Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.
Identifieur interne : 001A66 ( PubMed/Corpus ); précédent : 001A65; suivant : 001A67Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.
Auteurs : Jonathan M. Schott ; Sebastian J. Crutch ; Minerva M. Carrasquillo ; James Uphill ; Tim J. Shakespeare ; Natalie S. Ryan ; Keir X. Yong ; Manja Lehmann ; Nilufer Ertekin-Taner ; Neill R. Graff-Radford ; Bradley F. Boeve ; Melissa E. Murray ; Qurat Ul Ain Khan ; Ronald C. Petersen ; Dennis W. Dickson ; David S. Knopman ; Gil D. Rabinovici ; Bruce L. Miller ; Aida Suárez González ; Eulogio Gil-Néciga ; Julie S. Snowden ; Jenny Harris ; Stuart M. Pickering-Brown ; Eva Louwersheimer ; Wiesje M. Van Der Flier ; Philip Scheltens ; Yolande A. Pijnenburg ; Douglas Galasko ; Marie Sarazin ; Bruno Dubois ; Eloi Magnin ; Daniela Galimberti ; Elio Scarpini ; Stefano F. Cappa ; John R. Hodges ; Glenda M. Halliday ; Lauren Bartley ; Maria C. Carrillo ; Jose T. Bras ; John Hardy ; Martin N. Rossor ; John Collinge ; Nick C. Fox ; Simon MeadSource :
- Alzheimer's & dementia : the journal of the Alzheimer's Association [ 1552-5279 ] ; 2016.
English descriptors
- KwdEn :
- Age Factors, Aged, Alzheimer Disease (complications), Alzheimer Disease (genetics), Apolipoproteins E (genetics), Atrophy (etiology), Cell Adhesion Molecules, Neuronal (genetics), Cerebral Cortex (pathology), Female, Genetic Association Studies, Genetic Predisposition to Disease (genetics), Humans, Male, Membrane Transport Proteins (genetics), Middle Aged, Polymorphism, Single Nucleotide (genetics), Proteins (genetics), Receptors, Complement 3b (genetics), Risk Factors, Semaphorins (genetics).
- MESH :
- chemical , genetics : Apolipoproteins E, Cell Adhesion Molecules, Neuronal, Membrane Transport Proteins, Proteins, Receptors, Complement 3b, Semaphorins.
- complications : Alzheimer Disease.
- etiology : Atrophy.
- genetics : Alzheimer Disease, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide.
- pathology : Cerebral Cortex.
- Age Factors, Aged, Female, Genetic Association Studies, Humans, Male, Middle Aged, Risk Factors.
Abstract
The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain.
DOI: 10.1016/j.jalz.2016.01.010
PubMed: 26993346
Links to Exploration step
pubmed:26993346Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.</title>
<author><name sortKey="Schott, Jonathan M" sort="Schott, Jonathan M" uniqKey="Schott J" first="Jonathan M" last="Schott">Jonathan M. Schott</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK. Electronic address: j.schott@ucl.ac.uk.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Crutch, Sebastian J" sort="Crutch, Sebastian J" uniqKey="Crutch S" first="Sebastian J" last="Crutch">Sebastian J. Crutch</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M" last="Carrasquillo">Minerva M. Carrasquillo</name>
<affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Uphill, James" sort="Uphill, James" uniqKey="Uphill J" first="James" last="Uphill">James Uphill</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shakespeare, Tim J" sort="Shakespeare, Tim J" uniqKey="Shakespeare T" first="Tim J" last="Shakespeare">Tim J. Shakespeare</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ryan, Natalie S" sort="Ryan, Natalie S" uniqKey="Ryan N" first="Natalie S" last="Ryan">Natalie S. Ryan</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yong, Keir X" sort="Yong, Keir X" uniqKey="Yong K" first="Keir X" last="Yong">Keir X. Yong</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lehmann, Manja" sort="Lehmann, Manja" uniqKey="Lehmann M" first="Manja" last="Lehmann">Manja Lehmann</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilufer" last="Ertekin-Taner">Nilufer Ertekin-Taner</name>
<affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R" last="Graff-Radford">Neill R. Graff-Radford</name>
<affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F" last="Boeve">Bradley F. Boeve</name>
<affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Murray, Melissa E" sort="Murray, Melissa E" uniqKey="Murray M" first="Melissa E" last="Murray">Melissa E. Murray</name>
<affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Khan, Qurat Ul Ain" sort="Khan, Qurat Ul Ain" uniqKey="Khan Q" first="Qurat Ul Ain" last="Khan">Qurat Ul Ain Khan</name>
<affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name>
<affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name>
<affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S" last="Knopman">David S. Knopman</name>
<affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rabinovici, Gil D" sort="Rabinovici, Gil D" uniqKey="Rabinovici G" first="Gil D" last="Rabinovici">Gil D. Rabinovici</name>
<affiliation><nlm:affiliation>UCSF, San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name>
<affiliation><nlm:affiliation>UCSF, San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Aida Suarez" sort="Gonzalez, Aida Suarez" uniqKey="Gonzalez A" first="Aida Suárez" last="González">Aida Suárez González</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK; Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gil Neciga, Eulogio" sort="Gil Neciga, Eulogio" uniqKey="Gil Neciga E" first="Eulogio" last="Gil-Néciga">Eulogio Gil-Néciga</name>
<affiliation><nlm:affiliation>Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Snowden, Julie S" sort="Snowden, Julie S" uniqKey="Snowden J" first="Julie S" last="Snowden">Julie S. Snowden</name>
<affiliation><nlm:affiliation>Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Harris, Jenny" sort="Harris, Jenny" uniqKey="Harris J" first="Jenny" last="Harris">Jenny Harris</name>
<affiliation><nlm:affiliation>Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pickering Brown, Stuart M" sort="Pickering Brown, Stuart M" uniqKey="Pickering Brown S" first="Stuart M" last="Pickering-Brown">Stuart M. Pickering-Brown</name>
<affiliation><nlm:affiliation>Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Louwersheimer, Eva" sort="Louwersheimer, Eva" uniqKey="Louwersheimer E" first="Eva" last="Louwersheimer">Eva Louwersheimer</name>
<affiliation><nlm:affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Der Flier, Wiesje M" sort="Van Der Flier, Wiesje M" uniqKey="Van Der Flier W" first="Wiesje M" last="Van Der Flier">Wiesje M. Van Der Flier</name>
<affiliation><nlm:affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name>
<affiliation><nlm:affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pijnenburg, Yolande A" sort="Pijnenburg, Yolande A" uniqKey="Pijnenburg Y" first="Yolande A" last="Pijnenburg">Yolande A. Pijnenburg</name>
<affiliation><nlm:affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Galasko, Douglas" sort="Galasko, Douglas" uniqKey="Galasko D" first="Douglas" last="Galasko">Douglas Galasko</name>
<affiliation><nlm:affiliation>Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands; UC San Diego/VA San Diego Healthcare System, San Diego, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sarazin, Marie" sort="Sarazin, Marie" uniqKey="Sarazin M" first="Marie" last="Sarazin">Marie Sarazin</name>
<affiliation><nlm:affiliation>INSERM U610, Hôpital de la Salpêtrière, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name>
<affiliation><nlm:affiliation>Centre des Maladies Cognitives et Comportementales, IM2A, ICM, Paris 6 University, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Magnin, Eloi" sort="Magnin, Eloi" uniqKey="Magnin E" first="Eloi" last="Magnin">Eloi Magnin</name>
<affiliation><nlm:affiliation>Regional Memory Centre (CMRR), CHU Besançon, Besançon, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name>
<affiliation><nlm:affiliation>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name>
<affiliation><nlm:affiliation>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cappa, Stefano F" sort="Cappa, Stefano F" uniqKey="Cappa S" first="Stefano F" last="Cappa">Stefano F. Cappa</name>
<affiliation><nlm:affiliation>Vita-Salute San Raffaele University, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hodges, John R" sort="Hodges, John R" uniqKey="Hodges J" first="John R" last="Hodges">John R. Hodges</name>
<affiliation><nlm:affiliation>University of New South Wales, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M" last="Halliday">Glenda M. Halliday</name>
<affiliation><nlm:affiliation>University of New South Wales, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bartley, Lauren" sort="Bartley, Lauren" uniqKey="Bartley L" first="Lauren" last="Bartley">Lauren Bartley</name>
<affiliation><nlm:affiliation>University of New South Wales, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Carrillo, Maria C" sort="Carrillo, Maria C" uniqKey="Carrillo M" first="Maria C" last="Carrillo">Maria C. Carrillo</name>
<affiliation><nlm:affiliation>Alzheimer's Association, Chicago, IL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bras, Jose T" sort="Bras, Jose T" uniqKey="Bras J" first="Jose T" last="Bras">Jose T. Bras</name>
<affiliation><nlm:affiliation>Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation><nlm:affiliation>Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rossor, Martin N" sort="Rossor, Martin N" uniqKey="Rossor M" first="Martin N" last="Rossor">Martin N. Rossor</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">26993346</idno>
<idno type="doi">10.1016/j.jalz.2016.01.010</idno>
<idno type="wicri:Area/PubMed/Corpus">001A66</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.</title>
<author><name sortKey="Schott, Jonathan M" sort="Schott, Jonathan M" uniqKey="Schott J" first="Jonathan M" last="Schott">Jonathan M. Schott</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK. Electronic address: j.schott@ucl.ac.uk.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Crutch, Sebastian J" sort="Crutch, Sebastian J" uniqKey="Crutch S" first="Sebastian J" last="Crutch">Sebastian J. Crutch</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Carrasquillo, Minerva M" sort="Carrasquillo, Minerva M" uniqKey="Carrasquillo M" first="Minerva M" last="Carrasquillo">Minerva M. Carrasquillo</name>
<affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Uphill, James" sort="Uphill, James" uniqKey="Uphill J" first="James" last="Uphill">James Uphill</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Shakespeare, Tim J" sort="Shakespeare, Tim J" uniqKey="Shakespeare T" first="Tim J" last="Shakespeare">Tim J. Shakespeare</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ryan, Natalie S" sort="Ryan, Natalie S" uniqKey="Ryan N" first="Natalie S" last="Ryan">Natalie S. Ryan</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Yong, Keir X" sort="Yong, Keir X" uniqKey="Yong K" first="Keir X" last="Yong">Keir X. Yong</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lehmann, Manja" sort="Lehmann, Manja" uniqKey="Lehmann M" first="Manja" last="Lehmann">Manja Lehmann</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ertekin Taner, Nilufer" sort="Ertekin Taner, Nilufer" uniqKey="Ertekin Taner N" first="Nilufer" last="Ertekin-Taner">Nilufer Ertekin-Taner</name>
<affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Graff Radford, Neill R" sort="Graff Radford, Neill R" uniqKey="Graff Radford N" first="Neill R" last="Graff-Radford">Neill R. Graff-Radford</name>
<affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Boeve, Bradley F" sort="Boeve, Bradley F" uniqKey="Boeve B" first="Bradley F" last="Boeve">Bradley F. Boeve</name>
<affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Murray, Melissa E" sort="Murray, Melissa E" uniqKey="Murray M" first="Melissa E" last="Murray">Melissa E. Murray</name>
<affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Khan, Qurat Ul Ain" sort="Khan, Qurat Ul Ain" uniqKey="Khan Q" first="Qurat Ul Ain" last="Khan">Qurat Ul Ain Khan</name>
<affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Petersen, Ronald C" sort="Petersen, Ronald C" uniqKey="Petersen R" first="Ronald C" last="Petersen">Ronald C. Petersen</name>
<affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W" last="Dickson">Dennis W. Dickson</name>
<affiliation><nlm:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Knopman, David S" sort="Knopman, David S" uniqKey="Knopman D" first="David S" last="Knopman">David S. Knopman</name>
<affiliation><nlm:affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rabinovici, Gil D" sort="Rabinovici, Gil D" uniqKey="Rabinovici G" first="Gil D" last="Rabinovici">Gil D. Rabinovici</name>
<affiliation><nlm:affiliation>UCSF, San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Miller, Bruce L" sort="Miller, Bruce L" uniqKey="Miller B" first="Bruce L" last="Miller">Bruce L. Miller</name>
<affiliation><nlm:affiliation>UCSF, San Francisco, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gonzalez, Aida Suarez" sort="Gonzalez, Aida Suarez" uniqKey="Gonzalez A" first="Aida Suárez" last="González">Aida Suárez González</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK; Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gil Neciga, Eulogio" sort="Gil Neciga, Eulogio" uniqKey="Gil Neciga E" first="Eulogio" last="Gil-Néciga">Eulogio Gil-Néciga</name>
<affiliation><nlm:affiliation>Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Snowden, Julie S" sort="Snowden, Julie S" uniqKey="Snowden J" first="Julie S" last="Snowden">Julie S. Snowden</name>
<affiliation><nlm:affiliation>Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Harris, Jenny" sort="Harris, Jenny" uniqKey="Harris J" first="Jenny" last="Harris">Jenny Harris</name>
<affiliation><nlm:affiliation>Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pickering Brown, Stuart M" sort="Pickering Brown, Stuart M" uniqKey="Pickering Brown S" first="Stuart M" last="Pickering-Brown">Stuart M. Pickering-Brown</name>
<affiliation><nlm:affiliation>Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Louwersheimer, Eva" sort="Louwersheimer, Eva" uniqKey="Louwersheimer E" first="Eva" last="Louwersheimer">Eva Louwersheimer</name>
<affiliation><nlm:affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Van Der Flier, Wiesje M" sort="Van Der Flier, Wiesje M" uniqKey="Van Der Flier W" first="Wiesje M" last="Van Der Flier">Wiesje M. Van Der Flier</name>
<affiliation><nlm:affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Scheltens, Philip" sort="Scheltens, Philip" uniqKey="Scheltens P" first="Philip" last="Scheltens">Philip Scheltens</name>
<affiliation><nlm:affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pijnenburg, Yolande A" sort="Pijnenburg, Yolande A" uniqKey="Pijnenburg Y" first="Yolande A" last="Pijnenburg">Yolande A. Pijnenburg</name>
<affiliation><nlm:affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Galasko, Douglas" sort="Galasko, Douglas" uniqKey="Galasko D" first="Douglas" last="Galasko">Douglas Galasko</name>
<affiliation><nlm:affiliation>Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands; UC San Diego/VA San Diego Healthcare System, San Diego, CA, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sarazin, Marie" sort="Sarazin, Marie" uniqKey="Sarazin M" first="Marie" last="Sarazin">Marie Sarazin</name>
<affiliation><nlm:affiliation>INSERM U610, Hôpital de la Salpêtrière, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name>
<affiliation><nlm:affiliation>Centre des Maladies Cognitives et Comportementales, IM2A, ICM, Paris 6 University, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Magnin, Eloi" sort="Magnin, Eloi" uniqKey="Magnin E" first="Eloi" last="Magnin">Eloi Magnin</name>
<affiliation><nlm:affiliation>Regional Memory Centre (CMRR), CHU Besançon, Besançon, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Galimberti, Daniela" sort="Galimberti, Daniela" uniqKey="Galimberti D" first="Daniela" last="Galimberti">Daniela Galimberti</name>
<affiliation><nlm:affiliation>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Scarpini, Elio" sort="Scarpini, Elio" uniqKey="Scarpini E" first="Elio" last="Scarpini">Elio Scarpini</name>
<affiliation><nlm:affiliation>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cappa, Stefano F" sort="Cappa, Stefano F" uniqKey="Cappa S" first="Stefano F" last="Cappa">Stefano F. Cappa</name>
<affiliation><nlm:affiliation>Vita-Salute San Raffaele University, Milan, Italy.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hodges, John R" sort="Hodges, John R" uniqKey="Hodges J" first="John R" last="Hodges">John R. Hodges</name>
<affiliation><nlm:affiliation>University of New South Wales, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Halliday, Glenda M" sort="Halliday, Glenda M" uniqKey="Halliday G" first="Glenda M" last="Halliday">Glenda M. Halliday</name>
<affiliation><nlm:affiliation>University of New South Wales, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bartley, Lauren" sort="Bartley, Lauren" uniqKey="Bartley L" first="Lauren" last="Bartley">Lauren Bartley</name>
<affiliation><nlm:affiliation>University of New South Wales, Sydney, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Carrillo, Maria C" sort="Carrillo, Maria C" uniqKey="Carrillo M" first="Maria C" last="Carrillo">Maria C. Carrillo</name>
<affiliation><nlm:affiliation>Alzheimer's Association, Chicago, IL, USA.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bras, Jose T" sort="Bras, Jose T" uniqKey="Bras J" first="Jose T" last="Bras">Jose T. Bras</name>
<affiliation><nlm:affiliation>Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<affiliation><nlm:affiliation>Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Rossor, Martin N" sort="Rossor, Martin N" uniqKey="Rossor M" first="Martin N" last="Rossor">Martin N. Rossor</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Collinge, John" sort="Collinge, John" uniqKey="Collinge J" first="John" last="Collinge">John Collinge</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Fox, Nick C" sort="Fox, Nick C" uniqKey="Fox N" first="Nick C" last="Fox">Nick C. Fox</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Mead, Simon" sort="Mead, Simon" uniqKey="Mead S" first="Simon" last="Mead">Simon Mead</name>
<affiliation><nlm:affiliation>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">Alzheimer's & dementia : the journal of the Alzheimer's Association</title>
<idno type="eISSN">1552-5279</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term>
<term>Aged</term>
<term>Alzheimer Disease (complications)</term>
<term>Alzheimer Disease (genetics)</term>
<term>Apolipoproteins E (genetics)</term>
<term>Atrophy (etiology)</term>
<term>Cell Adhesion Molecules, Neuronal (genetics)</term>
<term>Cerebral Cortex (pathology)</term>
<term>Female</term>
<term>Genetic Association Studies</term>
<term>Genetic Predisposition to Disease (genetics)</term>
<term>Humans</term>
<term>Male</term>
<term>Membrane Transport Proteins (genetics)</term>
<term>Middle Aged</term>
<term>Polymorphism, Single Nucleotide (genetics)</term>
<term>Proteins (genetics)</term>
<term>Receptors, Complement 3b (genetics)</term>
<term>Risk Factors</term>
<term>Semaphorins (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term>
<term>Cell Adhesion Molecules, Neuronal</term>
<term>Membrane Transport Proteins</term>
<term>Proteins</term>
<term>Receptors, Complement 3b</term>
<term>Semaphorins</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Alzheimer Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Atrophy</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Alzheimer Disease</term>
<term>Genetic Predisposition to Disease</term>
<term>Polymorphism, Single Nucleotide</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Cortex</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Aged</term>
<term>Female</term>
<term>Genetic Association Studies</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Risk Factors</term>
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<front><div type="abstract" xml:lang="en">The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26993346</PMID>
<DateCreated><Year>2016</Year>
<Month>08</Month>
<Day>09</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>10</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>10</Month>
<Day>06</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1552-5279</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>12</Volume>
<Issue>8</Issue>
<PubDate><Year>2016</Year>
<Month>Aug</Month>
</PubDate>
</JournalIssue>
<Title>Alzheimer's & dementia : the journal of the Alzheimer's Association</Title>
<ISOAbbreviation>Alzheimers Dement</ISOAbbreviation>
</Journal>
<ArticleTitle>Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease.</ArticleTitle>
<Pagination><MedlinePgn>862-71</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jalz.2016.01.010</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S1552-5260(16)00077-7</ELocationID>
<Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The genetics underlying posterior cortical atrophy (PCA), typically a rare variant of Alzheimer's disease (AD), remain uncertain.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We genotyped 302 PCA patients from 11 centers, calculated risk at 24 loci for AD/DLB and performed an exploratory genome-wide association study.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We confirm that variation in/near APOE/TOMM40 (P = 6 × 10(-14)) alters PCA risk, but with smaller effect than for typical AD (PCA: odds ratio [OR] = 2.03, typical AD: OR = 2.83, P = .0007). We found evidence for risk in/near CR1 (P = 7 × 10(-4)), ABCA7 (P = .02) and BIN1 (P = .04). ORs at variants near INPP5D and NME8 did not overlap between PCA and typical AD. Exploratory genome-wide association studies confirmed APOE and identified three novel loci: rs76854344 near CNTNAP5 (P = 8 × 10(-10) OR = 1.9 [1.5-2.3]); rs72907046 near FAM46A (P = 1 × 10(-9) OR = 3.2 [2.1-4.9]); and rs2525776 near SEMA3C (P = 1 × 10(-8), OR = 3.3 [2.1-5.1]).</AbstractText>
<AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">We provide evidence for genetic risk factors specifically related to PCA. We identify three candidate loci that, if replicated, may provide insights into selective vulnerability and phenotypic diversity in AD.</AbstractText>
<CopyrightInformation>Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schott</LastName>
<ForeName>Jonathan M</ForeName>
<Initials>JM</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK. Electronic address: j.schott@ucl.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Crutch</LastName>
<ForeName>Sebastian J</ForeName>
<Initials>SJ</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carrasquillo</LastName>
<ForeName>Minerva M</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Uphill</LastName>
<ForeName>James</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shakespeare</LastName>
<ForeName>Tim J</ForeName>
<Initials>TJ</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ryan</LastName>
<ForeName>Natalie S</ForeName>
<Initials>NS</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yong</LastName>
<ForeName>Keir X</ForeName>
<Initials>KX</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lehmann</LastName>
<ForeName>Manja</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ertekin-Taner</LastName>
<ForeName>Nilufer</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA; Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Graff-Radford</LastName>
<ForeName>Neill R</ForeName>
<Initials>NR</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic, Jacksonville, FL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Boeve</LastName>
<ForeName>Bradley F</ForeName>
<Initials>BF</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Murray</LastName>
<ForeName>Melissa E</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Khan</LastName>
<ForeName>Qurat Ul Ain</ForeName>
<Initials>QU</Initials>
<AffiliationInfo><Affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Petersen</LastName>
<ForeName>Ronald C</ForeName>
<Initials>RC</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dickson</LastName>
<ForeName>Dennis W</ForeName>
<Initials>DW</Initials>
<AffiliationInfo><Affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Knopman</LastName>
<ForeName>David S</ForeName>
<Initials>DS</Initials>
<AffiliationInfo><Affiliation>Department of Neurology, Mayo Clinic, Rochester, MN, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rabinovici</LastName>
<ForeName>Gil D</ForeName>
<Initials>GD</Initials>
<AffiliationInfo><Affiliation>UCSF, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Miller</LastName>
<ForeName>Bruce L</ForeName>
<Initials>BL</Initials>
<AffiliationInfo><Affiliation>UCSF, San Francisco, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>González</LastName>
<ForeName>Aida Suárez</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK; Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gil-Néciga</LastName>
<ForeName>Eulogio</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Memory Disorders Unit, Department of Neurology, University Hospital Virgen del Rocio, Seville, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Snowden</LastName>
<ForeName>Julie S</ForeName>
<Initials>JS</Initials>
<AffiliationInfo><Affiliation>Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Harris</LastName>
<ForeName>Jenny</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pickering-Brown</LastName>
<ForeName>Stuart M</ForeName>
<Initials>SM</Initials>
<AffiliationInfo><Affiliation>Institute of Brain, Behaviour and Mental Health, University of Manchester, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Louwersheimer</LastName>
<ForeName>Eva</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>van der Flier</LastName>
<ForeName>Wiesje M</ForeName>
<Initials>WM</Initials>
<AffiliationInfo><Affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scheltens</LastName>
<ForeName>Philip</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pijnenburg</LastName>
<ForeName>Yolande A</ForeName>
<Initials>YA</Initials>
<AffiliationInfo><Affiliation>Alzheimer Center, Department of Neurology, VU University Medical Center, Neuroscience Campus, Amsterdam, Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Galasko</LastName>
<ForeName>Douglas</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Epidemiology & Biostatistics, VU University Medical Center, Amsterdam, The Netherlands; UC San Diego/VA San Diego Healthcare System, San Diego, CA, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sarazin</LastName>
<ForeName>Marie</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>INSERM U610, Hôpital de la Salpêtrière, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dubois</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Centre des Maladies Cognitives et Comportementales, IM2A, ICM, Paris 6 University, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Magnin</LastName>
<ForeName>Eloi</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Regional Memory Centre (CMRR), CHU Besançon, Besançon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Galimberti</LastName>
<ForeName>Daniela</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Scarpini</LastName>
<ForeName>Elio</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>University of Milan, Fondazione Cà Granda, IRCCS Ospedale Policlinico, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cappa</LastName>
<ForeName>Stefano F</ForeName>
<Initials>SF</Initials>
<AffiliationInfo><Affiliation>Vita-Salute San Raffaele University, Milan, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hodges</LastName>
<ForeName>John R</ForeName>
<Initials>JR</Initials>
<AffiliationInfo><Affiliation>University of New South Wales, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Halliday</LastName>
<ForeName>Glenda M</ForeName>
<Initials>GM</Initials>
<AffiliationInfo><Affiliation>University of New South Wales, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bartley</LastName>
<ForeName>Lauren</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>University of New South Wales, Sydney, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Carrillo</LastName>
<ForeName>Maria C</ForeName>
<Initials>MC</Initials>
<AffiliationInfo><Affiliation>Alzheimer's Association, Chicago, IL, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bras</LastName>
<ForeName>Jose T</ForeName>
<Initials>JT</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hardy</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Molecular Neurosciences, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Rossor</LastName>
<ForeName>Martin N</ForeName>
<Initials>MN</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Collinge</LastName>
<ForeName>John</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fox</LastName>
<ForeName>Nick C</ForeName>
<Initials>NC</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mead</LastName>
<ForeName>Simon</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>MC_U123192748</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>P50 AG023501</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>MC_U123160657</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>P50 AG005131</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>P50 AG016574</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>MC_U123160651</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>P01 AG019724</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AG032990</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>MR/L023784/1</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>R01 NS080820</GrantID>
<Acronym>NS</Acronym>
<Agency>NINDS NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>U01 AG046139</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>N01HC25195</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant><GrantID>R01 AG045611</GrantID>
<Acronym>AG</Acronym>
<Agency>NIA NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>03</Month>
<Day>15</Day>
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