Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A/C Mutation Carriers.
Identifieur interne : 001642 ( PubMed/Corpus ); précédent : 001641; suivant : 001643Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A/C Mutation Carriers.
Auteurs : Saurabh Kumar ; Samuel H. Baldinger ; Estelle Gandjbakhch ; Philippe Maury ; Jean-Marc Sellal ; Alexander F A. Androulakis ; Xavier Waintraub ; Philippe Charron ; Anne Rollin ; Pascale Richard ; William G. Stevenson ; Ciorsti J. Macintyre ; Carolyn Y. Ho ; Tina Thompson ; Jitendra K. Vohra ; Jonathan M. Kalman ; Katja Zeppenfeld ; Frederic Sacher ; Usha B. Tedrow ; Neal K. LakdawalaSource :
- Journal of the American College of Cardiology [ 1558-3597 ] ; 2016.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Arrhythmias, Cardiac (epidemiology), Arrhythmias, Cardiac (genetics), Arrhythmias, Cardiac (physiopathology), Female, Follow-Up Studies, France (epidemiology), Humans, Incidence, Lamin Type A (genetics), Lamin Type A (metabolism), Male, Middle Aged, Mutation, Netherlands (epidemiology), Prevalence, Prognosis, Retrospective Studies, Survival Rate (trends), Time Factors, Ventricular Function, Left (physiology), Victoria (epidemiology), Young Adult.
- MESH :
- chemical , genetics : Lamin Type A.
- epidemiology : Arrhythmias, Cardiac, France, Netherlands, Victoria.
- genetics : Arrhythmias, Cardiac.
- chemical , metabolism : Lamin Type A.
- physiology : Ventricular Function, Left.
- physiopathology : Arrhythmias, Cardiac.
- trends : Survival Rate.
- Adolescent, Adult, Aged, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Mutation, Prevalence, Prognosis, Retrospective Studies, Time Factors, Young Adult.
Abstract
Mutations in LMNA are variably expressed and may cause cardiomyopathy, atrioventricular block (AVB), or atrial arrhythmias (AAs) and ventricular arrhythmias (VA). Detailed natural history studies of LMNA-associated arrhythmic and nonarrhythmic outcomes are limited, and the prognostic significance of the index cardiac phenotype remains uncertain.
DOI: 10.1016/j.jacc.2016.08.058
PubMed: 27884249
Links to Exploration step
pubmed:27884249Le document en format XML
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Baldinger</name><affiliation><nlm:affiliation>Department of Cardiology, Inselspital, Bern University Hospital, Bern, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gandjbakhch, Estelle" sort="Gandjbakhch, Estelle" uniqKey="Gandjbakhch E" first="Estelle" last="Gandjbakhch">Estelle Gandjbakhch</name><affiliation><nlm:affiliation>Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux De Paris (AP-HP), Department of Cardiology, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Maury, Philippe" sort="Maury, Philippe" uniqKey="Maury P" first="Philippe" last="Maury">Philippe Maury</name><affiliation><nlm:affiliation>Toulouse University Hospital, Rangueil, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sellal, Jean Marc" sort="Sellal, Jean Marc" uniqKey="Sellal J" first="Jean-Marc" last="Sellal">Jean-Marc Sellal</name><affiliation><nlm:affiliation>Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac, France; L'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Bordeaux, France; Institut Hospitalo-Universitaire (IHU), Bordeaux, France; Centre Hospitalier Universitaire de Nancy, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Androulakis, Alexander F A" sort="Androulakis, Alexander F A" uniqKey="Androulakis A" first="Alexander F A" last="Androulakis">Alexander F A. Androulakis</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Waintraub, Xavier" sort="Waintraub, Xavier" uniqKey="Waintraub X" first="Xavier" last="Waintraub">Xavier Waintraub</name><affiliation><nlm:affiliation>Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux De Paris (AP-HP), Department of Cardiology, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Charron, Philippe" sort="Charron, Philippe" uniqKey="Charron P" first="Philippe" last="Charron">Philippe Charron</name><affiliation><nlm:affiliation>Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux De Paris (AP-HP), Department of Cardiology, Paris, France; Centre de Référence Maladies Cardiaques Héréditaires, Institute for Cardiometabolism and Nutrition (ICAN), Paris, France; Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rollin, Anne" sort="Rollin, Anne" uniqKey="Rollin A" first="Anne" last="Rollin">Anne Rollin</name><affiliation><nlm:affiliation>Toulouse University Hospital, Rangueil, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Richard, Pascale" sort="Richard, Pascale" uniqKey="Richard P" first="Pascale" last="Richard">Pascale Richard</name><affiliation><nlm:affiliation>Cardiomyogenetics, Department of Biochemistry and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Stevenson, William G" sort="Stevenson, William G" uniqKey="Stevenson W" first="William G" last="Stevenson">William G. Stevenson</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Macintyre, Ciorsti J" sort="Macintyre, Ciorsti J" uniqKey="Macintyre C" first="Ciorsti J" last="Macintyre">Ciorsti J. Macintyre</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Ho, Carolyn Y" sort="Ho, Carolyn Y" uniqKey="Ho C" first="Carolyn Y" last="Ho">Carolyn Y. Ho</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Thompson, Tina" sort="Thompson, Tina" uniqKey="Thompson T" first="Tina" last="Thompson">Tina Thompson</name><affiliation><nlm:affiliation>Department of Genetic Medicine, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vohra, Jitendra K" sort="Vohra, Jitendra K" uniqKey="Vohra J" first="Jitendra K" last="Vohra">Jitendra K. Vohra</name><affiliation><nlm:affiliation>Department of Cardiology, Division of Medicine, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kalman, Jonathan M" sort="Kalman, Jonathan M" uniqKey="Kalman J" first="Jonathan M" last="Kalman">Jonathan M. Kalman</name><affiliation><nlm:affiliation>Department of Cardiology, Division of Medicine, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Zeppenfeld, Katja" sort="Zeppenfeld, Katja" uniqKey="Zeppenfeld K" first="Katja" last="Zeppenfeld">Katja Zeppenfeld</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sacher, Frederic" sort="Sacher, Frederic" uniqKey="Sacher F" first="Frederic" last="Sacher">Frederic Sacher</name><affiliation><nlm:affiliation>Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac, France; L'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Bordeaux, France; Institut Hospitalo-Universitaire (IHU), Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tedrow, Usha B" sort="Tedrow, Usha B" uniqKey="Tedrow U" first="Usha B" last="Tedrow">Usha B. Tedrow</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Lakdawala, Neal K" sort="Lakdawala, Neal K" uniqKey="Lakdawala N" first="Neal K" last="Lakdawala">Neal K. Lakdawala</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: nlakdawala@partners.org.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27884249</idno><idno type="pmid">27884249</idno><idno type="doi">10.1016/j.jacc.2016.08.058</idno><idno type="wicri:Area/PubMed/Corpus">001642</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001642</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A/C Mutation Carriers.</title><author><name sortKey="Kumar, Saurabh" sort="Kumar, Saurabh" uniqKey="Kumar S" first="Saurabh" last="Kumar">Saurabh Kumar</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Baldinger, Samuel H" sort="Baldinger, Samuel H" uniqKey="Baldinger S" first="Samuel H" last="Baldinger">Samuel H. Baldinger</name><affiliation><nlm:affiliation>Department of Cardiology, Inselspital, Bern University Hospital, Bern, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Gandjbakhch, Estelle" sort="Gandjbakhch, Estelle" uniqKey="Gandjbakhch E" first="Estelle" last="Gandjbakhch">Estelle Gandjbakhch</name><affiliation><nlm:affiliation>Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux De Paris (AP-HP), Department of Cardiology, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Maury, Philippe" sort="Maury, Philippe" uniqKey="Maury P" first="Philippe" last="Maury">Philippe Maury</name><affiliation><nlm:affiliation>Toulouse University Hospital, Rangueil, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sellal, Jean Marc" sort="Sellal, Jean Marc" uniqKey="Sellal J" first="Jean-Marc" last="Sellal">Jean-Marc Sellal</name><affiliation><nlm:affiliation>Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac, France; L'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Bordeaux, France; Institut Hospitalo-Universitaire (IHU), Bordeaux, France; Centre Hospitalier Universitaire de Nancy, Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Androulakis, Alexander F A" sort="Androulakis, Alexander F A" uniqKey="Androulakis A" first="Alexander F A" last="Androulakis">Alexander F A. Androulakis</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Waintraub, Xavier" sort="Waintraub, Xavier" uniqKey="Waintraub X" first="Xavier" last="Waintraub">Xavier Waintraub</name><affiliation><nlm:affiliation>Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux De Paris (AP-HP), Department of Cardiology, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Charron, Philippe" sort="Charron, Philippe" uniqKey="Charron P" first="Philippe" last="Charron">Philippe Charron</name><affiliation><nlm:affiliation>Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux De Paris (AP-HP), Department of Cardiology, Paris, France; Centre de Référence Maladies Cardiaques Héréditaires, Institute for Cardiometabolism and Nutrition (ICAN), Paris, France; Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France.</nlm:affiliation></affiliation></author><author><name sortKey="Rollin, Anne" sort="Rollin, Anne" uniqKey="Rollin A" first="Anne" last="Rollin">Anne Rollin</name><affiliation><nlm:affiliation>Toulouse University Hospital, Rangueil, Toulouse, France.</nlm:affiliation></affiliation></author><author><name sortKey="Richard, Pascale" sort="Richard, Pascale" uniqKey="Richard P" first="Pascale" last="Richard">Pascale Richard</name><affiliation><nlm:affiliation>Cardiomyogenetics, Department of Biochemistry and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Stevenson, William G" sort="Stevenson, William G" uniqKey="Stevenson W" first="William G" last="Stevenson">William G. Stevenson</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Macintyre, Ciorsti J" sort="Macintyre, Ciorsti J" uniqKey="Macintyre C" first="Ciorsti J" last="Macintyre">Ciorsti J. Macintyre</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Ho, Carolyn Y" sort="Ho, Carolyn Y" uniqKey="Ho C" first="Carolyn Y" last="Ho">Carolyn Y. Ho</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Thompson, Tina" sort="Thompson, Tina" uniqKey="Thompson T" first="Tina" last="Thompson">Tina Thompson</name><affiliation><nlm:affiliation>Department of Genetic Medicine, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vohra, Jitendra K" sort="Vohra, Jitendra K" uniqKey="Vohra J" first="Jitendra K" last="Vohra">Jitendra K. Vohra</name><affiliation><nlm:affiliation>Department of Cardiology, Division of Medicine, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Kalman, Jonathan M" sort="Kalman, Jonathan M" uniqKey="Kalman J" first="Jonathan M" last="Kalman">Jonathan M. Kalman</name><affiliation><nlm:affiliation>Department of Cardiology, Division of Medicine, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Victoria, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Zeppenfeld, Katja" sort="Zeppenfeld, Katja" uniqKey="Zeppenfeld K" first="Katja" last="Zeppenfeld">Katja Zeppenfeld</name><affiliation><nlm:affiliation>Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Sacher, Frederic" sort="Sacher, Frederic" uniqKey="Sacher F" first="Frederic" last="Sacher">Frederic Sacher</name><affiliation><nlm:affiliation>Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac, France; L'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Bordeaux, France; Institut Hospitalo-Universitaire (IHU), Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tedrow, Usha B" sort="Tedrow, Usha B" uniqKey="Tedrow U" first="Usha B" last="Tedrow">Usha B. Tedrow</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</nlm:affiliation></affiliation></author><author><name sortKey="Lakdawala, Neal K" sort="Lakdawala, Neal K" uniqKey="Lakdawala N" first="Neal K" last="Lakdawala">Neal K. Lakdawala</name><affiliation><nlm:affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: nlakdawala@partners.org.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of the American College of Cardiology</title><idno type="eISSN">1558-3597</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Arrhythmias, Cardiac (epidemiology)</term><term>Arrhythmias, Cardiac (genetics)</term><term>Arrhythmias, Cardiac (physiopathology)</term><term>Female</term><term>Follow-Up Studies</term><term>France (epidemiology)</term><term>Humans</term><term>Incidence</term><term>Lamin Type A (genetics)</term><term>Lamin Type A (metabolism)</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Netherlands (epidemiology)</term><term>Prevalence</term><term>Prognosis</term><term>Retrospective Studies</term><term>Survival Rate (trends)</term><term>Time Factors</term><term>Ventricular Function, Left (physiology)</term><term>Victoria (epidemiology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Lamin Type A</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Arrhythmias, Cardiac</term><term>France</term><term>Netherlands</term><term>Victoria</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arrhythmias, Cardiac</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lamin Type A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Ventricular Function, Left</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arrhythmias, Cardiac</term></keywords><keywords scheme="MESH" qualifier="trends" xml:lang="en"><term>Survival Rate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Incidence</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Prevalence</term><term>Prognosis</term><term>Retrospective Studies</term><term>Time Factors</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mutations in LMNA are variably expressed and may cause cardiomyopathy, atrioventricular block (AVB), or atrial arrhythmias (AAs) and ventricular arrhythmias (VA). Detailed natural history studies of LMNA-associated arrhythmic and nonarrhythmic outcomes are limited, and the prognostic significance of the index cardiac phenotype remains uncertain.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27884249</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>25</Day></DateCreated><DateCompleted><Year>2017</Year><Month>06</Month><Day>30</Day></DateCompleted><DateRevised><Year>2017</Year><Month>06</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1558-3597</ISSN><JournalIssue CitedMedium="Internet"><Volume>68</Volume><Issue>21</Issue><PubDate><Year>2016</Year><Month>Nov</Month><Day>29</Day></PubDate></JournalIssue><Title>Journal of the American College of Cardiology</Title><ISOAbbreviation>J. Am. Coll. Cardiol.</ISOAbbreviation></Journal><ArticleTitle>Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A/C Mutation Carriers.</ArticleTitle><Pagination><MedlinePgn>2299-2307</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0735-1097(16)36236-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jacc.2016.08.058</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Mutations in LMNA are variably expressed and may cause cardiomyopathy, atrioventricular block (AVB), or atrial arrhythmias (AAs) and ventricular arrhythmias (VA). Detailed natural history studies of LMNA-associated arrhythmic and nonarrhythmic outcomes are limited, and the prognostic significance of the index cardiac phenotype remains uncertain.</AbstractText><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">This study sought to describe the arrhythmic and nonarrhythmic outcomes of LMNA mutation carriers and to assess the prognostic significance of the index cardiac phenotype.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The incidence of AVB, AA, sustained VA, left ventricular systolic dysfunction (LVD) (= left ventricular ejection fraction ≤50%), and end-stage heart failure (HF) was retrospectively determined in 122 consecutive LMNA mutation carriers followed at 5 referral centers for a median of 7 years from first clinical contact. Predictors of VA and end-stage HF or death were determined.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The prevalence of clinical manifestations increased broadly from index evaluation to median follow-up: AVB, 46% to 57%; AA, 39% to 63%; VA, 16% to 34%; and LVD, 44% to 57%. Implantable cardioverter-defibrillators were placed in 59% of patients for new LVD or AVB. End-stage HF developed in 19% of patients, and 13% died. In patients without LVD at presentation, 24% developed new LVD, and 7% developed end-stage HF. Male sex (p = 0.01), nonmissense mutations (p = 0.03), and LVD at index evaluation (p = 0.004) were associated with development of VA, whereas LVD was associated with end-stage HF or death (p < 0.001). Mode of presentation (with isolated or combination of clinical features) did not predict sustained VA or end-stage HF or death.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">LMNA-related heart disease was associated with a high incidence of phenotypic progression and adverse arrhythmic and nonarrhythmic events over long-term follow-up. The index cardiac phenotype did not predict adverse events. Genetic diagnosis and subsequent follow-up, including anticipatory planning for therapies to prevent sudden death and manage HF, is warranted.</AbstractText><CopyrightInformation>Copyright © 2016 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Saurabh</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baldinger</LastName><ForeName>Samuel H</ForeName><Initials>SH</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Inselspital, Bern University Hospital, Bern, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gandjbakhch</LastName><ForeName>Estelle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux De Paris (AP-HP), Department of Cardiology, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maury</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Toulouse University Hospital, Rangueil, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sellal</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac, France; L'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Bordeaux, France; Institut Hospitalo-Universitaire (IHU), Bordeaux, France; Centre Hospitalier Universitaire de Nancy, Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Androulakis</LastName><ForeName>Alexander F A</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Waintraub</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux De Paris (AP-HP), Department of Cardiology, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Charron</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Hôpital Pitié-Salpêtrière, Assistance Publique Hôpitaux De Paris (AP-HP), Department of Cardiology, Paris, France; Centre de Référence Maladies Cardiaques Héréditaires, Institute for Cardiometabolism and Nutrition (ICAN), Paris, France; Université de Versailles-Saint Quentin, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rollin</LastName><ForeName>Anne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Toulouse University Hospital, Rangueil, Toulouse, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Richard</LastName><ForeName>Pascale</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Cardiomyogenetics, Department of Biochemistry and INSERM U582, University Hospital Pitié-Salpêtrière, AP-HP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stevenson</LastName><ForeName>William G</ForeName><Initials>WG</Initials><AffiliationInfo><Affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Macintyre</LastName><ForeName>Ciorsti J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ho</LastName><ForeName>Carolyn Y</ForeName><Initials>CY</Initials><AffiliationInfo><Affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>Tina</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Genetic Medicine, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vohra</LastName><ForeName>Jitendra K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Division of Medicine, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kalman</LastName><ForeName>Jonathan M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Division of Medicine, The Royal Melbourne Hospital and University of Melbourne, Melbourne, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeppenfeld</LastName><ForeName>Katja</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sacher</LastName><ForeName>Frederic</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Hôpital Cardiologique du Haut-Lévêque (CHU), Bordeaux-Pessac, France; L'Institut de Rythmologie et Modélisation Cardiaque (LIRYC), Bordeaux, France; Institut Hospitalo-Universitaire (IHU), Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tedrow</LastName><ForeName>Usha B</ForeName><Initials>UB</Initials><AffiliationInfo><Affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lakdawala</LastName><ForeName>Neal K</ForeName><Initials>NK</Initials><AffiliationInfo><Affiliation>Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address: nlakdawala@partners.org.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Am Coll Cardiol</MedlineTA><NlmUniqueID>8301365</NlmUniqueID><ISSNLinking>0735-1097</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D034904">Lamin Type A</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001145" MajorTopicYN="N">Arrhythmias, Cardiac</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N">France</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D034904" MajorTopicYN="N">Lamin Type A</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="Y">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009426" MajorTopicYN="N">Netherlands</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015995" MajorTopicYN="N">Prevalence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015996" MajorTopicYN="N">Survival Rate</DescriptorName><QualifierName UI="Q000639" MajorTopicYN="N">trends</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016277" MajorTopicYN="N">Ventricular Function, Left</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014739" MajorTopicYN="N">Victoria</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">atrial fibrillation</Keyword><Keyword MajorTopicYN="N">cardiomyopathy</Keyword><Keyword MajorTopicYN="N">complete atrioventricular block</Keyword><Keyword MajorTopicYN="N">genetics</Keyword><Keyword MajorTopicYN="N">heart failure</Keyword><Keyword MajorTopicYN="N">ventricular tachycardia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>06</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>08</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>08</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>7</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27884249</ArticleId><ArticleId IdType="pii">S0735-1097(16)36236-2</ArticleId><ArticleId IdType="doi">10.1016/j.jacc.2016.08.058</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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