Unrelated Cord Blood Transplantation for Acute Leukemia Diagnosed in the First Year of Life: Outcomes and Risk Factor Analysis.
Identifieur interne : 001367 ( PubMed/Corpus ); précédent : 001366; suivant : 001368Unrelated Cord Blood Transplantation for Acute Leukemia Diagnosed in the First Year of Life: Outcomes and Risk Factor Analysis.
Auteurs : Annalisa Ruggeri ; Fernanda Volt ; Franco Locatelli ; Gerard Michel ; Cristina Diaz De Heredia ; Manuel Abecasis ; Marco Zecca ; Ajay Vora ; Karima Yakouben ; Tracey A. O'Brien ; Stefano Giardino ; Jacqueline Cornish ; Vanderson Rocha ; Christina Peters ; Peter Bader ; Eliane Gluckman ; Jean Hugues DalleSource :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [ 1523-6536 ] ; 2017.
Abstract
Infant acute leukemia still has a poor prognosis, and allogeneic hematopoietic stem cell transplantation is indicated in selected patients. Umbilical cord blood (UCB) is an attractive cell source for this population because of the low risk of chronic graft-versus-host disease (GVHD), the strong graft-versus-leukemia effect, and prompt donor availability. This retrospective, registry-based study reported UCB transplantation (UCBT) outcomes in 252 children with acute lymphoblastic leukemia (ALL; n = 157) or acute myelogenous leukemia (AML; n = 95) diagnosed before 1 year of age who received a single-unit UCBT after myeloablative conditioning between 1996 and 2012 in European Society for Blood and Marrow Transplantation centers. Median age at UCBT was 1.1 years, and median follow-up was 42 months. Most patients (57%) received a graft with 1 HLA disparity and were transplanted in first complete remission (CR; 55%). Cumulative incidence function (CIF) of day 100 acute GVHD (grades II to IV) was 40% ± 3% and of 4-year chronic GVHD was 13% ± 2%. CIF of 1-year transplant-related mortality was 23% ± 3% and of 4-year relapse was 27% ± 3%. Leukemia-free-survival (LFS) at 4 years was 50% ± 3%; it was 40% and 66% for those transplanted for ALL and AML, respectively (P = .001). LFS was better for patients transplanted in first CR, regardless of diagnosis. In multivariate model, diagnosis of ALL (P = .001), advanced disease status at UCBT (<.001), age at diagnosis younger than 3 months (P = .012), and date of transplant before 2004 were independently associated with worse LFS. UCBT is a suitable option for patients diagnosed with infant acute leukemia who achieve CR. In this cohort, patients with AML had better survival than those with ALL.
DOI: 10.1016/j.bbmt.2016.10.014
PubMed: 27777140
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Electronic address: annalisa.ruggeri@aphp.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Volt, Fernanda" sort="Volt, Fernanda" uniqKey="Volt F" first="Fernanda" last="Volt">Fernanda Volt</name><affiliation><nlm:affiliation>Eurocord, University Paris VII IUH Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><affiliation><nlm:affiliation>Dipartimento di Oncoematologia Pediatrica, Ospedale Bambino Gesù, IRCSS, Roma, Università di Pavia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Michel, Gerard" sort="Michel, Gerard" uniqKey="Michel G" first="Gerard" last="Michel">Gerard Michel</name><affiliation><nlm:affiliation>Hôpital d'Enfants de la Timone, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Diaz De Heredia, Cristina" sort="Diaz De Heredia, Cristina" uniqKey="Diaz De Heredia C" first="Cristina" last="Diaz De Heredia">Cristina Diaz De Heredia</name><affiliation><nlm:affiliation>Servicio de Hematologia y Oncologia Pediátrica, Hospital Vall d'Hebron, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Abecasis, Manuel" sort="Abecasis, Manuel" uniqKey="Abecasis M" first="Manuel" last="Abecasis">Manuel Abecasis</name><affiliation><nlm:affiliation>BMT Unit, Inst. Portugues Oncologia, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Zecca, Marco" sort="Zecca, Marco" uniqKey="Zecca M" first="Marco" last="Zecca">Marco Zecca</name><affiliation><nlm:affiliation>Unità di Onco-Ematologia, IRCCS Policlinico San Matteo, Pavia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Vora, Ajay" sort="Vora, Ajay" uniqKey="Vora A" first="Ajay" last="Vora">Ajay Vora</name><affiliation><nlm:affiliation>Department of Haematology, Sheffield Children's Hospital and University of Sheffield, Sheffield, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Yakouben, Karima" sort="Yakouben, Karima" uniqKey="Yakouben K" first="Karima" last="Yakouben">Karima Yakouben</name><affiliation><nlm:affiliation>Service d'Hématologie, Hôpital Robert Debré, APHP, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="O Brien, Tracey A" sort="O Brien, Tracey A" uniqKey="O Brien T" first="Tracey A" last="O'Brien">Tracey A. O'Brien</name><affiliation><nlm:affiliation>Sydney Children's Hospital, Kids Cancer Centre, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Giardino, Stefano" sort="Giardino, Stefano" uniqKey="Giardino S" first="Stefano" last="Giardino">Stefano Giardino</name><affiliation><nlm:affiliation>UOSD Trapianto di Midollo, Istituto G. Gaslini, Largo G. Gaslini, Genova, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cornish, Jacqueline" sort="Cornish, Jacqueline" uniqKey="Cornish J" first="Jacqueline" last="Cornish">Jacqueline Cornish</name><affiliation><nlm:affiliation>Bristol Royal Hospital for Children, Bristol, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name><affiliation><nlm:affiliation>Eurocord, University Paris VII IUH Paris, France; Sirio Libanes Hospital and University of Sao Paulo, Sao Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, Christina" sort="Peters, Christina" uniqKey="Peters C" first="Christina" last="Peters">Christina Peters</name><affiliation><nlm:affiliation>BMT Unit, St. Anna Kinderspital, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Bader, Peter" sort="Bader, Peter" uniqKey="Bader P" first="Peter" last="Bader">Peter Bader</name><affiliation><nlm:affiliation>Universitätsklinikum Frankfurt, Goethe-Universität, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name><affiliation><nlm:affiliation>Eurocord, University Paris VII IUH Paris, France; Monacord Centre Scientifique de Monaco, Monaco.</nlm:affiliation></affiliation></author><author><name sortKey="Dalle, Jean Hugues" sort="Dalle, Jean Hugues" uniqKey="Dalle J" first="Jean Hugues" last="Dalle">Jean Hugues Dalle</name><affiliation><nlm:affiliation>Service d'Hématologie, Hôpital Robert Debré, APHP, Paris, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27777140</idno><idno type="pmid">27777140</idno><idno type="doi">10.1016/j.bbmt.2016.10.014</idno><idno type="wicri:Area/PubMed/Corpus">001367</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001367</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Unrelated Cord Blood Transplantation for Acute Leukemia Diagnosed in the First Year of Life: Outcomes and Risk Factor Analysis.</title><author><name sortKey="Ruggeri, Annalisa" sort="Ruggeri, Annalisa" uniqKey="Ruggeri A" first="Annalisa" last="Ruggeri">Annalisa Ruggeri</name><affiliation><nlm:affiliation>Service d'Hématologie et Therapie cellulaire, Hôpital Saint Antoine, Paris, France; Eurocord, University Paris VII IUH Paris, France. Electronic address: annalisa.ruggeri@aphp.fr.</nlm:affiliation></affiliation></author><author><name sortKey="Volt, Fernanda" sort="Volt, Fernanda" uniqKey="Volt F" first="Fernanda" last="Volt">Fernanda Volt</name><affiliation><nlm:affiliation>Eurocord, University Paris VII IUH Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Locatelli, Franco" sort="Locatelli, Franco" uniqKey="Locatelli F" first="Franco" last="Locatelli">Franco Locatelli</name><affiliation><nlm:affiliation>Dipartimento di Oncoematologia Pediatrica, Ospedale Bambino Gesù, IRCSS, Roma, Università di Pavia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Michel, Gerard" sort="Michel, Gerard" uniqKey="Michel G" first="Gerard" last="Michel">Gerard Michel</name><affiliation><nlm:affiliation>Hôpital d'Enfants de la Timone, Marseille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Diaz De Heredia, Cristina" sort="Diaz De Heredia, Cristina" uniqKey="Diaz De Heredia C" first="Cristina" last="Diaz De Heredia">Cristina Diaz De Heredia</name><affiliation><nlm:affiliation>Servicio de Hematologia y Oncologia Pediátrica, Hospital Vall d'Hebron, Barcelona, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Abecasis, Manuel" sort="Abecasis, Manuel" uniqKey="Abecasis M" first="Manuel" last="Abecasis">Manuel Abecasis</name><affiliation><nlm:affiliation>BMT Unit, Inst. Portugues Oncologia, Porto, Portugal.</nlm:affiliation></affiliation></author><author><name sortKey="Zecca, Marco" sort="Zecca, Marco" uniqKey="Zecca M" first="Marco" last="Zecca">Marco Zecca</name><affiliation><nlm:affiliation>Unità di Onco-Ematologia, IRCCS Policlinico San Matteo, Pavia, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Vora, Ajay" sort="Vora, Ajay" uniqKey="Vora A" first="Ajay" last="Vora">Ajay Vora</name><affiliation><nlm:affiliation>Department of Haematology, Sheffield Children's Hospital and University of Sheffield, Sheffield, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Yakouben, Karima" sort="Yakouben, Karima" uniqKey="Yakouben K" first="Karima" last="Yakouben">Karima Yakouben</name><affiliation><nlm:affiliation>Service d'Hématologie, Hôpital Robert Debré, APHP, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="O Brien, Tracey A" sort="O Brien, Tracey A" uniqKey="O Brien T" first="Tracey A" last="O'Brien">Tracey A. O'Brien</name><affiliation><nlm:affiliation>Sydney Children's Hospital, Kids Cancer Centre, Sydney, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Giardino, Stefano" sort="Giardino, Stefano" uniqKey="Giardino S" first="Stefano" last="Giardino">Stefano Giardino</name><affiliation><nlm:affiliation>UOSD Trapianto di Midollo, Istituto G. Gaslini, Largo G. Gaslini, Genova, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Cornish, Jacqueline" sort="Cornish, Jacqueline" uniqKey="Cornish J" first="Jacqueline" last="Cornish">Jacqueline Cornish</name><affiliation><nlm:affiliation>Bristol Royal Hospital for Children, Bristol, United Kingdom.</nlm:affiliation></affiliation></author><author><name sortKey="Rocha, Vanderson" sort="Rocha, Vanderson" uniqKey="Rocha V" first="Vanderson" last="Rocha">Vanderson Rocha</name><affiliation><nlm:affiliation>Eurocord, University Paris VII IUH Paris, France; Sirio Libanes Hospital and University of Sao Paulo, Sao Paulo, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Peters, Christina" sort="Peters, Christina" uniqKey="Peters C" first="Christina" last="Peters">Christina Peters</name><affiliation><nlm:affiliation>BMT Unit, St. Anna Kinderspital, Vienna, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Bader, Peter" sort="Bader, Peter" uniqKey="Bader P" first="Peter" last="Bader">Peter Bader</name><affiliation><nlm:affiliation>Universitätsklinikum Frankfurt, Goethe-Universität, Frankfurt, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Gluckman, Eliane" sort="Gluckman, Eliane" uniqKey="Gluckman E" first="Eliane" last="Gluckman">Eliane Gluckman</name><affiliation><nlm:affiliation>Eurocord, University Paris VII IUH Paris, France; Monacord Centre Scientifique de Monaco, Monaco.</nlm:affiliation></affiliation></author><author><name sortKey="Dalle, Jean Hugues" sort="Dalle, Jean Hugues" uniqKey="Dalle J" first="Jean Hugues" last="Dalle">Jean Hugues Dalle</name><affiliation><nlm:affiliation>Service d'Hématologie, Hôpital Robert Debré, APHP, Paris, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</title><idno type="eISSN">1523-6536</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infant acute leukemia still has a poor prognosis, and allogeneic hematopoietic stem cell transplantation is indicated in selected patients. Umbilical cord blood (UCB) is an attractive cell source for this population because of the low risk of chronic graft-versus-host disease (GVHD), the strong graft-versus-leukemia effect, and prompt donor availability. This retrospective, registry-based study reported UCB transplantation (UCBT) outcomes in 252 children with acute lymphoblastic leukemia (ALL; n = 157) or acute myelogenous leukemia (AML; n = 95) diagnosed before 1 year of age who received a single-unit UCBT after myeloablative conditioning between 1996 and 2012 in European Society for Blood and Marrow Transplantation centers. Median age at UCBT was 1.1 years, and median follow-up was 42 months. Most patients (57%) received a graft with 1 HLA disparity and were transplanted in first complete remission (CR; 55%). Cumulative incidence function (CIF) of day 100 acute GVHD (grades II to IV) was 40% ± 3% and of 4-year chronic GVHD was 13% ± 2%. CIF of 1-year transplant-related mortality was 23% ± 3% and of 4-year relapse was 27% ± 3%. Leukemia-free-survival (LFS) at 4 years was 50% ± 3%; it was 40% and 66% for those transplanted for ALL and AML, respectively (P = .001). LFS was better for patients transplanted in first CR, regardless of diagnosis. In multivariate model, diagnosis of ALL (P = .001), advanced disease status at UCBT (<.001), age at diagnosis younger than 3 months (P = .012), and date of transplant before 2004 were independently associated with worse LFS. UCBT is a suitable option for patients diagnosed with infant acute leukemia who achieve CR. In this cohort, patients with AML had better survival than those with ALL.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27777140</PMID><DateCreated><Year>2016</Year><Month>10</Month><Day>25</Day></DateCreated><DateRevised><Year>2016</Year><Month>12</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1523-6536</ISSN><JournalIssue CitedMedium="Internet"><Volume>23</Volume><Issue>1</Issue><PubDate><Year>2017</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation</Title><ISOAbbreviation>Biol. Blood Marrow Transplant.</ISOAbbreviation></Journal><ArticleTitle>Unrelated Cord Blood Transplantation for Acute Leukemia Diagnosed in the First Year of Life: Outcomes and Risk Factor Analysis.</ArticleTitle><Pagination><MedlinePgn>96-102</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1083-8791(16)30428-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbmt.2016.10.014</ELocationID><Abstract><AbstractText>Infant acute leukemia still has a poor prognosis, and allogeneic hematopoietic stem cell transplantation is indicated in selected patients. Umbilical cord blood (UCB) is an attractive cell source for this population because of the low risk of chronic graft-versus-host disease (GVHD), the strong graft-versus-leukemia effect, and prompt donor availability. This retrospective, registry-based study reported UCB transplantation (UCBT) outcomes in 252 children with acute lymphoblastic leukemia (ALL; n = 157) or acute myelogenous leukemia (AML; n = 95) diagnosed before 1 year of age who received a single-unit UCBT after myeloablative conditioning between 1996 and 2012 in European Society for Blood and Marrow Transplantation centers. Median age at UCBT was 1.1 years, and median follow-up was 42 months. Most patients (57%) received a graft with 1 HLA disparity and were transplanted in first complete remission (CR; 55%). Cumulative incidence function (CIF) of day 100 acute GVHD (grades II to IV) was 40% ± 3% and of 4-year chronic GVHD was 13% ± 2%. CIF of 1-year transplant-related mortality was 23% ± 3% and of 4-year relapse was 27% ± 3%. Leukemia-free-survival (LFS) at 4 years was 50% ± 3%; it was 40% and 66% for those transplanted for ALL and AML, respectively (P = .001). LFS was better for patients transplanted in first CR, regardless of diagnosis. In multivariate model, diagnosis of ALL (P = .001), advanced disease status at UCBT (<.001), age at diagnosis younger than 3 months (P = .012), and date of transplant before 2004 were independently associated with worse LFS. UCBT is a suitable option for patients diagnosed with infant acute leukemia who achieve CR. In this cohort, patients with AML had better survival than those with ALL.</AbstractText><CopyrightInformation>Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ruggeri</LastName><ForeName>Annalisa</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Service d'Hématologie et Therapie cellulaire, Hôpital Saint Antoine, Paris, France; Eurocord, University Paris VII IUH Paris, France. Electronic address: annalisa.ruggeri@aphp.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Volt</LastName><ForeName>Fernanda</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Eurocord, University Paris VII IUH Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Locatelli</LastName><ForeName>Franco</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Dipartimento di Oncoematologia Pediatrica, Ospedale Bambino Gesù, IRCSS, Roma, Università di Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michel</LastName><ForeName>Gerard</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Hôpital d'Enfants de la Timone, Marseille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diaz de Heredia</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Servicio de Hematologia y Oncologia Pediátrica, Hospital Vall d'Hebron, Barcelona, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abecasis</LastName><ForeName>Manuel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>BMT Unit, Inst. Portugues Oncologia, Porto, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zecca</LastName><ForeName>Marco</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Unità di Onco-Ematologia, IRCCS Policlinico San Matteo, Pavia, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vora</LastName><ForeName>Ajay</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Haematology, Sheffield Children's Hospital and University of Sheffield, Sheffield, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yakouben</LastName><ForeName>Karima</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Service d'Hématologie, Hôpital Robert Debré, APHP, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Brien</LastName><ForeName>Tracey A</ForeName><Initials>TA</Initials><AffiliationInfo><Affiliation>Sydney Children's Hospital, Kids Cancer Centre, Sydney, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giardino</LastName><ForeName>Stefano</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>UOSD Trapianto di Midollo, Istituto G. Gaslini, Largo G. Gaslini, Genova, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cornish</LastName><ForeName>Jacqueline</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Bristol Royal Hospital for Children, Bristol, United Kingdom.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rocha</LastName><ForeName>Vanderson</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Eurocord, University Paris VII IUH Paris, France; Sirio Libanes Hospital and University of Sao Paulo, Sao Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peters</LastName><ForeName>Christina</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>BMT Unit, St. Anna Kinderspital, Vienna, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bader</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Universitätsklinikum Frankfurt, Goethe-Universität, Frankfurt, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gluckman</LastName><ForeName>Eliane</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Eurocord, University Paris VII IUH Paris, France; Monacord Centre Scientifique de Monaco, Monaco.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dalle</LastName><ForeName>Jean Hugues</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Service d'Hématologie, Hôpital Robert Debré, APHP, Paris, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>10</Month><Day>21</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biol Blood Marrow Transplant</MedlineTA><NlmUniqueID>9600628</NlmUniqueID><ISSNLinking>1083-8791</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute leukemia</Keyword><Keyword MajorTopicYN="N">Cord blood transplantation</Keyword><Keyword MajorTopicYN="N">Infant</Keyword><Keyword MajorTopicYN="N">MLL-rearranged leukemia</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>08</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>10</Month><Day>15</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>10</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27777140</ArticleId><ArticleId IdType="pii">S1083-8791(16)30428-1</ArticleId><ArticleId IdType="doi">10.1016/j.bbmt.2016.10.014</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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