Toward a theory of organisms: Three founding principles in search of a useful integration.
Identifieur interne : 001829 ( PubMed/Corpus ); précédent : 001828; suivant : 001830Toward a theory of organisms: Three founding principles in search of a useful integration.
Auteurs : Ana M. Soto ; Giuseppe Longo ; Paul-Antoine Miquel ; Maël Montevil ; Matteo Mossio ; Nicole Perret ; Arnaud Pocheville ; Carlos SonnenscheinSource :
- Progress in biophysics and molecular biology [ 1873-1732 ] ; 2016.
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Abstract
Organisms, be they uni- or multi-cellular, are agents capable of creating their own norms; they are continuously harmonizing their ability to create novelty and stability, that is, they combine plasticity with robustness. Here we articulate the three principles for a theory of organisms, namely: the default state of proliferation with variation and motility, the principle of variation and the principle of organization. These principles profoundly change both biological observables and their determination with respect to the theoretical framework of physical theories. This radical change opens up the possibility of anchoring mathematical modeling in biologically proper principles.
DOI: 10.1016/j.pbiomolbio.2016.07.006
PubMed: 27498204
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<front><div type="abstract" xml:lang="en">Organisms, be they uni- or multi-cellular, are agents capable of creating their own norms; they are continuously harmonizing their ability to create novelty and stability, that is, they combine plasticity with robustness. Here we articulate the three principles for a theory of organisms, namely: the default state of proliferation with variation and motility, the principle of variation and the principle of organization. These principles profoundly change both biological observables and their determination with respect to the theoretical framework of physical theories. This radical change opens up the possibility of anchoring mathematical modeling in biologically proper principles.</div>
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