Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG.
Identifieur interne : 001079 ( PubMed/Corpus ); précédent : 001078; suivant : 001080Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG.
Auteurs : Oleg V. Pyankov ; Yin Xiang Setoh ; Sergey A. Bodnev ; Judith H. Edmonds ; Olga G. Pyankova ; Stepan A. Pyankov ; Gabor Pali ; Shane Belford ; Louis Lu ; Mylinh La ; George Lovrecz ; Valentina A. Volchkova ; Keith J. Chappell ; Daniel Watterson ; Glenn Marsh ; Paul R. Young ; Alexander A. Agafonov ; Jillann F. Farmer ; Victor E. Volchkov ; Andreas Suhrbier ; Alexander A. KhromykhSource :
- Scientific reports [ 2045-2322 ] ; 2017.
Abstract
Herein we describe production of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting with Kunjin replicon virus-like particles both encoding a modified Ebola glycoprotein. Administration of the equine IgG over 5 days to cynomolgus macaques infected 24 hours previously with a lethal dose of Ebola virus suppressed viral loads by more than 5 logs and protected animals from mortality. Animals generated their own Ebola glycoprotein-specific IgG responses 9-15 days after infection, with circulating virus undetectable by day 15-17. Such equine IgG may find utility as a post-exposure prophylactic for Ebola infection and provides a low cost, scalable alternative to monoclonal antibodies, with extensive human safety data and WHO-standardized international manufacturing capability available in both high and low income countries.
DOI: 10.1038/srep41537
PubMed: 28155869
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG.</title><author><name sortKey="Pyankov, Oleg V" sort="Pyankov, Oleg V" uniqKey="Pyankov O" first="Oleg V" last="Pyankov">Oleg V. Pyankov</name><affiliation><nlm:affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Setoh, Yin Xiang" sort="Setoh, Yin Xiang" uniqKey="Setoh Y" first="Yin Xiang" last="Setoh">Yin Xiang Setoh</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bodnev, Sergey A" sort="Bodnev, Sergey A" uniqKey="Bodnev S" first="Sergey A" last="Bodnev">Sergey A. Bodnev</name><affiliation><nlm:affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Edmonds, Judith H" sort="Edmonds, Judith H" uniqKey="Edmonds J" first="Judith H" last="Edmonds">Judith H. Edmonds</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pyankova, Olga G" sort="Pyankova, Olga G" uniqKey="Pyankova O" first="Olga G" last="Pyankova">Olga G. Pyankova</name><affiliation><nlm:affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Pyankov, Stepan A" sort="Pyankov, Stepan A" uniqKey="Pyankov S" first="Stepan A" last="Pyankov">Stepan A. Pyankov</name><affiliation><nlm:affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Pali, Gabor" sort="Pali, Gabor" uniqKey="Pali G" first="Gabor" last="Pali">Gabor Pali</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Belford, Shane" sort="Belford, Shane" uniqKey="Belford S" first="Shane" last="Belford">Shane Belford</name><affiliation><nlm:affiliation>Plasvacc Pty. Ltd., Kalbar, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lu, Louis" sort="Lu, Louis" uniqKey="Lu L" first="Louis" last="Lu">Louis Lu</name><affiliation><nlm:affiliation>Bio Medical Manufacturing, Fermentation and Protein Production Facility, CSIRO, Clayton, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="La, Mylinh" sort="La, Mylinh" uniqKey="La M" first="Mylinh" last="La">Mylinh La</name><affiliation><nlm:affiliation>Bio Medical Manufacturing, Fermentation and Protein Production Facility, CSIRO, Clayton, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lovrecz, George" sort="Lovrecz, George" uniqKey="Lovrecz G" first="George" last="Lovrecz">George Lovrecz</name><affiliation><nlm:affiliation>Bio Medical Manufacturing, Fermentation and Protein Production Facility, CSIRO, Clayton, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Volchkova, Valentina A" sort="Volchkova, Valentina A" uniqKey="Volchkova V" first="Valentina A" last="Volchkova">Valentina A. Volchkova</name><affiliation><nlm:affiliation>Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chappell, Keith J" sort="Chappell, Keith J" uniqKey="Chappell K" first="Keith J" last="Chappell">Keith J. Chappell</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Watterson, Daniel" sort="Watterson, Daniel" uniqKey="Watterson D" first="Daniel" last="Watterson">Daniel Watterson</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Marsh, Glenn" sort="Marsh, Glenn" uniqKey="Marsh G" first="Glenn" last="Marsh">Glenn Marsh</name><affiliation><nlm:affiliation>Australian Animal Health Laboratory, CSIRO Health and Biosecurity, Geelong, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Paul R" sort="Young, Paul R" uniqKey="Young P" first="Paul R" last="Young">Paul R. Young</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Agafonov, Alexander A" sort="Agafonov, Alexander A" uniqKey="Agafonov A" first="Alexander A" last="Agafonov">Alexander A. Agafonov</name><affiliation><nlm:affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Farmer, Jillann F" sort="Farmer, Jillann F" uniqKey="Farmer J" first="Jillann F" last="Farmer">Jillann F. Farmer</name><affiliation><nlm:affiliation>United Nations Medical Service, New York, NY 10017, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Volchkov, Victor E" sort="Volchkov, Victor E" uniqKey="Volchkov V" first="Victor E" last="Volchkov">Victor E. Volchkov</name><affiliation><nlm:affiliation>Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name><affiliation><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Khromykh, Alexander A" sort="Khromykh, Alexander A" uniqKey="Khromykh A" first="Alexander A" last="Khromykh">Alexander A. Khromykh</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28155869</idno><idno type="pmid">28155869</idno><idno type="doi">10.1038/srep41537</idno><idno type="wicri:Area/PubMed/Corpus">001079</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001079</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG.</title><author><name sortKey="Pyankov, Oleg V" sort="Pyankov, Oleg V" uniqKey="Pyankov O" first="Oleg V" last="Pyankov">Oleg V. Pyankov</name><affiliation><nlm:affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Setoh, Yin Xiang" sort="Setoh, Yin Xiang" uniqKey="Setoh Y" first="Yin Xiang" last="Setoh">Yin Xiang Setoh</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Bodnev, Sergey A" sort="Bodnev, Sergey A" uniqKey="Bodnev S" first="Sergey A" last="Bodnev">Sergey A. Bodnev</name><affiliation><nlm:affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Edmonds, Judith H" sort="Edmonds, Judith H" uniqKey="Edmonds J" first="Judith H" last="Edmonds">Judith H. Edmonds</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Pyankova, Olga G" sort="Pyankova, Olga G" uniqKey="Pyankova O" first="Olga G" last="Pyankova">Olga G. Pyankova</name><affiliation><nlm:affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Pyankov, Stepan A" sort="Pyankov, Stepan A" uniqKey="Pyankov S" first="Stepan A" last="Pyankov">Stepan A. Pyankov</name><affiliation><nlm:affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Pali, Gabor" sort="Pali, Gabor" uniqKey="Pali G" first="Gabor" last="Pali">Gabor Pali</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Belford, Shane" sort="Belford, Shane" uniqKey="Belford S" first="Shane" last="Belford">Shane Belford</name><affiliation><nlm:affiliation>Plasvacc Pty. Ltd., Kalbar, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lu, Louis" sort="Lu, Louis" uniqKey="Lu L" first="Louis" last="Lu">Louis Lu</name><affiliation><nlm:affiliation>Bio Medical Manufacturing, Fermentation and Protein Production Facility, CSIRO, Clayton, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="La, Mylinh" sort="La, Mylinh" uniqKey="La M" first="Mylinh" last="La">Mylinh La</name><affiliation><nlm:affiliation>Bio Medical Manufacturing, Fermentation and Protein Production Facility, CSIRO, Clayton, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lovrecz, George" sort="Lovrecz, George" uniqKey="Lovrecz G" first="George" last="Lovrecz">George Lovrecz</name><affiliation><nlm:affiliation>Bio Medical Manufacturing, Fermentation and Protein Production Facility, CSIRO, Clayton, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Volchkova, Valentina A" sort="Volchkova, Valentina A" uniqKey="Volchkova V" first="Valentina A" last="Volchkova">Valentina A. Volchkova</name><affiliation><nlm:affiliation>Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chappell, Keith J" sort="Chappell, Keith J" uniqKey="Chappell K" first="Keith J" last="Chappell">Keith J. Chappell</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Watterson, Daniel" sort="Watterson, Daniel" uniqKey="Watterson D" first="Daniel" last="Watterson">Daniel Watterson</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Marsh, Glenn" sort="Marsh, Glenn" uniqKey="Marsh G" first="Glenn" last="Marsh">Glenn Marsh</name><affiliation><nlm:affiliation>Australian Animal Health Laboratory, CSIRO Health and Biosecurity, Geelong, VIC, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Young, Paul R" sort="Young, Paul R" uniqKey="Young P" first="Paul R" last="Young">Paul R. Young</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Agafonov, Alexander A" sort="Agafonov, Alexander A" uniqKey="Agafonov A" first="Alexander A" last="Agafonov">Alexander A. Agafonov</name><affiliation><nlm:affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</nlm:affiliation></affiliation></author><author><name sortKey="Farmer, Jillann F" sort="Farmer, Jillann F" uniqKey="Farmer J" first="Jillann F" last="Farmer">Jillann F. Farmer</name><affiliation><nlm:affiliation>United Nations Medical Service, New York, NY 10017, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Volchkov, Victor E" sort="Volchkov, Victor E" uniqKey="Volchkov V" first="Victor E" last="Volchkov">Victor E. Volchkov</name><affiliation><nlm:affiliation>Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Suhrbier, Andreas" sort="Suhrbier, Andreas" uniqKey="Suhrbier A" first="Andreas" last="Suhrbier">Andreas Suhrbier</name><affiliation><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Khromykh, Alexander A" sort="Khromykh, Alexander A" uniqKey="Khromykh A" first="Alexander A" last="Khromykh">Alexander A. Khromykh</name><affiliation><nlm:affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Scientific reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Herein we describe production of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting with Kunjin replicon virus-like particles both encoding a modified Ebola glycoprotein. Administration of the equine IgG over 5 days to cynomolgus macaques infected 24 hours previously with a lethal dose of Ebola virus suppressed viral loads by more than 5 logs and protected animals from mortality. Animals generated their own Ebola glycoprotein-specific IgG responses 9-15 days after infection, with circulating virus undetectable by day 15-17. Such equine IgG may find utility as a post-exposure prophylactic for Ebola infection and provides a low cost, scalable alternative to monoclonal antibodies, with extensive human safety data and WHO-standardized international manufacturing capability available in both high and low income countries.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28155869</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>03</Day></DateCreated><DateRevised><Year>2017</Year><Month>02</Month><Day>24</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2045-2322</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><PubDate><Year>2017</Year><Month>Feb</Month><Day>03</Day></PubDate></JournalIssue><Title>Scientific reports</Title><ISOAbbreviation>Sci Rep</ISOAbbreviation></Journal><ArticleTitle>Successful post-exposure prophylaxis of Ebola infected non-human primates using Ebola glycoprotein-specific equine IgG.</ArticleTitle><Pagination><MedlinePgn>41537</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/srep41537</ELocationID><Abstract><AbstractText>Herein we describe production of purified equine IgG obtained from horses immunized with plasmid DNA followed by boosting with Kunjin replicon virus-like particles both encoding a modified Ebola glycoprotein. Administration of the equine IgG over 5 days to cynomolgus macaques infected 24 hours previously with a lethal dose of Ebola virus suppressed viral loads by more than 5 logs and protected animals from mortality. Animals generated their own Ebola glycoprotein-specific IgG responses 9-15 days after infection, with circulating virus undetectable by day 15-17. Such equine IgG may find utility as a post-exposure prophylactic for Ebola infection and provides a low cost, scalable alternative to monoclonal antibodies, with extensive human safety data and WHO-standardized international manufacturing capability available in both high and low income countries.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pyankov</LastName><ForeName>Oleg V</ForeName><Initials>OV</Initials><AffiliationInfo><Affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Setoh</LastName><ForeName>Yin Xiang</ForeName><Initials>YX</Initials><AffiliationInfo><Affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bodnev</LastName><ForeName>Sergey A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Edmonds</LastName><ForeName>Judith H</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pyankova</LastName><ForeName>Olga G</ForeName><Initials>OG</Initials><AffiliationInfo><Affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pyankov</LastName><ForeName>Stepan A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pali</LastName><ForeName>Gabor</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Belford</LastName><ForeName>Shane</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Plasvacc Pty. Ltd., Kalbar, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lu</LastName><ForeName>Louis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Bio Medical Manufacturing, Fermentation and Protein Production Facility, CSIRO, Clayton, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>La</LastName><ForeName>Mylinh</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Bio Medical Manufacturing, Fermentation and Protein Production Facility, CSIRO, Clayton, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lovrecz</LastName><ForeName>George</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Bio Medical Manufacturing, Fermentation and Protein Production Facility, CSIRO, Clayton, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Volchkova</LastName><ForeName>Valentina A</ForeName><Initials>VA</Initials><AffiliationInfo><Affiliation>Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chappell</LastName><ForeName>Keith J</ForeName><Initials>KJ</Initials><AffiliationInfo><Affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watterson</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marsh</LastName><ForeName>Glenn</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Australian Animal Health Laboratory, CSIRO Health and Biosecurity, Geelong, VIC, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Young</LastName><ForeName>Paul R</ForeName><Initials>PR</Initials><AffiliationInfo><Affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agafonov</LastName><ForeName>Alexander A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>State Center for Virology and Biotechnology Vector, Koltsovo, Russian Federation.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Farmer</LastName><ForeName>Jillann F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>United Nations Medical Service, New York, NY 10017, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Volchkov</LastName><ForeName>Victor E</ForeName><Initials>VE</Initials><AffiliationInfo><Affiliation>Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suhrbier</LastName><ForeName>Andreas</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Khromykh</LastName><ForeName>Alexander A</ForeName><Initials>AA</Initials><AffiliationInfo><Affiliation>Australian Infectious Diseases Research Centre, School of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Brisbane, QLD, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>02</Month><Day>03</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Sci Rep</MedlineTA><NlmUniqueID>101563288</NlmUniqueID><ISSNLinking>2045-2322</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Nat Biotechnol. 2007 Feb;25(2):173-7</RefSource><PMID Version="1">17287747</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2000 Nov 30;408(6812):605-9</RefSource><PMID Version="1">11117750</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS One. 2016 Jun 09;11(6):e0156775</RefSource><PMID Version="1">27280712</PMID></CommentsCorrections><CommentsCorrections 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JFF is employed by the United Nations and views expressed herein are those of the author(s) and do not necessarily reflect the views of the United Nations.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>11</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>12</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>2</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>2</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28155869</ArticleId><ArticleId IdType="pii">srep41537</ArticleId><ArticleId IdType="doi">10.1038/srep41537</ArticleId><ArticleId IdType="pmc">PMC5290740</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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