In-hospital and 1-year mortality associated with diabetes in patients with acute heart failure: results from the ESC-HFA Heart Failure Long-Term Registry.
Identifieur interne : 001268 ( PubMed/Corpus ); précédent : 001267; suivant : 001269In-hospital and 1-year mortality associated with diabetes in patients with acute heart failure: results from the ESC-HFA Heart Failure Long-Term Registry.
Auteurs : Giovanni Targher ; Marco Dauriz ; Cécile Laroche ; Pier Luigi Temporelli ; Mahmoud Hassanein ; Petar M. Seferovic ; Jaroslaw Drozdz ; Roberto Ferrari ; Stephan Anker ; Andrew Coats ; Gerasimos Filippatos ; Maria G. Crespo-Leiro ; Alexandre Mebazaa ; Massimo F. Piepoli ; Aldo Pietro Maggioni ; Luigi TavazziSource :
- European journal of heart failure [ 1879-0844 ] ; 2017.
English descriptors
- KwdEn :
- Acute Disease, Aged, Aged, 80 and over, Cause of Death, Cohort Studies, Diabetes Mellitus (epidemiology), Female, Heart Failure (epidemiology), Hospital Mortality, Humans, Hyperglycemia (epidemiology), Male, Middle Aged, Mortality, Patient Readmission, Prognosis, Proportional Hazards Models, Registries.
- MESH :
Abstract
The aim of this study was to evaluate the in-hospital and 1-year prognostic impact of diabetes and elevated blood glucose levels at hospital admission in patients with acute heart failure (HF).
DOI: 10.1002/ejhf.679
PubMed: 27790816
Links to Exploration step
pubmed:27790816Le document en format XML
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<author><name sortKey="Maggioni, Aldo Pietro" sort="Maggioni, Aldo Pietro" uniqKey="Maggioni A" first="Aldo Pietro" last="Maggioni">Aldo Pietro Maggioni</name>
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<term>Cause of Death</term>
<term>Cohort Studies</term>
<term>Diabetes Mellitus (epidemiology)</term>
<term>Female</term>
<term>Heart Failure (epidemiology)</term>
<term>Hospital Mortality</term>
<term>Humans</term>
<term>Hyperglycemia (epidemiology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mortality</term>
<term>Patient Readmission</term>
<term>Prognosis</term>
<term>Proportional Hazards Models</term>
<term>Registries</term>
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<front><div type="abstract" xml:lang="en">The aim of this study was to evaluate the in-hospital and 1-year prognostic impact of diabetes and elevated blood glucose levels at hospital admission in patients with acute heart failure (HF).</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27790816</PMID>
<DateCreated><Year>2016</Year>
<Month>10</Month>
<Day>28</Day>
</DateCreated>
<DateCompleted><Year>2017</Year>
<Month>11</Month>
<Day>09</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>09</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-0844</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>19</Volume>
<Issue>1</Issue>
<PubDate><Year>2017</Year>
<Month>Jan</Month>
</PubDate>
</JournalIssue>
<Title>European journal of heart failure</Title>
<ISOAbbreviation>Eur. J. Heart Fail.</ISOAbbreviation>
</Journal>
<ArticleTitle>In-hospital and 1-year mortality associated with diabetes in patients with acute heart failure: results from the ESC-HFA Heart Failure Long-Term Registry.</ArticleTitle>
<Pagination><MedlinePgn>54-65</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1002/ejhf.679</ELocationID>
<Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">The aim of this study was to evaluate the in-hospital and 1-year prognostic impact of diabetes and elevated blood glucose levels at hospital admission in patients with acute heart failure (HF).</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">We studied a multinational cohort of 6926 hospitalized patients with acute HF enrolled in the European Society of Cardiology (ESC) and Heart Failure Association (HFA) Long-Term Registry, of whom 49.4% (n = 3422) had known or previously undiagnosed diabetes (defined as self-reported history, or medication use, or fasting glucose levels ≥7.0 mmol/L or haemoglobin A1c ≥6.5%). Compared with those without diabetes, patients with known or previously undiagnosed diabetes had higher cumulative rates of in-hospital mortality, 1-year mortality, and 1-year HF re-hospitalization that occurred independently of multiple clinical risk factors: in-hospital mortality [6.8 vs. 4.4%; adjusted hazard ratio (HR) 1.774; 95% confidence interval (CI) 1.282-2.456, P < 0.001], 1-year all-cause mortality (27.5 vs. 24%; adjusted HR 1.162; 95% CI 1.020-1.325, P = 0.024), and 1-year hospital re-admissions for HF (23.2 vs. 18.5%; adjusted HR 1.320; 95% CI 1.139-1.530, P < 0.001). Moreover, elevated admission blood glucose concentrations were powerfully prognostic for in-hospital mortality, but not for 1-year mortality or re-hospitalizations, in both patients with and without diabetes.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Among patients hospitalized for acute HF, the presence of diabetes is independently associated with an increased risk of in-hospital mortality, 1-year all-cause mortality, and 1-year re-hospitalizations for HF, underscoring the need for more effective and personalized treatments of diabetes in this particularly high-risk patient population.</AbstractText>
<CopyrightInformation>© 2016 The Authors. European Journal of Heart Failure © 2016 European Society of Cardiology.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Targher</LastName>
<ForeName>Giovanni</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dauriz</LastName>
<ForeName>Marco</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laroche</LastName>
<ForeName>Cécile</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>EURObservational Research Programme, European Society of Cardiology, Sophia-Antipolis, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Temporelli</LastName>
<ForeName>Pier Luigi</ForeName>
<Initials>PL</Initials>
<AffiliationInfo><Affiliation>Cardiology Division, IRCCS Fondazione Salvatore Maugeri, Veruno, NO, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hassanein</LastName>
<ForeName>Mahmoud</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Alexandria University, Alexandria, Egypt.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seferovic</LastName>
<ForeName>Petar M</ForeName>
<Initials>PM</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Drozdz</LastName>
<ForeName>Jaroslaw</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Medical University, Lodz, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ferrari</LastName>
<ForeName>Roberto</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology and LTTA Centre, University Hospital of Ferrara and Maria Cecilia Hospital, GVM Care & Research, E.S: Health Science Foundation, Cotignola, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Anker</LastName>
<ForeName>Stephan</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Innovative Clinical Trials, Department of Cardiology & Pneumology, University Medical Center Göttingen (UMG), Göttingen, Germany.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Coats</LastName>
<ForeName>Andrew</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Monash University, Australia and University of Warwick, Coventry, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Filippatos</LastName>
<ForeName>Gerasimos</ForeName>
<Initials>G</Initials>
<AffiliationInfo><Affiliation>Cardiology Department, University Hospital 12 de Octubre, Madrid, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Crespo-Leiro</LastName>
<ForeName>Maria G</ForeName>
<Initials>MG</Initials>
<AffiliationInfo><Affiliation>Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco, Complexo Hospitalario, Universitario A Coruna, CHUAC, La Coruna, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mebazaa</LastName>
<ForeName>Alexandre</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Inserm 942, Hôpital Lariboisière, Université Paris Diderot, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Piepoli</LastName>
<ForeName>Massimo F</ForeName>
<Initials>MF</Initials>
<AffiliationInfo><Affiliation>Department of Cardiology, Polichirurgico Hospital G. da Saliceto, Piacenza, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maggioni</LastName>
<ForeName>Aldo Pietro</ForeName>
<Initials>AP</Initials>
<AffiliationInfo><Affiliation>EURObservational Research Programme, European Society of Cardiology, Sophia-Antipolis, France.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>ANMCO Research Center, Florence, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tavazzi</LastName>
<ForeName>Luigi</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Maria Cecilia Hospital, GVM Care & Research, E.S. Health Science Foundation, Cotignola, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><CollectiveName>ESC-HFA HF Long-Term Registry investigators</CollectiveName>
</Author>
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<Language>eng</Language>
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<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>10</Month>
<Day>28</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Eur J Heart Fail</MedlineTA>
<NlmUniqueID>100887595</NlmUniqueID>
<ISSNLinking>1388-9842</ISSNLinking>
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<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Acute heart failure</Keyword>
<Keyword MajorTopicYN="N">Co-morbidities</Keyword>
<Keyword MajorTopicYN="N">Diabetes</Keyword>
<Keyword MajorTopicYN="N">Observational outcome study</Keyword>
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<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>05</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>08</Month>
<Day>24</Day>
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<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>09</Month>
<Day>20</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>10</Month>
<Day>30</Day>
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<PubMedPubDate PubStatus="medline"><Year>2017</Year>
<Month>11</Month>
<Day>10</Day>
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<Minute>0</Minute>
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<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>10</Month>
<Day>30</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27790816</ArticleId>
<ArticleId IdType="doi">10.1002/ejhf.679</ArticleId>
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