Garber">Judy Garber</name>
<affiliation><nlm:affiliation>Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Garcia Barberan, Vanesa" sort="Garcia Barberan, Vanesa" uniqKey="Garcia Barberan V" first="Vanesa" last="Garcia-Barberan">Vanesa Garcia-Barberan</name>
<affiliation><nlm:affiliation>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gauthier Villars, Marion" sort="Gauthier Villars, Marion" uniqKey="Gauthier Villars M" first="Marion" last="Gauthier-Villars">Marion Gauthier-Villars</name>
<affiliation><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gehrig, Andrea" sort="Gehrig, Andrea" uniqKey="Gehrig A" first="Andrea" last="Gehrig">Andrea Gehrig</name>
<affiliation><nlm:affiliation>Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, Rigshospitalet 4062, Blegdamsvej 9, København Ø, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Giraud, Sophie" sort="Giraud, Sophie" uniqKey="Giraud S" first="Sophie" last="Giraud">Sophie Giraud</name>
<affiliation><nlm:affiliation>Service de Génétique Moléculaire et Clinique, Hospices Civils de Lyon, Lyon cedex 04, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K" last="Godwin">Andrew K. Godwin</name>
<affiliation><nlm:affiliation>Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS 3040, University of Kansas Medical Center, Kansas City, Kansas, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Goldgar, David E" sort="Goldgar, David E" uniqKey="Goldgar D" first="David E" last="Goldgar">David E. Goldgar</name>
<affiliation><nlm:affiliation>Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, SOM 4B454, Salt Lake City, UT 84132, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hake, Christopher R" sort="Hake, Christopher R" uniqKey="Hake C" first="Christopher R" last="Hake">Christopher R. Hake</name>
<affiliation><nlm:affiliation>City of Hope Clinical Cancer Genetics Community Research Network, 1500 East Duarte Road, Duarte, CA 91010, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V O" last="Hansen">Thomas V O. Hansen</name>
<affiliation><nlm:affiliation>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name>
<affiliation><nlm:affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name>
<affiliation><nlm:affiliation>Medical Genetics Unit, St George's, University of London, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B L" last="Hogervorst">Frans B L. Hogervorst</name>
<affiliation><nlm:affiliation>Family Cancer Clinic, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Houdayer, Claude" sort="Houdayer, Claude" uniqKey="Houdayer C" first="Claude" last="Houdayer">Claude Houdayer</name>
<affiliation><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hulick, Peter J" sort="Hulick, Peter J" uniqKey="Hulick P" first="Peter J" last="Hulick">Peter J. Hulick</name>
<affiliation><nlm:affiliation>Center for Medical Genetics, NorthShore University Health System, University of Chicago Pritzker School of Medicine, 1000 Central Street, Suite 620, Evanston, IL 60201, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N" last="Imyanitov">Evgeny N. Imyanitov</name>
<affiliation><nlm:affiliation>N.N. Petrov Institute of Oncology, St.-Petersburg 197758, Russia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Isaacs, Claudine" sort="Isaacs, Claudine" uniqKey="Isaacs C" first="Claudine" last="Isaacs">Claudine Isaacs</name>
<affiliation><nlm:affiliation>Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name>
<affiliation><nlm:affiliation>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Izquierdo, Angel" sort="Izquierdo, Angel" uniqKey="Izquierdo A" first="Angel" last="Izquierdo">Angel Izquierdo</name>
<affiliation><nlm:affiliation>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Av. França s/n. 1707 Girona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jacobs, Lauren" sort="Jacobs, Lauren" uniqKey="Jacobs L" first="Lauren" last="Jacobs">Lauren Jacobs</name>
<affiliation><nlm:affiliation>Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jakubowska, Anna" sort="Jakubowska, Anna" uniqKey="Jakubowska A" first="Anna" last="Jakubowska">Anna Jakubowska</name>
<affiliation><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Janavicius, Ramunas" sort="Janavicius, Ramunas" uniqKey="Janavicius R" first="Ramunas" last="Janavicius">Ramunas Janavicius</name>
<affiliation><nlm:affiliation>Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Santariskiu st., State Research Institute Centre for Innovative medicine, Zygymantu st. 9, Vilnius, Lithuania.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jaworska Bieniek, Katarzyna" sort="Jaworska Bieniek, Katarzyna" uniqKey="Jaworska Bieniek K" first="Katarzyna" last="Jaworska-Bieniek">Katarzyna Jaworska-Bieniek</name>
<affiliation><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jensen, Uffe Birk" sort="Jensen, Uffe Birk" uniqKey="Jensen U" first="Uffe Birk" last="Jensen">Uffe Birk Jensen</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, Aarhus University Hospital, Brendstrupgaardsvej 21C, Aarhus N, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M" last="John">Esther M. John</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Vijai, Joseph" sort="Vijai, Joseph" uniqKey="Vijai J" first="Joseph" last="Vijai">Joseph Vijai</name>
<affiliation><nlm:affiliation>Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Karlan, Beth Y" sort="Karlan, Beth Y" uniqKey="Karlan B" first="Beth Y" last="Karlan">Beth Y. Karlan</name>
<affiliation><nlm:affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kast, Karin" sort="Kast, Karin" uniqKey="Kast K" first="Karin" last="Kast">Karin Kast</name>
<affiliation><nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Investigators, Kconfab" sort="Investigators, Kconfab" uniqKey="Investigators K" first="Kconfab" last="Investigators">Kconfab Investigators</name>
<affiliation><nlm:affiliation>Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Khan, Sofia" sort="Khan, Sofia" uniqKey="Khan S" first="Sofia" last="Khan">Sofia Khan</name>
<affiliation><nlm:affiliation>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700 (Haartmaninkatu 8), 00029 HUS, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kwong, Ava" sort="Kwong, Ava" uniqKey="Kwong A" first="Ava" last="Kwong">Ava Kwong</name>
<affiliation><nlm:affiliation>The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong China.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name>
<affiliation><nlm:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, Israel.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lester, Jenny" sort="Lester, Jenny" uniqKey="Lester J" first="Jenny" last="Lester">Jenny Lester</name>
<affiliation><nlm:affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lesueur, Fabienne" sort="Lesueur, Fabienne" uniqKey="Lesueur F" first="Fabienne" last="Lesueur">Fabienne Lesueur</name>
<affiliation><nlm:affiliation>Genetic Epidemiology of Cancer team, Inserm U900, Institut Curie, Mines ParisTech, 26 rue d'Ulm, 75248 Paris cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Liljegren, Annelie" sort="Liljegren, Annelie" uniqKey="Liljegren A" first="Annelie" last="Liljegren">Annelie Liljegren</name>
<affiliation><nlm:affiliation>Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lubinski, Jan" sort="Lubinski, Jan" uniqKey="Lubinski J" first="Jan" last="Lubinski">Jan Lubinski</name>
<affiliation><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L" last="Mai">Phuong L. Mai</name>
<affiliation><nlm:affiliation>Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Manoukian, Siranoush" sort="Manoukian, Siranoush" uniqKey="Manoukian S" first="Siranoush" last="Manoukian">Siranoush Manoukian</name>
<affiliation><nlm:affiliation>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Sylvie" sort="Mazoyer, Sylvie" uniqKey="Mazoyer S" first="Sylvie" last="Mazoyer">Sylvie Mazoyer</name>
<affiliation><nlm:affiliation>Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation><nlm:affiliation>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mensenkamp, Arjen R" sort="Mensenkamp, Arjen R" uniqKey="Mensenkamp A" first="Arjen R" last="Mensenkamp">Arjen R. Mensenkamp</name>
<affiliation><nlm:affiliation>Department of Human Genetics, Radboud university medical centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name>
<affiliation><nlm:affiliation>Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L" last="Nathanson">Katherine L. Nathanson</name>
<affiliation><nlm:affiliation>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L" last="Neuhausen">Susan L. Neuhausen</name>
<affiliation><nlm:affiliation>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation><nlm:affiliation>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700 (Haartmaninkatu 8), 00029 HUS, Finland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name>
<affiliation><nlm:affiliation>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Olah, Edith" sort="Olah, Edith" uniqKey="Olah E" first="Edith" last="Olah">Edith Olah</name>
<affiliation><nlm:affiliation>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Olopade, Olufunmilayo I" sort="Olopade, Olufunmilayo I" uniqKey="Olopade O" first="Olufunmilayo I" last="Olopade">Olufunmilayo I. Olopade</name>
<affiliation><nlm:affiliation>The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago, IL 60637.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ong, Kai Ren" sort="Ong, Kai Ren" uniqKey="Ong K" first="Kai-Ren" last="Ong">Kai-Ren Ong</name>
<affiliation><nlm:affiliation>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name>
<affiliation><nlm:affiliation>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Park, Sue Kyung" sort="Park, Sue Kyung" uniqKey="Park S" first="Sue Kyung" last="Park">Sue Kyung Park</name>
<affiliation><nlm:affiliation>Department of Preventive Medicine, Seoul National University College of Medicine, Department of Biomedical Science, Seoul National University Graduate School, and Cancer Research Institute, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Paulsson Karlsson, Ylva" sort="Paulsson Karlsson, Ylva" uniqKey="Paulsson Karlsson Y" first="Ylva" last="Paulsson-Karlsson">Ylva Paulsson-Karlsson</name>
<affiliation><nlm:affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pedersen, Inge Sokilde" sort="Pedersen, Inge Sokilde" uniqKey="Pedersen I" first="Inge Sokilde" last="Pedersen">Inge Sokilde Pedersen</name>
<affiliation><nlm:affiliation>Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Reberbansgade 15, Aalborg, Denmark.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name>
<affiliation><nlm:affiliation>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name>
<affiliation><nlm:affiliation>IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, c/o IFOM-IEO campus, via Adamello 16, 20139 Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pfeiler, Georg" sort="Pfeiler, Georg" uniqKey="Pfeiler G" first="Georg" last="Pfeiler">Georg Pfeiler</name>
<affiliation><nlm:affiliation>Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Phelan, Catherine M" sort="Phelan, Catherine M" uniqKey="Phelan C" first="Catherine M" last="Phelan">Catherine M. Phelan</name>
<affiliation><nlm:affiliation>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name>
<affiliation><nlm:affiliation>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY 14263, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Poppe, Bruce" sort="Poppe, Bruce" uniqKey="Poppe B" first="Bruce" last="Poppe">Bruce Poppe</name>
<affiliation><nlm:affiliation>Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pujana, Miquel Angel" sort="Pujana, Miquel Angel" uniqKey="Pujana M" first="Miquel Angel" last="Pujana">Miquel Angel Pujana</name>
<affiliation><nlm:affiliation>Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name>
<affiliation><nlm:affiliation>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133 Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name>
<affiliation><nlm:affiliation>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, 7 Michal St., Haifa 34362, Israel.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C" last="Rodriguez">Gustavo C. Rodriguez</name>
<affiliation><nlm:affiliation>Division of Gynecologic Oncology, NorthShore University HealthSystem, Univ of Chicago, 2650 Ridge Avenue Suite 1507 Walgreens, Evanston, IL 60201, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A" last="Rookus">Matti A. Rookus</name>
<affiliation><nlm:affiliation>Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ross, Eric A" sort="Ross, Eric A" uniqKey="Ross E" first="Eric A" last="Ross">Eric A. Ross</name>
<affiliation><nlm:affiliation>Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita Katharina" sort="Schmutzler, Rita Katharina" uniqKey="Schmutzler R" first="Rita Katharina" last="Schmutzler">Rita Katharina Schmutzler</name>
<affiliation><nlm:affiliation>Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name>
<affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Singer, Christian F" sort="Singer, Christian F" uniqKey="Singer C" first="Christian F" last="Singer">Christian F. Singer</name>
<affiliation><nlm:affiliation>Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Slavin, Thomas P" sort="Slavin, Thomas P" uniqKey="Slavin T" first="Thomas P" last="Slavin">Thomas P. Slavin</name>
<affiliation><nlm:affiliation>Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Soucy, Penny" sort="Soucy, Penny" uniqKey="Soucy P" first="Penny" last="Soucy">Penny Soucy</name>
<affiliation><nlm:affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa" sort="Southey, Melissa" uniqKey="Southey M" first="Melissa" last="Southey">Melissa Southey</name>
<affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Steinemann, Doris" sort="Steinemann, Doris" uniqKey="Steinemann D" first="Doris" last="Steinemann">Doris Steinemann</name>
<affiliation><nlm:affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name>
<affiliation><nlm:affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sukiennicki, Grzegorz" sort="Sukiennicki, Grzegorz" uniqKey="Sukiennicki G" first="Grzegorz" last="Sukiennicki">Grzegorz Sukiennicki</name>
<affiliation><nlm:affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sutter, Christian" sort="Sutter, Christian" uniqKey="Sutter C" first="Christian" last="Sutter">Christian Sutter</name>
<affiliation><nlm:affiliation>Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I" last="Szabo">Csilla I. Szabo</name>
<affiliation><nlm:affiliation>National Human Genome Research Institute, National Institutes of Health, Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD 20892-8004, United States of America.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Tea, Muy Kheng" sort="Tea, Muy Kheng" uniqKey="Tea M" first="Muy-Kheng" last="Tea">Muy-Kheng Tea</name>
<affiliation><nlm:affiliation>Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Teixeira, Manuel R" sort="Teixeira, Manuel R" uniqKey="Teixeira M" first="Manuel R" last="Teixeira">Manuel R. Teixeira</name>
<affiliation><nlm:affiliation>Department of Genetics, Portuguese Oncology Institute, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Teo, Soo Hwang" sort="Teo, Soo Hwang" uniqKey="Teo S" first="Soo-Hwang" last="Teo">Soo-Hwang Teo</name>
<affiliation><nlm:affiliation>Cancer Research Initiatives Foundation, Sime Darby Medical Centre, 1 Jalan SS12/1A, Subang Jaya, 47500 Malaysia.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Epidemiology, Columbia University, New York, NY, United States of America.</nlm:affiliation>
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<author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name>
<affiliation><nlm:affiliation>Department of Clinical Genetics, Odense University Hospital, Sonder Boulevard 29, Odense C, Denmark.</nlm:affiliation>
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<author><name sortKey="Tibiletti, Maria Grazia" sort="Tibiletti, Maria Grazia" uniqKey="Tibiletti M" first="Maria Grazia" last="Tibiletti">Maria Grazia Tibiletti</name>
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</author>
<author><name sortKey="Tihomirova, Laima" sort="Tihomirova, Laima" uniqKey="Tihomirova L" first="Laima" last="Tihomirova">Laima Tihomirova</name>
<affiliation><nlm:affiliation>Latvian Biomedical Research and Study Centre, Ratsupites str 1, Riga, Latvia.</nlm:affiliation>
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</author>
<author><name sortKey="Tognazzo, Silvia" sort="Tognazzo, Silvia" uniqKey="Tognazzo S" first="Silvia" last="Tognazzo">Silvia Tognazzo</name>
<affiliation><nlm:affiliation>Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy.</nlm:affiliation>
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<author><name sortKey="Van Rensburg, Elizabeth J" sort="Van Rensburg, Elizabeth J" uniqKey="Van Rensburg E" first="Elizabeth J" last="Van Rensburg">Elizabeth J. Van Rensburg</name>
<affiliation><nlm:affiliation>Cancer Genetics Laboratory, Department of Genetics, University of Pretoria, Private Bag X323, Arcadia 0007, South Africa.</nlm:affiliation>
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<affiliation><nlm:affiliation>Divison of Human Cancer Genetics, Departments of Internal Medicine and Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, 998 Biomedical Research Tower, Columbus, OH, United States of America.</nlm:affiliation>
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<affiliation><nlm:affiliation>Clinical Genetics Research Laboratory, Dept. of Medicine, Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America.</nlm:affiliation>
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<affiliation><nlm:affiliation>Department of Oncology, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
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<author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name>
<affiliation><nlm:affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029.</nlm:affiliation>
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<author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C" last="Antoniou">Antonis C. Antoniou</name>
<affiliation><nlm:affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation>
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</analytic>
<series><title level="j">PloS one</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosome Mapping</term>
<term>Chromosomes, Human, Pair 9</term>
<term>Female</term>
<term>Genes, BRCA1</term>
<term>Genes, BRCA2</term>
<term>Genetic Predisposition to Disease</term>
<term>Heterozygote Detection</term>
<term>Humans</term>
<term>Ovarian Neoplasms (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Ovarian Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Chromosome Mapping</term>
<term>Chromosomes, Human, Pair 9</term>
<term>Female</term>
<term>Genes, BRCA1</term>
<term>Genes, BRCA2</term>
<term>Genetic Predisposition to Disease</term>
<term>Heterozygote Detection</term>
<term>Humans</term>
<term>Polymorphism, Single Nucleotide</term>
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<front><div type="abstract" xml:lang="en">Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 mutation carriers. Genotype data were available for 15,252 (2,462 ovarian cancer cases) BRCA1 and 8,211 (631 ovarian cancer cases) BRCA2 mutation carriers. Following genotype imputation, ovarian cancer associations were assessed for 4,873 and 5,020 SNPs in BRCA1 and BRCA 2 mutation carriers respectively, within a retrospective cohort analytical framework. In BRCA1 mutation carriers one set of eight correlated candidate causal variants for ovarian cancer risk modification was identified (top SNP rs10124837, HR: 0.73, 95%CI: 0.68 to 0.79, p-value 2× 10-16). These variants were located up to 20 kb upstream of BNC2. In BRCA2 mutation carriers one region, up to 45 kb upstream of BNC2, and containing 100 correlated SNPs was identified as candidate causal (top SNP rs62543585, HR: 0.69, 95%CI: 0.59 to 0.80, p-value 1.0 × 10-6). The candidate causal in BRCA1 mutation carriers did not include the strongest associated variant at this locus in the general population. In sum, we identified a set of candidate causal variants in a region that encompasses the BNC2 transcription start site. The ovarian cancer association at 9p22.2 may be mediated by different variants in BRCA1 mutation carriers and in the general population. Thus, potentially different mechanisms may underlie ovarian cancer risk for mutation carriers and the general population.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27463617</PMID>
<DateCreated><Year>2016</Year>
<Month>07</Month>
<Day>28</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>07</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<Issue>7</Issue>
<PubDate><Year>2016</Year>
</PubDate>
</JournalIssue>
<Title>PloS one</Title>
<ISOAbbreviation>PLoS ONE</ISOAbbreviation>
</Journal>
<ArticleTitle>Fine-Scale Mapping at 9p22.2 Identifies Candidate Causal Variants That Modify Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers.</ArticleTitle>
<Pagination><MedlinePgn>e0158801</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0158801</ELocationID>
<Abstract><AbstractText>Population-based genome wide association studies have identified a locus at 9p22.2 associated with ovarian cancer risk, which also modifies ovarian cancer risk in BRCA1 and BRCA2 mutation carriers. We conducted fine-scale mapping at 9p22.2 to identify potential causal variants in BRCA1 and BRCA2 mutation carriers. Genotype data were available for 15,252 (2,462 ovarian cancer cases) BRCA1 and 8,211 (631 ovarian cancer cases) BRCA2 mutation carriers. Following genotype imputation, ovarian cancer associations were assessed for 4,873 and 5,020 SNPs in BRCA1 and BRCA 2 mutation carriers respectively, within a retrospective cohort analytical framework. In BRCA1 mutation carriers one set of eight correlated candidate causal variants for ovarian cancer risk modification was identified (top SNP rs10124837, HR: 0.73, 95%CI: 0.68 to 0.79, p-value 2× 10-16). These variants were located up to 20 kb upstream of BNC2. In BRCA2 mutation carriers one region, up to 45 kb upstream of BNC2, and containing 100 correlated SNPs was identified as candidate causal (top SNP rs62543585, HR: 0.69, 95%CI: 0.59 to 0.80, p-value 1.0 × 10-6). The candidate causal in BRCA1 mutation carriers did not include the strongest associated variant at this locus in the general population. In sum, we identified a set of candidate causal variants in a region that encompasses the BNC2 transcription start site. The ovarian cancer association at 9p22.2 may be mediated by different variants in BRCA1 mutation carriers and in the general population. Thus, potentially different mechanisms may underlie ovarian cancer risk for mutation carriers and the general population.</AbstractText>
</Abstract>
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<AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</Affiliation>
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<AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029.</Affiliation>
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<Initials>A</Initials>
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<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Genetics, Vejle Hospital, Kabbeltoft 25, Vejle, Denmark.</Affiliation>
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<ForeName>Bernardo</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Division of Cancer Prevention and Genetics, Istituto Europeo di Oncologia (IEO), via Ripamonti 435, 20141 Milan, Italy.</Affiliation>
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<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Genetics, Royal Devon & Exeter Hospital, Exeter, United Kingdom.</Affiliation>
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<Initials>T</Initials>
<AffiliationInfo><Affiliation>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain.</Affiliation>
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<ForeName>Maria A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Section of Genetic Oncology, Dept. of Laboratory Medicine, University and University Hospital of Pisa, Pisa Italy.</Affiliation>
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<AffiliationInfo><Affiliation>Research Division, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett Street, Melbourne, VIC 8006, Australia.</Affiliation>
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<ForeName>Kathleen B M</ForeName>
<Initials>KB</Initials>
<AffiliationInfo><Affiliation>Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium.</Affiliation>
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<ForeName>David E</ForeName>
<Initials>DE</Initials>
<AffiliationInfo><Affiliation>Ohio State University Columbus Cancer Council GYN Oncology, 3651 Ridge Mill Drive, Columbus, OH 43026, United States of America.</Affiliation>
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<ForeName>Jackie</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Sheffield Clinical Genetics Service, Sheffield Children's Hospital, Sheffield, United Kingdom.</Affiliation>
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<ForeName>Mary B</ForeName>
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<AffiliationInfo><Affiliation>Department of Clinical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, United States of America.</Affiliation>
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<ForeName>Francesca</ForeName>
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<AffiliationInfo><Affiliation>Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.</Affiliation>
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<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, United Kingdom.</Affiliation>
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<ForeName>Antoine de</ForeName>
<Initials>Ad</Initials>
<AffiliationInfo><Affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</Affiliation>
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<Initials>O</Initials>
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<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America.</Affiliation>
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<AffiliationInfo><Affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</Affiliation>
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<ForeName>Bernd</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Institute of Human Genetics, University of Münster, Münster, Germany.</Affiliation>
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<ForeName>Douglas F</ForeName>
<Initials>DF</Initials>
<AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.</Affiliation>
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<ForeName>Diana</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>University of Southampton Faculty of Medicine, Southampton University Hospitals NHS Trust, Southampton, United Kingdom.</Affiliation>
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<ForeName>Christina</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Department of Radiation Sciences, Oncology, Umeå University, Umea, Sweden.</Affiliation>
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<ForeName>Ros</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.</Affiliation>
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<ForeName>Bent</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.</Affiliation>
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<ForeName>Steve</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom.</Affiliation>
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<ForeName>D Gareth</ForeName>
<Initials>DG</Initials>
<AffiliationInfo><Affiliation>Genomic Medicine, Manchester Academic Health Sciences Centre, Institute of Human Development, Manchester University, Central Manchester University Hospitals NHS Foundation Trust, Manchester, United Kingdom.</Affiliation>
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<Initials>L</Initials>
<AffiliationInfo><Affiliation>Molecular Diagnostic Unit, Hereditary Cancer Program, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Gran Via de l'Hospitalet, 199-203, 08908 L'Hospitalet, Barcelona, Spain.</Affiliation>
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<Initials>F</Initials>
<AffiliationInfo><Affiliation>Molecular Diagnostics Laboratory, (INRASTES) Institute of Nuclear and Radiological Sciences and Technology, National Centre for Scientific Research "Demokritos", Patriarchou Gregoriou & Neapoleos str., Aghia Paraskevi, Attiki, Athens, Greece.</Affiliation>
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<ForeName>William D</ForeName>
<Initials>WD</Initials>
<AffiliationInfo><Affiliation>Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montreal, Quebec, Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Friedman</LastName>
<ForeName>Eitan</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, and Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel.</Affiliation>
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<Author ValidYN="Y"><LastName>Frost</LastName>
<ForeName>Debra</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom.</Affiliation>
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<Author ValidYN="Y"><LastName>Gaddam</LastName>
<ForeName>Pragna</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Clinical Cancer Genetics Laboratory, Memorial Sloane Kettering Cancer Center, New York, NY, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Ganz</LastName>
<ForeName>Patricia A</ForeName>
<Initials>PA</Initials>
<AffiliationInfo><Affiliation>UCLA Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, 650 Charles Young Drive South, Room A2-125 HS, Los Angeles, CA 90095-6900, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Garber</LastName>
<ForeName>Judy</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Garcia-Barberan</LastName>
<ForeName>Vanesa</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC (El Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Martin Lagos s/n, Madrid, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Gauthier-Villars</LastName>
<ForeName>Marion</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</Affiliation>
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<Author ValidYN="Y"><LastName>Gehrig</LastName>
<ForeName>Andrea</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centre of Familial Breast and Ovarian Cancer, Department of Medical Genetics, Institute of Human Genetics, University Würzburg, Würzburg, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Gerdes</LastName>
<ForeName>Anne-Marie</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Genetics, Rigshospitalet 4062, Blegdamsvej 9, København Ø, Denmark.</Affiliation>
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<Author ValidYN="Y"><LastName>Giraud</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Service de Génétique Moléculaire et Clinique, Hospices Civils de Lyon, Lyon cedex 04, France.</Affiliation>
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<Author ValidYN="Y"><LastName>Godwin</LastName>
<ForeName>Andrew K</ForeName>
<Initials>AK</Initials>
<AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, 3901 Rainbow Boulevard, 4019 Wahl Hall East, MS 3040, University of Kansas Medical Center, Kansas City, Kansas, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Goldgar</LastName>
<ForeName>David E</ForeName>
<Initials>DE</Initials>
<AffiliationInfo><Affiliation>Department of Dermatology, University of Utah School of Medicine, 30 North 1900 East, SOM 4B454, Salt Lake City, UT 84132, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Hake</LastName>
<ForeName>Christopher R</ForeName>
<Initials>CR</Initials>
<AffiliationInfo><Affiliation>City of Hope Clinical Cancer Genetics Community Research Network, 1500 East Duarte Road, Duarte, CA 91010, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Hansen</LastName>
<ForeName>Thomas V O</ForeName>
<Initials>TV</Initials>
<AffiliationInfo><Affiliation>Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Healey</LastName>
<ForeName>Sue</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Genetics, QIMR Berghofer Medical Research Institute, Herston Road, Brisbane, Australia, 4029.</Affiliation>
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<Author ValidYN="Y"><LastName>Hodgson</LastName>
<ForeName>Shirley</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Medical Genetics Unit, St George's, University of London, London, United Kingdom.</Affiliation>
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<Author ValidYN="Y"><LastName>Hogervorst</LastName>
<ForeName>Frans B L</ForeName>
<Initials>FB</Initials>
<AffiliationInfo><Affiliation>Family Cancer Clinic, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands.</Affiliation>
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<Author ValidYN="Y"><LastName>Houdayer</LastName>
<ForeName>Claude</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</Affiliation>
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<Author ValidYN="Y"><LastName>Hulick</LastName>
<ForeName>Peter J</ForeName>
<Initials>PJ</Initials>
<AffiliationInfo><Affiliation>Center for Medical Genetics, NorthShore University Health System, University of Chicago Pritzker School of Medicine, 1000 Central Street, Suite 620, Evanston, IL 60201, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Imyanitov</LastName>
<ForeName>Evgeny N</ForeName>
<Initials>EN</Initials>
<AffiliationInfo><Affiliation>N.N. Petrov Institute of Oncology, St.-Petersburg 197758, Russia.</Affiliation>
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<Author ValidYN="Y"><LastName>Isaacs</LastName>
<ForeName>Claudine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Izatt</LastName>
<ForeName>Louise</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Clinical Genetics, Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom.</Affiliation>
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<Author ValidYN="Y"><LastName>Izquierdo</LastName>
<ForeName>Angel</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, Av. França s/n. 1707 Girona, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Jacobs</LastName>
<ForeName>Lauren</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Jakubowska</LastName>
<ForeName>Anna</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</Affiliation>
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<Author ValidYN="Y"><LastName>Janavicius</LastName>
<ForeName>Ramunas</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Vilnius University Hospital Santariskiu Clinics, Hematology, oncology and transfusion medicine center, Dept. of Molecular and Regenerative Medicine, Santariskiu st., State Research Institute Centre for Innovative medicine, Zygymantu st. 9, Vilnius, Lithuania.</Affiliation>
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<Author ValidYN="Y"><LastName>Jaworska-Bieniek</LastName>
<ForeName>Katarzyna</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</Affiliation>
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<Author ValidYN="Y"><LastName>Jensen</LastName>
<ForeName>Uffe Birk</ForeName>
<Initials>UB</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Genetics, Aarhus University Hospital, Brendstrupgaardsvej 21C, Aarhus N, Denmark.</Affiliation>
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<Author ValidYN="Y"><LastName>John</LastName>
<ForeName>Esther M</ForeName>
<Initials>EM</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Vijai</LastName>
<ForeName>Joseph</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Clinical Genetics Research Laboratory, Dept. of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10044, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Karlan</LastName>
<ForeName>Beth Y</ForeName>
<Initials>BY</Initials>
<AffiliationInfo><Affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Kast</LastName>
<ForeName>Karin</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Gynaecology and Obstetrics, University Hospital Carl Gustav Carus, Technical University Dresden, Dresden, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Investigators</LastName>
<ForeName>KConFab</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Kathleen Cuningham Consortium for Research into Familial Breast Cancer, Peter MacCallum Cancer Center, Melbourne, Australia.</Affiliation>
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<Author ValidYN="Y"><LastName>Khan</LastName>
<ForeName>Sofia</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700 (Haartmaninkatu 8), 00029 HUS, Finland.</Affiliation>
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<Author ValidYN="Y"><LastName>Kwong</LastName>
<ForeName>Ava</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>The Hong Kong Hereditary Breast Cancer Family Registry, Cancer Genetics Center, Hong Kong Sanatorium and Hospital, Hong Kong China.</Affiliation>
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<Author ValidYN="Y"><LastName>Laitman</LastName>
<ForeName>Yael</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>The Susanne Levy Gertner Oncogenetics Unit, Institute of Human Genetics, Chaim Sheba Medical Center, Ramat Gan 52621, Israel.</Affiliation>
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<Author ValidYN="Y"><LastName>Lester</LastName>
<ForeName>Jenny</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Suite 290W, Los Angeles, CA, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Lesueur</LastName>
<ForeName>Fabienne</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Genetic Epidemiology of Cancer team, Inserm U900, Institut Curie, Mines ParisTech, 26 rue d'Ulm, 75248 Paris cedex 05, France.</Affiliation>
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<Author ValidYN="Y"><LastName>Liljegren</LastName>
<ForeName>Annelie</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.</Affiliation>
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<Author ValidYN="Y"><LastName>Lubinski</LastName>
<ForeName>Jan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</Affiliation>
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<Author ValidYN="Y"><LastName>Mai</LastName>
<ForeName>Phuong L</ForeName>
<Initials>PL</Initials>
<AffiliationInfo><Affiliation>Clinical Genetics Branch, DCEG, NCI, NIH, 9609 Medical Center Drive, Room 6E-454, Bethesda, MD, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Manoukian</LastName>
<ForeName>Siranoush</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Mazoyer</LastName>
<ForeName>Sylvie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Bâtiment Cheney D, Centre Léon Bérard, 28 rue Laënnec, Lyon, France.</Affiliation>
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<Author ValidYN="Y"><LastName>Meindl</LastName>
<ForeName>Alfons</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Gynaecology and Obstetrics, Division of Tumor Genetics, Klinikum rechts der Isar, Technical University Munich, Munich, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Mensenkamp</LastName>
<ForeName>Arjen R</ForeName>
<Initials>AR</Initials>
<AffiliationInfo><Affiliation>Department of Human Genetics, Radboud university medical centre, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.</Affiliation>
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<Author ValidYN="Y"><LastName>Montagna</LastName>
<ForeName>Marco</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV-IRCCS, Via Gattamelata 64, Padua, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Nathanson</LastName>
<ForeName>Katherine L</ForeName>
<Initials>KL</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Neuhausen</LastName>
<ForeName>Susan L</ForeName>
<Initials>SL</Initials>
<AffiliationInfo><Affiliation>Department of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Nevanlinna</LastName>
<ForeName>Heli</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Biomedicum Helsinki, P.O. BOX 700 (Haartmaninkatu 8), 00029 HUS, Finland.</Affiliation>
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<Author ValidYN="Y"><LastName>Niederacher</LastName>
<ForeName>Dieter</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Gynaecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Olah</LastName>
<ForeName>Edith</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.</Affiliation>
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<Author ValidYN="Y"><LastName>Olopade</LastName>
<ForeName>Olufunmilayo I</ForeName>
<Initials>OI</Initials>
<AffiliationInfo><Affiliation>The University of Chicago Medicine, 5841 South Maryland Avenue, MC 2115 Chicago, IL 60637.</Affiliation>
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<Author ValidYN="Y"><LastName>Ong</LastName>
<ForeName>Kai-Ren</ForeName>
<Initials>KR</Initials>
<AffiliationInfo><Affiliation>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, United Kingdom.</Affiliation>
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<Author ValidYN="Y"><LastName>Osorio</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Human Genetics Group, Spanish National Cancer Centre (CNIO), Madrid, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Park</LastName>
<ForeName>Sue Kyung</ForeName>
<Initials>SK</Initials>
<AffiliationInfo><Affiliation>Department of Preventive Medicine, Seoul National University College of Medicine, Department of Biomedical Science, Seoul National University Graduate School, and Cancer Research Institute, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Korea.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Paulsson-Karlsson</LastName>
<ForeName>Ylva</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Department of Immunology, Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden.</Affiliation>
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<Author ValidYN="Y"><LastName>Pedersen</LastName>
<ForeName>Inge Sokilde</ForeName>
<Initials>IS</Initials>
<AffiliationInfo><Affiliation>Section of Molecular Diagnostics, Department of Biochemistry, Aalborg University Hospital, Reberbansgade 15, Aalborg, Denmark.</Affiliation>
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<Author ValidYN="Y"><LastName>Peissel</LastName>
<ForeName>Bernard</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Unit of Medical Genetics, Department of Preventive and Predictive Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), Via Giacomo Venezian 1, 20133 Milan, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Peterlongo</LastName>
<ForeName>Paolo</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, c/o IFOM-IEO campus, via Adamello 16, 20139 Milan, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Pfeiler</LastName>
<ForeName>Georg</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.</Affiliation>
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<Author ValidYN="Y"><LastName>Phelan</LastName>
<ForeName>Catherine M</ForeName>
<Initials>CM</Initials>
<AffiliationInfo><Affiliation>Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Piedmonte</LastName>
<ForeName>Marion</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Elm St & Carlton St, Buffalo, NY 14263, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Poppe</LastName>
<ForeName>Bruce</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Center for Medical Genetics, Ghent University, De Pintelaan 185, 9000 Gent, Belgium.</Affiliation>
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<Author ValidYN="Y"><LastName>Pujana</LastName>
<ForeName>Miquel Angel</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Translational Research Laboratory, IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, Barcelona, Spain.</Affiliation>
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<Author ValidYN="Y"><LastName>Radice</LastName>
<ForeName>Paolo</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predicted Medicine, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori (INT), c/o Amaedeolab, via GA Amadeo 42, 20133 Milan, Italy.</Affiliation>
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<Author ValidYN="Y"><LastName>Rennert</LastName>
<ForeName>Gad</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Clalit National Israeli Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, 7 Michal St., Haifa 34362, Israel.</Affiliation>
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<Author ValidYN="Y"><LastName>Rodriguez</LastName>
<ForeName>Gustavo C</ForeName>
<Initials>GC</Initials>
<AffiliationInfo><Affiliation>Division of Gynecologic Oncology, NorthShore University HealthSystem, Univ of Chicago, 2650 Ridge Avenue Suite 1507 Walgreens, Evanston, IL 60201, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Rookus</LastName>
<ForeName>Matti A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology, Netherlands Cancer Institute, P.O. Box 90203, 1000 BE, Amsterdam, The Netherlands.</Affiliation>
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<Author ValidYN="Y"><LastName>Ross</LastName>
<ForeName>Eric A</ForeName>
<Initials>EA</Initials>
<AffiliationInfo><Affiliation>Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Schmutzler</LastName>
<ForeName>Rita Katharina</ForeName>
<Initials>RK</Initials>
<AffiliationInfo><Affiliation>Center for Hereditary Breast and Ovarian Cancer, Medical Faculty, University Hospital Cologne, Cologne, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Simard</LastName>
<ForeName>Jacques</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Singer</LastName>
<ForeName>Christian F</ForeName>
<Initials>CF</Initials>
<AffiliationInfo><Affiliation>Dept of OB/GYN, Medical University of Vienna, Vienna, Austria, and Waehringer Guertel 18-20, A 1090 Vienna, Austria.</Affiliation>
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<Author ValidYN="Y"><LastName>Slavin</LastName>
<ForeName>Thomas P</ForeName>
<Initials>TP</Initials>
<AffiliationInfo><Affiliation>Clinical Cancer Genetics, City of Hope, 1500 East Duarte Road, Duarte, California 91010, United States of America.</Affiliation>
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<Author ValidYN="Y"><LastName>Soucy</LastName>
<ForeName>Penny</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Genomics Center, Centre Hospitalier Universitaire de Québec Research Center and Laval University, 2705 Laurier Boulevard, Quebec City (Quebec), Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Southey</LastName>
<ForeName>Melissa</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.</Affiliation>
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<Author ValidYN="Y"><LastName>Steinemann</LastName>
<ForeName>Doris</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Stoppa-Lyonnet</LastName>
<ForeName>Dominique</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Service de Génétique Oncologique, Institut Curie, 26, rue d'Ulm, Paris Cedex 05, France.</Affiliation>
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<Author ValidYN="Y"><LastName>Sukiennicki</LastName>
<ForeName>Grzegorz</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Department of Genetics and Pathology, Pomeranian Medical University, Polabska 4, Szczecin, Poland.</Affiliation>
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<Author ValidYN="Y"><LastName>Sutter</LastName>
<ForeName>Christian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Institute of Human Genetics, Department of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Szabo</LastName>
<ForeName>Csilla I</ForeName>
<Initials>CI</Initials>
<AffiliationInfo><Affiliation>National Human Genome Research Institute, National Institutes of Health, Building 50, Room 5312, 50 South Drive, MSC 004, Bethesda, MD 20892-8004, United States of America.</Affiliation>
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<ForeName>Susan J</ForeName>
<Initials>SJ</Initials>
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<ForeName>Mark H</ForeName>
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<Initials>FJ</Initials>
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<Agency>Cancer Research UK</Agency>
<Country>United Kingdom</Country>
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<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
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<Country>United Kingdom</Country>
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<Agency>Cancer Research UK</Agency>
<Country>United Kingdom</Country>
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<Acronym>CA</Acronym>
<Agency>NCI NIH HHS</Agency>
<Country>United States</Country>
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<Month>07</Month>
<Day>27</Day>
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<MeshHeading><DescriptorName UI="D002899" MajorTopicYN="Y">Chromosomes, Human, Pair 9</DescriptorName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
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<MeshHeading><DescriptorName UI="D019398" MajorTopicYN="Y">Genes, BRCA1</DescriptorName>
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<MeshHeading><DescriptorName UI="D024522" MajorTopicYN="Y">Genes, BRCA2</DescriptorName>
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<MeshHeading><DescriptorName UI="D020022" MajorTopicYN="Y">Genetic Predisposition to Disease</DescriptorName>
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<MeshHeading><DescriptorName UI="D006580" MajorTopicYN="Y">Heterozygote Detection</DescriptorName>
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<MeshHeading><DescriptorName UI="D010051" MajorTopicYN="N">Ovarian Neoplasms</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
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<MeshHeading><DescriptorName UI="D020641" MajorTopicYN="N">Polymorphism, Single Nucleotide</DescriptorName>
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<Month>03</Month>
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