Identification of a new locus at 16q12 associated with time to asthma onset.
Identifieur interne : 001765 ( PubMed/Corpus ); précédent : 001764; suivant : 001766Identification of a new locus at 16q12 associated with time to asthma onset.
Auteurs : Chloé Sarnowski ; Pierre-Emmanuel Sugier ; Raquel Granell ; Debbie Jarvis ; Marie-Hélène Dizier ; Markus Ege ; Medea Imboden ; Catherine Laprise ; Elza K. Khusnutdinova ; Maxim B. Freidin ; William O C. Cookson ; Miriam Moffatt ; Mark Lathrop ; Valérie Siroux ; Ludmila M. Ogorodova ; Alexandra S. Karunas ; Alan James ; Nicole M. Probst-Hensch ; Erika Von Mutius ; Isabelle Pin ; Manolis Kogevinas ; A John Henderson ; Florence Demenais ; Emmanuelle BouzigonSource :
- The Journal of allergy and clinical immunology [ 1097-6825 ] ; 2016.
English descriptors
- KwdEn :
- Adolescent, Age of Onset, Asthma (genetics), Child, Chromosomes, Human, Pair 16 (genetics), European Continental Ancestry Group (genetics), Female, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Male, Nod2 Signaling Adaptor Protein (genetics), Tumor Suppressor Proteins (genetics).
- MESH :
- chemical , genetics : Nod2 Signaling Adaptor Protein, Tumor Suppressor Proteins.
- genetics : Asthma, Chromosomes, Human, Pair 16, European Continental Ancestry Group.
- Adolescent, Age of Onset, Child, Female, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Male.
Abstract
Asthma is a heterogeneous disease in which age of onset plays an important role.
DOI: 10.1016/j.jaci.2016.03.018
PubMed: 27130862
Links to Exploration step
pubmed:27130862Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of a new locus at 16q12 associated with time to asthma onset.</title><author><name sortKey="Sarnowski, Chloe" sort="Sarnowski, Chloe" uniqKey="Sarnowski C" first="Chloé" last="Sarnowski">Chloé Sarnowski</name><affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sugier, Pierre Emmanuel" sort="Sugier, Pierre Emmanuel" uniqKey="Sugier P" first="Pierre-Emmanuel" last="Sugier">Pierre-Emmanuel Sugier</name><affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Granell, Raquel" sort="Granell, Raquel" uniqKey="Granell R" first="Raquel" last="Granell">Raquel Granell</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Jarvis, Debbie" sort="Jarvis, Debbie" uniqKey="Jarvis D" first="Debbie" last="Jarvis">Debbie Jarvis</name><affiliation><nlm:affiliation>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom; MRC-PHE Centre for Environment & Health, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Dizier, Marie Helene" sort="Dizier, Marie Helene" uniqKey="Dizier M" first="Marie-Hélène" last="Dizier">Marie-Hélène Dizier</name><affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ege, Markus" sort="Ege, Markus" uniqKey="Ege M" first="Markus" last="Ege">Markus Ege</name><affiliation><nlm:affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Laprise, Catherine" sort="Laprise, Catherine" uniqKey="Laprise C" first="Catherine" last="Laprise">Catherine Laprise</name><affiliation><nlm:affiliation>Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Khusnutdinova, Elza K" sort="Khusnutdinova, Elza K" uniqKey="Khusnutdinova E" first="Elza K" last="Khusnutdinova">Elza K. Khusnutdinova</name><affiliation><nlm:affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Freidin, Maxim B" sort="Freidin, Maxim B" uniqKey="Freidin M" first="Maxim B" last="Freidin">Maxim B. Freidin</name><affiliation><nlm:affiliation>Research Institute for Medical Genetics, Tomsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Cookson, William O C" sort="Cookson, William O C" uniqKey="Cookson W" first="William O C" last="Cookson">William O C. Cookson</name><affiliation><nlm:affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name><affiliation><nlm:affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:affiliation>McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Siroux, Valerie" sort="Siroux, Valerie" uniqKey="Siroux V" first="Valérie" last="Siroux">Valérie Siroux</name><affiliation><nlm:affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ogorodova, Ludmila M" sort="Ogorodova, Ludmila M" uniqKey="Ogorodova L" first="Ludmila M" last="Ogorodova">Ludmila M. Ogorodova</name><affiliation><nlm:affiliation>Siberian State Medical University, Tomsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Karunas, Alexandra S" sort="Karunas, Alexandra S" uniqKey="Karunas A" first="Alexandra S" last="Karunas">Alexandra S. Karunas</name><affiliation><nlm:affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="James, Alan" sort="James, Alan" uniqKey="James A" first="Alan" last="James">Alan James</name><affiliation><nlm:affiliation>Busselton Population Medical Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, and the School of Population Health, University of Western Australia, Crawley, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M" last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Von Mutius, Erika" sort="Von Mutius, Erika" uniqKey="Von Mutius E" first="Erika" last="Von Mutius">Erika Von Mutius</name><affiliation><nlm:affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name><affiliation><nlm:affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, Pediatrics, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation><nlm:affiliation>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Henderson, A John" sort="Henderson, A John" uniqKey="Henderson A" first="A John" last="Henderson">A John Henderson</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name><affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France. Electronic address: emmanuelle.bouzigon@inserm.fr.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27130862</idno><idno type="pmid">27130862</idno><idno type="doi">10.1016/j.jaci.2016.03.018</idno><idno type="wicri:Area/PubMed/Corpus">001765</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001765</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of a new locus at 16q12 associated with time to asthma onset.</title><author><name sortKey="Sarnowski, Chloe" sort="Sarnowski, Chloe" uniqKey="Sarnowski C" first="Chloé" last="Sarnowski">Chloé Sarnowski</name><affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sugier, Pierre Emmanuel" sort="Sugier, Pierre Emmanuel" uniqKey="Sugier P" first="Pierre-Emmanuel" last="Sugier">Pierre-Emmanuel Sugier</name><affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Granell, Raquel" sort="Granell, Raquel" uniqKey="Granell R" first="Raquel" last="Granell">Raquel Granell</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Jarvis, Debbie" sort="Jarvis, Debbie" uniqKey="Jarvis D" first="Debbie" last="Jarvis">Debbie Jarvis</name><affiliation><nlm:affiliation>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom; MRC-PHE Centre for Environment & Health, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Dizier, Marie Helene" sort="Dizier, Marie Helene" uniqKey="Dizier M" first="Marie-Hélène" last="Dizier">Marie-Hélène Dizier</name><affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ege, Markus" sort="Ege, Markus" uniqKey="Ege M" first="Markus" last="Ege">Markus Ege</name><affiliation><nlm:affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name><affiliation><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Laprise, Catherine" sort="Laprise, Catherine" uniqKey="Laprise C" first="Catherine" last="Laprise">Catherine Laprise</name><affiliation><nlm:affiliation>Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Khusnutdinova, Elza K" sort="Khusnutdinova, Elza K" uniqKey="Khusnutdinova E" first="Elza K" last="Khusnutdinova">Elza K. Khusnutdinova</name><affiliation><nlm:affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Freidin, Maxim B" sort="Freidin, Maxim B" uniqKey="Freidin M" first="Maxim B" last="Freidin">Maxim B. Freidin</name><affiliation><nlm:affiliation>Research Institute for Medical Genetics, Tomsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Cookson, William O C" sort="Cookson, William O C" uniqKey="Cookson W" first="William O C" last="Cookson">William O C. Cookson</name><affiliation><nlm:affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name><affiliation><nlm:affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name><affiliation><nlm:affiliation>McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Siroux, Valerie" sort="Siroux, Valerie" uniqKey="Siroux V" first="Valérie" last="Siroux">Valérie Siroux</name><affiliation><nlm:affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Ogorodova, Ludmila M" sort="Ogorodova, Ludmila M" uniqKey="Ogorodova L" first="Ludmila M" last="Ogorodova">Ludmila M. Ogorodova</name><affiliation><nlm:affiliation>Siberian State Medical University, Tomsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Karunas, Alexandra S" sort="Karunas, Alexandra S" uniqKey="Karunas A" first="Alexandra S" last="Karunas">Alexandra S. Karunas</name><affiliation><nlm:affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="James, Alan" sort="James, Alan" uniqKey="James A" first="Alan" last="James">Alan James</name><affiliation><nlm:affiliation>Busselton Population Medical Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, and the School of Population Health, University of Western Australia, Crawley, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M" last="Probst-Hensch">Nicole M. Probst-Hensch</name><affiliation><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Von Mutius, Erika" sort="Von Mutius, Erika" uniqKey="Von Mutius E" first="Erika" last="Von Mutius">Erika Von Mutius</name><affiliation><nlm:affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name><affiliation><nlm:affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, Pediatrics, Grenoble, France.</nlm:affiliation></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation><nlm:affiliation>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Henderson, A John" sort="Henderson, A John" uniqKey="Henderson A" first="A John" last="Henderson">A John Henderson</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name><affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name><affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France. Electronic address: emmanuelle.bouzigon@inserm.fr.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The Journal of allergy and clinical immunology</title><idno type="eISSN">1097-6825</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Age of Onset</term><term>Asthma (genetics)</term><term>Child</term><term>Chromosomes, Human, Pair 16 (genetics)</term><term>European Continental Ancestry Group (genetics)</term><term>Female</term><term>Genetic Variation</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term><term>Nod2 Signaling Adaptor Protein (genetics)</term><term>Tumor Suppressor Proteins (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nod2 Signaling Adaptor Protein</term><term>Tumor Suppressor Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asthma</term><term>Chromosomes, Human, Pair 16</term><term>European Continental Ancestry Group</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Age of Onset</term><term>Child</term><term>Female</term><term>Genetic Variation</term><term>Genome-Wide Association Study</term><term>Genotype</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Asthma is a heterogeneous disease in which age of onset plays an important role.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27130862</PMID><DateCreated><Year>2016</Year><Month>04</Month><Day>30</Day></DateCreated><DateCompleted><Year>2017</Year><Month>07</Month><Day>05</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-6825</ISSN><JournalIssue CitedMedium="Internet"><Volume>138</Volume><Issue>4</Issue><PubDate><Year>2016</Year><Month>Oct</Month></PubDate></JournalIssue><Title>The Journal of allergy and clinical immunology</Title><ISOAbbreviation>J. Allergy Clin. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Identification of a new locus at 16q12 associated with time to asthma onset.</ArticleTitle><Pagination><MedlinePgn>1071-1080</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0091-6749(16)30016-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jaci.2016.03.018</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Asthma is a heterogeneous disease in which age of onset plays an important role.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We sought to identify the genetic variants associated with time to asthma onset (TAO).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a large-scale meta-analysis of 9 genome-wide association studies of TAO (total of 5462 asthmatic patients with a broad range of age of asthma onset and 8424 control subjects of European ancestry) performed by using survival analysis techniques.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">We detected 5 regions associated with TAO at the genome-wide significant level (P < 5 × 10(-8)). We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]). Conditional analyses identified 2 distinct signals at 9p24 (both upstream of IL33) and 17q12-q21 (near ZPBP2 and within GSDMA). Together, these 7 distinct loci explained 6.0% of the variance in TAO. In addition, we showed that genetic variants at 9p24 and 17q12-q21 were strongly associated with an earlier onset of childhood asthma (P ≤ .002), whereas the 16q12 single nucleotide polymorphism was associated with later asthma onset (P = .04). A high burden of disease risk alleles at these loci was associated with earlier age of asthma onset (4 vs 9-12 years, P = 10(-4)).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The new susceptibility region for TAO at 16q12 harbors variants that correlate with the expression of CYLD and nucleotide-binding oligomerization domain 2 (NOD2), 2 strong candidates for asthma. This study demonstrates that incorporating the variability of age of asthma onset in asthma modeling is a helpful approach in the search for disease susceptibility genes.</AbstractText><CopyrightInformation>Copyright © 2016 American Academy of Allergy, Asthma & Immunology. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sarnowski</LastName><ForeName>Chloé</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sugier</LastName><ForeName>Pierre-Emmanuel</ForeName><Initials>PE</Initials><AffiliationInfo><Affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Granell</LastName><ForeName>Raquel</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jarvis</LastName><ForeName>Debbie</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom; MRC-PHE Centre for Environment & Health, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dizier</LastName><ForeName>Marie-Hélène</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ege</LastName><ForeName>Markus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Imboden</LastName><ForeName>Medea</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laprise</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khusnutdinova</LastName><ForeName>Elza K</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Freidin</LastName><ForeName>Maxim B</ForeName><Initials>MB</Initials><AffiliationInfo><Affiliation>Research Institute for Medical Genetics, Tomsk, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cookson</LastName><ForeName>William O C</ForeName><Initials>WOC</Initials><AffiliationInfo><Affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moffatt</LastName><ForeName>Miriam</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lathrop</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Siroux</LastName><ForeName>Valérie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ogorodova</LastName><ForeName>Ludmila M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Siberian State Medical University, Tomsk, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Karunas</LastName><ForeName>Alexandra S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>James</LastName><ForeName>Alan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Busselton Population Medical Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, and the School of Population Health, University of Western Australia, Crawley, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Probst-Hensch</LastName><ForeName>Nicole M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>von Mutius</LastName><ForeName>Erika</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pin</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, Pediatrics, Grenoble, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kogevinas</LastName><ForeName>Manolis</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Henderson</LastName><ForeName>A John</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demenais</LastName><ForeName>Florence</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bouzigon</LastName><ForeName>Emmanuelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France. Electronic address: emmanuelle.bouzigon@inserm.fr.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>102215</GrantID><Agency>Wellcome Trust</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0401540</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G9815508</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_PC_15018</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D017418">Meta-Analysis</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>04</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Allergy Clin Immunol</MedlineTA><NlmUniqueID>1275002</NlmUniqueID><ISSNLinking>0091-6749</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C409984">CYLD protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C429018">NOD2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053473">Nod2 Signaling Adaptor Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D025521">Tumor Suppressor Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017668" MajorTopicYN="N">Age of Onset</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002885" MajorTopicYN="N">Chromosomes, Human, Pair 16</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D044465" MajorTopicYN="N">European Continental Ancestry Group</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055106" MajorTopicYN="N">Genome-Wide Association Study</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053473" MajorTopicYN="N">Nod2 Signaling Adaptor Protein</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025521" MajorTopicYN="N">Tumor Suppressor Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Asthma</Keyword><Keyword MajorTopicYN="N">CYLD</Keyword><Keyword MajorTopicYN="N">NOD2</Keyword><Keyword MajorTopicYN="N">age of onset</Keyword><Keyword MajorTopicYN="N">conditional analysis</Keyword><Keyword MajorTopicYN="N">genetics</Keyword><Keyword MajorTopicYN="N">genome-wide association study</Keyword><Keyword MajorTopicYN="N">survival analysis</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>08</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>02</Month><Day>05</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>03</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27130862</ArticleId><ArticleId IdType="pii">S0091-6749(16)30016-1</ArticleId><ArticleId IdType="doi">10.1016/j.jaci.2016.03.018</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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