Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
Identifieur interne : 001075 ( PubMed/Corpus ); précédent : 001074; suivant : 001076Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.
Auteurs : Philip J. Law ; Sonja I. Berndt ; Helen E. Speedy ; Nicola J. Camp ; Georgina P. Sava ; Christine F. Skibola ; Amy Holroyd ; Vijai Joseph ; Nicola J. Sunter ; Alexandra Nieters ; Silvia Bea ; Alain Monnereau ; David Martin-Garcia ; Lynn R. Goldin ; Guillem Clot ; Lauren R. Teras ; Inés Quintela ; Brenda M. Birmann ; Sandrine Jayne ; Wendy Cozen ; Aneela Majid ; Karin E. Smedby ; Qing Lan ; Claire Dearden ; Angela R. Brooks-Wilson ; Andrew G. Hall ; Mark P. Purdue ; Tryfonia Mainou-Fowler ; Claire M. Vajdic ; Graham H. Jackson ; Pierluigi Cocco ; Helen Marr ; Yawei Zhang ; Tongzhang Zheng ; Graham G. Giles ; Charles Lawrence ; Timothy G. Call ; Mark Liebow ; Mads Melbye ; Bengt Glimelius ; Larry Mansouri ; Martha Glenn ; Karen Curtin ; W Ryan Diver ; Brian K. Link ; Lucia Conde ; Paige M. Bracci ; Elizabeth A. Holly ; Rebecca D. Jackson ; Lesley F. Tinker ; Yolanda Benavente ; Paolo Boffetta ; Paul Brennan ; Marc Maynadie ; James Mckay ; Demetrius Albanes ; Stephanie Weinstein ; Zhaoming Wang ; Neil E. Caporaso ; Lindsay M. Morton ; Richard K. Severson ; Elio Riboli ; Paolo Vineis ; Roel C H. Vermeulen ; Melissa C. Southey ; Roger L. Milne ; Jacqueline Clavel ; Sabine Topka ; John J. Spinelli ; Peter Kraft ; Maria Grazia Ennas ; Geoffrey Summerfield ; Giovanni M. Ferri ; Robert J. Harris ; Lucia Miligi ; Andrew R. Pettitt ; Kari E. North ; David J. Allsup ; Joseph F. Fraumeni ; James R. Bailey ; Kenneth Offit ; Guy Pratt ; Henrik Hjalgrim ; Chris Pepper ; Stephen J. Chanock ; Chris Fegan ; Richard Rosenquist ; Silvia De Sanjose ; Angel Carracedo ; Martin J S. Dyer ; Daniel Catovsky ; Elias Campo ; James R. Cerhan ; James M. Allan ; Nathanial Rothman ; Richard Houlston ; Susan SlagerSource :
- Nature communications [ 2041-1723 ] ; 2017.
Abstract
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10(-13)), 1q42.13 (rs41271473, P=1.06 × 10(-10)), 4q24 (rs71597109, P=1.37 × 10(-10)), 4q35.1 (rs57214277, P=3.69 × 10(-8)), 6p21.31 (rs3800461, P=1.97 × 10(-8)), 11q23.2 (rs61904987, P=2.64 × 10(-11)), 18q21.1 (rs1036935, P=3.27 × 10(-8)), 19p13.3 (rs7254272, P=4.67 × 10(-8)) and 22q13.33 (rs140522, P=2.70 × 10(-9)). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.
DOI: 10.1038/ncomms14175
PubMed: 28165464
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.</title><author><name sortKey="Law, Philip J" sort="Law, Philip J" uniqKey="Law P" first="Philip J" last="Law">Philip J. Law</name><affiliation><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Speedy, Helen E" sort="Speedy, Helen E" uniqKey="Speedy H" first="Helen E" last="Speedy">Helen E. Speedy</name><affiliation><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J" last="Camp">Nicola J. Camp</name><affiliation><nlm:affiliation>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sava, Georgina P" sort="Sava, Georgina P" uniqKey="Sava G" first="Georgina P" last="Sava">Georgina P. Sava</name><affiliation><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Skibola, Christine F" sort="Skibola, Christine F" uniqKey="Skibola C" first="Christine F" last="Skibola">Christine F. Skibola</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holroyd, Amy" sort="Holroyd, Amy" uniqKey="Holroyd A" first="Amy" last="Holroyd">Amy Holroyd</name><affiliation><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Joseph, Vijai" sort="Joseph, Vijai" uniqKey="Joseph V" first="Vijai" last="Joseph">Vijai Joseph</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sunter, Nicola J" sort="Sunter, Nicola J" uniqKey="Sunter N" first="Nicola J" last="Sunter">Nicola J. Sunter</name><affiliation><nlm:affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name><affiliation><nlm:affiliation>Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bea, Silvia" sort="Bea, Silvia" uniqKey="Bea S" first="Silvia" last="Bea">Silvia Bea</name><affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Monnereau, Alain" sort="Monnereau, Alain" uniqKey="Monnereau A" first="Alain" last="Monnereau">Alain Monnereau</name><affiliation><nlm:affiliation>Registre des hémopathies malignes de la Gironde, Institut Bergonié, Inserm U1219 EPICENE, 33076 Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Martin Garcia, David" sort="Martin Garcia, David" uniqKey="Martin Garcia D" first="David" last="Martin-Garcia">David Martin-Garcia</name><affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Goldin, Lynn R" sort="Goldin, Lynn R" uniqKey="Goldin L" first="Lynn R" last="Goldin">Lynn R. Goldin</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Clot, Guillem" sort="Clot, Guillem" uniqKey="Clot G" first="Guillem" last="Clot">Guillem Clot</name><affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Teras, Lauren R" sort="Teras, Lauren R" uniqKey="Teras L" first="Lauren R" last="Teras">Lauren R. Teras</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Quintela, Ines" sort="Quintela, Ines" uniqKey="Quintela I" first="Inés" last="Quintela">Inés Quintela</name><affiliation><nlm:affiliation>Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Birmann, Brenda M" sort="Birmann, Brenda M" uniqKey="Birmann B" first="Brenda M" last="Birmann">Brenda M. Birmann</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jayne, Sandrine" sort="Jayne, Sandrine" uniqKey="Jayne S" first="Sandrine" last="Jayne">Sandrine Jayne</name><affiliation><nlm:affiliation>Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Majid, Aneela" sort="Majid, Aneela" uniqKey="Majid A" first="Aneela" last="Majid">Aneela Majid</name><affiliation><nlm:affiliation>Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Smedby, Karin E" sort="Smedby, Karin E" uniqKey="Smedby K" first="Karin E" last="Smedby">Karin E. Smedby</name><affiliation><nlm:affiliation>Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Hematology Center, Karolinsak University Hospital, Stockholm 17176, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lan, Qing" sort="Lan, Qing" uniqKey="Lan Q" first="Qing" last="Lan">Qing Lan</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name><affiliation><nlm:affiliation>The Royal Marsden NHS Foundation Trust, London SM2 5PT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Brooks Wilson, Angela R" sort="Brooks Wilson, Angela R" uniqKey="Brooks Wilson A" first="Angela R" last="Brooks-Wilson">Angela R. 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Jackson</name><affiliation><nlm:affiliation>Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name><affiliation><nlm:affiliation>Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Marr, Helen" sort="Marr, Helen" uniqKey="Marr H" first="Helen" last="Marr">Helen Marr</name><affiliation><nlm:affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name><affiliation><nlm:affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Tongzhang" sort="Zheng, Tongzhang" uniqKey="Zheng T" first="Tongzhang" last="Zheng">Tongzhang Zheng</name><affiliation><nlm:affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. 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Chan School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ennas, Maria Grazia" sort="Ennas, Maria Grazia" uniqKey="Ennas M" first="Maria Grazia" last="Ennas">Maria Grazia Ennas</name><affiliation><nlm:affiliation>Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Summerfield, Geoffrey" sort="Summerfield, Geoffrey" uniqKey="Summerfield G" first="Geoffrey" last="Summerfield">Geoffrey Summerfield</name><affiliation><nlm:affiliation>Department of Haematology, Queen Elizabeth Hospital, Gateshead NE9 6SX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ferri, Giovanni M" sort="Ferri, Giovanni M" uniqKey="Ferri G" first="Giovanni M" last="Ferri">Giovanni M. Ferri</name><affiliation><nlm:affiliation>Interdisciplinary Department of Medicine, University of Bari, Bari 70124, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Harris, Robert J" sort="Harris, Robert J" uniqKey="Harris R" first="Robert J" last="Harris">Robert J. Harris</name><affiliation><nlm:affiliation>Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name><affiliation><nlm:affiliation>Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence 50139, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Pettitt, Andrew R" sort="Pettitt, Andrew R" uniqKey="Pettitt A" first="Andrew R" last="Pettitt">Andrew R. Pettitt</name><affiliation><nlm:affiliation>Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E" last="North">Kari E. North</name><affiliation><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Allsup, David J" sort="Allsup, David J" uniqKey="Allsup D" first="David J" last="Allsup">David J. Allsup</name><affiliation><nlm:affiliation>Queens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fraumeni, Joseph F" sort="Fraumeni, Joseph F" uniqKey="Fraumeni J" first="Joseph F" last="Fraumeni">Joseph F. Fraumeni</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bailey, James R" sort="Bailey, James R" uniqKey="Bailey J" first="James R" last="Bailey">James R. Bailey</name><affiliation><nlm:affiliation>Queens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pratt, Guy" sort="Pratt, Guy" uniqKey="Pratt G" first="Guy" last="Pratt">Guy Pratt</name><affiliation><nlm:affiliation>Department of Haematology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hjalgrim, Henrik" sort="Hjalgrim, Henrik" uniqKey="Hjalgrim H" first="Henrik" last="Hjalgrim">Henrik Hjalgrim</name><affiliation><nlm:affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Pepper, Chris" sort="Pepper, Chris" uniqKey="Pepper C" first="Chris" last="Pepper">Chris Pepper</name><affiliation><nlm:affiliation>Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fegan, Chris" sort="Fegan, Chris" uniqKey="Fegan C" first="Chris" last="Fegan">Chris Fegan</name><affiliation><nlm:affiliation>Cardiff and Vale National Health Service Trust, Heath Park, Cardiff CF14 4XW, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Rosenquist, Richard" sort="Rosenquist, Richard" uniqKey="Rosenquist R" first="Richard" last="Rosenquist">Richard Rosenquist</name><affiliation><nlm:affiliation>Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjose">Silvia De Sanjose</name><affiliation><nlm:affiliation>The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carracedo, Angel" sort="Carracedo, Angel" uniqKey="Carracedo A" first="Angel" last="Carracedo">Angel Carracedo</name><affiliation><nlm:affiliation>Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Dyer, Martin J S" sort="Dyer, Martin J S" uniqKey="Dyer M" first="Martin J S" last="Dyer">Martin J S. Dyer</name><affiliation><nlm:affiliation>Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Catovsky, Daniel" sort="Catovsky, Daniel" uniqKey="Catovsky D" first="Daniel" last="Catovsky">Daniel Catovsky</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Campo, Elias" sort="Campo, Elias" uniqKey="Campo E" first="Elias" last="Campo">Elias Campo</name><affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cerhan, James R" sort="Cerhan, James R" uniqKey="Cerhan J" first="James R" last="Cerhan">James R. Cerhan</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Allan, James M" sort="Allan, James M" uniqKey="Allan J" first="James M" last="Allan">James M. Allan</name><affiliation><nlm:affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Rothman, Nathanial" sort="Rothman, Nathanial" uniqKey="Rothman N" first="Nathanial" last="Rothman">Nathanial Rothman</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Houlston, Richard" sort="Houlston, Richard" uniqKey="Houlston R" first="Richard" last="Houlston">Richard Houlston</name><affiliation><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28165464</idno><idno type="pmid">28165464</idno><idno type="doi">10.1038/ncomms14175</idno><idno type="wicri:Area/PubMed/Corpus">001075</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001075</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.</title><author><name sortKey="Law, Philip J" sort="Law, Philip J" uniqKey="Law P" first="Philip J" last="Law">Philip J. Law</name><affiliation><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Speedy, Helen E" sort="Speedy, Helen E" uniqKey="Speedy H" first="Helen E" last="Speedy">Helen E. Speedy</name><affiliation><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Camp, Nicola J" sort="Camp, Nicola J" uniqKey="Camp N" first="Nicola J" last="Camp">Nicola J. Camp</name><affiliation><nlm:affiliation>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sava, Georgina P" sort="Sava, Georgina P" uniqKey="Sava G" first="Georgina P" last="Sava">Georgina P. Sava</name><affiliation><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Skibola, Christine F" sort="Skibola, Christine F" uniqKey="Skibola C" first="Christine F" last="Skibola">Christine F. Skibola</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holroyd, Amy" sort="Holroyd, Amy" uniqKey="Holroyd A" first="Amy" last="Holroyd">Amy Holroyd</name><affiliation><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Joseph, Vijai" sort="Joseph, Vijai" uniqKey="Joseph V" first="Vijai" last="Joseph">Vijai Joseph</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Sunter, Nicola J" sort="Sunter, Nicola J" uniqKey="Sunter N" first="Nicola J" last="Sunter">Nicola J. Sunter</name><affiliation><nlm:affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Nieters, Alexandra" sort="Nieters, Alexandra" uniqKey="Nieters A" first="Alexandra" last="Nieters">Alexandra Nieters</name><affiliation><nlm:affiliation>Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Bea, Silvia" sort="Bea, Silvia" uniqKey="Bea S" first="Silvia" last="Bea">Silvia Bea</name><affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Monnereau, Alain" sort="Monnereau, Alain" uniqKey="Monnereau A" first="Alain" last="Monnereau">Alain Monnereau</name><affiliation><nlm:affiliation>Registre des hémopathies malignes de la Gironde, Institut Bergonié, Inserm U1219 EPICENE, 33076 Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Martin Garcia, David" sort="Martin Garcia, David" uniqKey="Martin Garcia D" first="David" last="Martin-Garcia">David Martin-Garcia</name><affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Goldin, Lynn R" sort="Goldin, Lynn R" uniqKey="Goldin L" first="Lynn R" last="Goldin">Lynn R. Goldin</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Clot, Guillem" sort="Clot, Guillem" uniqKey="Clot G" first="Guillem" last="Clot">Guillem Clot</name><affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Teras, Lauren R" sort="Teras, Lauren R" uniqKey="Teras L" first="Lauren R" last="Teras">Lauren R. Teras</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Quintela, Ines" sort="Quintela, Ines" uniqKey="Quintela I" first="Inés" last="Quintela">Inés Quintela</name><affiliation><nlm:affiliation>Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Birmann, Brenda M" sort="Birmann, Brenda M" uniqKey="Birmann B" first="Brenda M" last="Birmann">Brenda M. Birmann</name><affiliation><nlm:affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jayne, Sandrine" sort="Jayne, Sandrine" uniqKey="Jayne S" first="Sandrine" last="Jayne">Sandrine Jayne</name><affiliation><nlm:affiliation>Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cozen, Wendy" sort="Cozen, Wendy" uniqKey="Cozen W" first="Wendy" last="Cozen">Wendy Cozen</name><affiliation><nlm:affiliation>Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Majid, Aneela" sort="Majid, Aneela" uniqKey="Majid A" first="Aneela" last="Majid">Aneela Majid</name><affiliation><nlm:affiliation>Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Smedby, Karin E" sort="Smedby, Karin E" uniqKey="Smedby K" first="Karin E" last="Smedby">Karin E. Smedby</name><affiliation><nlm:affiliation>Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Hematology Center, Karolinsak University Hospital, Stockholm 17176, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Lan, Qing" sort="Lan, Qing" uniqKey="Lan Q" first="Qing" last="Lan">Qing Lan</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Dearden, Claire" sort="Dearden, Claire" uniqKey="Dearden C" first="Claire" last="Dearden">Claire Dearden</name><affiliation><nlm:affiliation>The Royal Marsden NHS Foundation Trust, London SM2 5PT, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Brooks Wilson, Angela R" sort="Brooks Wilson, Angela R" uniqKey="Brooks Wilson A" first="Angela R" last="Brooks-Wilson">Angela R. Brooks-Wilson</name><affiliation><nlm:affiliation>Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</nlm:affiliation></affiliation></author><author><name sortKey="Hall, Andrew G" sort="Hall, Andrew G" uniqKey="Hall A" first="Andrew G" last="Hall">Andrew G. Hall</name><affiliation><nlm:affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Purdue, Mark P" sort="Purdue, Mark P" uniqKey="Purdue M" first="Mark P" last="Purdue">Mark P. Purdue</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Mainou Fowler, Tryfonia" sort="Mainou Fowler, Tryfonia" uniqKey="Mainou Fowler T" first="Tryfonia" last="Mainou-Fowler">Tryfonia Mainou-Fowler</name><affiliation><nlm:affiliation>Haematological Sciences, Medical School, Newcastle University, Newcastle-upon-Tyne NE2 4HH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vajdic, Claire M" sort="Vajdic, Claire M" uniqKey="Vajdic C" first="Claire M" last="Vajdic">Claire M. Vajdic</name><affiliation><nlm:affiliation>Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, Graham H" sort="Jackson, Graham H" uniqKey="Jackson G" first="Graham H" last="Jackson">Graham H. Jackson</name><affiliation><nlm:affiliation>Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Cocco, Pierluigi" sort="Cocco, Pierluigi" uniqKey="Cocco P" first="Pierluigi" last="Cocco">Pierluigi Cocco</name><affiliation><nlm:affiliation>Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Marr, Helen" sort="Marr, Helen" uniqKey="Marr H" first="Helen" last="Marr">Helen Marr</name><affiliation><nlm:affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Zhang, Yawei" sort="Zhang, Yawei" uniqKey="Zhang Y" first="Yawei" last="Zhang">Yawei Zhang</name><affiliation><nlm:affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Zheng, Tongzhang" sort="Zheng, Tongzhang" uniqKey="Zheng T" first="Tongzhang" last="Zheng">Tongzhang Zheng</name><affiliation><nlm:affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G" last="Giles">Graham G. Giles</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Lawrence, Charles" sort="Lawrence, Charles" uniqKey="Lawrence C" first="Charles" last="Lawrence">Charles Lawrence</name><affiliation><nlm:affiliation>Westat, Rockville, Maryland 20850, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Call, Timothy G" sort="Call, Timothy G" uniqKey="Call T" first="Timothy G" last="Call">Timothy G. Call</name><affiliation><nlm:affiliation>Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Liebow, Mark" sort="Liebow, Mark" uniqKey="Liebow M" first="Mark" last="Liebow">Mark Liebow</name><affiliation><nlm:affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Melbye, Mads" sort="Melbye, Mads" uniqKey="Melbye M" first="Mads" last="Melbye">Mads Melbye</name><affiliation><nlm:affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Glimelius, Bengt" sort="Glimelius, Bengt" uniqKey="Glimelius B" first="Bengt" last="Glimelius">Bengt Glimelius</name><affiliation><nlm:affiliation>Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Mansouri, Larry" sort="Mansouri, Larry" uniqKey="Mansouri L" first="Larry" last="Mansouri">Larry Mansouri</name><affiliation><nlm:affiliation>Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Glenn, Martha" sort="Glenn, Martha" uniqKey="Glenn M" first="Martha" last="Glenn">Martha Glenn</name><affiliation><nlm:affiliation>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Curtin, Karen" sort="Curtin, Karen" uniqKey="Curtin K" first="Karen" last="Curtin">Karen Curtin</name><affiliation><nlm:affiliation>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Diver, W Ryan" sort="Diver, W Ryan" uniqKey="Diver W" first="W Ryan" last="Diver">W Ryan Diver</name><affiliation><nlm:affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Link, Brian K" sort="Link, Brian K" uniqKey="Link B" first="Brian K" last="Link">Brian K. Link</name><affiliation><nlm:affiliation>Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Conde, Lucia" sort="Conde, Lucia" uniqKey="Conde L" first="Lucia" last="Conde">Lucia Conde</name><affiliation><nlm:affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bracci, Paige M" sort="Bracci, Paige M" uniqKey="Bracci P" first="Paige M" last="Bracci">Paige M. Bracci</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Holly, Elizabeth A" sort="Holly, Elizabeth A" uniqKey="Holly E" first="Elizabeth A" last="Holly">Elizabeth A. Holly</name><affiliation><nlm:affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Jackson, Rebecca D" sort="Jackson, Rebecca D" uniqKey="Jackson R" first="Rebecca D" last="Jackson">Rebecca D. Jackson</name><affiliation><nlm:affiliation>Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, Ohio 43210, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Tinker, Lesley F" sort="Tinker, Lesley F" uniqKey="Tinker L" first="Lesley F" last="Tinker">Lesley F. Tinker</name><affiliation><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Benavente, Yolanda" sort="Benavente, Yolanda" uniqKey="Benavente Y" first="Yolanda" last="Benavente">Yolanda Benavente</name><affiliation><nlm:affiliation>Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Boffetta, Paolo" sort="Boffetta, Paolo" uniqKey="Boffetta P" first="Paolo" last="Boffetta">Paolo Boffetta</name><affiliation><nlm:affiliation>The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation><nlm:affiliation>International Agency for Research on Cancer, Lyon 69372, France.</nlm:affiliation></affiliation></author><author><name sortKey="Maynadie, Marc" sort="Maynadie, Marc" uniqKey="Maynadie M" first="Marc" last="Maynadie">Marc Maynadie</name><affiliation><nlm:affiliation>Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon 21070, France.</nlm:affiliation></affiliation></author><author><name sortKey="Mckay, James" sort="Mckay, James" uniqKey="Mckay J" first="James" last="Mckay">James Mckay</name><affiliation><nlm:affiliation>International Agency for Research on Cancer, Lyon 69372, France.</nlm:affiliation></affiliation></author><author><name sortKey="Albanes, Demetrius" sort="Albanes, Demetrius" uniqKey="Albanes D" first="Demetrius" last="Albanes">Demetrius Albanes</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Weinstein, Stephanie" sort="Weinstein, Stephanie" uniqKey="Weinstein S" first="Stephanie" last="Weinstein">Stephanie Weinstein</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name><affiliation><nlm:affiliation>Department of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Caporaso, Neil E" sort="Caporaso, Neil E" uniqKey="Caporaso N" first="Neil E" last="Caporaso">Neil E. Caporaso</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Morton, Lindsay M" sort="Morton, Lindsay M" uniqKey="Morton L" first="Lindsay M" last="Morton">Lindsay M. Morton</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Severson, Richard K" sort="Severson, Richard K" uniqKey="Severson R" first="Richard K" last="Severson">Richard K. Severson</name><affiliation><nlm:affiliation>Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Riboli, Elio" sort="Riboli, Elio" uniqKey="Riboli E" first="Elio" last="Riboli">Elio Riboli</name><affiliation><nlm:affiliation>School of Public Health, Imperial College London, London W2 1PG, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vineis, Paolo" sort="Vineis, Paolo" uniqKey="Vineis P" first="Paolo" last="Vineis">Paolo Vineis</name><affiliation><nlm:affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Vermeulen, Roel C H" sort="Vermeulen, Roel C H" uniqKey="Vermeulen R" first="Roel C H" last="Vermeulen">Roel C H. Vermeulen</name><affiliation><nlm:affiliation>Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, The Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C" last="Southey">Melissa C. Southey</name><affiliation><nlm:affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Milne, Roger L" sort="Milne, Roger L" uniqKey="Milne R" first="Roger L" last="Milne">Roger L. Milne</name><affiliation><nlm:affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Clavel, Jacqueline" sort="Clavel, Jacqueline" uniqKey="Clavel J" first="Jacqueline" last="Clavel">Jacqueline Clavel</name><affiliation><nlm:affiliation>Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris F-94807, France.</nlm:affiliation></affiliation></author><author><name sortKey="Topka, Sabine" sort="Topka, Sabine" uniqKey="Topka S" first="Sabine" last="Topka">Sabine Topka</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J" last="Spinelli">John J. Spinelli</name><affiliation><nlm:affiliation>Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</nlm:affiliation></affiliation></author><author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name><affiliation><nlm:affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Ennas, Maria Grazia" sort="Ennas, Maria Grazia" uniqKey="Ennas M" first="Maria Grazia" last="Ennas">Maria Grazia Ennas</name><affiliation><nlm:affiliation>Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Summerfield, Geoffrey" sort="Summerfield, Geoffrey" uniqKey="Summerfield G" first="Geoffrey" last="Summerfield">Geoffrey Summerfield</name><affiliation><nlm:affiliation>Department of Haematology, Queen Elizabeth Hospital, Gateshead NE9 6SX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Ferri, Giovanni M" sort="Ferri, Giovanni M" uniqKey="Ferri G" first="Giovanni M" last="Ferri">Giovanni M. Ferri</name><affiliation><nlm:affiliation>Interdisciplinary Department of Medicine, University of Bari, Bari 70124, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Harris, Robert J" sort="Harris, Robert J" uniqKey="Harris R" first="Robert J" last="Harris">Robert J. Harris</name><affiliation><nlm:affiliation>Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Miligi, Lucia" sort="Miligi, Lucia" uniqKey="Miligi L" first="Lucia" last="Miligi">Lucia Miligi</name><affiliation><nlm:affiliation>Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence 50139, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Pettitt, Andrew R" sort="Pettitt, Andrew R" uniqKey="Pettitt A" first="Andrew R" last="Pettitt">Andrew R. Pettitt</name><affiliation><nlm:affiliation>Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="North, Kari E" sort="North, Kari E" uniqKey="North K" first="Kari E" last="North">Kari E. North</name><affiliation><nlm:affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Allsup, David J" sort="Allsup, David J" uniqKey="Allsup D" first="David J" last="Allsup">David J. Allsup</name><affiliation><nlm:affiliation>Queens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Fraumeni, Joseph F" sort="Fraumeni, Joseph F" uniqKey="Fraumeni J" first="Joseph F" last="Fraumeni">Joseph F. Fraumeni</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Bailey, James R" sort="Bailey, James R" uniqKey="Bailey J" first="James R" last="Bailey">James R. Bailey</name><affiliation><nlm:affiliation>Queens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Pratt, Guy" sort="Pratt, Guy" uniqKey="Pratt G" first="Guy" last="Pratt">Guy Pratt</name><affiliation><nlm:affiliation>Department of Haematology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Hjalgrim, Henrik" sort="Hjalgrim, Henrik" uniqKey="Hjalgrim H" first="Henrik" last="Hjalgrim">Henrik Hjalgrim</name><affiliation><nlm:affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</nlm:affiliation></affiliation></author><author><name sortKey="Pepper, Chris" sort="Pepper, Chris" uniqKey="Pepper C" first="Chris" last="Pepper">Chris Pepper</name><affiliation><nlm:affiliation>Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J" last="Chanock">Stephen J. Chanock</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Fegan, Chris" sort="Fegan, Chris" uniqKey="Fegan C" first="Chris" last="Fegan">Chris Fegan</name><affiliation><nlm:affiliation>Cardiff and Vale National Health Service Trust, Heath Park, Cardiff CF14 4XW, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Rosenquist, Richard" sort="Rosenquist, Richard" uniqKey="Rosenquist R" first="Richard" last="Rosenquist">Richard Rosenquist</name><affiliation><nlm:affiliation>Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="De Sanjose, Silvia" sort="De Sanjose, Silvia" uniqKey="De Sanjose S" first="Silvia" last="De Sanjose">Silvia De Sanjose</name><affiliation><nlm:affiliation>The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Carracedo, Angel" sort="Carracedo, Angel" uniqKey="Carracedo A" first="Angel" last="Carracedo">Angel Carracedo</name><affiliation><nlm:affiliation>Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Dyer, Martin J S" sort="Dyer, Martin J S" uniqKey="Dyer M" first="Martin J S" last="Dyer">Martin J S. Dyer</name><affiliation><nlm:affiliation>Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Catovsky, Daniel" sort="Catovsky, Daniel" uniqKey="Catovsky D" first="Daniel" last="Catovsky">Daniel Catovsky</name><affiliation><nlm:affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Campo, Elias" sort="Campo, Elias" uniqKey="Campo E" first="Elias" last="Campo">Elias Campo</name><affiliation><nlm:affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</nlm:affiliation></affiliation></author><author><name sortKey="Cerhan, James R" sort="Cerhan, James R" uniqKey="Cerhan J" first="James R" last="Cerhan">James R. Cerhan</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Allan, James M" sort="Allan, James M" uniqKey="Allan J" first="James M" last="Allan">James M. Allan</name><affiliation><nlm:affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Rothman, Nathanial" sort="Rothman, Nathanial" uniqKey="Rothman N" first="Nathanial" last="Rothman">Nathanial Rothman</name><affiliation><nlm:affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</nlm:affiliation></affiliation></author><author><name sortKey="Houlston, Richard" sort="Houlston, Richard" uniqKey="Houlston R" first="Richard" last="Houlston">Richard Houlston</name><affiliation><nlm:affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</nlm:affiliation></affiliation></author><author><name sortKey="Slager, Susan" sort="Slager, Susan" uniqKey="Slager S" first="Susan" last="Slager">Susan Slager</name><affiliation><nlm:affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10(-13)), 1q42.13 (rs41271473, P=1.06 × 10(-10)), 4q24 (rs71597109, P=1.37 × 10(-10)), 4q35.1 (rs57214277, P=3.69 × 10(-8)), 6p21.31 (rs3800461, P=1.97 × 10(-8)), 11q23.2 (rs61904987, P=2.64 × 10(-11)), 18q21.1 (rs1036935, P=3.27 × 10(-8)), 19p13.3 (rs7254272, P=4.67 × 10(-8)) and 22q13.33 (rs140522, P=2.70 × 10(-9)). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">28165464</PMID><DateCreated><Year>2017</Year><Month>02</Month><Day>06</Day></DateCreated><DateRevised><Year>2017</Year><Month>10</Month><Day>27</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><PubDate><Year>2017</Year><Month>Feb</Month><Day>06</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.</ArticleTitle><Pagination><MedlinePgn>14175</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/ncomms14175</ELocationID><Abstract><AbstractText>Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10(-13)), 1q42.13 (rs41271473, P=1.06 × 10(-10)), 4q24 (rs71597109, P=1.37 × 10(-10)), 4q35.1 (rs57214277, P=3.69 × 10(-8)), 6p21.31 (rs3800461, P=1.97 × 10(-8)), 11q23.2 (rs61904987, P=2.64 × 10(-11)), 18q21.1 (rs1036935, P=3.27 × 10(-8)), 19p13.3 (rs7254272, P=4.67 × 10(-8)) and 22q13.33 (rs140522, P=2.70 × 10(-9)). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Law</LastName><ForeName>Philip J</ForeName><Initials>PJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9663-4611</Identifier><AffiliationInfo><Affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berndt</LastName><ForeName>Sonja I</ForeName><Initials>SI</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Speedy</LastName><ForeName>Helen E</ForeName><Initials>HE</Initials><AffiliationInfo><Affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Camp</LastName><ForeName>Nicola J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sava</LastName><ForeName>Georgina P</ForeName><Initials>GP</Initials><AffiliationInfo><Affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Skibola</LastName><ForeName>Christine F</ForeName><Initials>CF</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holroyd</LastName><ForeName>Amy</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Joseph</LastName><ForeName>Vijai</ForeName><Initials>V</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-7933-151X</Identifier><AffiliationInfo><Affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sunter</LastName><ForeName>Nicola J</ForeName><Initials>NJ</Initials><AffiliationInfo><Affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nieters</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Baden-Württemberg 79108, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bea</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monnereau</LastName><ForeName>Alain</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Registre des hémopathies malignes de la Gironde, Institut Bergonié, Inserm U1219 EPICENE, 33076 Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité, Paris, F-94807, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Paris Descartes, Paris 75270, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Martin-Garcia</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goldin</LastName><ForeName>Lynn R</ForeName><Initials>LR</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clot</LastName><ForeName>Guillem</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Teras</LastName><ForeName>Lauren R</ForeName><Initials>LR</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Quintela</LastName><ForeName>Inés</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Birmann</LastName><ForeName>Brenda M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jayne</LastName><ForeName>Sandrine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cozen</LastName><ForeName>Wendy</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Preventive Medicine, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Norris Comprehensive Cancer Center, USC Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Majid</LastName><ForeName>Aneela</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Smedby</LastName><ForeName>Karin E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Hematology Center, Karolinsak University Hospital, Stockholm 17176, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lan</LastName><ForeName>Qing</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dearden</LastName><ForeName>Claire</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>The Royal Marsden NHS Foundation Trust, London SM2 5PT, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brooks-Wilson</LastName><ForeName>Angela R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia V5A1S6, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hall</LastName><ForeName>Andrew G</ForeName><Initials>AG</Initials><AffiliationInfo><Affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Purdue</LastName><ForeName>Mark P</ForeName><Initials>MP</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mainou-Fowler</LastName><ForeName>Tryfonia</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Haematological Sciences, Medical School, Newcastle University, Newcastle-upon-Tyne NE2 4HH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vajdic</LastName><ForeName>Claire M</ForeName><Initials>CM</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3612-8298</Identifier><AffiliationInfo><Affiliation>Centre for Big Data Research in Health, University of New South Wales, Sydney, New South Wales 2052, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>Graham H</ForeName><Initials>GH</Initials><AffiliationInfo><Affiliation>Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cocco</LastName><ForeName>Pierluigi</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Monserrato, Cagliari 09042, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marr</LastName><ForeName>Helen</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yawei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zheng</LastName><ForeName>Tongzhang</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut 06520, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giles</LastName><ForeName>Graham G</ForeName><Initials>GG</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lawrence</LastName><ForeName>Charles</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Westat, Rockville, Maryland 20850, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Call</LastName><ForeName>Timothy G</ForeName><Initials>TG</Initials><AffiliationInfo><Affiliation>Division of Hematology, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liebow</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Melbye</LastName><ForeName>Mads</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glimelius</LastName><ForeName>Bengt</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mansouri</LastName><ForeName>Larry</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Glenn</LastName><ForeName>Martha</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Curtin</LastName><ForeName>Karen</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diver</LastName><ForeName>W Ryan</ForeName><Initials>WR</Initials><AffiliationInfo><Affiliation>Epidemiology Research Program, American Cancer Society, Atlanta, Georgia 30303, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Link</LastName><ForeName>Brian K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Department of Internal Medicine, Carver College of Medicine, The University of Iowa, Iowa City, Iowa 52242, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Conde</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, School of Public Health and Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bracci</LastName><ForeName>Paige M</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holly</LastName><ForeName>Elizabeth A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California 94118, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>Rebecca D</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>Division of Endocrinology, Diabetes and Metabolism, Ohio State University, Columbus, Ohio 43210, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tinker</LastName><ForeName>Lesley F</ForeName><Initials>LF</Initials><AffiliationInfo><Affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98117, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Benavente</LastName><ForeName>Yolanda</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Cancer Epidemiology Research Programme, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona 08908, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CIBER de Epidemiología y Salud Pública (CIBERESP), Barcelona 08036, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boffetta</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brennan</LastName><ForeName>Paul</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer, Lyon 69372, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Maynadie</LastName><ForeName>Marc</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Registre des Hémopathies Malignes de Côte d'Or, University of Burgundy and Dijon University Hospital, Dijon 21070, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McKay</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>International Agency for Research on Cancer, Lyon 69372, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Albanes</LastName><ForeName>Demetrius</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weinstein</LastName><ForeName>Stephanie</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Zhaoming</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Computational Biology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Caporaso</LastName><ForeName>Neil E</ForeName><Initials>NE</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morton</LastName><ForeName>Lindsay M</ForeName><Initials>LM</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Severson</LastName><ForeName>Richard K</ForeName><Initials>RK</Initials><AffiliationInfo><Affiliation>Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan 48201, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riboli</LastName><ForeName>Elio</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>School of Public Health, Imperial College London, London W2 1PG, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vineis</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Human Genetics Foundation, 10126 Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vermeulen</LastName><ForeName>Roel C H</ForeName><Initials>RC</Initials><AffiliationInfo><Affiliation>Institute for Risk Assessment Sciences, Utrecht University, Utrecht 3508 TD, The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Southey</LastName><ForeName>Melissa C</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Victoria 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Milne</LastName><ForeName>Roger L</ForeName><Initials>RL</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5764-7268</Identifier><AffiliationInfo><Affiliation>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria 3004, Australia.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria 3010, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clavel</LastName><ForeName>Jacqueline</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Epidemiology of Childhood and Adolescent Cancers Group, Inserm, Center of Research in Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris F-94807, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Université Paris Descartes, 75270 Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Topka</LastName><ForeName>Sabine</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spinelli</LastName><ForeName>John J</ForeName><Initials>JJ</Initials><AffiliationInfo><Affiliation>Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada V5Z1L3.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z3.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kraft</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ennas</LastName><ForeName>Maria Grazia</ForeName><Initials>MG</Initials><AffiliationInfo><Affiliation>Department of Biomedical Science, University of Cagliari, Monserrato, Cagliari 09042, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Summerfield</LastName><ForeName>Geoffrey</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Haematology, Queen Elizabeth Hospital, Gateshead NE9 6SX, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferri</LastName><ForeName>Giovanni M</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Interdisciplinary Department of Medicine, University of Bari, Bari 70124, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Harris</LastName><ForeName>Robert J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miligi</LastName><ForeName>Lucia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Environmental and Occupational Epidemiology Unit, Cancer Prevention and Research Institute (ISPO), Florence 50139, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pettitt</LastName><ForeName>Andrew R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool L69 3BX, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>North</LastName><ForeName>Kari E</ForeName><Initials>KE</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allsup</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-6159-6109</Identifier><AffiliationInfo><Affiliation>Queens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fraumeni</LastName><ForeName>Joseph F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bailey</LastName><ForeName>James R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Queens Centre for Haematology and Oncology, Castle Hill Hospital, Hull and East Yorkshire NHS Trust, Cottingham HU16 5JQ, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Offit</LastName><ForeName>Kenneth</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pratt</LastName><ForeName>Guy</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Department of Haematology, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hjalgrim</LastName><ForeName>Henrik</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Epidemiology Research, Division of Health Surveillance and Research, Statens Serum Institut, 2300 Copenhagen, Denmark.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pepper</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Division of Cancer and Genetics, School of Medicine, Cardiff University, Cardiff CF14 4XN, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chanock</LastName><ForeName>Stephen J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fegan</LastName><ForeName>Chris</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Cardiff and Vale National Health Service Trust, Heath Park, Cardiff CF14 4XW, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rosenquist</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, 75105 Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Sanjose</LastName><ForeName>Silvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>International Agency for Research on Cancer, Lyon 69372, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carracedo</LastName><ForeName>Angel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado (CeGen-PRB2-ISCIII), CIBERER, 15782 Santiago de Compostela, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah 21589, KSA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dyer</LastName><ForeName>Martin J S</ForeName><Initials>MJ</Initials><AffiliationInfo><Affiliation>Ernest and Helen Scott Haematological Research Institute, University of Leicester, Leicester LE2 7LX, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Catovsky</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Division of Molecular Pathology, The Institute of Cancer Research, London SW7 3RP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Campo</LastName><ForeName>Elias</ForeName><Initials>E</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9850-9793</Identifier><AffiliationInfo><Affiliation>Institut d'Investigacions Biomèdiques August Pi iSunyer (IDIBAPS), Hospital Clínic, Barcelona 08036, Spain.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unitat de Hematología, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona 08036, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cerhan</LastName><ForeName>James R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Allan</LastName><ForeName>James M</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rothman</LastName><ForeName>Nathanial</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Houlston</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Division of Genetics and Epidemiology, The Institute of Cancer Research, London SW7 3RP, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slager</LastName><ForeName>Susan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>N01 PC067009</GrantID><Acronym>CN</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100001I</GrantID><Acronym>HL</Acronym><Agency>NHLBI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN261201000035C</GrantID><Acronym>PC,CA</Acronym><Agency>None</Agency><Country>None</Country></Grant><Grant><GrantID>P30 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States</Country></Grant><Grant><GrantID>HHSN271201100004C</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA098661</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>UM1 CA186107</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN268201100002C</GrantID><Acronym>WH</Acronym><Agency>WHI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 CA015083</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA092153</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN261201000035I</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United 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HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01CO12400</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>N01 CN045165</GrantID><Acronym>CN</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 CA049449</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA149445</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA134674</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA045614</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSN261201000026C</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United 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