Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism.
Identifieur interne : 001447 ( PubMed/Corpus ); précédent : 001446; suivant : 001448Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism.
Auteurs : Blake J. Cochran ; Liming Hou ; Anil Paul Chirackal Manavalan ; Benjamin M. Moore ; Fatiha Tabet ; Afroza Sultana ; Luisa Cuesta Torres ; Shudi Tang ; Sudichhya Shrestha ; Praween Senanayake ; Mili Patel ; William J. Ryder ; Andre Bongers ; Marie Maraninchi ; Valerie C. Wasinger ; Marit Westerterp ; Alan R. Tall ; Philip J. Barter ; Kerry-Anne RyeSource :
- Diabetes [ 1939-327X ] ; 2016.
English descriptors
- KwdEn :
- ATP Binding Cassette Transporter 1 (deficiency), ATP Binding Cassette Transporter 1 (metabolism), ATP Binding Cassette Transporter, Sub-Family G, Member 1 (deficiency), ATP Binding Cassette Transporter, Sub-Family G, Member 1 (metabolism), Adipose Tissue (metabolism), Animals, Blotting, Western, Cholesterol (metabolism), Fatty Acid Synthases, Glucose (metabolism), Glycogen (metabolism), Homeostasis (genetics), Homeostasis (physiology), Insulin (metabolism), Insulin-Secreting Cells (metabolism), Lactic Acid (blood), Magnetic Resonance Imaging, Mass Spectrometry, Mice, Mice, Knockout, Muscle, Skeletal (metabolism), Polymerase Chain Reaction.
- MESH :
- chemical , blood : Lactic Acid.
- chemical , deficiency : ATP Binding Cassette Transporter 1, ATP Binding Cassette Transporter, Sub-Family G, Member 1.
- chemical , metabolism : ATP Binding Cassette Transporter 1, ATP Binding Cassette Transporter, Sub-Family G, Member 1, Cholesterol, Glucose, Glycogen, Insulin.
- genetics : Homeostasis.
- metabolism : Adipose Tissue, Insulin-Secreting Cells, Muscle, Skeletal.
- physiology : Homeostasis.
- Animals, Blotting, Western, Fatty Acid Synthases, Magnetic Resonance Imaging, Mass Spectrometry, Mice, Mice, Knockout, Polymerase Chain Reaction.
Abstract
Elevated pancreatic β-cell cholesterol levels impair insulin secretion and reduce plasma insulin levels. This study establishes that low plasma insulin levels have a detrimental effect on two major insulin target tissues: adipose tissue and skeletal muscle. Mice with increased β-cell cholesterol levels were generated by conditional deletion of the ATP-binding cassette transporters, ABCA1 and ABCG1, in β-cells (β-DKO mice). Insulin secretion was impaired in these mice under basal and high-glucose conditions, and glucose disposal was shifted from skeletal muscle to adipose tissue. The β-DKO mice also had increased body fat and adipose tissue macrophage content, elevated plasma interleukin-6 and MCP-1 levels, and decreased skeletal muscle mass. They were not, however, insulin resistant. The adipose tissue expansion and reduced skeletal muscle mass, but not the systemic inflammation or increased adipose tissue macrophage content, were reversed when plasma insulin levels were normalized by insulin supplementation. These studies identify a mechanism by which perturbation of β-cell cholesterol homeostasis and impaired insulin secretion increase adiposity, reduce skeletal muscle mass, and cause systemic inflammation. They further identify β-cell dysfunction as a potential therapeutic target in people at increased risk of developing type 2 diabetes.
DOI: 10.2337/db16-0668
PubMed: 27702832
Links to Exploration step
pubmed:27702832Le document en format XML
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Cochran</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hou, Liming" sort="Hou, Liming" uniqKey="Hou L" first="Liming" last="Hou">Liming Hou</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Manavalan, Anil Paul Chirackal" sort="Manavalan, Anil Paul Chirackal" uniqKey="Manavalan A" first="Anil Paul Chirackal" last="Manavalan">Anil Paul Chirackal Manavalan</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Moore, Benjamin M" sort="Moore, Benjamin M" uniqKey="Moore B" first="Benjamin M" last="Moore">Benjamin M. 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Ryder</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bongers, Andre" sort="Bongers, Andre" uniqKey="Bongers A" first="Andre" last="Bongers">Andre Bongers</name><affiliation><nlm:affiliation>Biological Resource Imaging Laboratory, Mark Wainwright Analytical Centre, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Maraninchi, Marie" sort="Maraninchi, Marie" uniqKey="Maraninchi M" first="Marie" last="Maraninchi">Marie Maraninchi</name><affiliation><nlm:affiliation>Aix-Marseille Université, UMR_S1062, UMR_A1260, Nutrition, Obésité et Risque Thrombotique, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wasinger, Valerie C" sort="Wasinger, Valerie C" uniqKey="Wasinger V" first="Valerie C" last="Wasinger">Valerie C. Wasinger</name><affiliation><nlm:affiliation>Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Westerterp, Marit" sort="Westerterp, Marit" uniqKey="Westerterp M" first="Marit" last="Westerterp">Marit Westerterp</name><affiliation><nlm:affiliation>Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Tall, Alan R" sort="Tall, Alan R" uniqKey="Tall A" first="Alan R" last="Tall">Alan R. Tall</name><affiliation><nlm:affiliation>Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J" last="Barter">Philip J. Barter</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia k.rye@unsw.edu.au karye@ozemail.com.au.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27702832</idno><idno type="pmid">27702832</idno><idno type="doi">10.2337/db16-0668</idno><idno type="wicri:Area/PubMed/Corpus">001447</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001447</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism.</title><author><name sortKey="Cochran, Blake J" sort="Cochran, Blake J" uniqKey="Cochran B" first="Blake J" last="Cochran">Blake J. Cochran</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Hou, Liming" sort="Hou, Liming" uniqKey="Hou L" first="Liming" last="Hou">Liming Hou</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Manavalan, Anil Paul Chirackal" sort="Manavalan, Anil Paul Chirackal" uniqKey="Manavalan A" first="Anil Paul Chirackal" last="Manavalan">Anil Paul Chirackal Manavalan</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Moore, Benjamin M" sort="Moore, Benjamin M" uniqKey="Moore B" first="Benjamin M" last="Moore">Benjamin M. Moore</name><affiliation><nlm:affiliation>Division of Medicine, Royal Prince Alfred Hospital, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tabet, Fatiha" sort="Tabet, Fatiha" uniqKey="Tabet F" first="Fatiha" last="Tabet">Fatiha Tabet</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Sultana, Afroza" sort="Sultana, Afroza" uniqKey="Sultana A" first="Afroza" last="Sultana">Afroza Sultana</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cuesta Torres, Luisa" sort="Cuesta Torres, Luisa" uniqKey="Cuesta Torres L" first="Luisa" last="Cuesta Torres">Luisa Cuesta Torres</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Tang, Shudi" sort="Tang, Shudi" uniqKey="Tang S" first="Shudi" last="Tang">Shudi Tang</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Shrestha, Sudichhya" sort="Shrestha, Sudichhya" uniqKey="Shrestha S" first="Sudichhya" last="Shrestha">Sudichhya Shrestha</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Senanayake, Praween" sort="Senanayake, Praween" uniqKey="Senanayake P" first="Praween" last="Senanayake">Praween Senanayake</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Mili" sort="Patel, Mili" uniqKey="Patel M" first="Mili" last="Patel">Mili Patel</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ryder, William J" sort="Ryder, William J" uniqKey="Ryder W" first="William J" last="Ryder">William J. Ryder</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bongers, Andre" sort="Bongers, Andre" uniqKey="Bongers A" first="Andre" last="Bongers">Andre Bongers</name><affiliation><nlm:affiliation>Biological Resource Imaging Laboratory, Mark Wainwright Analytical Centre, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Maraninchi, Marie" sort="Maraninchi, Marie" uniqKey="Maraninchi M" first="Marie" last="Maraninchi">Marie Maraninchi</name><affiliation><nlm:affiliation>Aix-Marseille Université, UMR_S1062, UMR_A1260, Nutrition, Obésité et Risque Thrombotique, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wasinger, Valerie C" sort="Wasinger, Valerie C" uniqKey="Wasinger V" first="Valerie C" last="Wasinger">Valerie C. Wasinger</name><affiliation><nlm:affiliation>Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Westerterp, Marit" sort="Westerterp, Marit" uniqKey="Westerterp M" first="Marit" last="Westerterp">Marit Westerterp</name><affiliation><nlm:affiliation>Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Tall, Alan R" sort="Tall, Alan R" uniqKey="Tall A" first="Alan R" last="Tall">Alan R. Tall</name><affiliation><nlm:affiliation>Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY.</nlm:affiliation></affiliation></author><author><name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J" last="Barter">Philip J. Barter</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name><affiliation><nlm:affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia k.rye@unsw.edu.au karye@ozemail.com.au.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Diabetes</title><idno type="eISSN">1939-327X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ATP Binding Cassette Transporter 1 (deficiency)</term><term>ATP Binding Cassette Transporter 1 (metabolism)</term><term>ATP Binding Cassette Transporter, Sub-Family G, Member 1 (deficiency)</term><term>ATP Binding Cassette Transporter, Sub-Family G, Member 1 (metabolism)</term><term>Adipose Tissue (metabolism)</term><term>Animals</term><term>Blotting, Western</term><term>Cholesterol (metabolism)</term><term>Fatty Acid Synthases</term><term>Glucose (metabolism)</term><term>Glycogen (metabolism)</term><term>Homeostasis (genetics)</term><term>Homeostasis (physiology)</term><term>Insulin (metabolism)</term><term>Insulin-Secreting Cells (metabolism)</term><term>Lactic Acid (blood)</term><term>Magnetic Resonance Imaging</term><term>Mass Spectrometry</term><term>Mice</term><term>Mice, Knockout</term><term>Muscle, Skeletal (metabolism)</term><term>Polymerase Chain Reaction</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Lactic Acid</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>ATP Binding Cassette Transporter 1</term><term>ATP Binding Cassette Transporter, Sub-Family G, Member 1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>ATP Binding Cassette Transporter 1</term><term>ATP Binding Cassette Transporter, Sub-Family G, Member 1</term><term>Cholesterol</term><term>Glucose</term><term>Glycogen</term><term>Insulin</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Homeostasis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adipose Tissue</term><term>Insulin-Secreting Cells</term><term>Muscle, Skeletal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Homeostasis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Blotting, Western</term><term>Fatty Acid Synthases</term><term>Magnetic Resonance Imaging</term><term>Mass Spectrometry</term><term>Mice</term><term>Mice, Knockout</term><term>Polymerase Chain Reaction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Elevated pancreatic β-cell cholesterol levels impair insulin secretion and reduce plasma insulin levels. This study establishes that low plasma insulin levels have a detrimental effect on two major insulin target tissues: adipose tissue and skeletal muscle. Mice with increased β-cell cholesterol levels were generated by conditional deletion of the ATP-binding cassette transporters, ABCA1 and ABCG1, in β-cells (β-DKO mice). Insulin secretion was impaired in these mice under basal and high-glucose conditions, and glucose disposal was shifted from skeletal muscle to adipose tissue. The β-DKO mice also had increased body fat and adipose tissue macrophage content, elevated plasma interleukin-6 and MCP-1 levels, and decreased skeletal muscle mass. They were not, however, insulin resistant. The adipose tissue expansion and reduced skeletal muscle mass, but not the systemic inflammation or increased adipose tissue macrophage content, were reversed when plasma insulin levels were normalized by insulin supplementation. These studies identify a mechanism by which perturbation of β-cell cholesterol homeostasis and impaired insulin secretion increase adiposity, reduce skeletal muscle mass, and cause systemic inflammation. They further identify β-cell dysfunction as a potential therapeutic target in people at increased risk of developing type 2 diabetes.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27702832</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>05</Day></DateCreated><DateCompleted><Year>2017</Year><Month>05</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>05</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1939-327X</ISSN><JournalIssue CitedMedium="Internet"><Volume>65</Volume><Issue>12</Issue><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Diabetes</Title><ISOAbbreviation>Diabetes</ISOAbbreviation></Journal><ArticleTitle>Impact of Perturbed Pancreatic β-Cell Cholesterol Homeostasis on Adipose Tissue and Skeletal Muscle Metabolism.</ArticleTitle><Pagination><MedlinePgn>3610-3620</MedlinePgn></Pagination><Abstract><AbstractText>Elevated pancreatic β-cell cholesterol levels impair insulin secretion and reduce plasma insulin levels. This study establishes that low plasma insulin levels have a detrimental effect on two major insulin target tissues: adipose tissue and skeletal muscle. Mice with increased β-cell cholesterol levels were generated by conditional deletion of the ATP-binding cassette transporters, ABCA1 and ABCG1, in β-cells (β-DKO mice). Insulin secretion was impaired in these mice under basal and high-glucose conditions, and glucose disposal was shifted from skeletal muscle to adipose tissue. The β-DKO mice also had increased body fat and adipose tissue macrophage content, elevated plasma interleukin-6 and MCP-1 levels, and decreased skeletal muscle mass. They were not, however, insulin resistant. The adipose tissue expansion and reduced skeletal muscle mass, but not the systemic inflammation or increased adipose tissue macrophage content, were reversed when plasma insulin levels were normalized by insulin supplementation. These studies identify a mechanism by which perturbation of β-cell cholesterol homeostasis and impaired insulin secretion increase adiposity, reduce skeletal muscle mass, and cause systemic inflammation. They further identify β-cell dysfunction as a potential therapeutic target in people at increased risk of developing type 2 diabetes.</AbstractText><CopyrightInformation>© 2016 by the American Diabetes Association.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cochran</LastName><ForeName>Blake J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hou</LastName><ForeName>Liming</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manavalan</LastName><ForeName>Anil Paul Chirackal</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moore</LastName><ForeName>Benjamin M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Division of Medicine, Royal Prince Alfred Hospital, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tabet</LastName><ForeName>Fatiha</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sultana</LastName><ForeName>Afroza</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cuesta Torres</LastName><ForeName>Luisa</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Shudi</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shrestha</LastName><ForeName>Sudichhya</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Senanayake</LastName><ForeName>Praween</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Mili</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ryder</LastName><ForeName>William J</ForeName><Initials>WJ</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bongers</LastName><ForeName>Andre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Biological Resource Imaging Laboratory, Mark Wainwright Analytical Centre, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maraninchi</LastName><ForeName>Marie</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Aix-Marseille Université, UMR_S1062, UMR_A1260, Nutrition, Obésité et Risque Thrombotique, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wasinger</LastName><ForeName>Valerie C</ForeName><Initials>VC</Initials><AffiliationInfo><Affiliation>Bioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westerterp</LastName><ForeName>Marit</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tall</LastName><ForeName>Alan R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barter</LastName><ForeName>Philip J</ForeName><Initials>PJ</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rye</LastName><ForeName>Kerry-Anne</ForeName><Initials>KA</Initials><AffiliationInfo><Affiliation>Lipid Research Group, School of Medical Sciences, Faculty of Medicine, University of New South Wales Australia, Sydney, Australia k.rye@unsw.edu.au karye@ozemail.com.au.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Faculty of Medicine, University of Sydney, Sydney, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P01 HL087123</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United 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Stress Chaperones. 2011 Sep;16(5):539-48</RefSource><PMID Version="1">21472505</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D064286" MajorTopicYN="N">ATP Binding Cassette Transporter 1</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000070998" MajorTopicYN="N">ATP Binding Cassette Transporter, Sub-Family G, Member 1</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000273" MajorTopicYN="N">Adipose Tissue</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" 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Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018482" MajorTopicYN="N">Muscle, Skeletal</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2017</Year><Month>12</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27702832</ArticleId><ArticleId IdType="pii">db16-0668</ArticleId><ArticleId IdType="doi">10.2337/db16-0668</ArticleId><ArticleId IdType="pmc">PMC5132410</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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