Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.
Identifieur interne : 001575 ( PubMed/Corpus ); précédent : 001574; suivant : 001576Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.
Auteurs : Daniel Y. Bargieri ; Sabine Thiberge ; Chwen L. Tay ; Alison F. Carey ; Alice Rantz ; Florian Hischen ; Audrey Lorthiois ; Ursula Straschil ; Pallavi Singh ; Shailja Singh ; Tony Triglia ; Takafumi Tsuboi ; Alan Cowman ; Chetan Chitnis ; Pietro Alano ; Jake Baum ; Gabriele Pradel ; Catherine Lavazec ; Robert MénardSource :
- Cell host & microbe [ 1934-6069 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Protozoan Proteins.
- metabolism : Membranes.
- parasitology : Erythrocytes, Vacuoles.
- physiology : Merozoites, Plasmodium berghei, Plasmodium falciparum.
- Animals, Culicidae, Exocytosis, Humans, Mice.
Abstract
Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play an integral role in parasite motility and cell invasion by linking the extracellular environment with the parasite submembrane actomyosin motor. Blood stage forms of the malaria parasite Plasmodium express a TRAP family protein called merozoite-TRAP (MTRAP) that has been implicated in erythrocyte invasion. Using MTRAP-deficient mutants of the rodent-infecting P. berghei and human-infecting P. falciparum parasites, we show that MTRAP is dispensable for erythrocyte invasion. Instead, MTRAP is essential for gamete egress from erythrocytes, where it is necessary for the disruption of the gamete-containing parasitophorous vacuole membrane, and thus for parasite transmission to mosquitoes. This indicates that motor-binding TRAP family members function not just in parasite motility and cell invasion but also in membrane disruption and cell egress.
DOI: 10.1016/j.chom.2016.10.015
PubMed: 27832590
Links to Exploration step
pubmed:27832590Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.</title><author><name sortKey="Bargieri, Daniel Y" sort="Bargieri, Daniel Y" uniqKey="Bargieri D" first="Daniel Y" last="Bargieri">Daniel Y. Bargieri</name><affiliation><nlm:affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France; Department of Parasitology, University of São Paulo-USP, São Paulo 05508-000, SP, Brazil. Electronic address: danielbargieri@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Thiberge, Sabine" sort="Thiberge, Sabine" uniqKey="Thiberge S" first="Sabine" last="Thiberge">Sabine Thiberge</name><affiliation><nlm:affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tay, Chwen L" sort="Tay, Chwen L" uniqKey="Tay C" first="Chwen L" last="Tay">Chwen L. Tay</name><affiliation><nlm:affiliation>Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Carey, Alison F" sort="Carey, Alison F" uniqKey="Carey A" first="Alison F" last="Carey">Alison F. Carey</name><affiliation><nlm:affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rantz, Alice" sort="Rantz, Alice" uniqKey="Rantz A" first="Alice" last="Rantz">Alice Rantz</name><affiliation><nlm:affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hischen, Florian" sort="Hischen, Florian" uniqKey="Hischen F" first="Florian" last="Hischen">Florian Hischen</name><affiliation><nlm:affiliation>Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen 52074, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lorthiois, Audrey" sort="Lorthiois, Audrey" uniqKey="Lorthiois A" first="Audrey" last="Lorthiois">Audrey Lorthiois</name><affiliation><nlm:affiliation>Inserm U1016, CNRS UMR 8104, Université Paris Descartes, Institut Cochin, Paris 75014, France.</nlm:affiliation></affiliation></author><author><name sortKey="Straschil, Ursula" sort="Straschil, Ursula" uniqKey="Straschil U" first="Ursula" last="Straschil">Ursula Straschil</name><affiliation><nlm:affiliation>Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Singh, Pallavi" sort="Singh, Pallavi" uniqKey="Singh P" first="Pallavi" last="Singh">Pallavi Singh</name><affiliation><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author><author><name sortKey="Singh, Shailja" sort="Singh, Shailja" uniqKey="Singh S" first="Shailja" last="Singh">Shailja Singh</name><affiliation><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author><author><name sortKey="Triglia, Tony" sort="Triglia, Tony" uniqKey="Triglia T" first="Tony" last="Triglia">Tony Triglia</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tsuboi, Takafumi" sort="Tsuboi, Takafumi" uniqKey="Tsuboi T" first="Takafumi" last="Tsuboi">Takafumi Tsuboi</name><affiliation><nlm:affiliation>Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime 790-8577, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Cowman, Alan" sort="Cowman, Alan" uniqKey="Cowman A" first="Alan" last="Cowman">Alan Cowman</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville 3052, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name><affiliation><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author><author><name sortKey="Alano, Pietro" sort="Alano, Pietro" uniqKey="Alano P" first="Pietro" last="Alano">Pietro Alano</name><affiliation><nlm:affiliation>Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Rome 00161, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Baum, Jake" sort="Baum, Jake" uniqKey="Baum J" first="Jake" last="Baum">Jake Baum</name><affiliation><nlm:affiliation>Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pradel, Gabriele" sort="Pradel, Gabriele" uniqKey="Pradel G" first="Gabriele" last="Pradel">Gabriele Pradel</name><affiliation><nlm:affiliation>Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen 52074, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lavazec, Catherine" sort="Lavazec, Catherine" uniqKey="Lavazec C" first="Catherine" last="Lavazec">Catherine Lavazec</name><affiliation><nlm:affiliation>Inserm U1016, CNRS UMR 8104, Université Paris Descartes, Institut Cochin, Paris 75014, France.</nlm:affiliation></affiliation></author><author><name sortKey="Menard, Robert" sort="Menard, Robert" uniqKey="Menard R" first="Robert" last="Ménard">Robert Ménard</name><affiliation><nlm:affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27832590</idno><idno type="pmid">27832590</idno><idno type="doi">10.1016/j.chom.2016.10.015</idno><idno type="wicri:Area/PubMed/Corpus">001575</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001575</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.</title><author><name sortKey="Bargieri, Daniel Y" sort="Bargieri, Daniel Y" uniqKey="Bargieri D" first="Daniel Y" last="Bargieri">Daniel Y. Bargieri</name><affiliation><nlm:affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France; Department of Parasitology, University of São Paulo-USP, São Paulo 05508-000, SP, Brazil. Electronic address: danielbargieri@gmail.com.</nlm:affiliation></affiliation></author><author><name sortKey="Thiberge, Sabine" sort="Thiberge, Sabine" uniqKey="Thiberge S" first="Sabine" last="Thiberge">Sabine Thiberge</name><affiliation><nlm:affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author><author><name sortKey="Tay, Chwen L" sort="Tay, Chwen L" uniqKey="Tay C" first="Chwen L" last="Tay">Chwen L. Tay</name><affiliation><nlm:affiliation>Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Carey, Alison F" sort="Carey, Alison F" uniqKey="Carey A" first="Alison F" last="Carey">Alison F. Carey</name><affiliation><nlm:affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Rantz, Alice" sort="Rantz, Alice" uniqKey="Rantz A" first="Alice" last="Rantz">Alice Rantz</name><affiliation><nlm:affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author><author><name sortKey="Hischen, Florian" sort="Hischen, Florian" uniqKey="Hischen F" first="Florian" last="Hischen">Florian Hischen</name><affiliation><nlm:affiliation>Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen 52074, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lorthiois, Audrey" sort="Lorthiois, Audrey" uniqKey="Lorthiois A" first="Audrey" last="Lorthiois">Audrey Lorthiois</name><affiliation><nlm:affiliation>Inserm U1016, CNRS UMR 8104, Université Paris Descartes, Institut Cochin, Paris 75014, France.</nlm:affiliation></affiliation></author><author><name sortKey="Straschil, Ursula" sort="Straschil, Ursula" uniqKey="Straschil U" first="Ursula" last="Straschil">Ursula Straschil</name><affiliation><nlm:affiliation>Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Singh, Pallavi" sort="Singh, Pallavi" uniqKey="Singh P" first="Pallavi" last="Singh">Pallavi Singh</name><affiliation><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author><author><name sortKey="Singh, Shailja" sort="Singh, Shailja" uniqKey="Singh S" first="Shailja" last="Singh">Shailja Singh</name><affiliation><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author><author><name sortKey="Triglia, Tony" sort="Triglia, Tony" uniqKey="Triglia T" first="Tony" last="Triglia">Tony Triglia</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tsuboi, Takafumi" sort="Tsuboi, Takafumi" uniqKey="Tsuboi T" first="Takafumi" last="Tsuboi">Takafumi Tsuboi</name><affiliation><nlm:affiliation>Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime 790-8577, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Cowman, Alan" sort="Cowman, Alan" uniqKey="Cowman A" first="Alan" last="Cowman">Alan Cowman</name><affiliation><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville 3052, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Chitnis, Chetan" sort="Chitnis, Chetan" uniqKey="Chitnis C" first="Chetan" last="Chitnis">Chetan Chitnis</name><affiliation><nlm:affiliation>Malaria Parasite Biology and Vaccines Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author><author><name sortKey="Alano, Pietro" sort="Alano, Pietro" uniqKey="Alano P" first="Pietro" last="Alano">Pietro Alano</name><affiliation><nlm:affiliation>Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Rome 00161, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Baum, Jake" sort="Baum, Jake" uniqKey="Baum J" first="Jake" last="Baum">Jake Baum</name><affiliation><nlm:affiliation>Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pradel, Gabriele" sort="Pradel, Gabriele" uniqKey="Pradel G" first="Gabriele" last="Pradel">Gabriele Pradel</name><affiliation><nlm:affiliation>Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen 52074, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lavazec, Catherine" sort="Lavazec, Catherine" uniqKey="Lavazec C" first="Catherine" last="Lavazec">Catherine Lavazec</name><affiliation><nlm:affiliation>Inserm U1016, CNRS UMR 8104, Université Paris Descartes, Institut Cochin, Paris 75014, France.</nlm:affiliation></affiliation></author><author><name sortKey="Menard, Robert" sort="Menard, Robert" uniqKey="Menard R" first="Robert" last="Ménard">Robert Ménard</name><affiliation><nlm:affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cell host & microbe</title><idno type="eISSN">1934-6069</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Culicidae</term><term>Erythrocytes (parasitology)</term><term>Exocytosis</term><term>Humans</term><term>Membranes (metabolism)</term><term>Merozoites (physiology)</term><term>Mice</term><term>Plasmodium berghei (physiology)</term><term>Plasmodium falciparum (physiology)</term><term>Protozoan Proteins (metabolism)</term><term>Vacuoles (parasitology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Protozoan Proteins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Membranes</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Erythrocytes</term><term>Vacuoles</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Merozoites</term><term>Plasmodium berghei</term><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Culicidae</term><term>Exocytosis</term><term>Humans</term><term>Mice</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play an integral role in parasite motility and cell invasion by linking the extracellular environment with the parasite submembrane actomyosin motor. Blood stage forms of the malaria parasite Plasmodium express a TRAP family protein called merozoite-TRAP (MTRAP) that has been implicated in erythrocyte invasion. Using MTRAP-deficient mutants of the rodent-infecting P. berghei and human-infecting P. falciparum parasites, we show that MTRAP is dispensable for erythrocyte invasion. Instead, MTRAP is essential for gamete egress from erythrocytes, where it is necessary for the disruption of the gamete-containing parasitophorous vacuole membrane, and thus for parasite transmission to mosquitoes. This indicates that motor-binding TRAP family members function not just in parasite motility and cell invasion but also in membrane disruption and cell egress.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27832590</PMID><DateCreated><Year>2016</Year><Month>11</Month><Day>10</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>06</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1934-6069</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>5</Issue><PubDate><Year>2016</Year><Month>Nov</Month><Day>09</Day></PubDate></JournalIssue><Title>Cell host & microbe</Title><ISOAbbreviation>Cell Host Microbe</ISOAbbreviation></Journal><ArticleTitle>Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes.</ArticleTitle><Pagination><MedlinePgn>618-630</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1931-3128(16)30441-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.chom.2016.10.015</ELocationID><Abstract><AbstractText>Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites. TRAP proteins are thought to play an integral role in parasite motility and cell invasion by linking the extracellular environment with the parasite submembrane actomyosin motor. Blood stage forms of the malaria parasite Plasmodium express a TRAP family protein called merozoite-TRAP (MTRAP) that has been implicated in erythrocyte invasion. Using MTRAP-deficient mutants of the rodent-infecting P. berghei and human-infecting P. falciparum parasites, we show that MTRAP is dispensable for erythrocyte invasion. Instead, MTRAP is essential for gamete egress from erythrocytes, where it is necessary for the disruption of the gamete-containing parasitophorous vacuole membrane, and thus for parasite transmission to mosquitoes. This indicates that motor-binding TRAP family members function not just in parasite motility and cell invasion but also in membrane disruption and cell egress.</AbstractText><CopyrightInformation>Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bargieri</LastName><ForeName>Daniel Y</ForeName><Initials>DY</Initials><AffiliationInfo><Affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France; Department of Parasitology, University of São Paulo-USP, São Paulo 05508-000, SP, Brazil. Electronic address: danielbargieri@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thiberge</LastName><ForeName>Sabine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tay</LastName><ForeName>Chwen L</ForeName><Initials>CL</Initials><AffiliationInfo><Affiliation>Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carey</LastName><ForeName>Alison F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France; Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rantz</LastName><ForeName>Alice</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hischen</LastName><ForeName>Florian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen 52074, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lorthiois</LastName><ForeName>Audrey</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Inserm U1016, CNRS UMR 8104, Université Paris Descartes, Institut Cochin, Paris 75014, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Straschil</LastName><ForeName>Ursula</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Pallavi</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Malaria Parasite Biology and Vaccines Unit, Pasteur Institute, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Shailja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Malaria Parasite Biology and Vaccines Unit, Pasteur Institute, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Triglia</LastName><ForeName>Tony</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsuboi</LastName><ForeName>Takafumi</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Ehime 790-8577, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cowman</LastName><ForeName>Alan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, VIC, Australia; Department of Medical Biology, University of Melbourne, Parkville 3052, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chitnis</LastName><ForeName>Chetan</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Malaria Parasite Biology and Vaccines Unit, Pasteur Institute, Paris 75015, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Alano</LastName><ForeName>Pietro</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanità, Rome 00161, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baum</LastName><ForeName>Jake</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Life Sciences, Imperial College London, South Kensington, London SW7 2AZ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pradel</LastName><ForeName>Gabriele</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Division of Cellular and Applied Infection Biology, Institute of Zoology, RWTH Aachen University, Aachen 52074, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lavazec</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Inserm U1016, CNRS UMR 8104, Université Paris Descartes, Institut Cochin, Paris 75014, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ménard</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Malaria Biology and Genetics Unit, Pasteur Institute, Paris 75015, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Host Microbe</MedlineTA><NlmUniqueID>101302316</NlmUniqueID><ISSNLinking>1931-3128</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015800">Protozoan Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Int J Parasitol. 2004 Aug;34(9):991-6</RefSource><PMID Version="1">15313126</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Cell. 2004 May 14;117(4):503-14</RefSource><PMID Version="1">15137943</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Cell Sci. 2012 Apr 15;125(Pt 8):2053-63</RefSource><PMID 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PubStatus="received"><Year>2016</Year><Month>05</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>09</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>10</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>11</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>11</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27832590</ArticleId><ArticleId IdType="pii">S1931-3128(16)30441-3</ArticleId><ArticleId IdType="doi">10.1016/j.chom.2016.10.015</ArticleId><ArticleId 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