Repeated Measurements of Hepatitis B Surface Antigen Identify Carriers of Inactive HBV During Long-term Follow-up.
Identifieur interne : 001767 ( PubMed/Corpus ); précédent : 001766; suivant : 001768Repeated Measurements of Hepatitis B Surface Antigen Identify Carriers of Inactive HBV During Long-term Follow-up.
Auteurs : Willem P. Brouwer ; Henry Lik-Yuen Chan ; Maurizia R. Brunetto ; Michelle Martinot-Peignoux ; Pauline Arends ; Markus Cornberg ; Beatrice Cherubini ; Alex J V. Thompson ; Yun-Fan Liaw ; Patrick Marcellin ; Harry L A. Janssen ; Bettina E. HansenSource :
- Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [ 1542-7714 ] ; 2016.
English descriptors
- KwdEn :
- Adult, Aged, Alanine Transaminase (blood), Asia, Australia, Carrier State (diagnosis), DNA, Viral (blood), Diagnostic Tests, Routine (methods), Europe, Female, Hepatitis B Surface Antigens (blood), Hepatitis B, Chronic (diagnosis), Humans, Longitudinal Studies, Male, Middle Aged, Outpatients, Retrospective Studies, Sensitivity and Specificity, Tertiary Care Centers.
- MESH :
- chemical , blood : Alanine Transaminase, DNA, Viral, Hepatitis B Surface Antigens.
- diagnosis : Carrier State, Hepatitis B, Chronic.
- methods : Diagnostic Tests, Routine.
- Adult, Aged, Asia, Australia, Europe, Female, Humans, Longitudinal Studies, Male, Middle Aged, Outpatients, Retrospective Studies, Sensitivity and Specificity, Tertiary Care Centers.
Abstract
Measurements of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA might help to identify carriers of inactive HBV. We assessed the performance of repeated measurements of HBsAg over a median time period of 8 years.
DOI: 10.1016/j.cgh.2016.01.019
PubMed: 26872398
Links to Exploration step
pubmed:26872398Le document en format XML
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<author><name sortKey="Chan, Henry Lik Yuen" sort="Chan, Henry Lik Yuen" uniqKey="Chan H" first="Henry Lik-Yuen" last="Chan">Henry Lik-Yuen Chan</name>
<affiliation><nlm:affiliation>Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China.</nlm:affiliation>
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<author><name sortKey="Cornberg, Markus" sort="Cornberg, Markus" uniqKey="Cornberg M" first="Markus" last="Cornberg">Markus Cornberg</name>
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<author><name sortKey="Janssen, Harry L A" sort="Janssen, Harry L A" uniqKey="Janssen H" first="Harry L A" last="Janssen">Harry L A. Janssen</name>
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<author><name sortKey="Hansen, Bettina E" sort="Hansen, Bettina E" uniqKey="Hansen B" first="Bettina E" last="Hansen">Bettina E. Hansen</name>
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<author><name sortKey="Marcellin, Patrick" sort="Marcellin, Patrick" uniqKey="Marcellin P" first="Patrick" last="Marcellin">Patrick Marcellin</name>
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</affiliation>
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<author><name sortKey="Janssen, Harry L A" sort="Janssen, Harry L A" uniqKey="Janssen H" first="Harry L A" last="Janssen">Harry L A. Janssen</name>
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</affiliation>
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<author><name sortKey="Hansen, Bettina E" sort="Hansen, Bettina E" uniqKey="Hansen B" first="Bettina E" last="Hansen">Bettina E. Hansen</name>
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<term>Asia</term>
<term>Australia</term>
<term>Carrier State (diagnosis)</term>
<term>DNA, Viral (blood)</term>
<term>Diagnostic Tests, Routine (methods)</term>
<term>Europe</term>
<term>Female</term>
<term>Hepatitis B Surface Antigens (blood)</term>
<term>Hepatitis B, Chronic (diagnosis)</term>
<term>Humans</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Outpatients</term>
<term>Retrospective Studies</term>
<term>Sensitivity and Specificity</term>
<term>Tertiary Care Centers</term>
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<front><div type="abstract" xml:lang="en">Measurements of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA might help to identify carriers of inactive HBV. We assessed the performance of repeated measurements of HBsAg over a median time period of 8 years.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26872398</PMID>
<DateCreated><Year>2016</Year>
<Month>09</Month>
<Day>19</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>08</Month>
<Day>07</Day>
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<DateRevised><Year>2017</Year>
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<JournalIssue CitedMedium="Internet"><Volume>14</Volume>
<Issue>10</Issue>
<PubDate><Year>2016</Year>
<Month>Oct</Month>
</PubDate>
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<Title>Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association</Title>
<ISOAbbreviation>Clin. Gastroenterol. Hepatol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Repeated Measurements of Hepatitis B Surface Antigen Identify Carriers of Inactive HBV During Long-term Follow-up.</ArticleTitle>
<Pagination><MedlinePgn>1481-1489.e5</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cgh.2016.01.019</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">S1542-3565(16)00122-1</ELocationID>
<Abstract><AbstractText Label="BACKGROUND & AIMS" NlmCategory="OBJECTIVE">Measurements of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA might help to identify carriers of inactive HBV. We assessed the performance of repeated measurements of HBsAg over a median time period of 8 years.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We performed a retrospective study of 292 HBe antigen-negative patients with chronic HBV infection, normal levels of alanine aminotransferase (ALT), levels of HBV DNA <20,000 IU/mL, and no cirrhosis who visited the outpatient clinics at 8 tertiary care centers in Europe, Asia, and Australia from 1990 through 2011. Patients were determined to be carriers of inactive HBV (level of HBV DNA <2000 IU/mL and serum levels of ALT that remained normal) or to have HBV activity (level of HBV DNA fluctuating >2000 IU/mL and/or abnormal levels of ALT) after each year of follow-up. Patients were followed for a median time of 8 years (range, 4-9 years). Dynamic regression analysis was used to study changes in level of HBsAg and HBV phase and to update the risk of HBV activity.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">One year after study enrollment, 189 patients (65%) had inactive HBV and 103 patients (35%) had HBV activity. Based on dynamic analysis, the probability that a patient would have HBV at any following year differed according to level of HBsAg; odds were 97% for patients with initial level of HBsAg <100 IU/mL, 85% for patients with initial levels 100-1000 IU/mL, and 76% for patients with initial levels >1000 IU/mL (P < .001). Having inactive virus for any 2 consecutive years predicted having inactive virus in any third year. However, 15% of patients with level of HBsAg >100 IU/mL had HBV activity in the third year. The combination of HBsAg level <100 IU/mL and HBV DNA level <2000 IU/mL identified patients whose virus remained inactive for the entire follow-up period, with 98% specificity and a positive predictive value of 97%, for all HBV genotypes. Patients with HBV activity who had levels of HBV DNA <5000 IU/mL and decreases in HBsAg of 0.5 log IU/mL or more for 1 year had a high probability of becoming carriers of inactive HBV in the next year.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In a retrospective, dynamic analysis of almost 300 patients with chronic HBV infection, we found that levels of HBsAg <100 IU/mL identify patients with inactive virus with a high level of specificity. HBsAg levels should therefore be used to define phases of HBV infection in HBe antigen-negative patients.</AbstractText>
<CopyrightInformation>Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brouwer</LastName>
<ForeName>Willem P</ForeName>
<Initials>WP</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, the Netherlands. Electronic address: w.p.brouwer@erasmusmc.nl.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chan</LastName>
<ForeName>Henry Lik-Yuen</ForeName>
<Initials>HL</Initials>
<AffiliationInfo><Affiliation>Department of Medicine & Therapeutics, Chinese University of Hong Kong, Hong Kong SAR, China.</Affiliation>
</AffiliationInfo>
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<ForeName>Maurizia R</ForeName>
<Initials>MR</Initials>
<AffiliationInfo><Affiliation>Hepatology Unit, University of Pisa, Pisa, Italy.</Affiliation>
</AffiliationInfo>
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<ForeName>Michelle</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre de Recherche Biomédicale Bichat-Beaujon, Université Paris-Diderot, Clichy, France.</Affiliation>
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<ForeName>Pauline</ForeName>
<Initials>P</Initials>
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</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Cornberg</LastName>
<ForeName>Markus</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>Beatrice</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Hepatology Unit, University of Pisa, Pisa, Italy.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Thompson</LastName>
<ForeName>Alex J V</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>St. Vincent's Hospital and the University of Melbourne, Melbourne, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liaw</LastName>
<ForeName>Yun-Fan</ForeName>
<Initials>YF</Initials>
<AffiliationInfo><Affiliation>Liver Research Unit, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marcellin</LastName>
<ForeName>Patrick</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Centre de Recherche Biomédicale Bichat-Beaujon, Université Paris-Diderot, Clichy, France.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Janssen</LastName>
<ForeName>Harry L A</ForeName>
<Initials>HL</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, the Netherlands; UHN Liver Clinic, Toronto Western and General Hospital, University Health Network Toronto, Toronto, Canada.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hansen</LastName>
<ForeName>Bettina E</ForeName>
<Initials>BE</Initials>
<AffiliationInfo><Affiliation>Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, the Netherlands; Department of Public Health, Erasmus MC, Rotterdam, the Netherlands.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>Good Practice in using HBsAg in Chronic Hepatitis B Study Group (GPs-CHB Study Group)</CollectiveName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Dynamic Prediction</Keyword>
<Keyword MajorTopicYN="N">HBe Antigen</Keyword>
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<Keyword MajorTopicYN="N">Inactive Carrier</Keyword>
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