Dementia risk with antihypertensive use and blood pressure variability: A cohort study.
Identifieur interne : 001B19 ( PubMed/Corpus ); précédent : 001B18; suivant : 001B20Dementia risk with antihypertensive use and blood pressure variability: A cohort study.
Auteurs : Phillip J. Tully ; Jean-François Dartigues ; Stephanie Debette ; Catherine Helmer ; Sylvaine Artero ; Christophe TzourioSource :
- Neurology [ 1526-632X ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Antihypertensive Agents, Calcium Channel Blockers, Diuretics.
- epidemiology : Dementia, France.
- physiology : Blood Pressure.
- physiopathology : Dementia.
- Aged, Aged, 80 and over, Female, Humans, Male, Prospective Studies.
Abstract
To determine the association between discrete antihypertensive drug classes and incident dementia controlling for blood pressure variability (BPV) in the preceding 4 years.
DOI: 10.1212/WNL.0000000000002946
PubMed: 27402894
Links to Exploration step
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Tully</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France. christophe.tzourio@u-bordeaux.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27402894</idno><idno type="pmid">27402894</idno><idno type="doi">10.1212/WNL.0000000000002946</idno><idno type="wicri:Area/PubMed/Corpus">001B19</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dementia risk with antihypertensive use and blood pressure variability: A cohort study.</title><author><name sortKey="Tully, Phillip J" sort="Tully, Phillip J" uniqKey="Tully P" first="Phillip J" last="Tully">Phillip J. Tully</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Dartigues, Jean Francois" sort="Dartigues, Jean Francois" uniqKey="Dartigues J" first="Jean-François" last="Dartigues">Jean-François Dartigues</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation><nlm:affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France. christophe.tzourio@u-bordeaux.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Neurology</title><idno type="eISSN">1526-632X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Antihypertensive Agents (therapeutic use)</term><term>Blood Pressure (physiology)</term><term>Calcium Channel Blockers (therapeutic use)</term><term>Dementia (epidemiology)</term><term>Dementia (physiopathology)</term><term>Diuretics (therapeutic use)</term><term>Female</term><term>France (epidemiology)</term><term>Humans</term><term>Male</term><term>Prospective Studies</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antihypertensive Agents</term><term>Calcium Channel Blockers</term><term>Diuretics</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Dementia</term><term>France</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dementia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Prospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To determine the association between discrete antihypertensive drug classes and incident dementia controlling for blood pressure variability (BPV) in the preceding 4 years.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27402894</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>09</Day></DateCreated><DateCompleted><Year>2017</Year><Month>06</Month><Day>01</Day></DateCompleted><DateRevised><Year>2017</Year><Month>06</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1526-632X</ISSN><JournalIssue CitedMedium="Internet"><Volume>87</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>Aug</Month><Day>09</Day></PubDate></JournalIssue><Title>Neurology</Title><ISOAbbreviation>Neurology</ISOAbbreviation></Journal><ArticleTitle>Dementia risk with antihypertensive use and blood pressure variability: A cohort study.</ArticleTitle><Pagination><MedlinePgn>601-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1212/WNL.0000000000002946</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To determine the association between discrete antihypertensive drug classes and incident dementia controlling for blood pressure variability (BPV) in the preceding 4 years.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A total of 6,537 participants (mean age 79 years, 62% women) in a prospective population-based cohort were followed up for incident dementia. A 4-year time lag period was created to classify drug exposure and measure blood pressure. BPV (percent coefficient of variation [CV]) was regressed against 9 antihypertensive drug classes (BPVreg). Cox regression models were employed to determine hazard ratios (HRs) for incident dementia thereafter according to drug class, adjusted for mean blood pressure, covariates, and BPV or BPVreg.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Over a median 8.4 years follow-up (interquartile range 6.7-9.0), lower dementia risk was associated with nondihydropyridine calcium channel blocker (HR 0.56; 95% confidence interval [CI] 0.31-1.00, p = 0.05) and loop diuretics (HR 0.45; 95% CI 0.22-0.93, p = 0.03) after adjusting for CV-BPV. Similar findings were obtained in analyses restricted to antihypertensive drug users for nondihydropyridine calcium channel blocker (HR 0.52; 95% CI 0.28-0.95, p = 0.03) and loop diuretics (HR 0.40; 95% CI 0.19-0.83, p = 0.01). All systolic BPV × antihypertensive drug interaction terms were not different from p < 0.05.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Nondihydropyridine calcium channel blocker and loop diuretics were associated with a reduced dementia risk independent of CV-BPV in the preceding 4 years. Systolic BPV was not the primary mechanism through which antihypertensive drug classes lower dementia risk.</AbstractText><CopyrightInformation>© 2016 American Academy of Neurology.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tully</LastName><ForeName>Phillip J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dartigues</LastName><ForeName>Jean-François</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Debette</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Helmer</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Artero</LastName><ForeName>Sylvaine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tzourio</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>From Neuroepidemiology, UMR897 (P.J.T., S.D., C.T.), and Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897 (J.-F.D., C.H.), University of Bordeaux, France; Freemasons Foundation Centre for Men's Health (P.J.T.), Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; Department of Neurology (S.D.), Bordeaux University Hospital, France; Department of Neurology (S.D.), Framingham Heart Study, Boston University School of Medicine, MA; INSERM U1061 (S.A.), La Colombière Hospital, University of Montpellier UM1; and INSERM (P.J.T., C.T.), Neuroepidemiology, UMR897, Bordeaux, France. christophe.tzourio@u-bordeaux.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurology</MedlineTA><NlmUniqueID>0401060</NlmUniqueID><ISSNLinking>0028-3878</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000959">Antihypertensive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002121">Calcium Channel Blockers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004232">Diuretics</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000959" MajorTopicYN="N">Antihypertensive Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001794" MajorTopicYN="N">Blood Pressure</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002121" MajorTopicYN="N">Calcium Channel Blockers</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003704" MajorTopicYN="N">Dementia</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004232" MajorTopicYN="N">Diuretics</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N">France</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>11</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>04</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>7</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>7</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27402894</ArticleId><ArticleId IdType="pii">WNL.0000000000002946</ArticleId><ArticleId IdType="doi">10.1212/WNL.0000000000002946</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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