Reduced Activity of SRY and its Target Enhancer Sox9-TESCO in a Mouse Species with X*Y Sex Reversal.
Identifieur interne : 001144 ( PubMed/Corpus ); précédent : 001143; suivant : 001145Reduced Activity of SRY and its Target Enhancer Sox9-TESCO in a Mouse Species with X*Y Sex Reversal.
Auteurs : Liang Zhao ; Alexander Quinn ; Ee Ting Ng ; Frederic Veyrunes ; Peter KoopmanSource :
- Scientific reports [ 2045-2322 ] ; 2017.
Abstract
In most eutherian mammals, sex determination is governed by the Y-linked gene Sry, but in African pygmy mice Mus minutoides, Sry action is overridden by a variant X chromosome (X*), yielding X*Y females. We hypothesized that X*Y sex reversal may be underpinned not only by neomorphic X chromosome functionality, but also by a compromised Sry pathway. Here, we show that neither M. minutoides SRY nor its target, the Sox9-TESCO enhancer, had appreciable transcriptional activity in in vitro assays, correlating with sequence degradation compared to Mus musculus counterparts. However, M. minutoides SRY activated its cognate TESCO to a moderate degree, and can clearly engage the male pathway in M. minutoides in the wild, indicating that SRY and TESCO may have co-evolved in M. minutoides to retain function above a threshold level. We suggest that weakening of the SRY/TESCO nexus may have facilitated the rise and spread of a variant X* chromosome carrying female-inducing modifier gene(s).
DOI: 10.1038/srep41378
PubMed: 28155866
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Reduced Activity of SRY and its Target Enhancer Sox9-TESCO in a Mouse Species with X*Y Sex Reversal.</title><author><name sortKey="Zhao, Liang" sort="Zhao, Liang" uniqKey="Zhao L" first="Liang" last="Zhao">Liang Zhao</name><affiliation><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Quinn, Alexander" sort="Quinn, Alexander" uniqKey="Quinn A" first="Alexander" last="Quinn">Alexander Quinn</name><affiliation><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, Ee Ting" sort="Ng, Ee Ting" uniqKey="Ng E" first="Ee Ting" last="Ng">Ee Ting Ng</name><affiliation><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Veyrunes, Frederic" sort="Veyrunes, Frederic" uniqKey="Veyrunes F" first="Frederic" last="Veyrunes">Frederic Veyrunes</name><affiliation><nlm:affiliation>Institut des Sciences de l'Evolution de Montpellier, Université Montpellier II, CNRS, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Koopman, Peter" sort="Koopman, Peter" uniqKey="Koopman P" first="Peter" last="Koopman">Peter Koopman</name><affiliation><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28155866</idno><idno type="pmid">28155866</idno><idno type="doi">10.1038/srep41378</idno><idno type="wicri:Area/PubMed/Corpus">001144</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001144</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reduced Activity of SRY and its Target Enhancer Sox9-TESCO in a Mouse Species with X*Y Sex Reversal.</title><author><name sortKey="Zhao, Liang" sort="Zhao, Liang" uniqKey="Zhao L" first="Liang" last="Zhao">Liang Zhao</name><affiliation><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Quinn, Alexander" sort="Quinn, Alexander" uniqKey="Quinn A" first="Alexander" last="Quinn">Alexander Quinn</name><affiliation><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Ng, Ee Ting" sort="Ng, Ee Ting" uniqKey="Ng E" first="Ee Ting" last="Ng">Ee Ting Ng</name><affiliation><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Veyrunes, Frederic" sort="Veyrunes, Frederic" uniqKey="Veyrunes F" first="Frederic" last="Veyrunes">Frederic Veyrunes</name><affiliation><nlm:affiliation>Institut des Sciences de l'Evolution de Montpellier, Université Montpellier II, CNRS, Montpellier, France.</nlm:affiliation></affiliation></author><author><name sortKey="Koopman, Peter" sort="Koopman, Peter" uniqKey="Koopman P" first="Peter" last="Koopman">Peter Koopman</name><affiliation><nlm:affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In most eutherian mammals, sex determination is governed by the Y-linked gene Sry, but in African pygmy mice Mus minutoides, Sry action is overridden by a variant X chromosome (X*), yielding X*Y females. We hypothesized that X*Y sex reversal may be underpinned not only by neomorphic X chromosome functionality, but also by a compromised Sry pathway. Here, we show that neither M. minutoides SRY nor its target, the Sox9-TESCO enhancer, had appreciable transcriptional activity in in vitro assays, correlating with sequence degradation compared to Mus musculus counterparts. However, M. minutoides SRY activated its cognate TESCO to a moderate degree, and can clearly engage the male pathway in M. minutoides in the wild, indicating that SRY and TESCO may have co-evolved in M. minutoides to retain function above a threshold level. We suggest that weakening of the SRY/TESCO nexus may have facilitated the rise and spread of a variant X* chromosome carrying female-inducing modifier gene(s).</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28155866</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>03</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>24</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><PubDate><Year>2017</Year><Month>Feb</Month><Day>03</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>Reduced Activity of SRY and its Target Enhancer Sox9-TESCO in a Mouse Species with X*Y Sex Reversal.</ArticleTitle><Pagination><MedlinePgn>41378</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/srep41378</ELocationID><Abstract><AbstractText>In most eutherian mammals, sex determination is governed by the Y-linked gene Sry, but in African pygmy mice Mus minutoides, Sry action is overridden by a variant X chromosome (X*), yielding X*Y females. We hypothesized that X*Y sex reversal may be underpinned not only by neomorphic X chromosome functionality, but also by a compromised Sry pathway. Here, we show that neither M. minutoides SRY nor its target, the Sox9-TESCO enhancer, had appreciable transcriptional activity in in vitro assays, correlating with sequence degradation compared to Mus musculus counterparts. However, M. minutoides SRY activated its cognate TESCO to a moderate degree, and can clearly engage the male pathway in M. minutoides in the wild, indicating that SRY and TESCO may have co-evolved in M. minutoides to retain function above a threshold level. We suggest that weakening of the SRY/TESCO nexus may have facilitated the rise and spread of a variant X* chromosome carrying female-inducing modifier gene(s).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Liang</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quinn</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ng</LastName><ForeName>Ee Ting</ForeName><Initials>ET</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Veyrunes</LastName><ForeName>Frederic</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Institut des Sciences de l'Evolution de Montpellier, Université Montpellier II, CNRS, Montpellier, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Koopman</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>02</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci 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