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Ocular Complications in Survivors of the Ebola Outbreak in Guinea.

Identifieur interne : 001037 ( PubMed/Corpus ); précédent : 001036; suivant : 001038

Ocular Complications in Survivors of the Ebola Outbreak in Guinea.

Auteurs : Esther Hereth-Hebert ; Mamadou Oury Bah ; Jean François Etard ; Mamadou Saliou Sow ; Serge Resnikoff ; Christine Fardeau ; Abdoulaye Toure ; Alexis Niouma Ouendeno ; Isaac Ceougna Sagno ; Laura March ; Suzanne Izard ; Pierre Louis Lama ; Moumié Barry ; Eric Delaporte

Source :

RBID : pubmed:27998698

English descriptors

Abstract

The Ebola outbreak of 2013-2016 severely affected West Africa and resulted in 2544 deaths and 1270 survivors in Guinea, the country where it began. This Ebola virus was the Zaire strain of the virus family Filoviridae. In this outbreak the case fatality rate was about 67%. The survivors, declared cured after 2 negative blood polymerase chain reaction (PCR) results, face psychosocial disorders and rheumatic, ear-nose-throat, neurocognitive, and ophthalmologic complications. The goal of this study was to detect and describe ocular complications afflicting these survivors and to observe their occurrence and recurrences.

DOI: 10.1016/j.ajo.2016.12.005
PubMed: 27998698

Links to Exploration step

pubmed:27998698

Le document en format XML

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<div type="abstract" xml:lang="en">The Ebola outbreak of 2013-2016 severely affected West Africa and resulted in 2544 deaths and 1270 survivors in Guinea, the country where it began. This Ebola virus was the Zaire strain of the virus family Filoviridae. In this outbreak the case fatality rate was about 67%. The survivors, declared cured after 2 negative blood polymerase chain reaction (PCR) results, face psychosocial disorders and rheumatic, ear-nose-throat, neurocognitive, and ophthalmologic complications. The goal of this study was to detect and describe ocular complications afflicting these survivors and to observe their occurrence and recurrences.</div>
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<Month>Mar</Month>
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<Title>American journal of ophthalmology</Title>
<ISOAbbreviation>Am. J. Ophthalmol.</ISOAbbreviation>
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<ArticleTitle>Ocular Complications in Survivors of the Ebola Outbreak in Guinea.</ArticleTitle>
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<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">The Ebola outbreak of 2013-2016 severely affected West Africa and resulted in 2544 deaths and 1270 survivors in Guinea, the country where it began. This Ebola virus was the Zaire strain of the virus family Filoviridae. In this outbreak the case fatality rate was about 67%. The survivors, declared cured after 2 negative blood polymerase chain reaction (PCR) results, face psychosocial disorders and rheumatic, ear-nose-throat, neurocognitive, and ophthalmologic complications. The goal of this study was to detect and describe ocular complications afflicting these survivors and to observe their occurrence and recurrences.</AbstractText>
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<AbstractText Label="METHODS" NlmCategory="METHODS">This prospective observational multicenter cohort study was initiated in March 2015. The cohort study included 341 survivors followed up in the infectious disease ward of Conakry, Forecariah, and Nzérékoré as of May 2016. The patients received multidisciplinary medical follow-up expected to last at least 1 year that included an eye examination as part of complete, free treatment.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Systematic examination of 341 patients revealed 46 cases of uveitis (13.5%), 6 cases of episcleritis (1.8%), and 3 cases of interstitial keratitis (0.9%). Uveitis was most frequently unilateral (78.3%) and anterior (47.8%) and occurred within the 2 months after discharge from the Ebola treatment center. Moreover, uveitis relapses were found up to 13 months after the negative PCR result for Ebola in the blood.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Nearly 1 out of 6 survivors presented ocular disorders after discharge from the Ebola treatment center. An ophthalmologic follow-up for Ebola-infected patients should start, if possible, during the acute phase of the disease and last more than 1 year. Treatment guidelines need to be urgently developed and implemented.</AbstractText>
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<LastName>Barry</LastName>
<ForeName>Moumié</ForeName>
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<Affiliation>Infectious Disease Department, Donka University National Hospital, Conakry, Guinea.</Affiliation>
</AffiliationInfo>
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<Affiliation>IRD UMI 233 INSERM U 1175, University of Montpellier, Montpellier, France.</Affiliation>
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