Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.
Identifieur interne : 001445 ( PubMed/Corpus ); précédent : 001444; suivant : 001446Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.
Auteurs : John G. Laffey ; Giacomo Bellani ; Tài Pham ; Eddy Fan ; Fabiana Madotto ; Ednan K. Bajwa ; Laurent Brochard ; Kevin Clarkson ; Andres Esteban ; Luciano Gattinoni ; Frank Van Haren ; Leo M. Heunks ; Kiyoyasu Kurahashi ; Jon Henrik Laake ; Anders Larsson ; Daniel F. Mcauley ; Lia Mcnamee ; Nicolas Nin ; Haibo Qiu ; Marco Ranieri ; Gordon D. Rubenfeld ; B Taylor Thompson ; Hermann Wrigge ; Arthur S. Slutsky ; Antonio PesentiSource :
- Intensive care medicine [ 1432-1238 ] ; 2016.
English descriptors
- KwdEn :
- Adult, Aged, Comorbidity, Female, Hospital Mortality, Humans, Intensive Care Units (statistics & numerical data), Male, Middle Aged, Prospective Studies, Respiration, Artificial (statistics & numerical data), Respiratory Distress Syndrome, Adult (mortality), Respiratory Distress Syndrome, Adult (therapy), Risk Factors, Severity of Illness Index, Tidal Volume, Treatment Outcome.
- MESH :
- mortality : Respiratory Distress Syndrome, Adult.
- statistics & numerical data : Intensive Care Units, Respiration, Artificial.
- therapy : Respiratory Distress Syndrome, Adult.
- Adult, Aged, Comorbidity, Female, Hospital Mortality, Humans, Male, Middle Aged, Prospective Studies, Risk Factors, Severity of Illness Index, Tidal Volume, Treatment Outcome.
Abstract
To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality.
DOI: 10.1007/s00134-016-4571-5
PubMed: 27757516
Links to Exploration step
pubmed:27757516Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.</title><author><name sortKey="Laffey, John G" sort="Laffey, John G" uniqKey="Laffey J" first="John G" last="Laffey">John G. Laffey</name><affiliation><nlm:affiliation>Departments of Anesthesia and Critical Care Medicine, Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Canada. laffeyj@smh.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Bellani, Giacomo" sort="Bellani, Giacomo" uniqKey="Bellani G" first="Giacomo" last="Bellani">Giacomo Bellani</name><affiliation><nlm:affiliation>School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Pham, Tai" sort="Pham, Tai" uniqKey="Pham T" first="Tài" last="Pham">Tài Pham</name><affiliation><nlm:affiliation>AP-HP, Hôpital Tenon, Unité de Réanimation médico-chirurgicale, Pôle Thorax Voies aériennes, Groupe hospitalier des Hôpitaux Universitaires de l'Est Parisien, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Eddy" sort="Fan, Eddy" uniqKey="Fan E" first="Eddy" last="Fan">Eddy Fan</name><affiliation><nlm:affiliation>Department of Medicine, University Health Network, Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Madotto, Fabiana" sort="Madotto, Fabiana" uniqKey="Madotto F" first="Fabiana" last="Madotto">Fabiana Madotto</name><affiliation><nlm:affiliation>Research Center on Public Health, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bajwa, Ednan K" sort="Bajwa, Ednan K" uniqKey="Bajwa E" first="Ednan K" last="Bajwa">Ednan K. Bajwa</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Brochard, Laurent" sort="Brochard, Laurent" uniqKey="Brochard L" first="Laurent" last="Brochard">Laurent Brochard</name><affiliation><nlm:affiliation>Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Clarkson, Kevin" sort="Clarkson, Kevin" uniqKey="Clarkson K" first="Kevin" last="Clarkson">Kevin Clarkson</name><affiliation><nlm:affiliation>Department of Anaesthesia, National University of Ireland, Galway University Hospitals, Galway, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Esteban, Andres" sort="Esteban, Andres" uniqKey="Esteban A" first="Andres" last="Esteban">Andres Esteban</name><affiliation><nlm:affiliation>Hospital Universitario de Getafe, CIBER de Enfermedades Respiratorias, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gattinoni, Luciano" sort="Gattinoni, Luciano" uniqKey="Gattinoni L" first="Luciano" last="Gattinoni">Luciano Gattinoni</name><affiliation><nlm:affiliation>Department of Anesthesiology, Emergency and Intensive Care Medicine Universitätsmedizin Göttingen, Robert Koch Strasse 40, 37073, Göttingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Van Haren, Frank" sort="Van Haren, Frank" uniqKey="Van Haren F" first="Frank" last="Van Haren">Frank Van Haren</name><affiliation><nlm:affiliation>Intensive Care Unit, The Canberra Hospital, Australian National University, Canberra, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Heunks, Leo M" sort="Heunks, Leo M" uniqKey="Heunks L" first="Leo M" last="Heunks">Leo M. Heunks</name><affiliation><nlm:affiliation>Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kurahashi, Kiyoyasu" sort="Kurahashi, Kiyoyasu" uniqKey="Kurahashi K" first="Kiyoyasu" last="Kurahashi">Kiyoyasu Kurahashi</name><affiliation><nlm:affiliation>Department of Anesthesiology, Yokohama City University Medical Center, Kanagawa, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Laake, Jon Henrik" sort="Laake, Jon Henrik" uniqKey="Laake J" first="Jon Henrik" last="Laake">Jon Henrik Laake</name><affiliation><nlm:affiliation>Division of Critical Care, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Larsson, Anders" sort="Larsson, Anders" uniqKey="Larsson A" first="Anders" last="Larsson">Anders Larsson</name><affiliation><nlm:affiliation>Section of Anesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mcauley, Daniel F" sort="Mcauley, Daniel F" uniqKey="Mcauley D" first="Daniel F" last="Mcauley">Daniel F. Mcauley</name><affiliation><nlm:affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Wellcome-Wolfson Institute for Experimental Medicine, Belfast and Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mcnamee, Lia" sort="Mcnamee, Lia" uniqKey="Mcnamee L" first="Lia" last="Mcnamee">Lia Mcnamee</name><affiliation><nlm:affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Wellcome-Wolfson Institute for Experimental Medicine, Belfast and Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nin, Nicolas" sort="Nin, Nicolas" uniqKey="Nin N" first="Nicolas" last="Nin">Nicolas Nin</name><affiliation><nlm:affiliation>Hospital Universitario de Getafe, CIBER de Enfermedades Respiratorias, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Qiu, Haibo" sort="Qiu, Haibo" uniqKey="Qiu H" first="Haibo" last="Qiu">Haibo Qiu</name><affiliation><nlm:affiliation>Department of Critical Care Medicine, Nanjing Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Ranieri, Marco" sort="Ranieri, Marco" uniqKey="Ranieri M" first="Marco" last="Ranieri">Marco Ranieri</name><affiliation><nlm:affiliation>SAPIENZA Università di ROMA, Dipartimento di Anestesia e Rianimazione, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Rubenfeld, Gordon D" sort="Rubenfeld, Gordon D" uniqKey="Rubenfeld G" first="Gordon D" last="Rubenfeld">Gordon D. Rubenfeld</name><affiliation><nlm:affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto and Program in Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Center, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Thompson, B Taylor" sort="Thompson, B Taylor" uniqKey="Thompson B" first="B Taylor" last="Thompson">B Taylor Thompson</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wrigge, Hermann" sort="Wrigge, Hermann" uniqKey="Wrigge H" first="Hermann" last="Wrigge">Hermann Wrigge</name><affiliation><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, 04103, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S" last="Slutsky">Arthur S. Slutsky</name><affiliation><nlm:affiliation>Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Pesenti, Antonio" sort="Pesenti, Antonio" uniqKey="Pesenti A" first="Antonio" last="Pesenti">Antonio Pesenti</name><affiliation><nlm:affiliation>Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Toronto, Canada.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27757516</idno><idno type="pmid">27757516</idno><idno type="doi">10.1007/s00134-016-4571-5</idno><idno type="wicri:Area/PubMed/Corpus">001445</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001445</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.</title><author><name sortKey="Laffey, John G" sort="Laffey, John G" uniqKey="Laffey J" first="John G" last="Laffey">John G. Laffey</name><affiliation><nlm:affiliation>Departments of Anesthesia and Critical Care Medicine, Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Canada. laffeyj@smh.ca.</nlm:affiliation></affiliation></author><author><name sortKey="Bellani, Giacomo" sort="Bellani, Giacomo" uniqKey="Bellani G" first="Giacomo" last="Bellani">Giacomo Bellani</name><affiliation><nlm:affiliation>School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Pham, Tai" sort="Pham, Tai" uniqKey="Pham T" first="Tài" last="Pham">Tài Pham</name><affiliation><nlm:affiliation>AP-HP, Hôpital Tenon, Unité de Réanimation médico-chirurgicale, Pôle Thorax Voies aériennes, Groupe hospitalier des Hôpitaux Universitaires de l'Est Parisien, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fan, Eddy" sort="Fan, Eddy" uniqKey="Fan E" first="Eddy" last="Fan">Eddy Fan</name><affiliation><nlm:affiliation>Department of Medicine, University Health Network, Mount Sinai Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Madotto, Fabiana" sort="Madotto, Fabiana" uniqKey="Madotto F" first="Fabiana" last="Madotto">Fabiana Madotto</name><affiliation><nlm:affiliation>Research Center on Public Health, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Bajwa, Ednan K" sort="Bajwa, Ednan K" uniqKey="Bajwa E" first="Ednan K" last="Bajwa">Ednan K. Bajwa</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Brochard, Laurent" sort="Brochard, Laurent" uniqKey="Brochard L" first="Laurent" last="Brochard">Laurent Brochard</name><affiliation><nlm:affiliation>Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Clarkson, Kevin" sort="Clarkson, Kevin" uniqKey="Clarkson K" first="Kevin" last="Clarkson">Kevin Clarkson</name><affiliation><nlm:affiliation>Department of Anaesthesia, National University of Ireland, Galway University Hospitals, Galway, Ireland.</nlm:affiliation></affiliation></author><author><name sortKey="Esteban, Andres" sort="Esteban, Andres" uniqKey="Esteban A" first="Andres" last="Esteban">Andres Esteban</name><affiliation><nlm:affiliation>Hospital Universitario de Getafe, CIBER de Enfermedades Respiratorias, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Gattinoni, Luciano" sort="Gattinoni, Luciano" uniqKey="Gattinoni L" first="Luciano" last="Gattinoni">Luciano Gattinoni</name><affiliation><nlm:affiliation>Department of Anesthesiology, Emergency and Intensive Care Medicine Universitätsmedizin Göttingen, Robert Koch Strasse 40, 37073, Göttingen, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Van Haren, Frank" sort="Van Haren, Frank" uniqKey="Van Haren F" first="Frank" last="Van Haren">Frank Van Haren</name><affiliation><nlm:affiliation>Intensive Care Unit, The Canberra Hospital, Australian National University, Canberra, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Heunks, Leo M" sort="Heunks, Leo M" uniqKey="Heunks L" first="Leo M" last="Heunks">Leo M. Heunks</name><affiliation><nlm:affiliation>Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Kurahashi, Kiyoyasu" sort="Kurahashi, Kiyoyasu" uniqKey="Kurahashi K" first="Kiyoyasu" last="Kurahashi">Kiyoyasu Kurahashi</name><affiliation><nlm:affiliation>Department of Anesthesiology, Yokohama City University Medical Center, Kanagawa, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Laake, Jon Henrik" sort="Laake, Jon Henrik" uniqKey="Laake J" first="Jon Henrik" last="Laake">Jon Henrik Laake</name><affiliation><nlm:affiliation>Division of Critical Care, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo, Norway.</nlm:affiliation></affiliation></author><author><name sortKey="Larsson, Anders" sort="Larsson, Anders" uniqKey="Larsson A" first="Anders" last="Larsson">Anders Larsson</name><affiliation><nlm:affiliation>Section of Anesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mcauley, Daniel F" sort="Mcauley, Daniel F" uniqKey="Mcauley D" first="Daniel F" last="Mcauley">Daniel F. Mcauley</name><affiliation><nlm:affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Wellcome-Wolfson Institute for Experimental Medicine, Belfast and Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mcnamee, Lia" sort="Mcnamee, Lia" uniqKey="Mcnamee L" first="Lia" last="Mcnamee">Lia Mcnamee</name><affiliation><nlm:affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Wellcome-Wolfson Institute for Experimental Medicine, Belfast and Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nin, Nicolas" sort="Nin, Nicolas" uniqKey="Nin N" first="Nicolas" last="Nin">Nicolas Nin</name><affiliation><nlm:affiliation>Hospital Universitario de Getafe, CIBER de Enfermedades Respiratorias, Madrid, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Qiu, Haibo" sort="Qiu, Haibo" uniqKey="Qiu H" first="Haibo" last="Qiu">Haibo Qiu</name><affiliation><nlm:affiliation>Department of Critical Care Medicine, Nanjing Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Ranieri, Marco" sort="Ranieri, Marco" uniqKey="Ranieri M" first="Marco" last="Ranieri">Marco Ranieri</name><affiliation><nlm:affiliation>SAPIENZA Università di ROMA, Dipartimento di Anestesia e Rianimazione, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Rubenfeld, Gordon D" sort="Rubenfeld, Gordon D" uniqKey="Rubenfeld G" first="Gordon D" last="Rubenfeld">Gordon D. Rubenfeld</name><affiliation><nlm:affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto and Program in Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Center, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Thompson, B Taylor" sort="Thompson, B Taylor" uniqKey="Thompson B" first="B Taylor" last="Thompson">B Taylor Thompson</name><affiliation><nlm:affiliation>Division of Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wrigge, Hermann" sort="Wrigge, Hermann" uniqKey="Wrigge H" first="Hermann" last="Wrigge">Hermann Wrigge</name><affiliation><nlm:affiliation>Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, 04103, Leipzig, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Slutsky, Arthur S" sort="Slutsky, Arthur S" uniqKey="Slutsky A" first="Arthur S" last="Slutsky">Arthur S. Slutsky</name><affiliation><nlm:affiliation>Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Pesenti, Antonio" sort="Pesenti, Antonio" uniqKey="Pesenti A" first="Antonio" last="Pesenti">Antonio Pesenti</name><affiliation><nlm:affiliation>Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Toronto, Canada.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Intensive care medicine</title><idno type="eISSN">1432-1238</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Comorbidity</term><term>Female</term><term>Hospital Mortality</term><term>Humans</term><term>Intensive Care Units (statistics & numerical data)</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Respiration, Artificial (statistics & numerical data)</term><term>Respiratory Distress Syndrome, Adult (mortality)</term><term>Respiratory Distress Syndrome, Adult (therapy)</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Tidal Volume</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units</term><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Respiratory Distress Syndrome, Adult</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Comorbidity</term><term>Female</term><term>Hospital Mortality</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Prospective Studies</term><term>Risk Factors</term><term>Severity of Illness Index</term><term>Tidal Volume</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27757516</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>19</Day></DateCreated><DateCompleted><Year>2017</Year><Month>09</Month><Day>18</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN><JournalIssue CitedMedium="Internet"><Volume>42</Volume><Issue>12</Issue><PubDate><Year>2016</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Intensive care medicine</Title><ISOAbbreviation>Intensive Care Med</ISOAbbreviation></Journal><ArticleTitle>Potentially modifiable factors contributing to outcome from acute respiratory distress syndrome: the LUNG SAFE study.</ArticleTitle><Pagination><MedlinePgn>1865-1876</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-016-4571-5</ELocationID><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To improve the outcome of the acute respiratory distress syndrome (ARDS), one needs to identify potentially modifiable factors associated with mortality.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The large observational study to understand the global impact of severe acute respiratory failure (LUNG SAFE) was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted in the winter of 2014 in a convenience sample of 459 ICUs from 50 countries across five continents. A pre-specified secondary aim was to examine the factors associated with outcome. Analyses were restricted to patients (93.1 %) fulfilling ARDS criteria on day 1-2 who received invasive mechanical ventilation.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">2377 patients were included in the analysis. Potentially modifiable factors associated with increased hospital mortality in multivariable analyses include lower PEEP, higher peak inspiratory, plateau, and driving pressures, and increased respiratory rate. The impact of tidal volume on outcome was unclear. Having fewer ICU beds was also associated with higher hospital mortality. Non-modifiable factors associated with worsened outcome from ARDS included older age, active neoplasm, hematologic neoplasm, and chronic liver failure. Severity of illness indices including lower pH, lower PaO2/FiO2 ratio, and higher non-pulmonary SOFA score were associated with poorer outcome. Of the 578 (24.3 %) patients with a limitation of life-sustaining therapies or measures decision, 498 (86.0 %) died in hospital. Factors associated with increased likelihood of limitation of life-sustaining therapies or measures decision included older age, immunosuppression, neoplasia, lower pH and increased non-pulmonary SOFA scores.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Higher PEEP, lower peak, plateau, and driving pressures, and lower respiratory rate are associated with improved survival from ARDS.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">ClinicalTrials.gov NCT02010073.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Laffey</LastName><ForeName>John G</ForeName><Initials>JG</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-1246-9573</Identifier><AffiliationInfo><Affiliation>Departments of Anesthesia and Critical Care Medicine, Keenan Research Centre for Biomedical Science, St Michael's Hospital, Toronto, Canada. laffeyj@smh.ca.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Departments of Anesthesia, Physiology, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada. laffeyj@smh.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellani</LastName><ForeName>Giacomo</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>School of Medicine and Surgery, University of Milan-Bicocca, Monza, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Emergency and Intensive Care, San Gerardo Hospital, Monza, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pham</LastName><ForeName>Tài</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>AP-HP, Hôpital Tenon, Unité de Réanimation médico-chirurgicale, Pôle Thorax Voies aériennes, Groupe hospitalier des Hôpitaux Universitaires de l'Est Parisien, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMR 1153, Inserm, Sorbonne Paris Cité, ECSTRA Team, Université Paris Diderot, Paris, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>UMR 915, Inserm, Université Paris Est Créteil, Créteil, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fan</LastName><ForeName>Eddy</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medicine, University Health Network, Mount Sinai Hospital, Toronto, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Interdepartmental Division of Critical Care Medicine and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Madotto</LastName><ForeName>Fabiana</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Research Center on Public Health, School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bajwa</LastName><ForeName>Ednan K</ForeName><Initials>EK</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brochard</LastName><ForeName>Laurent</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clarkson</LastName><ForeName>Kevin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia, National University of Ireland, Galway University Hospitals, Galway, Ireland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Esteban</LastName><ForeName>Andres</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hospital Universitario de Getafe, CIBER de Enfermedades Respiratorias, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gattinoni</LastName><ForeName>Luciano</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology, Emergency and Intensive Care Medicine Universitätsmedizin Göttingen, Robert Koch Strasse 40, 37073, Göttingen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Haren</LastName><ForeName>Frank</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Intensive Care Unit, The Canberra Hospital, Australian National University, Canberra, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heunks</LastName><ForeName>Leo M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Department of Intensive Care Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kurahashi</LastName><ForeName>Kiyoyasu</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology, Yokohama City University Medical Center, Kanagawa, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Laake</LastName><ForeName>Jon Henrik</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Division of Critical Care, Department of Anaesthesiology, Rikshospitalet Medical Centre, Oslo University Hospital, Oslo, Norway.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larsson</LastName><ForeName>Anders</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Section of Anesthesiology and Intensive Care, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McAuley</LastName><ForeName>Daniel F</ForeName><Initials>DF</Initials><AffiliationInfo><Affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Wellcome-Wolfson Institute for Experimental Medicine, Belfast and Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McNamee</LastName><ForeName>Lia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Centre for Experimental Medicine, Queen's University of Belfast, Wellcome-Wolfson Institute for Experimental Medicine, Belfast and Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, Belfast, Northern Ireland, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nin</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Hospital Universitario de Getafe, CIBER de Enfermedades Respiratorias, Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qiu</LastName><ForeName>Haibo</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Critical Care Medicine, Nanjing Zhongda Hospital, School of Medicine, Southeast University, Nanjing, 210009, People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ranieri</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>SAPIENZA Università di ROMA, Dipartimento di Anestesia e Rianimazione, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rubenfeld</LastName><ForeName>Gordon D</ForeName><Initials>GD</Initials><AffiliationInfo><Affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto and Program in Trauma, Emergency and Critical Care, Sunnybrook Health Sciences Center, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thompson</LastName><ForeName>B Taylor</ForeName><Initials>BT</Initials><AffiliationInfo><Affiliation>Division of Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wrigge</LastName><ForeName>Hermann</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Anesthesiology and Intensive Care Medicine, University of Leipzig, 04103, Leipzig, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slutsky</LastName><ForeName>Arthur S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, University of Toronto, Toronto, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pesenti</LastName><ForeName>Antonio</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Dipartimento di Anestesia, Rianimazione ed Emergenza Urgenza, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Toronto, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti, Università degli Studi di Milano, Milan, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>LUNG SAFE Investigators and the ESICM Trials Group</CollectiveName></Author></AuthorList><Language>eng</Language><DataBankList CompleteYN="Y"><DataBank><DataBankName>ClinicalTrials.gov</DataBankName><AccessionNumberList><AccessionNumber>NCT02010073</AccessionNumber></AccessionNumberList></DataBank></DataBankList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016448">Multicenter Study</PublicationType><PublicationType UI="D064888">Observational Study</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Intensive Care Med</MedlineTA><NlmUniqueID>7704851</NlmUniqueID><ISSNLinking>0342-4642</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="CommentIn"><RefSource>J Thorac Dis. 2017 Feb;9(2):225-227</RefSource><PMID Version="1">28275464</PMID></CommentsCorrections><CommentsCorrections RefType="CommentIn"><RefSource>J Thorac Dis. 2017 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MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013990" MajorTopicYN="N">Tidal Volume</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute respiratory distress syndrome</Keyword><Keyword MajorTopicYN="N">Driving pressure</Keyword><Keyword MajorTopicYN="N">Patient outcome</Keyword><Keyword MajorTopicYN="N">Peak inspiratory pressure</Keyword><Keyword MajorTopicYN="N">Positive end-expiratory pressure</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>07</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>09</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>9</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27757516</ArticleId><ArticleId IdType="doi">10.1007/s00134-016-4571-5</ArticleId><ArticleId IdType="pii">10.1007/s00134-016-4571-5</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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