A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort.
Identifieur interne : 001997 ( PubMed/Corpus ); précédent : 001996; suivant : 001998A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort.
Auteurs : Kathryn L. Terry ; Helena Schock ; Renée T. Fortner ; Anika Hüsing ; Raina N. Fichorova ; Hidemi S. Yamamoto ; Allison F. Vitonis ; Theron Johnson ; Kim Overvad ; Anne Tj Nneland ; Marie-Christine Boutron-Ruault ; Sylvie Mesrine ; Gianluca Severi ; Laure Dossus ; Sabina Rinaldi ; Heiner Boeing ; Vassiliki Benetou ; Pagona Lagiou ; Antonia Trichopoulou ; Vittorio Krogh ; Elisabetta Kuhn ; Salvatore Panico ; H Bas Bueno-De-Mesquita ; N Charlotte Onland-Moret ; Petra H. Peeters ; Inger Torhild Gram ; Elisabete Weiderpass ; Eric J. Duell ; Maria-Jose Sanchez ; Eva Ardanaz ; Nerea Etxezarreta ; Carmen Navarro ; Annika Idahl ; Eva Lundin ; Karin Jirström ; Jonas Manjer ; Nicholas J. Wareham ; Kay-Tee Khaw ; Karl Smith Byrne ; Ruth C. Travis ; Marc J. Gunter ; Melissa A. Merritt ; Elio Riboli ; Daniel W. Cramer ; Rudolf KaaksSource :
- Clinical cancer research : an official journal of the American Association for Cancer Research [ 1078-0432 ] ; 2016.
Abstract
About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study.
DOI: 10.1158/1078-0432.CCR-16-0316
PubMed: 27060155
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort.</title><author><name sortKey="Terry, Kathryn L" sort="Terry, Kathryn L" uniqKey="Terry K" first="Kathryn L" last="Terry">Kathryn L. Terry</name><affiliation><nlm:affiliation>Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts. Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. r.kaaks@dkfz-heidelberg.de kterry@partners.org.</nlm:affiliation></affiliation></author><author><name sortKey="Schock, Helena" sort="Schock, Helena" uniqKey="Schock H" first="Helena" last="Schock">Helena Schock</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T" last="Fortner">Renée T. Fortner</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Husing, Anika" sort="Husing, Anika" uniqKey="Husing A" first="Anika" last="Hüsing">Anika Hüsing</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fichorova, Raina N" sort="Fichorova, Raina N" uniqKey="Fichorova R" first="Raina N" last="Fichorova">Raina N. Fichorova</name><affiliation><nlm:affiliation>Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Yamamoto, Hidemi S" sort="Yamamoto, Hidemi S" uniqKey="Yamamoto H" first="Hidemi S" last="Yamamoto">Hidemi S. Yamamoto</name><affiliation><nlm:affiliation>Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Vitonis, Allison F" sort="Vitonis, Allison F" uniqKey="Vitonis A" first="Allison F" last="Vitonis">Allison F. Vitonis</name><affiliation><nlm:affiliation>Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Theron" sort="Johnson, Theron" uniqKey="Johnson T" first="Theron" last="Johnson">Theron Johnson</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:affiliation>Department of Epidemiology, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation><nlm:affiliation>Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France. Gustave Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mesrine, Sylvie" sort="Mesrine, Sylvie" uniqKey="Mesrine S" first="Sylvie" last="Mesrine">Sylvie Mesrine</name><affiliation><nlm:affiliation>Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France. Gustave Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:affiliation>Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France. Gustave Roussy, Villejuif, France. Human Genetics Foundation (HuGeF), Torino, Italy. Cancer Council Victoria and University of Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name><affiliation><nlm:affiliation>Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rinaldi, Sabina" sort="Rinaldi, Sabina" uniqKey="Rinaldi S" first="Sabina" last="Rinaldi">Sabina Rinaldi</name><affiliation><nlm:affiliation>Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Benetou, Vassiliki" sort="Benetou, Vassiliki" uniqKey="Benetou V" first="Vassiliki" last="Benetou">Vassiliki Benetou</name><affiliation><nlm:affiliation>Helenic Health Foundation Athens, Athens, Greece. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><affiliation><nlm:affiliation>Helenic Health Foundation Athens, Athens, Greece. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation><nlm:affiliation>Helenic Health Foundation Athens, Athens, Greece. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Kuhn, Elisabetta" sort="Kuhn, Elisabetta" uniqKey="Kuhn E" first="Elisabetta" last="Kuhn">Elisabetta Kuhn</name><affiliation><nlm:affiliation>Department of Morphology, Surgery and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Centre, University of Ferrara, Ferrara, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation><nlm:affiliation>Dipartimento di Medicina Clinical e Chirurgia, Federico II University, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation><nlm:affiliation>National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name><affiliation><nlm:affiliation>Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:affiliation>Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. Department of Research, Cancer Registry of Norway, Institute of Population-Based Case Research, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation><nlm:affiliation>Unit of Nutrition and Cancer Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria-Jose" last="Sanchez">Maria-Jose Sanchez</name><affiliation><nlm:affiliation>Escuela Andaluza de Salud Publica, Instituto de Investigación Bionsanitaria ibs. Granada, Hospitales Universitarios de Granada, Granada, Spain. Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain. Navarra Public Health Institute, Pamplona, Spain. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Etxezarreta, Nerea" sort="Etxezarreta, Nerea" uniqKey="Etxezarreta N" first="Nerea" last="Etxezarreta">Nerea Etxezarreta</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain. Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Basque, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation><nlm:affiliation>Department of Clinical Sciences, Obstetrics and Gynecology Umeå, University of Umeå, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation><nlm:affiliation>Department of Medical Biosciences, Pathology Umeå, University of Umeå, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><affiliation><nlm:affiliation>Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden. Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Manjer, Jonas" sort="Manjer, Jonas" uniqKey="Manjer J" first="Jonas" last="Manjer">Jonas Manjer</name><affiliation><nlm:affiliation>Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden. Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:affiliation>Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:affiliation>Clinical Gerontology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Byrne, Karl Smith" sort="Byrne, Karl Smith" uniqKey="Byrne K" first="Karl Smith" last="Byrne">Karl Smith Byrne</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A" last="Merritt">Melissa A. Merritt</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Cramer, Daniel W" sort="Cramer, Daniel W" uniqKey="Cramer D" first="Daniel W" last="Cramer">Daniel W. Cramer</name><affiliation><nlm:affiliation>Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:affiliation>Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. r.kaaks@dkfz-heidelberg.de kterry@partners.org.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27060155</idno><idno type="pmid">27060155</idno><idno type="doi">10.1158/1078-0432.CCR-16-0316</idno><idno type="wicri:Area/PubMed/Corpus">001997</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001997</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort.</title><author><name sortKey="Terry, Kathryn L" sort="Terry, Kathryn L" uniqKey="Terry K" first="Kathryn L" last="Terry">Kathryn L. Terry</name><affiliation><nlm:affiliation>Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts. Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. r.kaaks@dkfz-heidelberg.de kterry@partners.org.</nlm:affiliation></affiliation></author><author><name sortKey="Schock, Helena" sort="Schock, Helena" uniqKey="Schock H" first="Helena" last="Schock">Helena Schock</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fortner, Renee T" sort="Fortner, Renee T" uniqKey="Fortner R" first="Renée T" last="Fortner">Renée T. Fortner</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Husing, Anika" sort="Husing, Anika" uniqKey="Husing A" first="Anika" last="Hüsing">Anika Hüsing</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Fichorova, Raina N" sort="Fichorova, Raina N" uniqKey="Fichorova R" first="Raina N" last="Fichorova">Raina N. Fichorova</name><affiliation><nlm:affiliation>Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Yamamoto, Hidemi S" sort="Yamamoto, Hidemi S" uniqKey="Yamamoto H" first="Hidemi S" last="Yamamoto">Hidemi S. Yamamoto</name><affiliation><nlm:affiliation>Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Vitonis, Allison F" sort="Vitonis, Allison F" uniqKey="Vitonis A" first="Allison F" last="Vitonis">Allison F. Vitonis</name><affiliation><nlm:affiliation>Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Johnson, Theron" sort="Johnson, Theron" uniqKey="Johnson T" first="Theron" last="Johnson">Theron Johnson</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Overvad, Kim" sort="Overvad, Kim" uniqKey="Overvad K" first="Kim" last="Overvad">Kim Overvad</name><affiliation><nlm:affiliation>Department of Epidemiology, Aarhus University, Aarhus, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Tj Nneland, Anne" sort="Tj Nneland, Anne" uniqKey="Tj Nneland A" first="Anne" last="Tj Nneland">Anne Tj Nneland</name><affiliation><nlm:affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Boutron Ruault, Marie Christine" sort="Boutron Ruault, Marie Christine" uniqKey="Boutron Ruault M" first="Marie-Christine" last="Boutron-Ruault">Marie-Christine Boutron-Ruault</name><affiliation><nlm:affiliation>Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France. Gustave Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mesrine, Sylvie" sort="Mesrine, Sylvie" uniqKey="Mesrine S" first="Sylvie" last="Mesrine">Sylvie Mesrine</name><affiliation><nlm:affiliation>Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France. Gustave Roussy, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Severi, Gianluca" sort="Severi, Gianluca" uniqKey="Severi G" first="Gianluca" last="Severi">Gianluca Severi</name><affiliation><nlm:affiliation>Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France. Gustave Roussy, Villejuif, France. Human Genetics Foundation (HuGeF), Torino, Italy. Cancer Council Victoria and University of Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Dossus, Laure" sort="Dossus, Laure" uniqKey="Dossus L" first="Laure" last="Dossus">Laure Dossus</name><affiliation><nlm:affiliation>Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rinaldi, Sabina" sort="Rinaldi, Sabina" uniqKey="Rinaldi S" first="Sabina" last="Rinaldi">Sabina Rinaldi</name><affiliation><nlm:affiliation>Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Boeing, Heiner" sort="Boeing, Heiner" uniqKey="Boeing H" first="Heiner" last="Boeing">Heiner Boeing</name><affiliation><nlm:affiliation>Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Benetou, Vassiliki" sort="Benetou, Vassiliki" uniqKey="Benetou V" first="Vassiliki" last="Benetou">Vassiliki Benetou</name><affiliation><nlm:affiliation>Helenic Health Foundation Athens, Athens, Greece. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Lagiou, Pagona" sort="Lagiou, Pagona" uniqKey="Lagiou P" first="Pagona" last="Lagiou">Pagona Lagiou</name><affiliation><nlm:affiliation>Helenic Health Foundation Athens, Athens, Greece. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Trichopoulou, Antonia" sort="Trichopoulou, Antonia" uniqKey="Trichopoulou A" first="Antonia" last="Trichopoulou">Antonia Trichopoulou</name><affiliation><nlm:affiliation>Helenic Health Foundation Athens, Athens, Greece. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.</nlm:affiliation></affiliation></author><author><name sortKey="Krogh, Vittorio" sort="Krogh, Vittorio" uniqKey="Krogh V" first="Vittorio" last="Krogh">Vittorio Krogh</name><affiliation><nlm:affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Kuhn, Elisabetta" sort="Kuhn, Elisabetta" uniqKey="Kuhn E" first="Elisabetta" last="Kuhn">Elisabetta Kuhn</name><affiliation><nlm:affiliation>Department of Morphology, Surgery and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Centre, University of Ferrara, Ferrara, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Panico, Salvatore" sort="Panico, Salvatore" uniqKey="Panico S" first="Salvatore" last="Panico">Salvatore Panico</name><affiliation><nlm:affiliation>Dipartimento di Medicina Clinical e Chirurgia, Federico II University, Naples, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bueno De Mesquita, H Bas" sort="Bueno De Mesquita, H Bas" uniqKey="Bueno De Mesquita H" first="H Bas" last="Bueno-De-Mesquita">H Bas Bueno-De-Mesquita</name><affiliation><nlm:affiliation>National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H" last="Peeters">Petra H. Peeters</name><affiliation><nlm:affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Gram, Inger Torhild" sort="Gram, Inger Torhild" uniqKey="Gram I" first="Inger Torhild" last="Gram">Inger Torhild Gram</name><affiliation><nlm:affiliation>Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Weiderpass, Elisabete" sort="Weiderpass, Elisabete" uniqKey="Weiderpass E" first="Elisabete" last="Weiderpass">Elisabete Weiderpass</name><affiliation><nlm:affiliation>Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. Department of Research, Cancer Registry of Norway, Institute of Population-Based Case Research, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.</nlm:affiliation></affiliation></author><author><name sortKey="Duell, Eric J" sort="Duell, Eric J" uniqKey="Duell E" first="Eric J" last="Duell">Eric J. Duell</name><affiliation><nlm:affiliation>Unit of Nutrition and Cancer Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria-Jose" last="Sanchez">Maria-Jose Sanchez</name><affiliation><nlm:affiliation>Escuela Andaluza de Salud Publica, Instituto de Investigación Bionsanitaria ibs. Granada, Hospitales Universitarios de Granada, Granada, Spain. Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Ardanaz, Eva" sort="Ardanaz, Eva" uniqKey="Ardanaz E" first="Eva" last="Ardanaz">Eva Ardanaz</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain. Navarra Public Health Institute, Pamplona, Spain. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Etxezarreta, Nerea" sort="Etxezarreta, Nerea" uniqKey="Etxezarreta N" first="Nerea" last="Etxezarreta">Nerea Etxezarreta</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain. Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Basque, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Navarro, Carmen" sort="Navarro, Carmen" uniqKey="Navarro C" first="Carmen" last="Navarro">Carmen Navarro</name><affiliation><nlm:affiliation>Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Idahl, Annika" sort="Idahl, Annika" uniqKey="Idahl A" first="Annika" last="Idahl">Annika Idahl</name><affiliation><nlm:affiliation>Department of Clinical Sciences, Obstetrics and Gynecology Umeå, University of Umeå, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lundin, Eva" sort="Lundin, Eva" uniqKey="Lundin E" first="Eva" last="Lundin">Eva Lundin</name><affiliation><nlm:affiliation>Department of Medical Biosciences, Pathology Umeå, University of Umeå, Umeå, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Jirstrom, Karin" sort="Jirstrom, Karin" uniqKey="Jirstrom K" first="Karin" last="Jirström">Karin Jirström</name><affiliation><nlm:affiliation>Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden. Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Manjer, Jonas" sort="Manjer, Jonas" uniqKey="Manjer J" first="Jonas" last="Manjer">Jonas Manjer</name><affiliation><nlm:affiliation>Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden. Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:affiliation>Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Khaw, Kay Tee" sort="Khaw, Kay Tee" uniqKey="Khaw K" first="Kay-Tee" last="Khaw">Kay-Tee Khaw</name><affiliation><nlm:affiliation>Clinical Gerontology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Byrne, Karl Smith" sort="Byrne, Karl Smith" uniqKey="Byrne K" first="Karl Smith" last="Byrne">Karl Smith Byrne</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C" last="Travis">Ruth C. Travis</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Gunter, Marc J" sort="Gunter, Marc J" uniqKey="Gunter M" first="Marc J" last="Gunter">Marc J. Gunter</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Merritt, Melissa A" sort="Merritt, Melissa A" uniqKey="Merritt M" first="Melissa A" last="Merritt">Melissa A. Merritt</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Cramer, Daniel W" sort="Cramer, Daniel W" uniqKey="Cramer D" first="Daniel W" last="Cramer">Daniel W. Cramer</name><affiliation><nlm:affiliation>Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name><affiliation><nlm:affiliation>Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. r.kaaks@dkfz-heidelberg.de kterry@partners.org.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Clinical cancer research : an official journal of the American Association for Cancer Research</title><idno type="ISSN">1078-0432</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27060155</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>16</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1078-0432</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>18</Issue><PubDate><Year>2016</Year><Month>Sep</Month><Day>15</Day></PubDate></JournalIssue><Title>Clinical cancer research : an official journal of the American Association for Cancer Research</Title><ISOAbbreviation>Clin. Cancer Res.</ISOAbbreviation></Journal><ArticleTitle>A Prospective Evaluation of Early Detection Biomarkers for Ovarian Cancer in the European EPIC Cohort.</ArticleTitle><Pagination><MedlinePgn>4664-75</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1158/1078-0432.CCR-16-0316</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">About 60% of ovarian cancers are diagnosed at late stage, when 5-year survival is less than 30% in contrast to 90% for local disease. This has prompted search for early detection biomarkers. For initial testing, specimens taken months or years before ovarian cancer diagnosis are the best source of information to evaluate early detection biomarkers. Here we evaluate the most promising ovarian cancer screening biomarkers in prospectively collected samples from the European Prospective Investigation into Cancer and Nutrition study.</AbstractText><AbstractText Label="EXPERIMENTAL DESIGN" NlmCategory="METHODS">We measured CA125, HE4, CA72.4, and CA15.3 in 810 invasive epithelial ovarian cancer cases and 1,939 controls. We calculated the sensitivity at 95% and 98% specificity as well as area under the receiver operator curve (C-statistic) for each marker individually and in combination. In addition, we evaluated marker performance by stage at diagnosis and time between blood draw and diagnosis.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We observed the best discrimination between cases and controls within 6 months of diagnosis for CA125 (C-statistic = 0.92), then HE4 (0.84), CA72.4 (0.77), and CA15.3 (0.73). Marker performance declined with longer time between blood draw and diagnosis and for earlier staged disease. However, assessment of discriminatory ability at early stage was limited by small numbers. Combinations of markers performed modestly, but significantly better than any single marker.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">CA125 remains the single best marker for the early detection of invasive epithelial ovarian cancer, but can be slightly improved by combining with other markers. Identifying novel markers for ovarian cancer will require studies including larger numbers of early-stage cases. Clin Cancer Res; 22(18); 4664-75. ©2016 AACRSee related commentary by Skates, p. 4542.</AbstractText><CopyrightInformation>©2016 American Association for Cancer Research.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Terry</LastName><ForeName>Kathryn L</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts. Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. r.kaaks@dkfz-heidelberg.de kterry@partners.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schock</LastName><ForeName>Helena</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fortner</LastName><ForeName>Renée T</ForeName><Initials>RT</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hüsing</LastName><ForeName>Anika</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fichorova</LastName><ForeName>Raina N</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamamoto</LastName><ForeName>Hidemi S</ForeName><Initials>HS</Initials><AffiliationInfo><Affiliation>Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. Genital Tract Biology Laboratory, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vitonis</LastName><ForeName>Allison F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Theron</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Overvad</LastName><ForeName>Kim</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Aarhus University, Aarhus, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tjønneland</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Danish Cancer Society Research Center, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boutron-Ruault</LastName><ForeName>Marie-Christine</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France. Gustave Roussy, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mesrine</LastName><ForeName>Sylvie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France. Gustave Roussy, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Severi</LastName><ForeName>Gianluca</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Université Paris-Sud, Centre de recherche en Épidémiologie et Santé des Populations (CESP), Institut Nationale de Santë et de Recherche Médicale (INSERM), Villejuif, France. Gustave Roussy, Villejuif, France. Human Genetics Foundation (HuGeF), Torino, Italy. Cancer Council Victoria and University of Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dossus</LastName><ForeName>Laure</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rinaldi</LastName><ForeName>Sabina</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Nutrition and Metabolism Section, International Agency for Research on Cancer, Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boeing</LastName><ForeName>Heiner</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benetou</LastName><ForeName>Vassiliki</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Helenic Health Foundation Athens, Athens, Greece. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lagiou</LastName><ForeName>Pagona</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Helenic Health Foundation Athens, Athens, Greece. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trichopoulou</LastName><ForeName>Antonia</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Helenic Health Foundation Athens, Athens, Greece. WHO Collaborating Center for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Krogh</LastName><ForeName>Vittorio</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuhn</LastName><ForeName>Elisabetta</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Morphology, Surgery and Experimental Medicine and Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA) Centre, University of Ferrara, Ferrara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panico</LastName><ForeName>Salvatore</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Dipartimento di Medicina Clinical e Chirurgia, Federico II University, Naples, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bueno-de-Mesquita</LastName><ForeName>H Bas</ForeName><Initials>HB</Initials><AffiliationInfo><Affiliation>National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Onland-Moret</LastName><ForeName>N Charlotte</ForeName><Initials>NC</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peeters</LastName><ForeName>Petra H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gram</LastName><ForeName>Inger Torhild</ForeName><Initials>IT</Initials><AffiliationInfo><Affiliation>Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weiderpass</LastName><ForeName>Elisabete</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Community Medicine, University of Tromsø, The Arctic University of Norway, Tromsø, Norway. Department of Research, Cancer Registry of Norway, Institute of Population-Based Case Research, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden. Genetic Epidemiology Group, Folkhälsan Research Center, Helsinki, Finland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duell</LastName><ForeName>Eric J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Unit of Nutrition and Cancer Cancer Epidemiology Research Program, Bellvitge Biomedical Research Institute, Catalan Institute of Oncology, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanchez</LastName><ForeName>Maria-Jose</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Escuela Andaluza de Salud Publica, Instituto de Investigación Bionsanitaria ibs. Granada, Hospitales Universitarios de Granada, Granada, Spain. Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ardanaz</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain. Navarra Public Health Institute, Pamplona, Spain. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Etxezarreta</LastName><ForeName>Nerea</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain. Public Health Division of Gipuzkoa, Regional Government of the Basque Country, Basque, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Navarro</LastName><ForeName>Carmen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Centro de Investigación Biomédica En Red (CIBER), Section Epidemiology and Public Health (CIBERESP), Madrid, Spain. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. Department of Health and Social Sciences, Universidad de Murcia, Murcia, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Idahl</LastName><ForeName>Annika</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences, Obstetrics and Gynecology Umeå, University of Umeå, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lundin</LastName><ForeName>Eva</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medical Biosciences, Pathology Umeå, University of Umeå, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jirström</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden. Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manjer</LastName><ForeName>Jonas</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Clinical Sciences Lund, Oncology and Pathology, Lund University, Lund, Sweden. Department of Surgery, Skåne University Hospital, Lund University, Malmö, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khaw</LastName><ForeName>Kay-Tee</ForeName><Initials>KT</Initials><AffiliationInfo><Affiliation>Clinical Gerontology, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Byrne</LastName><ForeName>Karl Smith</ForeName><Initials>KS</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Travis</LastName><ForeName>Ruth C</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gunter</LastName><ForeName>Marc J</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merritt</LastName><ForeName>Melissa A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riboli</LastName><ForeName>Elio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cramer</LastName><ForeName>Daniel W</ForeName><Initials>DW</Initials><AffiliationInfo><Affiliation>Ob/Gyn Epidemiology Center, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaaks</LastName><ForeName>Rudolf</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts. r.kaaks@dkfz-heidelberg.de kterry@partners.org.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G1000143</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 CA158119</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>MC_UU_12015/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_U106179471</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>14136</GrantID><Agency>Cancer Research UK</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0401527</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>08</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Clin Cancer Res</MedlineTA><NlmUniqueID>9502500</NlmUniqueID><ISSNLinking>1078-0432</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections 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