Multiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa.
Identifieur interne : 001025 ( PubMed/Corpus ); précédent : 001024; suivant : 001026Multiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa.
Auteurs : Koen Vandelannoote ; Conor J. Meehan ; Miriam Eddyani ; Dissou Affolabi ; Delphin Mavinga Phanzu ; Sara Eyangoh ; Kurt Jordaens ; Françoise Portaels ; Kirstie Mangas ; Torsten Seemann ; Laurent Marsollier ; Estelle Marion ; Annick Chauty ; Jordi Landier ; Arnaud Fontanet ; Herwig Leirs ; Timothy P. Stinear ; Bouke C. De JongSource :
- Genome biology and evolution [ 1759-6653 ] ; 2017.
English descriptors
- KwdEn :
- Africa, Buruli Ulcer (genetics), Buruli Ulcer (microbiology), Buruli Ulcer (transmission), Evolution, Molecular, Genetic Variation, Genetics, Population, Genome, Bacterial, Humans, Mycobacterium ulcerans (genetics), Mycobacterium ulcerans (pathogenicity), Phylogeny, Polymorphism, Single Nucleotide, Sequence Analysis, DNA.
- MESH :
- genetics : Buruli Ulcer, Mycobacterium ulcerans.
- microbiology : Buruli Ulcer.
- pathogenicity : Mycobacterium ulcerans.
- transmission : Buruli Ulcer.
- Africa, Evolution, Molecular, Genetic Variation, Genetics, Population, Genome, Bacterial, Humans, Phylogeny, Polymorphism, Single Nucleotide, Sequence Analysis, DNA.
Abstract
Buruli ulcer (BU) is an insidious neglected tropical disease. Cases are reported around the world but the rural regions of West and Central Africa are most affected. How BU is transmitted and spreads has remained a mystery, even though the causative agent, Mycobacterium ulcerans, has been known for more than 70 years. Here, using the tools of population genomics, we reconstruct the evolutionary history of M. ulcerans by comparing 165 isolates spanning 48 years and representing 11 endemic countries across Africa. The genetic diversity of African M. ulcerans was found to be restricted due to the bacterium's slow substitution rate coupled with its relatively recent origin. We identified two specific M. ulcerans lineages within the African continent, and inferred that M. ulcerans lineage Mu_A1 existed in Africa for several hundreds of years, unlike lineage Mu_A2, which was introduced much more recently, approximately during the 19th century. Additionally, we observed that specific M. ulcerans epidemic Mu_A1 clones were introduced during the same time period in the three hydrological basins that were well covered in our panel. The estimated time span of the introduction events coincides with the Neo-imperialism period, during which time the European colonial powers divided the African continent among themselves. Using this temporal association, and in the absence of a known BU reservoir or-vector on the continent, we postulate that the so-called "Scramble for Africa" played a significant role in the spread of the disease across the continent.
DOI: 10.1093/gbe/evx003
PubMed: 28137745
Links to Exploration step
pubmed:28137745Le document en format XML
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<author><name sortKey="Fontanet, Arnaud" sort="Fontanet, Arnaud" uniqKey="Fontanet A" first="Arnaud" last="Fontanet">Arnaud Fontanet</name>
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<author><name sortKey="Phanzu, Delphin Mavinga" sort="Phanzu, Delphin Mavinga" uniqKey="Phanzu D" first="Delphin Mavinga" last="Phanzu">Delphin Mavinga Phanzu</name>
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<author><name sortKey="Eyangoh, Sara" sort="Eyangoh, Sara" uniqKey="Eyangoh S" first="Sara" last="Eyangoh">Sara Eyangoh</name>
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<author><name sortKey="Seemann, Torsten" sort="Seemann, Torsten" uniqKey="Seemann T" first="Torsten" last="Seemann">Torsten Seemann</name>
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</affiliation>
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<author><name sortKey="Marsollier, Laurent" sort="Marsollier, Laurent" uniqKey="Marsollier L" first="Laurent" last="Marsollier">Laurent Marsollier</name>
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</affiliation>
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<author><name sortKey="Marion, Estelle" sort="Marion, Estelle" uniqKey="Marion E" first="Estelle" last="Marion">Estelle Marion</name>
<affiliation><nlm:affiliation>CRCNA Inserm U892 CNRS 6299, CHU & Université d'Angers, Angers, France.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Chauty, Annick" sort="Chauty, Annick" uniqKey="Chauty A" first="Annick" last="Chauty">Annick Chauty</name>
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</affiliation>
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<author><name sortKey="Landier, Jordi" sort="Landier, Jordi" uniqKey="Landier J" first="Jordi" last="Landier">Jordi Landier</name>
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</affiliation>
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<author><name sortKey="Fontanet, Arnaud" sort="Fontanet, Arnaud" uniqKey="Fontanet A" first="Arnaud" last="Fontanet">Arnaud Fontanet</name>
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</affiliation>
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<author><name sortKey="Leirs, Herwig" sort="Leirs, Herwig" uniqKey="Leirs H" first="Herwig" last="Leirs">Herwig Leirs</name>
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</affiliation>
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<author><name sortKey="Stinear, Timothy P" sort="Stinear, Timothy P" uniqKey="Stinear T" first="Timothy P" last="Stinear">Timothy P. Stinear</name>
<affiliation><nlm:affiliation>Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="De Jong, Bouke C" sort="De Jong, Bouke C" uniqKey="De Jong B" first="Bouke C" last="De Jong">Bouke C. De Jong</name>
<affiliation><nlm:affiliation>Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.</nlm:affiliation>
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<series><title level="j">Genome biology and evolution</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa</term>
<term>Buruli Ulcer (genetics)</term>
<term>Buruli Ulcer (microbiology)</term>
<term>Buruli Ulcer (transmission)</term>
<term>Evolution, Molecular</term>
<term>Genetic Variation</term>
<term>Genetics, Population</term>
<term>Genome, Bacterial</term>
<term>Humans</term>
<term>Mycobacterium ulcerans (genetics)</term>
<term>Mycobacterium ulcerans (pathogenicity)</term>
<term>Phylogeny</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Buruli Ulcer</term>
<term>Mycobacterium ulcerans</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Buruli Ulcer</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Mycobacterium ulcerans</term>
</keywords>
<keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Buruli Ulcer</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Africa</term>
<term>Evolution, Molecular</term>
<term>Genetic Variation</term>
<term>Genetics, Population</term>
<term>Genome, Bacterial</term>
<term>Humans</term>
<term>Phylogeny</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Sequence Analysis, DNA</term>
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<front><div type="abstract" xml:lang="en">Buruli ulcer (BU) is an insidious neglected tropical disease. Cases are reported around the world but the rural regions of West and Central Africa are most affected. How BU is transmitted and spreads has remained a mystery, even though the causative agent, Mycobacterium ulcerans, has been known for more than 70 years. Here, using the tools of population genomics, we reconstruct the evolutionary history of M. ulcerans by comparing 165 isolates spanning 48 years and representing 11 endemic countries across Africa. The genetic diversity of African M. ulcerans was found to be restricted due to the bacterium's slow substitution rate coupled with its relatively recent origin. We identified two specific M. ulcerans lineages within the African continent, and inferred that M. ulcerans lineage Mu_A1 existed in Africa for several hundreds of years, unlike lineage Mu_A2, which was introduced much more recently, approximately during the 19th century. Additionally, we observed that specific M. ulcerans epidemic Mu_A1 clones were introduced during the same time period in the three hydrological basins that were well covered in our panel. The estimated time span of the introduction events coincides with the Neo-imperialism period, during which time the European colonial powers divided the African continent among themselves. Using this temporal association, and in the absence of a known BU reservoir or-vector on the continent, we postulate that the so-called "Scramble for Africa" played a significant role in the spread of the disease across the continent.</div>
</front>
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<ArticleTitle>Multiple Introductions and Recent Spread of the Emerging Human Pathogen Mycobacterium ulcerans across Africa.</ArticleTitle>
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<Abstract><AbstractText>Buruli ulcer (BU) is an insidious neglected tropical disease. Cases are reported around the world but the rural regions of West and Central Africa are most affected. How BU is transmitted and spreads has remained a mystery, even though the causative agent, Mycobacterium ulcerans, has been known for more than 70 years. Here, using the tools of population genomics, we reconstruct the evolutionary history of M. ulcerans by comparing 165 isolates spanning 48 years and representing 11 endemic countries across Africa. The genetic diversity of African M. ulcerans was found to be restricted due to the bacterium's slow substitution rate coupled with its relatively recent origin. We identified two specific M. ulcerans lineages within the African continent, and inferred that M. ulcerans lineage Mu_A1 existed in Africa for several hundreds of years, unlike lineage Mu_A2, which was introduced much more recently, approximately during the 19th century. Additionally, we observed that specific M. ulcerans epidemic Mu_A1 clones were introduced during the same time period in the three hydrological basins that were well covered in our panel. The estimated time span of the introduction events coincides with the Neo-imperialism period, during which time the European colonial powers divided the African continent among themselves. Using this temporal association, and in the absence of a known BU reservoir or-vector on the continent, we postulate that the so-called "Scramble for Africa" played a significant role in the spread of the disease across the continent.</AbstractText>
<CopyrightInformation>© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vandelannoote</LastName>
<ForeName>Koen</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Evolutionary Ecology Group University of Antwerp, Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Meehan</LastName>
<ForeName>Conor J</ForeName>
<Initials>CJ</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eddyani</LastName>
<ForeName>Miriam</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Affolabi</LastName>
<ForeName>Dissou</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Référence des Mycobactéries, Cotonou, Benin.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Phanzu</LastName>
<ForeName>Delphin Mavinga</ForeName>
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<AffiliationInfo><Affiliation>Institut Médical Evangélique, Kimpese, Republic, Democratic of Congo.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Eyangoh</LastName>
<ForeName>Sara</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Service de Mycobactériologie, Centre Pasteur du Cameroun, Yaoundé, Cameroun.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Jordaens</LastName>
<ForeName>Kurt</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Evolutionary Ecology Group University of Antwerp, Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Invertebrates Section, Royal Museum for Central Africa, Tervuren, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Portaels</LastName>
<ForeName>Françoise</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Mangas</LastName>
<ForeName>Kirstie</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Seemann</LastName>
<ForeName>Torsten</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Victorian Life Sciences Computation Initiative University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marsollier</LastName>
<ForeName>Laurent</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>CRCNA Inserm U892 CNRS 6299, CHU & Université d'Angers, Angers, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Marion</LastName>
<ForeName>Estelle</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>CRCNA Inserm U892 CNRS 6299, CHU & Université d'Angers, Angers, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chauty</LastName>
<ForeName>Annick</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>CDTUB de Pobè, Pobè, Benin.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Landier</LastName>
<ForeName>Jordi</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Service de Mycobactériologie, Centre Pasteur du Cameroun, Yaoundé, Cameroun.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fontanet</LastName>
<ForeName>Arnaud</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Emerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Leirs</LastName>
<ForeName>Herwig</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Evolutionary Ecology Group University of Antwerp, Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Stinear</LastName>
<ForeName>Timothy P</ForeName>
<Initials>TP</Initials>
<AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>de Jong</LastName>
<ForeName>Bouke C</ForeName>
<Initials>BC</Initials>
<AffiliationInfo><Affiliation>Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
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<Language>eng</Language>
<GrantList CompleteYN="Y"><Grant><GrantID>311725</GrantID>
<Agency>European Research Council</Agency>
<Country>International</Country>
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