AustralieFrV1, PubMed, Corpus, bibRecord, 001B17

Bundle Formation in Biomimetic Hydrogels.

Identifieur interne : 001B17 ( PubMed/Corpus ); précédent : 001B16; suivant : 001B18

Bundle Formation in Biomimetic Hydrogels.

Auteurs : Maarten Jaspers ; A C H. Pape ; Ilja K. Voets ; Alan E. Rowan ; Giuseppe Portale ; Paul H J. Kouwer

Source :

Biomacromolecules [ 1526-4602 ] ; 2016.

RBID : pubmed:27409975

English descriptors

KwdEn :
- Biomimetics, Extracellular Matrix (chemistry), Hydrogels (chemistry), Polymers (chemistry), Rheology, Scattering, Small Angle, X-Ray Diffraction.
MESH :
- chemical , chemistry : Hydrogels, Polymers.
- chemistry : Extracellular Matrix.
- Biomimetics, Rheology, Scattering, Small Angle, X-Ray Diffraction.

Abstract

Bundling of single polymer chains is a crucial process in the formation of biopolymer network gels that make up the extracellular matrix and the cytoskeleton. This bundled architecture leads to gels with distinctive properties, including a large-pore-size gel formation at very low concentrations and mechanical responsiveness through nonlinear mechanics, properties that are rarely observed in synthetic hydrogels. Using small-angle X-ray scattering (SAXS), we study the bundle formation and hydrogelation process of polyisocyanide gels, a synthetic material that uniquely mimics the structure and mechanics of biogels. We show how the structure of the material changes at the (thermally induced) gelation point and how factors such as concentration and polymer length determine the architecture, and with that, the mechanical properties. The correlation of the gel mechanics and the structural parameters obtained from SAXS experiments is essential in the design of future (synthetic) mimics of biopolymer networks.

DOI: 10.1021/acs.biomac.6b00703
PubMed: 27409975

Links to Exploration step

pubmed:27409975

Le document en format XML

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<author><name sortKey="Jaspers, Maarten" sort="Jaspers, Maarten" uniqKey="Jaspers M" first="Maarten" last="Jaspers">Maarten Jaspers</name>
<affiliation><nlm:affiliation>Radboud University , Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pape, A C H" sort="Pape, A C H" uniqKey="Pape A" first="A C H" last="Pape">A C H. Pape</name>
<affiliation><nlm:affiliation>Eindhoven University of Technology , Laboratory for Macromolecular and Organic Chemistry, and Laboratory of Physical Chemistry, and Institute for Complex Molecular Systems, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Voets, Ilja K" sort="Voets, Ilja K" uniqKey="Voets I" first="Ilja K" last="Voets">Ilja K. Voets</name>
<affiliation><nlm:affiliation>Eindhoven University of Technology , Laboratory for Macromolecular and Organic Chemistry, and Laboratory of Physical Chemistry, and Institute for Complex Molecular Systems, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Rowan, Alan E" sort="Rowan, Alan E" uniqKey="Rowan A" first="Alan E" last="Rowan">Alan E. Rowan</name>
<affiliation><nlm:affiliation>Radboud University , Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Portale, Giuseppe" sort="Portale, Giuseppe" uniqKey="Portale G" first="Giuseppe" last="Portale">Giuseppe Portale</name>
<affiliation><nlm:affiliation>Netherlands Organisation for Scientific Research (NWO) , DUBBLE CRG at the ESRF, 6 rue Jules Horowitz, 38043 Grenoble Cedex, France.</nlm:affiliation>
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<author><name sortKey="Kouwer, Paul H J" sort="Kouwer, Paul H J" uniqKey="Kouwer P" first="Paul H J" last="Kouwer">Paul H J. Kouwer</name>
<affiliation><nlm:affiliation>Radboud University , Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.</nlm:affiliation>
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<author><name sortKey="Voets, Ilja K" sort="Voets, Ilja K" uniqKey="Voets I" first="Ilja K" last="Voets">Ilja K. Voets</name>
<affiliation><nlm:affiliation>Eindhoven University of Technology , Laboratory for Macromolecular and Organic Chemistry, and Laboratory of Physical Chemistry, and Institute for Complex Molecular Systems, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.</nlm:affiliation>
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<author><name sortKey="Rowan, Alan E" sort="Rowan, Alan E" uniqKey="Rowan A" first="Alan E" last="Rowan">Alan E. Rowan</name>
<affiliation><nlm:affiliation>Radboud University , Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.</nlm:affiliation>
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<author><name sortKey="Portale, Giuseppe" sort="Portale, Giuseppe" uniqKey="Portale G" first="Giuseppe" last="Portale">Giuseppe Portale</name>
<affiliation><nlm:affiliation>Netherlands Organisation for Scientific Research (NWO) , DUBBLE CRG at the ESRF, 6 rue Jules Horowitz, 38043 Grenoble Cedex, France.</nlm:affiliation>
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<author><name sortKey="Kouwer, Paul H J" sort="Kouwer, Paul H J" uniqKey="Kouwer P" first="Paul H J" last="Kouwer">Paul H J. Kouwer</name>
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<series><title level="j">Biomacromolecules</title>
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<term>Polymers (chemistry)</term>
<term>Rheology</term>
<term>Scattering, Small Angle</term>
<term>X-Ray Diffraction</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Hydrogels</term>
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<front><div type="abstract" xml:lang="en">Bundling of single polymer chains is a crucial process in the formation of biopolymer network gels that make up the extracellular matrix and the cytoskeleton. This bundled architecture leads to gels with distinctive properties, including a large-pore-size gel formation at very low concentrations and mechanical responsiveness through nonlinear mechanics, properties that are rarely observed in synthetic hydrogels. Using small-angle X-ray scattering (SAXS), we study the bundle formation and hydrogelation process of polyisocyanide gels, a synthetic material that uniquely mimics the structure and mechanics of biogels. We show how the structure of the material changes at the (thermally induced) gelation point and how factors such as concentration and polymer length determine the architecture, and with that, the mechanical properties. The correlation of the gel mechanics and the structural parameters obtained from SAXS experiments is essential in the design of future (synthetic) mimics of biopolymer networks.</div>
</front>
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<Title>Biomacromolecules</Title>
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<Abstract><AbstractText>Bundling of single polymer chains is a crucial process in the formation of biopolymer network gels that make up the extracellular matrix and the cytoskeleton. This bundled architecture leads to gels with distinctive properties, including a large-pore-size gel formation at very low concentrations and mechanical responsiveness through nonlinear mechanics, properties that are rarely observed in synthetic hydrogels. Using small-angle X-ray scattering (SAXS), we study the bundle formation and hydrogelation process of polyisocyanide gels, a synthetic material that uniquely mimics the structure and mechanics of biogels. We show how the structure of the material changes at the (thermally induced) gelation point and how factors such as concentration and polymer length determine the architecture, and with that, the mechanical properties. The correlation of the gel mechanics and the structural parameters obtained from SAXS experiments is essential in the design of future (synthetic) mimics of biopolymer networks.</AbstractText>
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<AffiliationInfo><Affiliation>The University of Queensland , Australian Institute for Bioengineering and Nanotechnology, Brisbane, Queensland 4072, Australia.</Affiliation>
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<AffiliationInfo><Affiliation>University of Groningen , Department of Macromolecular Chemistry and New Polymeric Materials, Nijenborgh 4, 9747 AG Groningen, The Netherlands.</Affiliation>
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Bundle Formation in Biomimetic Hydrogels.

Bundle Formation in Biomimetic Hydrogels.

Source :

English descriptors

Abstract

Links to Exploration step

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Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki