Identification of a new locus at 16q12 associated with time to asthma onset.
Identifieur interne : 001765 ( PubMed/Corpus ); précédent : 001764; suivant : 001766Identification of a new locus at 16q12 associated with time to asthma onset.
Auteurs : Chloé Sarnowski ; Pierre-Emmanuel Sugier ; Raquel Granell ; Debbie Jarvis ; Marie-Hélène Dizier ; Markus Ege ; Medea Imboden ; Catherine Laprise ; Elza K. Khusnutdinova ; Maxim B. Freidin ; William O C. Cookson ; Miriam Moffatt ; Mark Lathrop ; Valérie Siroux ; Ludmila M. Ogorodova ; Alexandra S. Karunas ; Alan James ; Nicole M. Probst-Hensch ; Erika Von Mutius ; Isabelle Pin ; Manolis Kogevinas ; A John Henderson ; Florence Demenais ; Emmanuelle BouzigonSource :
- The Journal of allergy and clinical immunology [ 1097-6825 ] ; 2016.
English descriptors
- KwdEn :
- Adolescent, Age of Onset, Asthma (genetics), Child, Chromosomes, Human, Pair 16 (genetics), European Continental Ancestry Group (genetics), Female, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Male, Nod2 Signaling Adaptor Protein (genetics), Tumor Suppressor Proteins (genetics).
- MESH :
- chemical , genetics : Nod2 Signaling Adaptor Protein, Tumor Suppressor Proteins.
- genetics : Asthma, Chromosomes, Human, Pair 16, European Continental Ancestry Group.
- Adolescent, Age of Onset, Child, Female, Genetic Variation, Genome-Wide Association Study, Genotype, Humans, Male.
Abstract
Asthma is a heterogeneous disease in which age of onset plays an important role.
DOI: 10.1016/j.jaci.2016.03.018
PubMed: 27130862
Links to Exploration step
pubmed:27130862Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of a new locus at 16q12 associated with time to asthma onset.</title>
<author><name sortKey="Sarnowski, Chloe" sort="Sarnowski, Chloe" uniqKey="Sarnowski C" first="Chloé" last="Sarnowski">Chloé Sarnowski</name>
<affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Sugier, Pierre Emmanuel" sort="Sugier, Pierre Emmanuel" uniqKey="Sugier P" first="Pierre-Emmanuel" last="Sugier">Pierre-Emmanuel Sugier</name>
<affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Granell, Raquel" sort="Granell, Raquel" uniqKey="Granell R" first="Raquel" last="Granell">Raquel Granell</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jarvis, Debbie" sort="Jarvis, Debbie" uniqKey="Jarvis D" first="Debbie" last="Jarvis">Debbie Jarvis</name>
<affiliation><nlm:affiliation>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom; MRC-PHE Centre for Environment & Health, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dizier, Marie Helene" sort="Dizier, Marie Helene" uniqKey="Dizier M" first="Marie-Hélène" last="Dizier">Marie-Hélène Dizier</name>
<affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ege, Markus" sort="Ege, Markus" uniqKey="Ege M" first="Markus" last="Ege">Markus Ege</name>
<affiliation><nlm:affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name>
<affiliation><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Laprise, Catherine" sort="Laprise, Catherine" uniqKey="Laprise C" first="Catherine" last="Laprise">Catherine Laprise</name>
<affiliation><nlm:affiliation>Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Khusnutdinova, Elza K" sort="Khusnutdinova, Elza K" uniqKey="Khusnutdinova E" first="Elza K" last="Khusnutdinova">Elza K. Khusnutdinova</name>
<affiliation><nlm:affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Freidin, Maxim B" sort="Freidin, Maxim B" uniqKey="Freidin M" first="Maxim B" last="Freidin">Maxim B. Freidin</name>
<affiliation><nlm:affiliation>Research Institute for Medical Genetics, Tomsk, Russia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cookson, William O C" sort="Cookson, William O C" uniqKey="Cookson W" first="William O C" last="Cookson">William O C. Cookson</name>
<affiliation><nlm:affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name>
<affiliation><nlm:affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation><nlm:affiliation>McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Siroux, Valerie" sort="Siroux, Valerie" uniqKey="Siroux V" first="Valérie" last="Siroux">Valérie Siroux</name>
<affiliation><nlm:affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ogorodova, Ludmila M" sort="Ogorodova, Ludmila M" uniqKey="Ogorodova L" first="Ludmila M" last="Ogorodova">Ludmila M. Ogorodova</name>
<affiliation><nlm:affiliation>Siberian State Medical University, Tomsk, Russia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Karunas, Alexandra S" sort="Karunas, Alexandra S" uniqKey="Karunas A" first="Alexandra S" last="Karunas">Alexandra S. Karunas</name>
<affiliation><nlm:affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="James, Alan" sort="James, Alan" uniqKey="James A" first="Alan" last="James">Alan James</name>
<affiliation><nlm:affiliation>Busselton Population Medical Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, and the School of Population Health, University of Western Australia, Crawley, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M" last="Probst-Hensch">Nicole M. Probst-Hensch</name>
<affiliation><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Von Mutius, Erika" sort="Von Mutius, Erika" uniqKey="Von Mutius E" first="Erika" last="Von Mutius">Erika Von Mutius</name>
<affiliation><nlm:affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name>
<affiliation><nlm:affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, Pediatrics, Grenoble, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name>
<affiliation><nlm:affiliation>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Henderson, A John" sort="Henderson, A John" uniqKey="Henderson A" first="A John" last="Henderson">A John Henderson</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
<affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name>
<affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France. Electronic address: emmanuelle.bouzigon@inserm.fr.</nlm:affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Identification of a new locus at 16q12 associated with time to asthma onset.</title>
<author><name sortKey="Sarnowski, Chloe" sort="Sarnowski, Chloe" uniqKey="Sarnowski C" first="Chloé" last="Sarnowski">Chloé Sarnowski</name>
<affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Sugier, Pierre Emmanuel" sort="Sugier, Pierre Emmanuel" uniqKey="Sugier P" first="Pierre-Emmanuel" last="Sugier">Pierre-Emmanuel Sugier</name>
<affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Granell, Raquel" sort="Granell, Raquel" uniqKey="Granell R" first="Raquel" last="Granell">Raquel Granell</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Jarvis, Debbie" sort="Jarvis, Debbie" uniqKey="Jarvis D" first="Debbie" last="Jarvis">Debbie Jarvis</name>
<affiliation><nlm:affiliation>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom; MRC-PHE Centre for Environment & Health, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Dizier, Marie Helene" sort="Dizier, Marie Helene" uniqKey="Dizier M" first="Marie-Hélène" last="Dizier">Marie-Hélène Dizier</name>
<affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ege, Markus" sort="Ege, Markus" uniqKey="Ege M" first="Markus" last="Ege">Markus Ege</name>
<affiliation><nlm:affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name>
<affiliation><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Laprise, Catherine" sort="Laprise, Catherine" uniqKey="Laprise C" first="Catherine" last="Laprise">Catherine Laprise</name>
<affiliation><nlm:affiliation>Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Khusnutdinova, Elza K" sort="Khusnutdinova, Elza K" uniqKey="Khusnutdinova E" first="Elza K" last="Khusnutdinova">Elza K. Khusnutdinova</name>
<affiliation><nlm:affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Freidin, Maxim B" sort="Freidin, Maxim B" uniqKey="Freidin M" first="Maxim B" last="Freidin">Maxim B. Freidin</name>
<affiliation><nlm:affiliation>Research Institute for Medical Genetics, Tomsk, Russia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Cookson, William O C" sort="Cookson, William O C" uniqKey="Cookson W" first="William O C" last="Cookson">William O C. Cookson</name>
<affiliation><nlm:affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Moffatt, Miriam" sort="Moffatt, Miriam" uniqKey="Moffatt M" first="Miriam" last="Moffatt">Miriam Moffatt</name>
<affiliation><nlm:affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Lathrop, Mark" sort="Lathrop, Mark" uniqKey="Lathrop M" first="Mark" last="Lathrop">Mark Lathrop</name>
<affiliation><nlm:affiliation>McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Siroux, Valerie" sort="Siroux, Valerie" uniqKey="Siroux V" first="Valérie" last="Siroux">Valérie Siroux</name>
<affiliation><nlm:affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Ogorodova, Ludmila M" sort="Ogorodova, Ludmila M" uniqKey="Ogorodova L" first="Ludmila M" last="Ogorodova">Ludmila M. Ogorodova</name>
<affiliation><nlm:affiliation>Siberian State Medical University, Tomsk, Russia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Karunas, Alexandra S" sort="Karunas, Alexandra S" uniqKey="Karunas A" first="Alexandra S" last="Karunas">Alexandra S. Karunas</name>
<affiliation><nlm:affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="James, Alan" sort="James, Alan" uniqKey="James A" first="Alan" last="James">Alan James</name>
<affiliation><nlm:affiliation>Busselton Population Medical Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, and the School of Population Health, University of Western Australia, Crawley, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M" last="Probst-Hensch">Nicole M. Probst-Hensch</name>
<affiliation><nlm:affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Von Mutius, Erika" sort="Von Mutius, Erika" uniqKey="Von Mutius E" first="Erika" last="Von Mutius">Erika Von Mutius</name>
<affiliation><nlm:affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Pin, Isabelle" sort="Pin, Isabelle" uniqKey="Pin I" first="Isabelle" last="Pin">Isabelle Pin</name>
<affiliation><nlm:affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, Pediatrics, Grenoble, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name>
<affiliation><nlm:affiliation>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Henderson, A John" sort="Henderson, A John" uniqKey="Henderson A" first="A John" last="Henderson">A John Henderson</name>
<affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Demenais, Florence" sort="Demenais, Florence" uniqKey="Demenais F" first="Florence" last="Demenais">Florence Demenais</name>
<affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Bouzigon, Emmanuelle" sort="Bouzigon, Emmanuelle" uniqKey="Bouzigon E" first="Emmanuelle" last="Bouzigon">Emmanuelle Bouzigon</name>
<affiliation><nlm:affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France. Electronic address: emmanuelle.bouzigon@inserm.fr.</nlm:affiliation>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of allergy and clinical immunology</title>
<idno type="eISSN">1097-6825</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Age of Onset</term>
<term>Asthma (genetics)</term>
<term>Child</term>
<term>Chromosomes, Human, Pair 16 (genetics)</term>
<term>European Continental Ancestry Group (genetics)</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Nod2 Signaling Adaptor Protein (genetics)</term>
<term>Tumor Suppressor Proteins (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nod2 Signaling Adaptor Protein</term>
<term>Tumor Suppressor Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Asthma</term>
<term>Chromosomes, Human, Pair 16</term>
<term>European Continental Ancestry Group</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Age of Onset</term>
<term>Child</term>
<term>Female</term>
<term>Genetic Variation</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Asthma is a heterogeneous disease in which age of onset plays an important role.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27130862</PMID>
<DateCreated><Year>2016</Year>
<Month>04</Month>
<Day>30</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>07</Month>
<Day>05</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-6825</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>138</Volume>
<Issue>4</Issue>
<PubDate><Year>2016</Year>
<Month>Oct</Month>
</PubDate>
</JournalIssue>
<Title>The Journal of allergy and clinical immunology</Title>
<ISOAbbreviation>J. Allergy Clin. Immunol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Identification of a new locus at 16q12 associated with time to asthma onset.</ArticleTitle>
<Pagination><MedlinePgn>1071-1080</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0091-6749(16)30016-1</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jaci.2016.03.018</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Asthma is a heterogeneous disease in which age of onset plays an important role.</AbstractText>
<AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">We sought to identify the genetic variants associated with time to asthma onset (TAO).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a large-scale meta-analysis of 9 genome-wide association studies of TAO (total of 5462 asthmatic patients with a broad range of age of asthma onset and 8424 control subjects of European ancestry) performed by using survival analysis techniques.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We detected 5 regions associated with TAO at the genome-wide significant level (P < 5 × 10(-8)). We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]). Conditional analyses identified 2 distinct signals at 9p24 (both upstream of IL33) and 17q12-q21 (near ZPBP2 and within GSDMA). Together, these 7 distinct loci explained 6.0% of the variance in TAO. In addition, we showed that genetic variants at 9p24 and 17q12-q21 were strongly associated with an earlier onset of childhood asthma (P ≤ .002), whereas the 16q12 single nucleotide polymorphism was associated with later asthma onset (P = .04). A high burden of disease risk alleles at these loci was associated with earlier age of asthma onset (4 vs 9-12 years, P = 10(-4)).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The new susceptibility region for TAO at 16q12 harbors variants that correlate with the expression of CYLD and nucleotide-binding oligomerization domain 2 (NOD2), 2 strong candidates for asthma. This study demonstrates that incorporating the variability of age of asthma onset in asthma modeling is a helpful approach in the search for disease susceptibility genes.</AbstractText>
<CopyrightInformation>Copyright © 2016 American Academy of Allergy, Asthma & Immunology. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sarnowski</LastName>
<ForeName>Chloé</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sugier</LastName>
<ForeName>Pierre-Emmanuel</ForeName>
<Initials>PE</Initials>
<AffiliationInfo><Affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</Affiliation>
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<Initials>R</Initials>
<AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Jarvis</LastName>
<ForeName>Debbie</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Respiratory Epidemiology, Occupational Medicine and Public Health, National Heart and Lung Institute, Imperial College, London, United Kingdom; MRC-PHE Centre for Environment & Health, London, United Kingdom.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Dizier</LastName>
<ForeName>Marie-Hélène</ForeName>
<Initials>MH</Initials>
<AffiliationInfo><Affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Ege</LastName>
<ForeName>Markus</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</Affiliation>
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<Author ValidYN="Y"><LastName>Imboden</LastName>
<ForeName>Medea</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laprise</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Khusnutdinova</LastName>
<ForeName>Elza K</ForeName>
<Initials>EK</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Freidin</LastName>
<ForeName>Maxim B</ForeName>
<Initials>MB</Initials>
<AffiliationInfo><Affiliation>Research Institute for Medical Genetics, Tomsk, Russia.</Affiliation>
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<Author ValidYN="Y"><LastName>Cookson</LastName>
<ForeName>William O C</ForeName>
<Initials>WOC</Initials>
<AffiliationInfo><Affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Moffatt</LastName>
<ForeName>Miriam</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>National Heart Lung Institute, Imperial College London, London, United Kingdom.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Lathrop</LastName>
<ForeName>Mark</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>McGill University and Génome Québec Innovation Centre, Montreal, Quebec, Canada.</Affiliation>
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<Author ValidYN="Y"><LastName>Siroux</LastName>
<ForeName>Valérie</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France.</Affiliation>
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<ForeName>Ludmila M</ForeName>
<Initials>LM</Initials>
<AffiliationInfo><Affiliation>Siberian State Medical University, Tomsk, Russia.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Karunas</LastName>
<ForeName>Alexandra S</ForeName>
<Initials>AS</Initials>
<AffiliationInfo><Affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Centre, Russian Academy of Sciences, Ufa, Russia; Department of Genetics and Fundamental Medicine, Bashkir State University, Ufa, Russia.</Affiliation>
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<Author ValidYN="Y"><LastName>James</LastName>
<ForeName>Alan</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Busselton Population Medical Research Institute, Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital, Nedlands, and the School of Population Health, University of Western Australia, Crawley, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Probst-Hensch</LastName>
<ForeName>Nicole M</ForeName>
<Initials>NM</Initials>
<AffiliationInfo><Affiliation>Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>von Mutius</LastName>
<ForeName>Erika</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Dr von Hauner Children's Hospital, Ludwig Maximilian University, Munich, Germany; Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research, Munich, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pin</LastName>
<ForeName>Isabelle</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Université Grenoble Alpes, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; Inserm, IAB, Team of Environmental Epidemiology applied to Reproduction and Respiratory Health, Grenoble, France; CHU de Grenoble, Pediatrics, Grenoble, France.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Kogevinas</LastName>
<ForeName>Manolis</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain.</Affiliation>
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</Author>
<Author ValidYN="Y"><LastName>Henderson</LastName>
<ForeName>A John</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom.</Affiliation>
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<Author ValidYN="Y"><LastName>Demenais</LastName>
<ForeName>Florence</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bouzigon</LastName>
<ForeName>Emmanuelle</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Inserm, UMR-946, Paris, France; Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, Paris, France. Electronic address: emmanuelle.bouzigon@inserm.fr.</Affiliation>
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<Language>eng</Language>
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<Agency>Wellcome Trust</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>G0401540</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>G9815508</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
<Grant><GrantID>MC_PC_15018</GrantID>
<Agency>Medical Research Council</Agency>
<Country>United Kingdom</Country>
</Grant>
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<PublicationType UI="D017418">Meta-Analysis</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>04</Month>
<Day>06</Day>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>J Allergy Clin Immunol</MedlineTA>
<NlmUniqueID>1275002</NlmUniqueID>
<ISSNLinking>0091-6749</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C409984">CYLD protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C429018">NOD2 protein, human</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D053473">Nod2 Signaling Adaptor Protein</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017668" MajorTopicYN="N">Age of Onset</DescriptorName>
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<MeshHeading><DescriptorName UI="D001249" MajorTopicYN="N">Asthma</DescriptorName>
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<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
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<MeshHeading><DescriptorName UI="D002885" MajorTopicYN="N">Chromosomes, Human, Pair 16</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
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<MeshHeading><DescriptorName UI="D044465" MajorTopicYN="N">European Continental Ancestry Group</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
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<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014644" MajorTopicYN="Y">Genetic Variation</DescriptorName>
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<MeshHeading><DescriptorName UI="D055106" MajorTopicYN="N">Genome-Wide Association Study</DescriptorName>
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<MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
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<MeshHeading><DescriptorName UI="D025521" MajorTopicYN="N">Tumor Suppressor Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Asthma</Keyword>
<Keyword MajorTopicYN="N">CYLD</Keyword>
<Keyword MajorTopicYN="N">NOD2</Keyword>
<Keyword MajorTopicYN="N">age of onset</Keyword>
<Keyword MajorTopicYN="N">conditional analysis</Keyword>
<Keyword MajorTopicYN="N">genetics</Keyword>
<Keyword MajorTopicYN="N">genome-wide association study</Keyword>
<Keyword MajorTopicYN="N">survival analysis</Keyword>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>08</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>02</Month>
<Day>05</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>03</Month>
<Day>16</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>5</Month>
<Day>1</Day>
<Hour>6</Hour>
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<Month>7</Month>
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<ArticleIdList><ArticleId IdType="pubmed">27130862</ArticleId>
<ArticleId IdType="pii">S0091-6749(16)30016-1</ArticleId>
<ArticleId IdType="doi">10.1016/j.jaci.2016.03.018</ArticleId>
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