PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.
Identifieur interne : 001162 ( PubMed/Corpus ); précédent : 001161; suivant : 001163PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.
Auteurs : Amand F. Schmidt ; Daniel I. Swerdlow ; Michael V. Holmes ; Riyaz S. Patel ; Zammy Fairhurst-Hunter ; Donald M. Lyall ; Fernando Pires Hartwig ; Bernardo Lessa Horta ; Elina Hyppönen ; Christine Power ; Max Moldovan ; Erik Van Iperen ; G Kees Hovingh ; Ilja Demuth ; Kristina Norman ; Elisabeth Steinhagen-Thiessen ; Juri Demuth ; Lars Bertram ; Tian Liu ; Stefan Coassin ; Johann Willeit ; Stefan Kiechl ; Karin Willeit ; Dan Mason ; John Wright ; Richard Morris ; Goya Wanamethee ; Peter Whincup ; Yoav Ben-Shlomo ; Stela Mclachlan ; Jackie F. Price ; Mika Kivimaki ; Catherine Welch ; Adelaida Sanchez-Galvez ; Pedro Marques-Vidal ; Andrew Nicolaides ; Andrie G. Panayiotou ; N Charlotte Onland-Moret ; Yvonne T. Van Der Schouw ; Giuseppe Matullo ; Giovanni Fiorito ; Simonetta Guarrera ; Carlotta Sacerdote ; Nicholas J. Wareham ; Claudia Langenberg ; Robert Scott ; Jian'An Luan ; Martin Bobak ; Sofia Malyutina ; Andrzej Paj K ; Ruzena Kubinova ; Abdonas Tamosiunas ; Hynek Pikhart ; Lise Lotte Nystrup Husemoen ; Niels Grarup ; Oluf Pedersen ; Torben Hansen ; Allan Linneberg ; Kenneth Starup Simonsen ; Jackie Cooper ; Steve E. Humphries ; Murray Brilliant ; Terrie Kitchner ; Hakon Hakonarson ; David S. Carrell ; Catherine A. Mccarty ; H Lester Kirchner ; Eric B. Larson ; David R. Crosslin ; Mariza De Andrade ; Dan M. Roden ; Joshua C. Denny ; Cara Carty ; Stephen Hancock ; John Attia ; Elizabeth Holliday ; Martin O'Donnell ; Salim Yusuf ; Michael Chong ; Guillaume Pare ; Pim Van Der Harst ; M Abdullah Said ; Ruben N. Eppinga ; Niek Verweij ; Harold Snieder ; Tim Christen ; Dennis O. Mook-Kanamori ; Stefan Gustafsson ; Lars Lind ; Erik Ingelsson ; Raha Pazoki ; Oscar Franco ; Albert Hofman ; Andre Uitterlinden ; Abbas Dehghan ; Alexander Teumer ; Sebastian Baumeister ; Marcus Dörr ; Markus M. Lerch ; Uwe Völker ; Henry Völzke ; Joey Ward ; Jill P. Pell ; Daniel J. Smith ; Tom Meade ; Anke H. Maitland-Van Der Zee ; Ekaterina V. Baranova ; Robin Young ; Ian Ford ; Archie Campbell ; Sandosh Padmanabhan ; Michiel L. Bots ; Diederick E. Grobbee ; Philippe Froguel ; Dorothée Thuillier ; Beverley Balkau ; Amélie Bonnefond ; Bertrand Cariou ; Melissa Smart ; Yanchun Bao ; Meena Kumari ; Anubha Mahajan ; Paul M. Ridker ; Daniel I. Chasman ; Alex P. Reiner ; Leslie A. Lange ; Marylyn D. Ritchie ; Folkert W. Asselbergs ; Juan-Pablo Casas ; Brendan J. Keating ; David Preiss ; Aroon D. Hingorani ; Naveed SattarSource :
- The lancet. Diabetes & endocrinology [ 2213-8595 ] ; 2017.
Abstract
Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.
DOI: 10.1016/S2213-8587(16)30396-5
PubMed: 27908689
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pubmed:27908689Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.</title><author><name sortKey="Schmidt, Amand F" sort="Schmidt, Amand F" uniqKey="Schmidt A" first="Amand F" last="Schmidt">Amand F. Schmidt</name><affiliation><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK. Electronic address: amand.schmidt@ucl.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Swerdlow, Daniel I" sort="Swerdlow, Daniel I" uniqKey="Swerdlow D" first="Daniel I" last="Swerdlow">Daniel I. Swerdlow</name><affiliation><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Department of Medicine, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Holmes, Michael V" sort="Holmes, Michael V" uniqKey="Holmes M" first="Michael V" last="Holmes">Michael V. Holmes</name><affiliation><nlm:affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Riyaz S" sort="Patel, Riyaz S" uniqKey="Patel R" first="Riyaz S" last="Patel">Riyaz S. Patel</name><affiliation><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; The Barts Heart Centre, St Bartholomew's Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fairhurst Hunter, Zammy" sort="Fairhurst Hunter, Zammy" uniqKey="Fairhurst Hunter Z" first="Zammy" last="Fairhurst-Hunter">Zammy Fairhurst-Hunter</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lyall, Donald M" sort="Lyall, Donald M" uniqKey="Lyall D" first="Donald M" last="Lyall">Donald M. Lyall</name><affiliation><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hartwig, Fernando Pires" sort="Hartwig, Fernando Pires" uniqKey="Hartwig F" first="Fernando Pires" last="Hartwig">Fernando Pires Hartwig</name><affiliation><nlm:affiliation>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Horta, Bernardo Lessa" sort="Horta, Bernardo Lessa" uniqKey="Horta B" first="Bernardo Lessa" last="Horta">Bernardo Lessa Horta</name><affiliation><nlm:affiliation>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:affiliation>Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Power, Christine" sort="Power, Christine" uniqKey="Power C" first="Christine" last="Power">Christine Power</name><affiliation><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Moldovan, Max" sort="Moldovan, Max" uniqKey="Moldovan M" first="Max" last="Moldovan">Max Moldovan</name><affiliation><nlm:affiliation>School of Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute-EMBL Australia, Adelaide, SA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Iperen, Erik" sort="Van Iperen, Erik" uniqKey="Van Iperen E" first="Erik" last="Van Iperen">Erik Van Iperen</name><affiliation><nlm:affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G Kees" last="Hovingh">G Kees Hovingh</name><affiliation><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center Amsterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Demuth, Ilja" sort="Demuth, Ilja" uniqKey="Demuth I" first="Ilja" last="Demuth">Ilja Demuth</name><affiliation><nlm:affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Norman, Kristina" sort="Norman, Kristina" uniqKey="Norman K" first="Kristina" last="Norman">Kristina Norman</name><affiliation><nlm:affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Steinhagen Thiessen, Elisabeth" sort="Steinhagen Thiessen, Elisabeth" uniqKey="Steinhagen Thiessen E" first="Elisabeth" last="Steinhagen-Thiessen">Elisabeth Steinhagen-Thiessen</name><affiliation><nlm:affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Demuth, Juri" sort="Demuth, Juri" uniqKey="Demuth J" first="Juri" last="Demuth">Juri Demuth</name><affiliation><nlm:affiliation>E.CA Economics GmbH, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation><nlm:affiliation>Neuroepidemiology and Ageing Research Unit, Imperial College London, London, UK; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Tian" sort="Liu, Tian" uniqKey="Liu T" first="Tian" last="Liu">Tian Liu</name><affiliation><nlm:affiliation>Max Planck Institute for Human Development, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name><affiliation><nlm:affiliation>Division of Genetic Epidemiology Innsbruck, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Kiechl, Stefan" sort="Kiechl, Stefan" uniqKey="Kiechl S" first="Stefan" last="Kiechl">Stefan Kiechl</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Willeit, Karin" sort="Willeit, Karin" uniqKey="Willeit K" first="Karin" last="Willeit">Karin Willeit</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Mason, Dan" sort="Mason, Dan" uniqKey="Mason D" first="Dan" last="Mason">Dan Mason</name><affiliation><nlm:affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, John" sort="Wright, John" uniqKey="Wright J" first="John" last="Wright">John Wright</name><affiliation><nlm:affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Morris, Richard" sort="Morris, Richard" uniqKey="Morris R" first="Richard" last="Morris">Richard Morris</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wanamethee, Goya" sort="Wanamethee, Goya" uniqKey="Wanamethee G" first="Goya" last="Wanamethee">Goya Wanamethee</name><affiliation><nlm:affiliation>Department of Primary Care & Population Health, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Whincup, Peter" sort="Whincup, Peter" uniqKey="Whincup P" first="Peter" last="Whincup">Peter Whincup</name><affiliation><nlm:affiliation>Population Health Research Institute, St George's, University of London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mclachlan, Stela" sort="Mclachlan, Stela" uniqKey="Mclachlan S" first="Stela" last="Mclachlan">Stela Mclachlan</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Welch, Catherine" sort="Welch, Catherine" uniqKey="Welch C" first="Catherine" last="Welch">Catherine Welch</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sanchez Galvez, Adelaida" sort="Sanchez Galvez, Adelaida" uniqKey="Sanchez Galvez A" first="Adelaida" last="Sanchez-Galvez">Adelaida Sanchez-Galvez</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation><nlm:affiliation>Internal Medicine Unit, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Nicolaides, Andrew" sort="Nicolaides, Andrew" uniqKey="Nicolaides A" first="Andrew" last="Nicolaides">Andrew Nicolaides</name><affiliation><nlm:affiliation>Department of Vascular Surgery, Imperial College London, London, UK; Department of Surgery, Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.</nlm:affiliation></affiliation></author><author><name sortKey="Panayiotou, Andrie G" sort="Panayiotou, Andrie G" uniqKey="Panayiotou A" first="Andrie G" last="Panayiotou">Andrie G. Panayiotou</name><affiliation><nlm:affiliation>Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.</nlm:affiliation></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Matullo, Giuseppe" sort="Matullo, Giuseppe" uniqKey="Matullo G" first="Giuseppe" last="Matullo">Giuseppe Matullo</name><affiliation><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fiorito, Giovanni" sort="Fiorito, Giovanni" uniqKey="Fiorito G" first="Giovanni" last="Fiorito">Giovanni Fiorito</name><affiliation><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Guarrera, Simonetta" sort="Guarrera, Simonetta" uniqKey="Guarrera S" first="Simonetta" last="Guarrera">Simonetta Guarrera</name><affiliation><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, San Giovanni Battista Hospital, Turin, Italy; Centre for Oncology Prevention, CPO Piemonte, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bobak, Martin" sort="Bobak, Martin" uniqKey="Bobak M" first="Martin" last="Bobak">Martin Bobak</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Malyutina, Sofia" sort="Malyutina, Sofia" uniqKey="Malyutina S" first="Sofia" last="Malyutina">Sofia Malyutina</name><affiliation><nlm:affiliation>Novosibirsk State Medical University, Novosibirsk, Russia; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Paj K, Andrzej" sort="Paj K, Andrzej" uniqKey="Paj K A" first="Andrzej" last="Paj K">Andrzej Paj K</name><affiliation><nlm:affiliation>Jagiellonian University Collegium Medicum, Krakow, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Kubinova, Ruzena" sort="Kubinova, Ruzena" uniqKey="Kubinova R" first="Ruzena" last="Kubinova">Ruzena Kubinova</name><affiliation><nlm:affiliation>National Institute of Public Health, Prague, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Tamosiunas, Abdonas" sort="Tamosiunas, Abdonas" uniqKey="Tamosiunas A" first="Abdonas" last="Tamosiunas">Abdonas Tamosiunas</name><affiliation><nlm:affiliation>Lithuanian University of Health Sciences, Kaunas, Lithuania.</nlm:affiliation></affiliation></author><author><name sortKey="Pikhart, Hynek" sort="Pikhart, Hynek" uniqKey="Pikhart H" first="Hynek" last="Pikhart">Hynek Pikhart</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Husemoen, Lise Lotte Nystrup" sort="Husemoen, Lise Lotte Nystrup" uniqKey="Husemoen L" first="Lise Lotte Nystrup" last="Husemoen">Lise Lotte Nystrup Husemoen</name><affiliation><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Grarup, Niels" sort="Grarup, Niels" uniqKey="Grarup N" first="Niels" last="Grarup">Niels Grarup</name><affiliation><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Pedersen, Oluf" sort="Pedersen, Oluf" uniqKey="Pedersen O" first="Oluf" last="Pedersen">Oluf Pedersen</name><affiliation><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Linneberg, Allan" sort="Linneberg, Allan" uniqKey="Linneberg A" first="Allan" last="Linneberg">Allan Linneberg</name><affiliation><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Simonsen, Kenneth Starup" sort="Simonsen, Kenneth Starup" uniqKey="Simonsen K" first="Kenneth Starup" last="Simonsen">Kenneth Starup Simonsen</name><affiliation><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Jackie" sort="Cooper, Jackie" uniqKey="Cooper J" first="Jackie" last="Cooper">Jackie Cooper</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Brilliant, Murray" sort="Brilliant, Murray" uniqKey="Brilliant M" first="Murray" last="Brilliant">Murray Brilliant</name><affiliation><nlm:affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kitchner, Terrie" sort="Kitchner, Terrie" uniqKey="Kitchner T" first="Terrie" last="Kitchner">Terrie Kitchner</name><affiliation><nlm:affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:affiliation>Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carrell, David S" sort="Carrell, David S" uniqKey="Carrell D" first="David S" last="Carrell">David S. Carrell</name><affiliation><nlm:affiliation>Group Health Research Institute in Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mccarty, Catherine A" sort="Mccarty, Catherine A" uniqKey="Mccarty C" first="Catherine A" last="Mccarty">Catherine A. Mccarty</name><affiliation><nlm:affiliation>Essentia Institute of Rural Health, Duluth, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kirchner, H Lester" sort="Kirchner, H Lester" uniqKey="Kirchner H" first="H Lester" last="Kirchner">H Lester Kirchner</name><affiliation><nlm:affiliation>Center for Health Research, Geisinger Clinic, Danville, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><affiliation><nlm:affiliation>Group Health Research Institute, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Crosslin, David R" sort="Crosslin, David R" uniqKey="Crosslin D" first="David R" last="Crosslin">David R. Crosslin</name><affiliation><nlm:affiliation>Group Health Research Institute, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation><nlm:affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Roden, Dan M" sort="Roden, Dan M" uniqKey="Roden D" first="Dan M" last="Roden">Dan M. Roden</name><affiliation><nlm:affiliation>Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C" last="Denny">Joshua C. Denny</name><affiliation><nlm:affiliation>Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carty, Cara" sort="Carty, Cara" uniqKey="Carty C" first="Cara" last="Carty">Cara Carty</name><affiliation><nlm:affiliation>George Washington University, Washington, DC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hancock, Stephen" sort="Hancock, Stephen" uniqKey="Hancock S" first="Stephen" last="Hancock">Stephen Hancock</name><affiliation><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Holliday, Elizabeth" sort="Holliday, Elizabeth" uniqKey="Holliday E" first="Elizabeth" last="Holliday">Elizabeth Holliday</name><affiliation><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="O Donnell, Martin" sort="O Donnell, Martin" uniqKey="O Donnell M" first="Martin" last="O'Donnell">Martin O'Donnell</name><affiliation><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name><affiliation><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Chong, Michael" sort="Chong, Michael" uniqKey="Chong M" first="Michael" last="Chong">Michael Chong</name><affiliation><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Pare">Guillaume Pare</name><affiliation><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Said, M Abdullah" sort="Said, M Abdullah" uniqKey="Said M" first="M Abdullah" last="Said">M Abdullah Said</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Eppinga, Ruben N" sort="Eppinga, Ruben N" uniqKey="Eppinga R" first="Ruben N" last="Eppinga">Ruben N. Eppinga</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:affiliation>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Christen, Tim" sort="Christen, Tim" uniqKey="Christen T" first="Tim" last="Christen">Tim Christen</name><affiliation><nlm:affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation><nlm:affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pazoki, Raha" sort="Pazoki, Raha" uniqKey="Pazoki R" first="Raha" last="Pazoki">Raha Pazoki</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Franco, Oscar" sort="Franco, Oscar" uniqKey="Franco O" first="Oscar" last="Franco">Oscar Franco</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Uitterlinden, Andre" sort="Uitterlinden, Andre" uniqKey="Uitterlinden A" first="Andre" last="Uitterlinden">Andre Uitterlinden</name><affiliation><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:affiliation>Faculty of Medicine, and Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation><nlm:affiliation>Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lerch, Markus M" sort="Lerch, Markus M" uniqKey="Lerch M" first="Markus M" last="Lerch">Markus M. Lerch</name><affiliation><nlm:affiliation>Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:affiliation>Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ward, Joey" sort="Ward, Joey" uniqKey="Ward J" first="Joey" last="Ward">Joey Ward</name><affiliation><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pell, Jill P" sort="Pell, Jill P" uniqKey="Pell J" first="Jill P" last="Pell">Jill P. Pell</name><affiliation><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Daniel J" sort="Smith, Daniel J" uniqKey="Smith D" first="Daniel J" last="Smith">Daniel J. Smith</name><affiliation><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Meade, Tom" sort="Meade, Tom" uniqKey="Meade T" first="Tom" last="Meade">Tom Meade</name><affiliation><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Maitland Van Der Zee, Anke H" sort="Maitland Van Der Zee, Anke H" uniqKey="Maitland Van Der Zee A" first="Anke H" last="Maitland-Van Der Zee">Anke H. Maitland-Van Der Zee</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Academic Medical Center Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Baranova, Ekaterina V" sort="Baranova, Ekaterina V" uniqKey="Baranova E" first="Ekaterina V" last="Baranova">Ekaterina V. Baranova</name><affiliation><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Robin" sort="Young, Robin" uniqKey="Young R" first="Robin" last="Young">Robin Young</name><affiliation><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Campbell, Archie" sort="Campbell, Archie" uniqKey="Campbell A" first="Archie" last="Campbell">Archie Campbell</name><affiliation><nlm:affiliation>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bots, Michiel L" sort="Bots, Michiel L" uniqKey="Bots M" first="Michiel L" last="Bots">Michiel L. Bots</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E" last="Grobbee">Diederick E. Grobbee</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Thuillier, Dorothee" sort="Thuillier, Dorothee" uniqKey="Thuillier D" first="Dorothée" last="Thuillier">Dorothée Thuillier</name><affiliation><nlm:affiliation>CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:affiliation>Renal and Cardiovascular Epidemiology, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), INSERM U1018, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonnefond, Amelie" sort="Bonnefond, Amelie" uniqKey="Bonnefond A" first="Amélie" last="Bonnefond">Amélie Bonnefond</name><affiliation><nlm:affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cariou, Bertrand" sort="Cariou, Bertrand" uniqKey="Cariou B" first="Bertrand" last="Cariou">Bertrand Cariou</name><affiliation><nlm:affiliation>I'institut du Thorax, INSERM, CNRS, University of Nantes, CHU de Nantes, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Smart, Melissa" sort="Smart, Melissa" uniqKey="Smart M" first="Melissa" last="Smart">Melissa Smart</name><affiliation><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bao, Yanchun" sort="Bao, Yanchun" uniqKey="Bao Y" first="Yanchun" last="Bao">Yanchun Bao</name><affiliation><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mahajan, Anubha" sort="Mahajan, Anubha" uniqKey="Mahajan A" first="Anubha" last="Mahajan">Anubha Mahajan</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name><affiliation><nlm:affiliation>Department of Epidemiology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name><affiliation><nlm:affiliation>Anschutz Medical Campus, University of Colorado Denver, Denver, CO, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ritchie, Marylyn D" sort="Ritchie, Marylyn D" uniqKey="Ritchie M" first="Marylyn D" last="Ritchie">Marylyn D. Ritchie</name><affiliation><nlm:affiliation>Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name><affiliation><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Casas, Juan Pablo" sort="Casas, Juan Pablo" uniqKey="Casas J" first="Juan-Pablo" last="Casas">Juan-Pablo Casas</name><affiliation><nlm:affiliation>Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name><affiliation><nlm:affiliation>Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Preiss, David" sort="Preiss, David" uniqKey="Preiss D" first="David" last="Preiss">David Preiss</name><affiliation><nlm:affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name><affiliation><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address: naveed.sattar@glasgow.ac.uk.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27908689</idno><idno type="pmid">27908689</idno><idno type="doi">10.1016/S2213-8587(16)30396-5</idno><idno type="wicri:Area/PubMed/Corpus">001162</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001162</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.</title><author><name sortKey="Schmidt, Amand F" sort="Schmidt, Amand F" uniqKey="Schmidt A" first="Amand F" last="Schmidt">Amand F. Schmidt</name><affiliation><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK. Electronic address: amand.schmidt@ucl.ac.uk.</nlm:affiliation></affiliation></author><author><name sortKey="Swerdlow, Daniel I" sort="Swerdlow, Daniel I" uniqKey="Swerdlow D" first="Daniel I" last="Swerdlow">Daniel I. Swerdlow</name><affiliation><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Department of Medicine, Imperial College London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Holmes, Michael V" sort="Holmes, Michael V" uniqKey="Holmes M" first="Michael V" last="Holmes">Michael V. Holmes</name><affiliation><nlm:affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Patel, Riyaz S" sort="Patel, Riyaz S" uniqKey="Patel R" first="Riyaz S" last="Patel">Riyaz S. Patel</name><affiliation><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; The Barts Heart Centre, St Bartholomew's Hospital, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fairhurst Hunter, Zammy" sort="Fairhurst Hunter, Zammy" uniqKey="Fairhurst Hunter Z" first="Zammy" last="Fairhurst-Hunter">Zammy Fairhurst-Hunter</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Lyall, Donald M" sort="Lyall, Donald M" uniqKey="Lyall D" first="Donald M" last="Lyall">Donald M. Lyall</name><affiliation><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hartwig, Fernando Pires" sort="Hartwig, Fernando Pires" uniqKey="Hartwig F" first="Fernando Pires" last="Hartwig">Fernando Pires Hartwig</name><affiliation><nlm:affiliation>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Horta, Bernardo Lessa" sort="Horta, Bernardo Lessa" uniqKey="Horta B" first="Bernardo Lessa" last="Horta">Bernardo Lessa Horta</name><affiliation><nlm:affiliation>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.</nlm:affiliation></affiliation></author><author><name sortKey="Hypponen, Elina" sort="Hypponen, Elina" uniqKey="Hypponen E" first="Elina" last="Hyppönen">Elina Hyppönen</name><affiliation><nlm:affiliation>Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Power, Christine" sort="Power, Christine" uniqKey="Power C" first="Christine" last="Power">Christine Power</name><affiliation><nlm:affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Moldovan, Max" sort="Moldovan, Max" uniqKey="Moldovan M" first="Max" last="Moldovan">Max Moldovan</name><affiliation><nlm:affiliation>School of Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute-EMBL Australia, Adelaide, SA, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Van Iperen, Erik" sort="Van Iperen, Erik" uniqKey="Van Iperen E" first="Erik" last="Van Iperen">Erik Van Iperen</name><affiliation><nlm:affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G Kees" last="Hovingh">G Kees Hovingh</name><affiliation><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center Amsterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Demuth, Ilja" sort="Demuth, Ilja" uniqKey="Demuth I" first="Ilja" last="Demuth">Ilja Demuth</name><affiliation><nlm:affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Norman, Kristina" sort="Norman, Kristina" uniqKey="Norman K" first="Kristina" last="Norman">Kristina Norman</name><affiliation><nlm:affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Steinhagen Thiessen, Elisabeth" sort="Steinhagen Thiessen, Elisabeth" uniqKey="Steinhagen Thiessen E" first="Elisabeth" last="Steinhagen-Thiessen">Elisabeth Steinhagen-Thiessen</name><affiliation><nlm:affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Demuth, Juri" sort="Demuth, Juri" uniqKey="Demuth J" first="Juri" last="Demuth">Juri Demuth</name><affiliation><nlm:affiliation>E.CA Economics GmbH, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bertram, Lars" sort="Bertram, Lars" uniqKey="Bertram L" first="Lars" last="Bertram">Lars Bertram</name><affiliation><nlm:affiliation>Neuroepidemiology and Ageing Research Unit, Imperial College London, London, UK; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Tian" sort="Liu, Tian" uniqKey="Liu T" first="Tian" last="Liu">Tian Liu</name><affiliation><nlm:affiliation>Max Planck Institute for Human Development, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name><affiliation><nlm:affiliation>Division of Genetic Epidemiology Innsbruck, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Willeit, Johann" sort="Willeit, Johann" uniqKey="Willeit J" first="Johann" last="Willeit">Johann Willeit</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Kiechl, Stefan" sort="Kiechl, Stefan" uniqKey="Kiechl S" first="Stefan" last="Kiechl">Stefan Kiechl</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Willeit, Karin" sort="Willeit, Karin" uniqKey="Willeit K" first="Karin" last="Willeit">Karin Willeit</name><affiliation><nlm:affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</nlm:affiliation></affiliation></author><author><name sortKey="Mason, Dan" sort="Mason, Dan" uniqKey="Mason D" first="Dan" last="Mason">Dan Mason</name><affiliation><nlm:affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wright, John" sort="Wright, John" uniqKey="Wright J" first="John" last="Wright">John Wright</name><affiliation><nlm:affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Morris, Richard" sort="Morris, Richard" uniqKey="Morris R" first="Richard" last="Morris">Richard Morris</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Wanamethee, Goya" sort="Wanamethee, Goya" uniqKey="Wanamethee G" first="Goya" last="Wanamethee">Goya Wanamethee</name><affiliation><nlm:affiliation>Department of Primary Care & Population Health, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Whincup, Peter" sort="Whincup, Peter" uniqKey="Whincup P" first="Peter" last="Whincup">Peter Whincup</name><affiliation><nlm:affiliation>Population Health Research Institute, St George's, University of London, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ben Shlomo, Yoav" sort="Ben Shlomo, Yoav" uniqKey="Ben Shlomo Y" first="Yoav" last="Ben-Shlomo">Yoav Ben-Shlomo</name><affiliation><nlm:affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mclachlan, Stela" sort="Mclachlan, Stela" uniqKey="Mclachlan S" first="Stela" last="Mclachlan">Stela Mclachlan</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Price, Jackie F" sort="Price, Jackie F" uniqKey="Price J" first="Jackie F" last="Price">Jackie F. Price</name><affiliation><nlm:affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kivimaki, Mika" sort="Kivimaki, Mika" uniqKey="Kivimaki M" first="Mika" last="Kivimaki">Mika Kivimaki</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Welch, Catherine" sort="Welch, Catherine" uniqKey="Welch C" first="Catherine" last="Welch">Catherine Welch</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sanchez Galvez, Adelaida" sort="Sanchez Galvez, Adelaida" uniqKey="Sanchez Galvez A" first="Adelaida" last="Sanchez-Galvez">Adelaida Sanchez-Galvez</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Marques Vidal, Pedro" sort="Marques Vidal, Pedro" uniqKey="Marques Vidal P" first="Pedro" last="Marques-Vidal">Pedro Marques-Vidal</name><affiliation><nlm:affiliation>Internal Medicine Unit, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.</nlm:affiliation></affiliation></author><author><name sortKey="Nicolaides, Andrew" sort="Nicolaides, Andrew" uniqKey="Nicolaides A" first="Andrew" last="Nicolaides">Andrew Nicolaides</name><affiliation><nlm:affiliation>Department of Vascular Surgery, Imperial College London, London, UK; Department of Surgery, Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.</nlm:affiliation></affiliation></author><author><name sortKey="Panayiotou, Andrie G" sort="Panayiotou, Andrie G" uniqKey="Panayiotou A" first="Andrie G" last="Panayiotou">Andrie G. Panayiotou</name><affiliation><nlm:affiliation>Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.</nlm:affiliation></affiliation></author><author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Matullo, Giuseppe" sort="Matullo, Giuseppe" uniqKey="Matullo G" first="Giuseppe" last="Matullo">Giuseppe Matullo</name><affiliation><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Fiorito, Giovanni" sort="Fiorito, Giovanni" uniqKey="Fiorito G" first="Giovanni" last="Fiorito">Giovanni Fiorito</name><affiliation><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Guarrera, Simonetta" sort="Guarrera, Simonetta" uniqKey="Guarrera S" first="Simonetta" last="Guarrera">Simonetta Guarrera</name><affiliation><nlm:affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Sacerdote, Carlotta" sort="Sacerdote, Carlotta" uniqKey="Sacerdote C" first="Carlotta" last="Sacerdote">Carlotta Sacerdote</name><affiliation><nlm:affiliation>Cancer Epidemiology Unit, San Giovanni Battista Hospital, Turin, Italy; Centre for Oncology Prevention, CPO Piemonte, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Wareham, Nicholas J" sort="Wareham, Nicholas J" uniqKey="Wareham N" first="Nicholas J" last="Wareham">Nicholas J. Wareham</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Langenberg, Claudia" sort="Langenberg, Claudia" uniqKey="Langenberg C" first="Claudia" last="Langenberg">Claudia Langenberg</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Scott, Robert" sort="Scott, Robert" uniqKey="Scott R" first="Robert" last="Scott">Robert Scott</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Luan, Jian An" sort="Luan, Jian An" uniqKey="Luan J" first="Jian'An" last="Luan">Jian'An Luan</name><affiliation><nlm:affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bobak, Martin" sort="Bobak, Martin" uniqKey="Bobak M" first="Martin" last="Bobak">Martin Bobak</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Malyutina, Sofia" sort="Malyutina, Sofia" uniqKey="Malyutina S" first="Sofia" last="Malyutina">Sofia Malyutina</name><affiliation><nlm:affiliation>Novosibirsk State Medical University, Novosibirsk, Russia; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.</nlm:affiliation></affiliation></author><author><name sortKey="Paj K, Andrzej" sort="Paj K, Andrzej" uniqKey="Paj K A" first="Andrzej" last="Paj K">Andrzej Paj K</name><affiliation><nlm:affiliation>Jagiellonian University Collegium Medicum, Krakow, Poland.</nlm:affiliation></affiliation></author><author><name sortKey="Kubinova, Ruzena" sort="Kubinova, Ruzena" uniqKey="Kubinova R" first="Ruzena" last="Kubinova">Ruzena Kubinova</name><affiliation><nlm:affiliation>National Institute of Public Health, Prague, Czech Republic.</nlm:affiliation></affiliation></author><author><name sortKey="Tamosiunas, Abdonas" sort="Tamosiunas, Abdonas" uniqKey="Tamosiunas A" first="Abdonas" last="Tamosiunas">Abdonas Tamosiunas</name><affiliation><nlm:affiliation>Lithuanian University of Health Sciences, Kaunas, Lithuania.</nlm:affiliation></affiliation></author><author><name sortKey="Pikhart, Hynek" sort="Pikhart, Hynek" uniqKey="Pikhart H" first="Hynek" last="Pikhart">Hynek Pikhart</name><affiliation><nlm:affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Husemoen, Lise Lotte Nystrup" sort="Husemoen, Lise Lotte Nystrup" uniqKey="Husemoen L" first="Lise Lotte Nystrup" last="Husemoen">Lise Lotte Nystrup Husemoen</name><affiliation><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Grarup, Niels" sort="Grarup, Niels" uniqKey="Grarup N" first="Niels" last="Grarup">Niels Grarup</name><affiliation><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Pedersen, Oluf" sort="Pedersen, Oluf" uniqKey="Pedersen O" first="Oluf" last="Pedersen">Oluf Pedersen</name><affiliation><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Hansen, Torben" sort="Hansen, Torben" uniqKey="Hansen T" first="Torben" last="Hansen">Torben Hansen</name><affiliation><nlm:affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Linneberg, Allan" sort="Linneberg, Allan" uniqKey="Linneberg A" first="Allan" last="Linneberg">Allan Linneberg</name><affiliation><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Simonsen, Kenneth Starup" sort="Simonsen, Kenneth Starup" uniqKey="Simonsen K" first="Kenneth Starup" last="Simonsen">Kenneth Starup Simonsen</name><affiliation><nlm:affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Cooper, Jackie" sort="Cooper, Jackie" uniqKey="Cooper J" first="Jackie" last="Cooper">Jackie Cooper</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Humphries, Steve E" sort="Humphries, Steve E" uniqKey="Humphries S" first="Steve E" last="Humphries">Steve E. Humphries</name><affiliation><nlm:affiliation>Centre for Cardiovascular Genetics, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Brilliant, Murray" sort="Brilliant, Murray" uniqKey="Brilliant M" first="Murray" last="Brilliant">Murray Brilliant</name><affiliation><nlm:affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kitchner, Terrie" sort="Kitchner, Terrie" uniqKey="Kitchner T" first="Terrie" last="Kitchner">Terrie Kitchner</name><affiliation><nlm:affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name><affiliation><nlm:affiliation>Children's Hospital of Philadelphia, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carrell, David S" sort="Carrell, David S" uniqKey="Carrell D" first="David S" last="Carrell">David S. Carrell</name><affiliation><nlm:affiliation>Group Health Research Institute in Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mccarty, Catherine A" sort="Mccarty, Catherine A" uniqKey="Mccarty C" first="Catherine A" last="Mccarty">Catherine A. Mccarty</name><affiliation><nlm:affiliation>Essentia Institute of Rural Health, Duluth, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Kirchner, H Lester" sort="Kirchner, H Lester" uniqKey="Kirchner H" first="H Lester" last="Kirchner">H Lester Kirchner</name><affiliation><nlm:affiliation>Center for Health Research, Geisinger Clinic, Danville, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Larson, Eric B" sort="Larson, Eric B" uniqKey="Larson E" first="Eric B" last="Larson">Eric B. Larson</name><affiliation><nlm:affiliation>Group Health Research Institute, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Crosslin, David R" sort="Crosslin, David R" uniqKey="Crosslin D" first="David R" last="Crosslin">David R. Crosslin</name><affiliation><nlm:affiliation>Group Health Research Institute, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name><affiliation><nlm:affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Roden, Dan M" sort="Roden, Dan M" uniqKey="Roden D" first="Dan M" last="Roden">Dan M. Roden</name><affiliation><nlm:affiliation>Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Denny, Joshua C" sort="Denny, Joshua C" uniqKey="Denny J" first="Joshua C" last="Denny">Joshua C. Denny</name><affiliation><nlm:affiliation>Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carty, Cara" sort="Carty, Cara" uniqKey="Carty C" first="Cara" last="Carty">Cara Carty</name><affiliation><nlm:affiliation>George Washington University, Washington, DC, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Hancock, Stephen" sort="Hancock, Stephen" uniqKey="Hancock S" first="Stephen" last="Hancock">Stephen Hancock</name><affiliation><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Attia, John" sort="Attia, John" uniqKey="Attia J" first="John" last="Attia">John Attia</name><affiliation><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Holliday, Elizabeth" sort="Holliday, Elizabeth" uniqKey="Holliday E" first="Elizabeth" last="Holliday">Elizabeth Holliday</name><affiliation><nlm:affiliation>University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="O Donnell, Martin" sort="O Donnell, Martin" uniqKey="O Donnell M" first="Martin" last="O'Donnell">Martin O'Donnell</name><affiliation><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Yusuf, Salim" sort="Yusuf, Salim" uniqKey="Yusuf S" first="Salim" last="Yusuf">Salim Yusuf</name><affiliation><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Chong, Michael" sort="Chong, Michael" uniqKey="Chong M" first="Michael" last="Chong">Michael Chong</name><affiliation><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Pare, Guillaume" sort="Pare, Guillaume" uniqKey="Pare G" first="Guillaume" last="Pare">Guillaume Pare</name><affiliation><nlm:affiliation>Population Health Research Institute, Hamilton, ON, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name><affiliation><nlm:affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Said, M Abdullah" sort="Said, M Abdullah" uniqKey="Said M" first="M Abdullah" last="Said">M Abdullah Said</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Eppinga, Ruben N" sort="Eppinga, Ruben N" uniqKey="Eppinga R" first="Ruben N" last="Eppinga">Ruben N. Eppinga</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Verweij, Niek" sort="Verweij, Niek" uniqKey="Verweij N" first="Niek" last="Verweij">Niek Verweij</name><affiliation><nlm:affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name><affiliation><nlm:affiliation>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Christen, Tim" sort="Christen, Tim" uniqKey="Christen T" first="Tim" last="Christen">Tim Christen</name><affiliation><nlm:affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Mook Kanamori, Dennis O" sort="Mook Kanamori, Dennis O" uniqKey="Mook Kanamori D" first="Dennis O" last="Mook-Kanamori">Dennis O. Mook-Kanamori</name><affiliation><nlm:affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Gustafsson, Stefan" sort="Gustafsson, Stefan" uniqKey="Gustafsson S" first="Stefan" last="Gustafsson">Stefan Gustafsson</name><affiliation><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lind, Lars" sort="Lind, Lars" uniqKey="Lind L" first="Lars" last="Lind">Lars Lind</name><affiliation><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Ingelsson, Erik" sort="Ingelsson, Erik" uniqKey="Ingelsson E" first="Erik" last="Ingelsson">Erik Ingelsson</name><affiliation><nlm:affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pazoki, Raha" sort="Pazoki, Raha" uniqKey="Pazoki R" first="Raha" last="Pazoki">Raha Pazoki</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Franco, Oscar" sort="Franco, Oscar" uniqKey="Franco O" first="Oscar" last="Franco">Oscar Franco</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation><nlm:affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Uitterlinden, Andre" sort="Uitterlinden, Andre" uniqKey="Uitterlinden A" first="Andre" last="Uitterlinden">Andre Uitterlinden</name><affiliation><nlm:affiliation>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name><affiliation><nlm:affiliation>Faculty of Medicine, and Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Baumeister, Sebastian" sort="Baumeister, Sebastian" uniqKey="Baumeister S" first="Sebastian" last="Baumeister">Sebastian Baumeister</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Dorr, Marcus" sort="Dorr, Marcus" uniqKey="Dorr M" first="Marcus" last="Dörr">Marcus Dörr</name><affiliation><nlm:affiliation>Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Lerch, Markus M" sort="Lerch, Markus M" uniqKey="Lerch M" first="Markus M" last="Lerch">Markus M. Lerch</name><affiliation><nlm:affiliation>Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name><affiliation><nlm:affiliation>Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation><nlm:affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ward, Joey" sort="Ward, Joey" uniqKey="Ward J" first="Joey" last="Ward">Joey Ward</name><affiliation><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Pell, Jill P" sort="Pell, Jill P" uniqKey="Pell J" first="Jill P" last="Pell">Jill P. Pell</name><affiliation><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Smith, Daniel J" sort="Smith, Daniel J" uniqKey="Smith D" first="Daniel J" last="Smith">Daniel J. Smith</name><affiliation><nlm:affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Meade, Tom" sort="Meade, Tom" uniqKey="Meade T" first="Tom" last="Meade">Tom Meade</name><affiliation><nlm:affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Maitland Van Der Zee, Anke H" sort="Maitland Van Der Zee, Anke H" uniqKey="Maitland Van Der Zee A" first="Anke H" last="Maitland-Van Der Zee">Anke H. Maitland-Van Der Zee</name><affiliation><nlm:affiliation>Department of Respiratory Medicine, Academic Medical Center Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Baranova, Ekaterina V" sort="Baranova, Ekaterina V" uniqKey="Baranova E" first="Ekaterina V" last="Baranova">Ekaterina V. Baranova</name><affiliation><nlm:affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Robin" sort="Young, Robin" uniqKey="Young R" first="Robin" last="Young">Robin Young</name><affiliation><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation><nlm:affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Campbell, Archie" sort="Campbell, Archie" uniqKey="Campbell A" first="Archie" last="Campbell">Archie Campbell</name><affiliation><nlm:affiliation>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bots, Michiel L" sort="Bots, Michiel L" uniqKey="Bots M" first="Michiel L" last="Bots">Michiel L. Bots</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Grobbee, Diederick E" sort="Grobbee, Diederick E" uniqKey="Grobbee D" first="Diederick E" last="Grobbee">Diederick E. Grobbee</name><affiliation><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Froguel, Philippe" sort="Froguel, Philippe" uniqKey="Froguel P" first="Philippe" last="Froguel">Philippe Froguel</name><affiliation><nlm:affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Thuillier, Dorothee" sort="Thuillier, Dorothee" uniqKey="Thuillier D" first="Dorothée" last="Thuillier">Dorothée Thuillier</name><affiliation><nlm:affiliation>CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Balkau, Beverley" sort="Balkau, Beverley" uniqKey="Balkau B" first="Beverley" last="Balkau">Beverley Balkau</name><affiliation><nlm:affiliation>Renal and Cardiovascular Epidemiology, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), INSERM U1018, Villejuif, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bonnefond, Amelie" sort="Bonnefond, Amelie" uniqKey="Bonnefond A" first="Amélie" last="Bonnefond">Amélie Bonnefond</name><affiliation><nlm:affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</nlm:affiliation></affiliation></author><author><name sortKey="Cariou, Bertrand" sort="Cariou, Bertrand" uniqKey="Cariou B" first="Bertrand" last="Cariou">Bertrand Cariou</name><affiliation><nlm:affiliation>I'institut du Thorax, INSERM, CNRS, University of Nantes, CHU de Nantes, Nantes, France.</nlm:affiliation></affiliation></author><author><name sortKey="Smart, Melissa" sort="Smart, Melissa" uniqKey="Smart M" first="Melissa" last="Smart">Melissa Smart</name><affiliation><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Bao, Yanchun" sort="Bao, Yanchun" uniqKey="Bao Y" first="Yanchun" last="Bao">Yanchun Bao</name><affiliation><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name><affiliation><nlm:affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Mahajan, Anubha" sort="Mahajan, Anubha" uniqKey="Mahajan A" first="Anubha" last="Mahajan">Anubha Mahajan</name><affiliation><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name><affiliation><nlm:affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name><affiliation><nlm:affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name><affiliation><nlm:affiliation>Department of Epidemiology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Lange, Leslie A" sort="Lange, Leslie A" uniqKey="Lange L" first="Leslie A" last="Lange">Leslie A. Lange</name><affiliation><nlm:affiliation>Anschutz Medical Campus, University of Colorado Denver, Denver, CO, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ritchie, Marylyn D" sort="Ritchie, Marylyn D" uniqKey="Ritchie M" first="Marylyn D" last="Ritchie">Marylyn D. Ritchie</name><affiliation><nlm:affiliation>Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name><affiliation><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Casas, Juan Pablo" sort="Casas, Juan Pablo" uniqKey="Casas J" first="Juan-Pablo" last="Casas">Juan-Pablo Casas</name><affiliation><nlm:affiliation>Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name><affiliation><nlm:affiliation>Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Preiss, David" sort="Preiss, David" uniqKey="Preiss D" first="David" last="Preiss">David Preiss</name><affiliation><nlm:affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hingorani, Aroon D" sort="Hingorani, Aroon D" uniqKey="Hingorani A" first="Aroon D" last="Hingorani">Aroon D. Hingorani</name><affiliation><nlm:affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Sattar, Naveed" sort="Sattar, Naveed" uniqKey="Sattar N" first="Naveed" last="Sattar">Naveed Sattar</name><affiliation><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address: naveed.sattar@glasgow.ac.uk.</nlm:affiliation></affiliation></author></analytic><series><title level="j">The lancet. Diabetes & endocrinology</title><idno type="eISSN">2213-8595</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27908689</PMID><DateCreated><Year>2016</Year><Month>12</Month><Day>02</Day></DateCreated><DateRevised><Year>2017</Year><Month>11</Month><Day>18</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2213-8595</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The lancet. Diabetes & endocrinology</Title><ISOAbbreviation>Lancet Diabetes Endocrinol</ISOAbbreviation></Journal><ArticleTitle>PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study.</ArticleTitle><Pagination><MedlinePgn>97-105</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S2213-8587(16)30396-5</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/S2213-8587(16)30396-5</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest hyperglycaemia, increased bodyweight, and modestly increased risk of type 2 diabetes, which in no way offsets their substantial benefits. We sought to investigate the associations of LDL cholesterol-lowering PCSK9 variants with type 2 diabetes and related biomarkers to gauge the likely effects of PCSK9 inhibitors on diabetes risk.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">In this mendelian randomisation study, we used data from cohort studies, randomised controlled trials, case control studies, and genetic consortia to estimate associations of PCSK9 genetic variants with LDL cholesterol, fasting blood glucose, HbA1c, fasting insulin, bodyweight, waist-to-hip ratio, BMI, and risk of type 2 diabetes, using a standardised analysis plan, meta-analyses, and weighted gene-centric scores.</AbstractText><AbstractText Label="FINDINGS" NlmCategory="RESULTS">Data were available for more than 550 000 individuals and 51 623 cases of type 2 diabetes. Combined analyses of four independent PCSK9 variants (rs11583680, rs11591147, rs2479409, and rs11206510) scaled to 1 mmol/L lower LDL cholesterol showed associations with increased fasting glucose (0·09 mmol/L, 95% CI 0·02 to 0·15), bodyweight (1·03 kg, 0·24 to 1·82), waist-to-hip ratio (0·006, 0·003 to 0·010), and an odds ratio for type diabetes of 1·29 (1·11 to 1·50). Based on the collected data, we did not identify associations with HbA1c (0·03%, -0·01 to 0·08), fasting insulin (0·00%, -0·06 to 0·07), and BMI (0·11 kg/m(2), -0·09 to 0·30).</AbstractText><AbstractText Label="INTERPRETATION" NlmCategory="CONCLUSIONS">PCSK9 variants associated with lower LDL cholesterol were also associated with circulating higher fasting glucose concentration, bodyweight, and waist-to-hip ratio, and an increased risk of type 2 diabetes. In trials of PCSK9 inhibitor drugs, investigators should carefully assess these safety outcomes and quantify the risks and benefits of PCSK9 inhibitor treatment, as was previously done for statins.</AbstractText><AbstractText Label="FUNDING" NlmCategory="BACKGROUND">British Heart Foundation, and University College London Hospitals NHS Foundation Trust (UCLH) National Institute for Health Research (NIHR) Biomedical Research Centre.</AbstractText><CopyrightInformation>Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license. Published by Elsevier Ltd.. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schmidt</LastName><ForeName>Amand F</ForeName><Initials>AF</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK. Electronic address: amand.schmidt@ucl.ac.uk.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Swerdlow</LastName><ForeName>Daniel I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK; Department of Medicine, Imperial College London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holmes</LastName><ForeName>Michael V</ForeName><Initials>MV</Initials><AffiliationInfo><Affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Riyaz S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; The Barts Heart Centre, St Bartholomew's Hospital, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fairhurst-Hunter</LastName><ForeName>Zammy</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lyall</LastName><ForeName>Donald M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hartwig</LastName><ForeName>Fernando Pires</ForeName><Initials>FP</Initials><AffiliationInfo><Affiliation>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Horta</LastName><ForeName>Bernardo Lessa</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hyppönen</LastName><ForeName>Elina</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Centre for Population Health Research, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia; Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK; South Australian Health and Medical Research Institute, Adelaide, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Power</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Moldovan</LastName><ForeName>Max</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>School of Health Sciences, University of South Australia, Adelaide, SA, Australia; South Australian Health and Medical Research Institute-EMBL Australia, Adelaide, SA, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van Iperen</LastName><ForeName>Erik</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center Amsterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hovingh</LastName><ForeName>G Kees</ForeName><Initials>GK</Initials><AffiliationInfo><Affiliation>Department of Vascular Medicine, Academic Medical Center Amsterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demuth</LastName><ForeName>Ilja</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany; Institute of Medical and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Norman</LastName><ForeName>Kristina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steinhagen-Thiessen</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Charité Research Group on Geriatrics, Charité-Universitätsmedizin Berlin, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Demuth</LastName><ForeName>Juri</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>E.CA Economics GmbH, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertram</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Neuroepidemiology and Ageing Research Unit, Imperial College London, London, UK; Lübeck Interdisciplinary Platform for Genome Analytics (LIGA), Institutes of Neurogenetics and Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Tian</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Max Planck Institute for Human Development, Berlin, Germany; Max Planck Institute for Molecular Genetics, Berlin, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coassin</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Genetic Epidemiology Innsbruck, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willeit</LastName><ForeName>Johann</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kiechl</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willeit</LastName><ForeName>Karin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mason</LastName><ForeName>Dan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wright</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Bradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morris</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wanamethee</LastName><ForeName>Goya</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Primary Care & Population Health, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Whincup</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, St George's, University of London, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ben-Shlomo</LastName><ForeName>Yoav</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>School of Social and Community Medicine, University of Bristol, Bristol, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McLachlan</LastName><ForeName>Stela</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Price</LastName><ForeName>Jackie F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kivimaki</LastName><ForeName>Mika</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Welch</LastName><ForeName>Catherine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sanchez-Galvez</LastName><ForeName>Adelaida</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marques-Vidal</LastName><ForeName>Pedro</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Internal Medicine Unit, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nicolaides</LastName><ForeName>Andrew</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Vascular Surgery, Imperial College London, London, UK; Department of Surgery, Nicosia Medical School, University of Nicosia, Nicosia, Cyprus.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Panayiotou</LastName><ForeName>Andrie G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Cyprus International Institute for Environmental and Public Health, Cyprus University of Technology, Limassol, Cyprus.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Onland-Moret</LastName><ForeName>N Charlotte</ForeName><Initials>NC</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Schouw</LastName><ForeName>Yvonne T</ForeName><Initials>YT</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matullo</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fiorito</LastName><ForeName>Giovanni</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Guarrera</LastName><ForeName>Simonetta</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Human Genetics Foundation, HuGeF, Turin, Italy; Department of Medical Sciences, University of Turin, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sacerdote</LastName><ForeName>Carlotta</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Unit, San Giovanni Battista Hospital, Turin, Italy; Centre for Oncology Prevention, CPO Piemonte, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wareham</LastName><ForeName>Nicholas J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Langenberg</LastName><ForeName>Claudia</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scott</LastName><ForeName>Robert</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Luan</LastName><ForeName>Jian'an</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bobak</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malyutina</LastName><ForeName>Sofia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Novosibirsk State Medical University, Novosibirsk, Russia; Institute of Internal and Preventive Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pająk</LastName><ForeName>Andrzej</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Jagiellonian University Collegium Medicum, Krakow, Poland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kubinova</LastName><ForeName>Ruzena</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>National Institute of Public Health, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tamosiunas</LastName><ForeName>Abdonas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Lithuanian University of Health Sciences, Kaunas, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pikhart</LastName><ForeName>Hynek</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Public Health, UCL Institute of Epidemiology and Health Care, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Husemoen</LastName><ForeName>Lise Lotte Nystrup</ForeName><Initials>LL</Initials><AffiliationInfo><Affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grarup</LastName><ForeName>Niels</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pedersen</LastName><ForeName>Oluf</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>Torben</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Linneberg</LastName><ForeName>Allan</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark; Department of Clinical Experimental Research, Rigshospitalet, Copenhagen, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Simonsen</LastName><ForeName>Kenneth Starup</ForeName><Initials>KS</Initials><AffiliationInfo><Affiliation>Research Centre for Prevention and Health, Capital Region of Denmark, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cooper</LastName><ForeName>Jackie</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Humphries</LastName><ForeName>Steve E</ForeName><Initials>SE</Initials><AffiliationInfo><Affiliation>Centre for Cardiovascular Genetics, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brilliant</LastName><ForeName>Murray</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kitchner</LastName><ForeName>Terrie</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, WI, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hakonarson</LastName><ForeName>Hakon</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Children's Hospital of Philadelphia, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carrell</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Group Health Research Institute in Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McCarty</LastName><ForeName>Catherine A</ForeName><Initials>CA</Initials><AffiliationInfo><Affiliation>Essentia Institute of Rural Health, Duluth, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kirchner</LastName><ForeName>H Lester</ForeName><Initials>HL</Initials><AffiliationInfo><Affiliation>Center for Health Research, Geisinger Clinic, Danville, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larson</LastName><ForeName>Eric B</ForeName><Initials>EB</Initials><AffiliationInfo><Affiliation>Group Health Research Institute, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Crosslin</LastName><ForeName>David R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Group Health Research Institute, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Andrade</LastName><ForeName>Mariza</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Roden</LastName><ForeName>Dan M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Denny</LastName><ForeName>Joshua C</ForeName><Initials>JC</Initials><AffiliationInfo><Affiliation>Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carty</LastName><ForeName>Cara</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>George Washington University, Washington, DC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hancock</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Attia</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holliday</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>University of Newcastle, Newcastle, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Donnell</LastName><ForeName>Martin</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yusuf</LastName><ForeName>Salim</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chong</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pare</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Population Health Research Institute, Hamilton, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Harst</LastName><ForeName>Pim</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Said</LastName><ForeName>M Abdullah</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eppinga</LastName><ForeName>Ruben N</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Verweij</LastName><ForeName>Niek</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Snieder</LastName><ForeName>Harold</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>LifeLines Cohort study group</CollectiveName></Author><Author ValidYN="Y"><LastName>Christen</LastName><ForeName>Tim</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mook-Kanamori</LastName><ForeName>Dennis O</ForeName><Initials>DO</Initials><AffiliationInfo><Affiliation>Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gustafsson</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lind</LastName><ForeName>Lars</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ingelsson</LastName><ForeName>Erik</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Molecular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pazoki</LastName><ForeName>Raha</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Franco</LastName><ForeName>Oscar</ForeName><Initials>O</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hofman</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Uitterlinden</LastName><ForeName>Andre</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dehghan</LastName><ForeName>Abbas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Faculty of Medicine, and Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teumer</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baumeister</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dörr</LastName><ForeName>Marcus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lerch</LastName><ForeName>Markus M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Department of Medicine A, University Medicine Greifswald, Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Völker</LastName><ForeName>Uwe</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Interfaculty Institute of Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Völzke</LastName><ForeName>Henry</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany; German Centre for Cardiovascular Research (DZHK), Greifswald, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ward</LastName><ForeName>Joey</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pell</LastName><ForeName>Jill P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smith</LastName><ForeName>Daniel J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meade</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maitland-van der Zee</LastName><ForeName>Anke H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Department of Respiratory Medicine, Academic Medical Center Amsterdam, Netherlands; Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baranova</LastName><ForeName>Ekaterina V</ForeName><Initials>EV</Initials><AffiliationInfo><Affiliation>Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Robin</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ford</LastName><ForeName>Ian</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campbell</LastName><ForeName>Archie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Padmanabhan</LastName><ForeName>Sandosh</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bots</LastName><ForeName>Michiel L</ForeName><Initials>ML</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grobbee</LastName><ForeName>Diederick E</ForeName><Initials>DE</Initials><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Froguel</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Thuillier</LastName><ForeName>Dorothée</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Balkau</LastName><ForeName>Beverley</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Renal and Cardiovascular Epidemiology, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), INSERM U1018, Villejuif, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bonnefond</LastName><ForeName>Amélie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Genomics of Common Disease, Imperial College London, London, UK; CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cariou</LastName><ForeName>Bertrand</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>I'institut du Thorax, INSERM, CNRS, University of Nantes, CHU de Nantes, Nantes, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smart</LastName><ForeName>Melissa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bao</LastName><ForeName>Yanchun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumari</LastName><ForeName>Meena</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Social and Economic Research, University of Essex, Colchester, Essex, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mahajan</LastName><ForeName>Anubha</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ridker</LastName><ForeName>Paul M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chasman</LastName><ForeName>Daniel I</ForeName><Initials>DI</Initials><AffiliationInfo><Affiliation>Harvard Medical School Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Boston, MA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Reiner</LastName><ForeName>Alex P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lange</LastName><ForeName>Leslie A</ForeName><Initials>LA</Initials><AffiliationInfo><Affiliation>Anschutz Medical Campus, University of Colorado Denver, Denver, CO, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ritchie</LastName><ForeName>Marylyn D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Biomedical and Translational Informatics, Geisinger Health System, Danville, PA, USA; Department of Biochemistry and Molecular Biology, Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Asselbergs</LastName><ForeName>Folkert W</ForeName><Initials>FW</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Casas</LastName><ForeName>Juan-Pablo</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Keating</LastName><ForeName>Brendan J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Preiss</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK; Medical Research Council Population Health Research Unit at the University of Oxford, University of Oxford, Oxford, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hingorani</LastName><ForeName>Aroon D</ForeName><Initials>AD</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular Science, University College London, UK; Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, University College London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>UCLEB consortium</CollectiveName></Author><Author ValidYN="Y"><LastName>Sattar</LastName><ForeName>Naveed</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. Electronic address: naveed.sattar@glasgow.ac.uk.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>G1001799</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG/08/008/25291</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K006665/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>PG/13/66/30442</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0802432</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_PC_13042</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG/08/013/25942</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MC_UU_12015/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>CZD/16/6/4</GrantID><Agency>Chief Scientist Office</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K006584/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>MR/K013351/1</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>PG/12/71/29684</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>RG/13/16/30528</GrantID><Agency>British Heart Foundation</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>R01 HL135313</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 HG008701</GrantID><Acronym>HG</Acronym><Agency>NHGRI NIH HHS</Agency><Country>United 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