The natural history of Modic changes in a community-based cohort.
Identifieur interne : 001050 ( PubMed/Corpus ); précédent : 001049; suivant : 001051The natural history of Modic changes in a community-based cohort.
Auteurs : Andrew J. Teichtahl ; Monica A. Finnin ; Yuanyuan Wang ; Anita E. Wluka ; Donna M. Urquhart ; Richard O'Sullivan ; Graeme Jones ; Flavia M. CicuttiniSource :
- Joint, bone, spine : revue du rhumatisme [ 1778-7254 ] ; 2017.
Abstract
Vertebral endplate (Modic) lesions are gaining interest, with varied phenotypes recognised to have distinct clinical and histological correlates. Nevertheless, the natural history of these lesions is unclear. This study examined the natural history of Modic changes and their potential relationship to the intervertebral disc.
DOI: 10.1016/j.jbspin.2016.03.011
PubMed: 27324605
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The natural history of Modic changes in a community-based cohort.</title><author><name sortKey="Teichtahl, Andrew J" sort="Teichtahl, Andrew J" uniqKey="Teichtahl A" first="Andrew J" last="Teichtahl">Andrew J. Teichtahl</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia; Baker IDI Heart and Diabetes Institute, Commercial Road, 3004 Melbourne, Australia. Electronic address: andrew.teichtahl@monash.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Finnin, Monica A" sort="Finnin, Monica A" uniqKey="Finnin M" first="Monica A" last="Finnin">Monica A. Finnin</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia; Baker IDI Heart and Diabetes Institute, Commercial Road, 3004 Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yuanyuan" sort="Wang, Yuanyuan" uniqKey="Wang Y" first="Yuanyuan" last="Wang">Yuanyuan Wang</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Wluka, Anita E" sort="Wluka, Anita E" uniqKey="Wluka A" first="Anita E" last="Wluka">Anita E. Wluka</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Urquhart, Donna M" sort="Urquhart, Donna M" uniqKey="Urquhart D" first="Donna M" last="Urquhart">Donna M. Urquhart</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="O Sullivan, Richard" sort="O Sullivan, Richard" uniqKey="O Sullivan R" first="Richard" last="O'Sullivan">Richard O'Sullivan</name><affiliation><nlm:affiliation>Healthcare Imaging Services, Epworth Hospital, 3121 Richmond, Australia; Department of Medicine, Central Clinical School, Monash University, 3004 Melbourne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Graeme" sort="Jones, Graeme" uniqKey="Jones G" first="Graeme" last="Jones">Graeme Jones</name><affiliation><nlm:affiliation>Menzies Research Institute, Tasmania, Private bag 23, 7000 Hobart, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cicuttini, Flavia M" sort="Cicuttini, Flavia M" uniqKey="Cicuttini F" first="Flavia M" last="Cicuttini">Flavia M. Cicuttini</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27324605</idno><idno type="pmid">27324605</idno><idno type="doi">10.1016/j.jbspin.2016.03.011</idno><idno type="wicri:Area/PubMed/Corpus">001050</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001050</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The natural history of Modic changes in a community-based cohort.</title><author><name sortKey="Teichtahl, Andrew J" sort="Teichtahl, Andrew J" uniqKey="Teichtahl A" first="Andrew J" last="Teichtahl">Andrew J. Teichtahl</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia; Baker IDI Heart and Diabetes Institute, Commercial Road, 3004 Melbourne, Australia. Electronic address: andrew.teichtahl@monash.edu.</nlm:affiliation></affiliation></author><author><name sortKey="Finnin, Monica A" sort="Finnin, Monica A" uniqKey="Finnin M" first="Monica A" last="Finnin">Monica A. Finnin</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia; Baker IDI Heart and Diabetes Institute, Commercial Road, 3004 Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Yuanyuan" sort="Wang, Yuanyuan" uniqKey="Wang Y" first="Yuanyuan" last="Wang">Yuanyuan Wang</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Wluka, Anita E" sort="Wluka, Anita E" uniqKey="Wluka A" first="Anita E" last="Wluka">Anita E. Wluka</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Urquhart, Donna M" sort="Urquhart, Donna M" uniqKey="Urquhart D" first="Donna M" last="Urquhart">Donna M. Urquhart</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="O Sullivan, Richard" sort="O Sullivan, Richard" uniqKey="O Sullivan R" first="Richard" last="O'Sullivan">Richard O'Sullivan</name><affiliation><nlm:affiliation>Healthcare Imaging Services, Epworth Hospital, 3121 Richmond, Australia; Department of Medicine, Central Clinical School, Monash University, 3004 Melbourne, France.</nlm:affiliation></affiliation></author><author><name sortKey="Jones, Graeme" sort="Jones, Graeme" uniqKey="Jones G" first="Graeme" last="Jones">Graeme Jones</name><affiliation><nlm:affiliation>Menzies Research Institute, Tasmania, Private bag 23, 7000 Hobart, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Cicuttini, Flavia M" sort="Cicuttini, Flavia M" uniqKey="Cicuttini F" first="Flavia M" last="Cicuttini">Flavia M. Cicuttini</name><affiliation><nlm:affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Joint, bone, spine : revue du rhumatisme</title><idno type="eISSN">1778-7254</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vertebral endplate (Modic) lesions are gaining interest, with varied phenotypes recognised to have distinct clinical and histological correlates. Nevertheless, the natural history of these lesions is unclear. This study examined the natural history of Modic changes and their potential relationship to the intervertebral disc.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27324605</PMID><DateCreated><Year>2016</Year><Month>06</Month><Day>21</Day></DateCreated><DateRevised><Year>2017</Year><Month>03</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1778-7254</ISSN><JournalIssue CitedMedium="Internet"><Volume>84</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Joint, bone, spine : revue du rhumatisme</Title><ISOAbbreviation>Joint Bone Spine</ISOAbbreviation></Journal><ArticleTitle>The natural history of Modic changes in a community-based cohort.</ArticleTitle><Pagination><MedlinePgn>197-202</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1297-319X(16)30073-2</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jbspin.2016.03.011</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Vertebral endplate (Modic) lesions are gaining interest, with varied phenotypes recognised to have distinct clinical and histological correlates. Nevertheless, the natural history of these lesions is unclear. This study examined the natural history of Modic changes and their potential relationship to the intervertebral disc.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Seventy-two community-based adults not selected for low back pain had lumbar spine magnetic resonance imaging (MRI) performed at baseline (2012) and approximately 2 years later to assess Modic lesions. Fifty-six participants completed the study. Intervertebral disc pathology was assessed by disc height and the Pfirrmann grading system at baseline.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">At baseline, 6 Modic type 1 lesions were present in 3 (4.2%) participants. At follow-up, 4 persisted, 2 changed to a Modic type 2 lesion, and there were 4 incident lesions. Only 1 participant (1.4%) had a baseline Modic type 3 lesion, which persisted at follow-up, with one further incident lesion. Modic type 2 lesions were most common (n=47, in 20 of 72 [27.8%] participants). Resolution of Modic type 2 lesions was uncommon (n=1, with 2 changing to a type 1 lesion). 18 incident lesions occurred in 7 (12.5%) participants, with most occurring both sides of the intervertebral disc. A reduction in the average baseline disc height was associated with an increased risk for type 2 incident lesions (OR 1.9, 95% CI 1.1 to 3.3, P=0.03). Similarly, severe baseline disc degeneration at L3/4, L4/5 and L5/S1 was associated with an increased risk for type 2 incident lesions (all P≤0.05).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">This longitudinal study has demonstrated that Modic type 2 are the most common of the Modic lesions in community-based adults and while resolution of these lesions is uncommon, incident disease develops on both sides of the intervertebral disc in the setting of severe disc degeneration. These results suggest that type 2 Modic changes are a sequel of disc degeneration.</AbstractText><CopyrightInformation>Copyright © 2016 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Teichtahl</LastName><ForeName>Andrew J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia; Baker IDI Heart and Diabetes Institute, Commercial Road, 3004 Melbourne, Australia. Electronic address: andrew.teichtahl@monash.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Finnin</LastName><ForeName>Monica A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia; Baker IDI Heart and Diabetes Institute, Commercial Road, 3004 Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yuanyuan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wluka</LastName><ForeName>Anita E</ForeName><Initials>AE</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Urquhart</LastName><ForeName>Donna M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>O'Sullivan</LastName><ForeName>Richard</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Healthcare Imaging Services, Epworth Hospital, 3121 Richmond, Australia; Department of Medicine, Central Clinical School, Monash University, 3004 Melbourne, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jones</LastName><ForeName>Graeme</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Menzies Research Institute, Tasmania, Private bag 23, 7000 Hobart, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cicuttini</LastName><ForeName>Flavia M</ForeName><Initials>FM</Initials><AffiliationInfo><Affiliation>Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, 3004 Melbourne, Australia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>06</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>France</Country><MedlineTA>Joint Bone Spine</MedlineTA><NlmUniqueID>100938016</NlmUniqueID><ISSNLinking>1297-319X</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Intervertebral disc</Keyword><Keyword MajorTopicYN="N">Lumbar spine</Keyword><Keyword MajorTopicYN="N">Modic</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>02</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>03</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27324605</ArticleId><ArticleId IdType="pii">S1297-319X(16)30073-2</ArticleId><ArticleId IdType="doi">10.1016/j.jbspin.2016.03.011</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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