Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants.
Identifieur interne : 001B77 ( PubMed/Corpus ); précédent : 001B76; suivant : 001B78Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants.
Auteurs : Mengmeng Du ; Shuo Jiao ; Stephanie A. Bien ; Manish Gala ; Goncalo Abecasis ; Stephane Bezieau ; Hermann Brenner ; Katja Butterbach ; Bette J. Caan ; Christopher S. Carlson ; Graham Casey ; Jenny Chang-Claude ; David V. Conti ; Keith R. Curtis ; David Duggan ; Steven Gallinger ; Robert W. Haile ; Tabitha A. Harrison ; Richard B. Hayes ; Michael Hoffmeister ; John L. Hopper ; Thomas J. Hudson ; Mark A. Jenkins ; Sébastien Küry ; Loic Le Marchand ; Suzanne M. Leal ; Polly A. Newcomb ; Deborah A. Nickerson ; John D. Potter ; Robert E. Schoen ; Fredrick R. Schumacher ; Daniela Seminara ; Martha L. Slattery ; Li Hsu ; Andrew T. Chan ; Emily White ; Sonja I. Berndt ; Ulrike PetersSource :
- PloS one [ 1932-6203 ] ; 2016.
English descriptors
- KwdEn :
- A549 Cells, Adult, Aged, Aged, 80 and over, Caco-2 Cells, Chromosome Mapping, Colorectal Neoplasms (genetics), Colorectal Neoplasms (pathology), Computational Biology (methods), Female, Genetic Predisposition to Disease (genetics), Genetic Variation, Genome-Wide Association Study (methods), Genotype, HCT116 Cells, Hep G2 Cells, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Registries (statistics & numerical data), Risk Factors, Young Adult.
- MESH :
- genetics : Colorectal Neoplasms, Genetic Predisposition to Disease.
- methods : Computational Biology, Genome-Wide Association Study.
- pathology : Colorectal Neoplasms.
- statistics & numerical data : Registries.
- A549 Cells, Adult, Aged, Aged, 80 and over, Caco-2 Cells, Chromosome Mapping, Female, Genetic Variation, Genotype, HCT116 Cells, Hep G2 Cells, Humans, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors, Young Adult.
Abstract
Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. These SNPs may tag correlated variants with biological importance. Fine-mapping around GWAS loci can facilitate detection of functional candidates and additional independent risk variants. We analyzed 11,900 cases and 14,311 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colon Cancer Family Registry. To fine-map genomic regions containing all known common risk variants, we imputed high-density genetic data from the 1000 Genomes Project. We tested single-variant associations with colorectal tumor risk for all variants spanning genomic regions 250-kb upstream or downstream of 31 GWAS-identified SNPs (index SNPs). We queried the University of California, Santa Cruz Genome Browser to examine evidence for biological function. Index SNPs did not show the strongest association signals with colorectal tumor risk in their respective genomic regions. Bioinformatics analysis of SNPs showing smaller P-values in each region revealed 21 functional candidates in 12 loci (5q31.1, 8q24, 11q13.4, 11q23, 12p13.32, 12q24.21, 14q22.2, 15q13, 18q21, 19q13.1, 20p12.3, and 20q13.33). We did not observe evidence of additional independent association signals in GWAS-identified regions. Our results support the utility of integrating data from comprehensive fine-mapping with expanding publicly available genomic databases to help clarify GWAS associations and identify functional candidates that warrant more onerous laboratory follow-up. Such efforts may aid the eventual discovery of disease-causing variant(s).
DOI: 10.1371/journal.pone.0157521
PubMed: 27379672
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Bien</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Gala, Manish" sort="Gala, Manish" uniqKey="Gala M" first="Manish" last="Gala">Manish Gala</name><affiliation><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Abecasis, Goncalo" sort="Abecasis, Goncalo" uniqKey="Abecasis G" first="Goncalo" last="Abecasis">Goncalo Abecasis</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation><nlm:affiliation>Service de Génétique Médicale, CHU Nantes, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J" last="Caan">Bette J. Caan</name><affiliation><nlm:affiliation>Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, CA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S" last="Carlson">Christopher S. Carlson</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><affiliation><nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Curtis, Keith R" sort="Curtis, Keith R" uniqKey="Curtis K" first="Keith R" last="Curtis">Keith R. Curtis</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><affiliation><nlm:affiliation>Translational Genomics Research Institute, Phoenix, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation><nlm:affiliation>Department of Surgery, Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W" last="Haile">Robert W. Haile</name><affiliation><nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B" last="Hayes">Richard B. Hayes</name><affiliation><nlm:affiliation>Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name><affiliation><nlm:affiliation>Ontario Institute for Cancer Research, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name><affiliation><nlm:affiliation>Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation><nlm:affiliation>Service de Génétique Médicale, CHU Nantes, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Leal, Suzanne M" sort="Leal, Suzanne M" uniqKey="Leal S" first="Suzanne M" last="Leal">Suzanne M. Leal</name><affiliation><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Nickerson, Deborah A" sort="Nickerson, Deborah A" uniqKey="Nickerson D" first="Deborah A" last="Nickerson">Deborah A. Nickerson</name><affiliation><nlm:affiliation>Genome Sciences, University of Washington, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D" last="Potter">John D. Potter</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><affiliation><nlm:affiliation>Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27379672</idno><idno type="pmid">27379672</idno><idno type="doi">10.1371/journal.pone.0157521</idno><idno type="wicri:Area/PubMed/Corpus">001B77</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B77</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants.</title><author><name sortKey="Du, Mengmeng" sort="Du, Mengmeng" uniqKey="Du M" first="Mengmeng" last="Du">Mengmeng Du</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Jiao, Shuo" sort="Jiao, Shuo" uniqKey="Jiao S" first="Shuo" last="Jiao">Shuo Jiao</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Bien, Stephanie A" sort="Bien, Stephanie A" uniqKey="Bien S" first="Stephanie A" last="Bien">Stephanie A. Bien</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Gala, Manish" sort="Gala, Manish" uniqKey="Gala M" first="Manish" last="Gala">Manish Gala</name><affiliation><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Abecasis, Goncalo" sort="Abecasis, Goncalo" uniqKey="Abecasis G" first="Goncalo" last="Abecasis">Goncalo Abecasis</name><affiliation><nlm:affiliation>Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name><affiliation><nlm:affiliation>Service de Génétique Médicale, CHU Nantes, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Butterbach, Katja" sort="Butterbach, Katja" uniqKey="Butterbach K" first="Katja" last="Butterbach">Katja Butterbach</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Caan, Bette J" sort="Caan, Bette J" uniqKey="Caan B" first="Bette J" last="Caan">Bette J. Caan</name><affiliation><nlm:affiliation>Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, CA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Carlson, Christopher S" sort="Carlson, Christopher S" uniqKey="Carlson C" first="Christopher S" last="Carlson">Christopher S. Carlson</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Casey, Graham" sort="Casey, Graham" uniqKey="Casey G" first="Graham" last="Casey">Graham Casey</name><affiliation><nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Conti, David V" sort="Conti, David V" uniqKey="Conti D" first="David V" last="Conti">David V. Conti</name><affiliation><nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Curtis, Keith R" sort="Curtis, Keith R" uniqKey="Curtis K" first="Keith R" last="Curtis">Keith R. Curtis</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Duggan, David" sort="Duggan, David" uniqKey="Duggan D" first="David" last="Duggan">David Duggan</name><affiliation><nlm:affiliation>Translational Genomics Research Institute, Phoenix, Arizona, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Gallinger, Steven" sort="Gallinger, Steven" uniqKey="Gallinger S" first="Steven" last="Gallinger">Steven Gallinger</name><affiliation><nlm:affiliation>Department of Surgery, Mount Sinai Hospital, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Haile, Robert W" sort="Haile, Robert W" uniqKey="Haile R" first="Robert W" last="Haile">Robert W. Haile</name><affiliation><nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Harrison, Tabitha A" sort="Harrison, Tabitha A" uniqKey="Harrison T" first="Tabitha A" last="Harrison">Tabitha A. Harrison</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hayes, Richard B" sort="Hayes, Richard B" uniqKey="Hayes R" first="Richard B" last="Hayes">Richard B. Hayes</name><affiliation><nlm:affiliation>Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hoffmeister, Michael" sort="Hoffmeister, Michael" uniqKey="Hoffmeister M" first="Michael" last="Hoffmeister">Michael Hoffmeister</name><affiliation><nlm:affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L" last="Hopper">John L. Hopper</name><affiliation><nlm:affiliation>Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J" last="Hudson">Thomas J. Hudson</name><affiliation><nlm:affiliation>Ontario Institute for Cancer Research, Toronto, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Jenkins, Mark A" sort="Jenkins, Mark A" uniqKey="Jenkins M" first="Mark A" last="Jenkins">Mark A. Jenkins</name><affiliation><nlm:affiliation>Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kury, Sebastien" sort="Kury, Sebastien" uniqKey="Kury S" first="Sébastien" last="Küry">Sébastien Küry</name><affiliation><nlm:affiliation>Service de Génétique Médicale, CHU Nantes, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Le Marchand, Loic" sort="Le Marchand, Loic" uniqKey="Le Marchand L" first="Loic" last="Le Marchand">Loic Le Marchand</name><affiliation><nlm:affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Leal, Suzanne M" sort="Leal, Suzanne M" uniqKey="Leal S" first="Suzanne M" last="Leal">Suzanne M. Leal</name><affiliation><nlm:affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A" last="Newcomb">Polly A. Newcomb</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Nickerson, Deborah A" sort="Nickerson, Deborah A" uniqKey="Nickerson D" first="Deborah A" last="Nickerson">Deborah A. Nickerson</name><affiliation><nlm:affiliation>Genome Sciences, University of Washington, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Potter, John D" sort="Potter, John D" uniqKey="Potter J" first="John D" last="Potter">John D. Potter</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E" last="Schoen">Robert E. Schoen</name><affiliation><nlm:affiliation>Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Schumacher, Fredrick R" sort="Schumacher, Fredrick R" uniqKey="Schumacher F" first="Fredrick R" last="Schumacher">Fredrick R. Schumacher</name><affiliation><nlm:affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name><affiliation><nlm:affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L" last="Slattery">Martha L. Slattery</name><affiliation><nlm:affiliation>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Hsu, Li" sort="Hsu, Li" uniqKey="Hsu L" first="Li" last="Hsu">Li Hsu</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T" last="Chan">Andrew T. Chan</name><affiliation><nlm:affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name><affiliation><nlm:affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</nlm:affiliation></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>A549 Cells</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Caco-2 Cells</term><term>Chromosome Mapping</term><term>Colorectal Neoplasms (genetics)</term><term>Colorectal Neoplasms (pathology)</term><term>Computational Biology (methods)</term><term>Female</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genetic Variation</term><term>Genome-Wide Association Study (methods)</term><term>Genotype</term><term>HCT116 Cells</term><term>Hep G2 Cells</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Registries (statistics & numerical data)</term><term>Risk Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Colorectal Neoplasms</term><term>Genetic Predisposition to Disease</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Computational Biology</term><term>Genome-Wide Association Study</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Colorectal Neoplasms</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Registries</term></keywords><keywords scheme="MESH" xml:lang="en"><term>A549 Cells</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Caco-2 Cells</term><term>Chromosome Mapping</term><term>Female</term><term>Genetic Variation</term><term>Genotype</term><term>HCT116 Cells</term><term>Hep G2 Cells</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Single Nucleotide</term><term>Risk Factors</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. These SNPs may tag correlated variants with biological importance. Fine-mapping around GWAS loci can facilitate detection of functional candidates and additional independent risk variants. We analyzed 11,900 cases and 14,311 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colon Cancer Family Registry. To fine-map genomic regions containing all known common risk variants, we imputed high-density genetic data from the 1000 Genomes Project. We tested single-variant associations with colorectal tumor risk for all variants spanning genomic regions 250-kb upstream or downstream of 31 GWAS-identified SNPs (index SNPs). We queried the University of California, Santa Cruz Genome Browser to examine evidence for biological function. Index SNPs did not show the strongest association signals with colorectal tumor risk in their respective genomic regions. Bioinformatics analysis of SNPs showing smaller P-values in each region revealed 21 functional candidates in 12 loci (5q31.1, 8q24, 11q13.4, 11q23, 12p13.32, 12q24.21, 14q22.2, 15q13, 18q21, 19q13.1, 20p12.3, and 20q13.33). We did not observe evidence of additional independent association signals in GWAS-identified regions. Our results support the utility of integrating data from comprehensive fine-mapping with expanding publicly available genomic databases to help clarify GWAS associations and identify functional candidates that warrant more onerous laboratory follow-up. Such efforts may aid the eventual discovery of disease-causing variant(s).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27379672</PMID><DateCreated><Year>2016</Year><Month>07</Month><Day>06</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>02</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>7</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>Fine-Mapping of Common Genetic Variants Associated with Colorectal Tumor Risk Identified Potential Functional Variants.</ArticleTitle><Pagination><MedlinePgn>e0157521</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0157521</ELocationID><Abstract><AbstractText>Genome-wide association studies (GWAS) have identified many common single nucleotide polymorphisms (SNPs) associated with colorectal cancer risk. These SNPs may tag correlated variants with biological importance. Fine-mapping around GWAS loci can facilitate detection of functional candidates and additional independent risk variants. We analyzed 11,900 cases and 14,311 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium and the Colon Cancer Family Registry. To fine-map genomic regions containing all known common risk variants, we imputed high-density genetic data from the 1000 Genomes Project. We tested single-variant associations with colorectal tumor risk for all variants spanning genomic regions 250-kb upstream or downstream of 31 GWAS-identified SNPs (index SNPs). We queried the University of California, Santa Cruz Genome Browser to examine evidence for biological function. Index SNPs did not show the strongest association signals with colorectal tumor risk in their respective genomic regions. Bioinformatics analysis of SNPs showing smaller P-values in each region revealed 21 functional candidates in 12 loci (5q31.1, 8q24, 11q13.4, 11q23, 12p13.32, 12q24.21, 14q22.2, 15q13, 18q21, 19q13.1, 20p12.3, and 20q13.33). We did not observe evidence of additional independent association signals in GWAS-identified regions. Our results support the utility of integrating data from comprehensive fine-mapping with expanding publicly available genomic databases to help clarify GWAS associations and identify functional candidates that warrant more onerous laboratory follow-up. Such efforts may aid the eventual discovery of disease-causing variant(s).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Du</LastName><ForeName>Mengmeng</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiao</LastName><ForeName>Shuo</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bien</LastName><ForeName>Stephanie A</ForeName><Initials>SA</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-8713-4583</Identifier><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, University of Washington, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gala</LastName><ForeName>Manish</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abecasis</LastName><ForeName>Goncalo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bezieau</LastName><ForeName>Stephane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service de Génétique Médicale, CHU Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brenner</LastName><ForeName>Hermann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>German Cancer Consortium (DKTK), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Butterbach</LastName><ForeName>Katja</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caan</LastName><ForeName>Bette J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Division of Research, Kaiser Permanente Medical Care Program of Northern California, Oakland, CA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carlson</LastName><ForeName>Christopher S</ForeName><Initials>CS</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casey</LastName><ForeName>Graham</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang-Claude</LastName><ForeName>Jenny</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conti</LastName><ForeName>David V</ForeName><Initials>DV</Initials><AffiliationInfo><Affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curtis</LastName><ForeName>Keith R</ForeName><Initials>KR</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duggan</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Translational Genomics Research Institute, Phoenix, Arizona, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gallinger</LastName><ForeName>Steven</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Surgery, Mount Sinai Hospital, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haile</LastName><ForeName>Robert W</ForeName><Initials>RW</Initials><AffiliationInfo><Affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harrison</LastName><ForeName>Tabitha A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hayes</LastName><ForeName>Richard B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoffmeister</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hopper</LastName><ForeName>John L</ForeName><Initials>JL</Initials><AffiliationInfo><Affiliation>Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hudson</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>Ontario Institute for Cancer Research, Toronto, ON, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departments of Medical Biophysics and Molecular Genetics, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jenkins</LastName><ForeName>Mark A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Küry</LastName><ForeName>Sébastien</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Service de Génétique Médicale, CHU Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Le Marchand</LastName><ForeName>Loic</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leal</LastName><ForeName>Suzanne M</ForeName><Initials>SM</Initials><AffiliationInfo><Affiliation>Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Newcomb</LastName><ForeName>Polly A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, University of Washington, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nickerson</LastName><ForeName>Deborah A</ForeName><Initials>DA</Initials><AffiliationInfo><Affiliation>Genome Sciences, University of Washington, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Potter</LastName><ForeName>John D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, University of Washington, Seattle, WA, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Public Health Research, Massey University, Wellington, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schoen</LastName><ForeName>Robert E</ForeName><Initials>RE</Initials><AffiliationInfo><Affiliation>Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schumacher</LastName><ForeName>Fredrick R</ForeName><Initials>FR</Initials><AffiliationInfo><Affiliation>Keck School of Medicine, University of Southern California, Los Angeles, CA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seminara</LastName><ForeName>Daniela</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slattery</LastName><ForeName>Martha L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hsu</LastName><ForeName>Li</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chan</LastName><ForeName>Andrew T</ForeName><Initials>AT</Initials><AffiliationInfo><Affiliation>Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>White</LastName><ForeName>Emily</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, University of Washington, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berndt</LastName><ForeName>Sonja I</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States of America.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Public Health, University of Washington, Seattle, WA, United States of America.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>R25 CA094880</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 ES000260</GrantID><Acronym>ES</Acronym><Agency>NIEHS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA008748</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA167551</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA071789</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>PLoS One</MedlineTA><NlmUniqueID>101285081</NlmUniqueID><ISSNLinking>1932-6203</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 2007 Sep;39(9):1074-82</RefSource><PMID Version="1">17676041</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Genet. 2009 May;10 (5):285-90</RefSource><PMID Version="1">19337289</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Genet. 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Source="NLM">PMC4933364</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>10</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>06</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>7</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>7</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27379672</ArticleId><ArticleId IdType="doi">10.1371/journal.pone.0157521</ArticleId><ArticleId IdType="pii">PONE-D-14-34114</ArticleId><ArticleId IdType="pmc">PMC4933364</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce 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